Incidental Mutation 'R9800:Map3k2'
ID 735190
Institutional Source Beutler Lab
Gene Symbol Map3k2
Ensembl Gene ENSMUSG00000024383
Gene Name mitogen-activated protein kinase kinase kinase 2
Synonyms MEK kinase 2, Mekk2, 9630061B06Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9800 (G1)
Quality Score 225.009
Status Not validated
Chromosome 18
Chromosomal Location 32163089-32236751 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32200016 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 81 (D81V)
Ref Sequence ENSEMBL: ENSMUSP00000094326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096575]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000096575
AA Change: D81V

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000094326
Gene: ENSMUSG00000024383
AA Change: D81V

DomainStartEndE-ValueType
PB1 43 122 6.96e-20 SMART
low complexity region 203 219 N/A INTRINSIC
low complexity region 300 315 N/A INTRINSIC
low complexity region 322 334 N/A INTRINSIC
S_TKc 356 616 2.86e-92 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene are grossly normal and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T A 7: 120,520,060 I1009N possibly damaging Het
Adcy8 T A 15: 64,699,246 N1213Y probably benign Het
Ahctf1 T C 1: 179,753,868 S1590G possibly damaging Het
Ahcyl1 A T 3: 107,670,272 N277K probably damaging Het
Ank2 A T 3: 126,946,500 S1912T unknown Het
Ank3 T A 10: 69,898,127 N740K unknown Het
Atp13a3 A C 16: 30,340,233 I800S probably benign Het
AU041133 T A 10: 82,150,845 C111S probably damaging Het
Azi2 T A 9: 118,055,856 I211N probably benign Het
Btbd11 C A 10: 85,388,215 A296E unknown Het
Camk2b T C 11: 5,972,408 N480S probably damaging Het
Card6 A G 15: 5,099,220 V898A probably benign Het
Copb2 T A 9: 98,579,028 M381K probably damaging Het
Crisp1 A T 17: 40,305,180 M102K probably damaging Het
Dcxr A T 11: 120,727,258 probably benign Het
Dennd5a C A 7: 109,901,167 R917L probably benign Het
Egflam T A 15: 7,250,044 T494S probably benign Het
Fkbpl T A 17: 34,645,717 M153K probably benign Het
Helz2 A T 2: 181,240,823 I59N probably damaging Het
Ldlrap1 T C 4: 134,749,992 T194A probably benign Het
Lman1l T C 9: 57,615,777 D133G probably damaging Het
Lrrc27 T C 7: 139,227,997 M340T probably benign Het
Lum T A 10: 97,568,295 S17R probably benign Het
Malrd1 A G 2: 15,842,594 K1182E unknown Het
Muc5b A T 7: 141,861,743 T2809S possibly damaging Het
Nle1 C A 11: 82,903,050 V387L probably benign Het
Nr1h4 T C 10: 89,454,756 D474G probably benign Het
Nup205 T C 6: 35,186,533 I144T possibly damaging Het
Olfr1122 G T 2: 87,388,164 C153F probably damaging Het
Olfr1309 G A 2: 111,983,849 S75L possibly damaging Het
Olfr23 C A 11: 73,941,160 L305I probably benign Het
Olfr444 A T 6: 42,956,157 I220F probably damaging Het
Olfr566 T C 7: 102,856,886 Y132C probably benign Het
Olfr732 G A 14: 50,282,244 T3I probably benign Het
Pkn3 C T 2: 30,083,278 R371* probably null Het
Plin2 A T 4: 86,668,505 S30T possibly damaging Het
Ppfibp1 T C 6: 147,016,271 V475A probably benign Het
Ppp2ca T C 11: 52,118,083 Y137H probably damaging Het
Rasgrf2 T A 13: 92,131,352 Q48L probably damaging Het
Rnf168 G C 16: 32,298,568 V316L probably benign Het
Shank1 G A 7: 44,312,918 S71N unknown Het
Spata31d1d T C 13: 59,726,823 H966R possibly damaging Het
Speg C A 1: 75,422,714 D2268E probably benign Het
Srp54c A G 12: 55,250,026 I170V probably benign Het
Syde2 A G 3: 145,998,609 R439G probably benign Het
Tcof1 T C 18: 60,816,486 K1155R unknown Het
Tmem184c T C 8: 77,596,458 I592V probably benign Het
Trav6-7-dv9 A G 14: 53,710,212 Y57C probably damaging Het
Trpc1 T A 9: 95,743,250 I108F probably damaging Het
Virma A T 4: 11,546,007 H1615L probably damaging Het
Vmn2r10 A T 5: 109,002,538 D213E probably damaging Het
Vmn2r116 T A 17: 23,401,425 V711E probably damaging Het
Vps16 T C 2: 130,440,485 F413L probably benign Het
Vwa1 G A 4: 155,772,879 P154L probably damaging Het
Wasf1 T C 10: 40,936,697 I494T unknown Het
Wdr36 A G 18: 32,852,647 D539G possibly damaging Het
Zfp81 A T 17: 33,335,437 C134* probably null Het
Other mutations in Map3k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00770:Map3k2 APN 18 32228239 missense probably benign 0.00
IGL00774:Map3k2 APN 18 32228239 missense probably benign 0.00
IGL01993:Map3k2 APN 18 32226631 nonsense probably null
IGL02043:Map3k2 APN 18 32207534 missense probably damaging 1.00
IGL02314:Map3k2 APN 18 32218500 splice site probably benign
IGL02441:Map3k2 APN 18 32200046 splice site probably benign
IGL03350:Map3k2 APN 18 32212148 missense probably damaging 0.98
IGL03097:Map3k2 UTSW 18 32200017 missense probably benign 0.01
PIT4434001:Map3k2 UTSW 18 32210035 missense possibly damaging 0.51
R0086:Map3k2 UTSW 18 32218468 missense probably damaging 1.00
R0374:Map3k2 UTSW 18 32212173 splice site probably null
R0445:Map3k2 UTSW 18 32217210 missense probably damaging 0.96
R1158:Map3k2 UTSW 18 32217158 missense probably benign 0.00
R1415:Map3k2 UTSW 18 32228277 missense possibly damaging 0.82
R1667:Map3k2 UTSW 18 32203792 splice site probably benign
R1926:Map3k2 UTSW 18 32203110 missense probably damaging 0.99
R3795:Map3k2 UTSW 18 32226648 missense probably benign 0.00
R4607:Map3k2 UTSW 18 32199977 missense probably damaging 1.00
R4793:Map3k2 UTSW 18 32228150 missense probably damaging 1.00
R5332:Map3k2 UTSW 18 32207456 missense probably damaging 0.98
R5492:Map3k2 UTSW 18 32228136 missense probably damaging 1.00
R6008:Map3k2 UTSW 18 32203051 missense probably damaging 1.00
R6317:Map3k2 UTSW 18 32203033 missense probably damaging 1.00
R6356:Map3k2 UTSW 18 32211970 missense probably damaging 1.00
R6841:Map3k2 UTSW 18 32226629 missense probably benign 0.12
R6928:Map3k2 UTSW 18 32207540 critical splice donor site probably null
R7475:Map3k2 UTSW 18 32199962 missense possibly damaging 0.61
R7696:Map3k2 UTSW 18 32220594 missense probably benign 0.00
R8774:Map3k2 UTSW 18 32212064 missense probably damaging 1.00
R8774-TAIL:Map3k2 UTSW 18 32212064 missense probably damaging 1.00
R9103:Map3k2 UTSW 18 32220572 missense possibly damaging 0.91
R9282:Map3k2 UTSW 18 32209752 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCAGTCTATTACACACATGCAC -3'
(R):5'- GTCTTAGCTATGTGCACAGTAGC -3'

Sequencing Primer
(F):5'- GATTTAAACACTCTCCTAAGTAGCAC -3'
(R):5'- GTAGCACCCCACTTAACAGTAAAATC -3'
Posted On 2022-11-14