Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01516:Tas2r115'

90412

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r115

Ensembl Gene

ENSMUSG00000071149

Gene Name

taste receptor, type 2, member 115

Synonyms

T2R15, mt2r49, Tas2r15, mGR15

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01516

Quality Score

Status

Chromosome

Chromosomal Location

132714017-132714949 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 132714576 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 125 (V125A)

Ref Sequence

ENSEMBL: ENSMUSP00000093043 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095394]

AlphaFold

Q7M719

Predicted Effect

probably damaging
Transcript: ENSMUST00000095394
AA Change: V125A

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000093043
Gene: ENSMUSG00000071149
AA Change: V125A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	299	2.2e-84	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921517D22Rik	A	G	13: 59,838,548 (GRCm39)	S95P	probably benign	Het
Abca6	T	A	11: 110,109,043 (GRCm39)	H709L	possibly damaging	Het
Bpifb1	A	G	2: 154,060,172 (GRCm39)	Y455C	probably benign	Het
Clk1	G	A	1: 58,453,563 (GRCm39)	T341I	probably damaging	Het
Corin	A	T	5: 72,611,830 (GRCm39)	Y77*	probably null	Het
Cps1	C	T	1: 67,269,443 (GRCm39)	R1481C	probably damaging	Het
Cspg5	A	G	9: 110,075,761 (GRCm39)	K166E	probably benign	Het
Dcxr	A	G	11: 120,616,584 (GRCm39)		probably null	Het
Epha5	C	A	5: 84,534,135 (GRCm39)	L65F	probably damaging	Het
Erbb4	T	A	1: 68,367,404 (GRCm39)	K438*	probably null	Het
Gldc	A	T	19: 30,076,432 (GRCm39)	C1005S	probably damaging	Het
Hs3st5	C	T	10: 36,709,047 (GRCm39)	T194I	probably damaging	Het
Hspa12a	T	A	19: 58,816,108 (GRCm39)	D45V	probably benign	Het
Il1rn	C	T	2: 24,239,551 (GRCm39)	T130I	probably damaging	Het
Klk1b22	G	T	7: 43,765,732 (GRCm39)	C196F	probably damaging	Het
Lamp1	C	T	8: 13,223,863 (GRCm39)	H332Y	probably damaging	Het
Limd2	T	C	11: 106,049,870 (GRCm39)	T40A	probably benign	Het
Lztr1	G	A	16: 17,340,255 (GRCm39)		probably null	Het
Mbd4	T	C	6: 115,826,491 (GRCm39)	T167A	probably damaging	Het
Mitf	T	A	6: 97,987,351 (GRCm39)		probably null	Het
Mlph	A	G	1: 90,867,112 (GRCm39)	D378G	probably damaging	Het
Mrgprb5	A	T	7: 47,818,132 (GRCm39)	L201Q	probably damaging	Het
Myo5b	A	T	18: 74,760,266 (GRCm39)	I261F	probably damaging	Het
Or8b3b	C	T	9: 38,584,159 (GRCm39)	V207I	probably benign	Het
Or9s23	A	T	1: 92,501,165 (GRCm39)	I91F	probably benign	Het
Paics	T	A	5: 77,104,578 (GRCm39)	L68I	probably damaging	Het
Pramel15	A	G	4: 144,104,337 (GRCm39)	V56A	probably damaging	Het
Prkca	C	T	11: 107,852,428 (GRCm39)	V102M	probably null	Het
Ptpn21	G	A	12: 98,681,448 (GRCm39)	T62I	probably damaging	Het
Ptpre	A	T	7: 135,266,728 (GRCm39)	E212V	probably damaging	Het
Rufy2	A	C	10: 62,847,212 (GRCm39)	K539Q	possibly damaging	Het
Serpinb9d	T	A	13: 33,386,654 (GRCm39)		probably null	Het
Smarcd1	T	C	15: 99,610,094 (GRCm39)	F442L	probably benign	Het
Tmem154	C	T	3: 84,591,897 (GRCm39)	H120Y	probably benign	Het
Tnrc6b	A	G	15: 80,786,823 (GRCm39)	K1321E	possibly damaging	Het
Trmt13	A	G	3: 116,383,459 (GRCm39)		probably benign	Het
Tsbp1	A	G	17: 34,668,234 (GRCm39)	D168G	possibly damaging	Het
Vmn1r19	T	C	6: 57,381,857 (GRCm39)	F137L	probably benign	Het
Vmn1r202	T	A	13: 22,685,632 (GRCm39)	T262S	possibly damaging	Het
Vmn2r57	A	G	7: 41,049,370 (GRCm39)	V793A	probably damaging	Het
Wapl	A	G	14: 34,414,038 (GRCm39)	N300S	probably damaging	Het
Xpot	T	A	10: 121,426,127 (GRCm39)		probably null	Het
Zfp784	G	A	7: 5,039,036 (GRCm39)		probably benign	Het
Zfyve26	G	T	12: 79,334,625 (GRCm39)	P131Q	probably benign	Het

Other mutations in Tas2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00565:Tas2r115	APN	6	132,714,741 (GRCm39)	missense	probably benign	0.11
IGL01285:Tas2r115	APN	6	132,714,641 (GRCm39)	missense	probably damaging	1.00
IGL01637:Tas2r115	APN	6	132,714,592 (GRCm39)	missense	probably damaging	0.99
IGL02041:Tas2r115	APN	6	132,714,430 (GRCm39)	missense	probably benign	0.13
IGL02178:Tas2r115	APN	6	132,714,271 (GRCm39)	missense	probably benign	0.11
R0467:Tas2r115	UTSW	6	132,714,682 (GRCm39)	missense	probably benign	0.02
R0553:Tas2r115	UTSW	6	132,714,922 (GRCm39)	missense	probably benign	0.18
R1425:Tas2r115	UTSW	6	132,714,442 (GRCm39)	missense	probably benign	0.02
R1770:Tas2r115	UTSW	6	132,714,934 (GRCm39)	missense	probably damaging	1.00
R2120:Tas2r115	UTSW	6	132,714,470 (GRCm39)	missense	possibly damaging	0.51
R2136:Tas2r115	UTSW	6	132,714,309 (GRCm39)	missense	probably damaging	0.99
R2141:Tas2r115	UTSW	6	132,714,321 (GRCm39)	missense	probably benign	0.43
R2142:Tas2r115	UTSW	6	132,714,321 (GRCm39)	missense	probably benign	0.43
R4479:Tas2r115	UTSW	6	132,714,495 (GRCm39)	missense	probably damaging	0.98
R4687:Tas2r115	UTSW	6	132,714,247 (GRCm39)	missense	possibly damaging	0.80
R4948:Tas2r115	UTSW	6	132,714,124 (GRCm39)	missense	probably damaging	1.00
R5097:Tas2r115	UTSW	6	132,714,216 (GRCm39)	missense	probably damaging	1.00
R5856:Tas2r115	UTSW	6	132,714,501 (GRCm39)	missense	possibly damaging	0.86
R6927:Tas2r115	UTSW	6	132,714,895 (GRCm39)	missense	probably damaging	1.00
R7473:Tas2r115	UTSW	6	132,714,214 (GRCm39)	missense	probably damaging	1.00
R7688:Tas2r115	UTSW	6	132,714,643 (GRCm39)	missense	probably damaging	1.00
R8415:Tas2r115	UTSW	6	132,714,798 (GRCm39)	missense	probably damaging	1.00
R8495:Tas2r115	UTSW	6	132,714,887 (GRCm39)	missense	probably damaging	1.00
R9032:Tas2r115	UTSW	6	132,714,327 (GRCm39)	missense	probably benign	0.37
R9085:Tas2r115	UTSW	6	132,714,327 (GRCm39)	missense	probably benign	0.37
R9318:Tas2r115	UTSW	6	132,714,472 (GRCm39)	missense	probably benign	0.01
R9665:Tas2r115	UTSW	6	132,714,390 (GRCm39)	missense	probably benign	0.31
R9751:Tas2r115	UTSW	6	132,714,918 (GRCm39)	missense	possibly damaging	0.85
Z1088:Tas2r115	UTSW	6	132,714,044 (GRCm39)	nonsense	probably null
Z1176:Tas2r115	UTSW	6	132,714,819 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09