Incidental Mutation 'R9800:Vmn2r10'
| ID |
735150 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
R9800 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109150404 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 213
(D213E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000079163
AA Change: D213E
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: D213E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.5%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
T |
A |
7: 120,119,283 (GRCm39) |
I1009N |
possibly damaging |
Het |
| Abtb3 |
C |
A |
10: 85,224,079 (GRCm39) |
A296E |
unknown |
Het |
| Adcy8 |
T |
A |
15: 64,571,095 (GRCm39) |
N1213Y |
probably benign |
Het |
| Ahctf1 |
T |
C |
1: 179,581,433 (GRCm39) |
S1590G |
possibly damaging |
Het |
| Ahcyl1 |
A |
T |
3: 107,577,588 (GRCm39) |
N277K |
probably damaging |
Het |
| Ank2 |
A |
T |
3: 126,740,149 (GRCm39) |
S1912T |
unknown |
Het |
| Ank3 |
T |
A |
10: 69,733,957 (GRCm39) |
N740K |
unknown |
Het |
| Atp13a3 |
A |
C |
16: 30,159,051 (GRCm39) |
I800S |
probably benign |
Het |
| AU041133 |
T |
A |
10: 81,986,679 (GRCm39) |
C111S |
probably damaging |
Het |
| Azi2 |
T |
A |
9: 117,884,924 (GRCm39) |
I211N |
probably benign |
Het |
| Camk2b |
T |
C |
11: 5,922,408 (GRCm39) |
N480S |
probably damaging |
Het |
| Card6 |
A |
G |
15: 5,128,702 (GRCm39) |
V898A |
probably benign |
Het |
| Copb2 |
T |
A |
9: 98,461,081 (GRCm39) |
M381K |
probably damaging |
Het |
| Cplx3 |
T |
C |
9: 57,523,060 (GRCm39) |
D133G |
probably damaging |
Het |
| Crisp1 |
A |
T |
17: 40,616,071 (GRCm39) |
M102K |
probably damaging |
Het |
| Dcxr |
A |
T |
11: 120,618,084 (GRCm39) |
|
probably benign |
Het |
| Dennd5a |
C |
A |
7: 109,500,374 (GRCm39) |
R917L |
probably benign |
Het |
| Egflam |
T |
A |
15: 7,279,525 (GRCm39) |
T494S |
probably benign |
Het |
| Fkbpl |
T |
A |
17: 34,864,691 (GRCm39) |
M153K |
probably benign |
Het |
| Helz2 |
A |
T |
2: 180,882,616 (GRCm39) |
I59N |
probably damaging |
Het |
| Ldlrap1 |
T |
C |
4: 134,477,303 (GRCm39) |
T194A |
probably benign |
Het |
| Lrrc27 |
T |
C |
7: 138,807,913 (GRCm39) |
M340T |
probably benign |
Het |
| Lum |
T |
A |
10: 97,404,157 (GRCm39) |
S17R |
probably benign |
Het |
| Malrd1 |
A |
G |
2: 15,847,405 (GRCm39) |
K1182E |
unknown |
Het |
| Map3k2 |
A |
T |
18: 32,333,069 (GRCm39) |
D81V |
possibly damaging |
Het |
| Muc5b |
A |
T |
7: 141,415,480 (GRCm39) |
T2809S |
possibly damaging |
Het |
| Nle1 |
C |
A |
11: 82,793,876 (GRCm39) |
V387L |
probably benign |
Het |
| Nr1h4 |
T |
C |
10: 89,290,618 (GRCm39) |
D474G |
probably benign |
Het |
| Nup205 |
T |
C |
6: 35,163,468 (GRCm39) |
I144T |
possibly damaging |
Het |
| Or10ag57 |
G |
T |
2: 87,218,508 (GRCm39) |
C153F |
probably damaging |
Het |
| Or1e17 |
C |
A |
11: 73,831,986 (GRCm39) |
L305I |
probably benign |
Het |
| Or2a56 |
A |
T |
6: 42,933,091 (GRCm39) |
I220F |
probably damaging |
Het |
| Or4f15 |
G |
A |
2: 111,814,194 (GRCm39) |
S75L |
possibly damaging |
Het |
| Or4n4 |
G |
A |
14: 50,519,701 (GRCm39) |
T3I |
probably benign |
Het |
| Or51f1 |
T |
C |
7: 102,506,093 (GRCm39) |
Y132C |
probably benign |
Het |
| Pkn3 |
C |
T |
2: 29,973,290 (GRCm39) |
R371* |
probably null |
Het |
| Plin2 |
A |
T |
4: 86,586,742 (GRCm39) |
S30T |
possibly damaging |
Het |
| Ppfibp1 |
T |
C |
6: 146,917,769 (GRCm39) |
V475A |
probably benign |
Het |
| Ppp2ca |
T |
C |
11: 52,008,910 (GRCm39) |
Y137H |
probably damaging |
Het |
| Rasgrf2 |
T |
A |
13: 92,267,860 (GRCm39) |
Q48L |
probably damaging |
Het |
| Rnf168 |
G |
C |
16: 32,117,386 (GRCm39) |
V316L |
probably benign |
Het |
| Shank1 |
G |
A |
7: 43,962,342 (GRCm39) |
S71N |
unknown |
Het |
| Spata31d1d |
T |
C |
13: 59,874,637 (GRCm39) |
H966R |
possibly damaging |
Het |
| Speg |
C |
A |
1: 75,399,358 (GRCm39) |
D2268E |
probably benign |
Het |
| Srp54c |
A |
G |
12: 55,296,811 (GRCm39) |
I170V |
probably benign |
Het |
| Syde2 |
A |
G |
3: 145,704,364 (GRCm39) |
R439G |
probably benign |
Het |
| Tcof1 |
T |
C |
18: 60,949,558 (GRCm39) |
K1155R |
unknown |
Het |
| Tmem184c |
T |
C |
8: 78,323,087 (GRCm39) |
I592V |
probably benign |
Het |
| Trav6-7-dv9 |
A |
G |
14: 53,947,669 (GRCm39) |
Y57C |
probably damaging |
Het |
| Trpc1 |
T |
A |
9: 95,625,303 (GRCm39) |
I108F |
probably damaging |
Het |
| Virma |
A |
T |
4: 11,546,007 (GRCm39) |
H1615L |
probably damaging |
Het |
| Vmn2r116 |
T |
A |
17: 23,620,399 (GRCm39) |
V711E |
probably damaging |
Het |
| Vps16 |
T |
C |
2: 130,282,405 (GRCm39) |
F413L |
probably benign |
Het |
| Vwa1 |
G |
A |
4: 155,857,336 (GRCm39) |
P154L |
probably damaging |
Het |
| Wasf1 |
T |
C |
10: 40,812,693 (GRCm39) |
I494T |
unknown |
Het |
| Wdr36 |
A |
G |
18: 32,985,700 (GRCm39) |
D539G |
possibly damaging |
Het |
| Zfp81 |
A |
T |
17: 33,554,411 (GRCm39) |
C134* |
probably null |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01985:Vmn2r10
|
APN |
5 |
109,154,125 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCTTCTAAAGCTAACTTCTAAGG -3'
(R):5'- CCTAACAATCTTATTCCTCATGTGG -3'
Sequencing Primer
(F):5'- CTTCTAAGGTAGAGTTCATTTCACC -3'
(R):5'- ATTCCTCATGTGGATGTTTTATTCTC -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation