Incidental Mutation 'R1902:Cnot1'
| ID |
212352 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cnot1
|
| Ensembl Gene |
ENSMUSG00000036550 |
| Gene Name |
CCR4-NOT transcription complex, subunit 1 |
| Synonyms |
6030411K04Rik |
| MMRRC Submission |
039922-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1902 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
96446079-96534092 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 96469749 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1369
(I1369V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063565
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068452]
[ENSMUST00000098473]
[ENSMUST00000211887]
[ENSMUST00000213006]
[ENSMUST00000213046]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000068452
AA Change: I1369V
PolyPhen 2
Score 0.504 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000063565
Gene: ENSMUSG00000036550
AA Change: I1369V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
PDB:4J8S|A
|
798 |
999 |
1e-137 |
PDB |
|
low complexity region
|
1011 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1055 |
N/A |
INTRINSIC |
|
PDB:4CT4|C
|
1056 |
1295 |
1e-148 |
PDB |
|
low complexity region
|
1296 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1345 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1381 |
1530 |
2.5e-56 |
PFAM |
|
low complexity region
|
1634 |
1648 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1991 |
2305 |
2.4e-125 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083155
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098473
AA Change: I1374V
PolyPhen 2
Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000096073
Gene: ENSMUSG00000036550
AA Change: I1374V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
181 |
189 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_HEAT
|
500 |
656 |
2.4e-57 |
PFAM |
|
low complexity region
|
687 |
698 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
796 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_TTP_bind
|
812 |
1004 |
1.4e-87 |
PFAM |
|
low complexity region
|
1016 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1060 |
N/A |
INTRINSIC |
|
Pfam:CNOT1_CAF1_bind
|
1087 |
1313 |
5.7e-99 |
PFAM |
|
low complexity region
|
1333 |
1350 |
N/A |
INTRINSIC |
|
Pfam:DUF3819
|
1387 |
1534 |
2.3e-57 |
PFAM |
|
low complexity region
|
1639 |
1653 |
N/A |
INTRINSIC |
|
Pfam:Not1
|
1998 |
2357 |
5.7e-157 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211887
AA Change: I1367V
PolyPhen 2
Score 0.322 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211973
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212195
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212340
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213006
AA Change: I1374V
PolyPhen 2
Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213046
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212415
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.7%
- 10x: 94.9%
- 20x: 91.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 128 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730507C01Rik |
C |
T |
12: 18,584,004 (GRCm39) |
Q355* |
probably null |
Het |
| Acacb |
A |
T |
5: 114,303,795 (GRCm39) |
R73* |
probably null |
Het |
| Adra1a |
T |
C |
14: 66,875,684 (GRCm39) |
S220P |
probably benign |
Het |
| Ano2 |
A |
T |
6: 125,849,647 (GRCm39) |
E126D |
probably damaging |
Het |
| Anpep |
C |
T |
7: 79,488,004 (GRCm39) |
E518K |
probably benign |
Het |
| Arhgap45 |
C |
A |
10: 79,861,300 (GRCm39) |
Q488K |
probably damaging |
Het |
| Arhgef7 |
C |
A |
8: 11,858,713 (GRCm39) |
|
probably null |
Het |
| Atxn7l3b |
A |
G |
10: 112,764,578 (GRCm39) |
I17T |
probably benign |
Het |
| Bpifb9a |
A |
T |
2: 154,103,911 (GRCm39) |
N118I |
probably benign |
Het |
| Btbd9 |
A |
T |
17: 30,749,202 (GRCm39) |
D37E |
probably damaging |
Het |
| C8a |
T |
C |
4: 104,713,798 (GRCm39) |
|
probably null |
Het |
| Capn13 |
G |
A |
17: 73,633,356 (GRCm39) |
S535F |
probably damaging |
Het |
| Carns1 |
G |
T |
19: 4,216,337 (GRCm39) |
P615Q |
probably damaging |
Het |
| Casz1 |
T |
C |
4: 149,020,652 (GRCm39) |
I479T |
possibly damaging |
Het |
| Ccdc88a |
G |
T |
11: 29,411,788 (GRCm39) |
M532I |
probably benign |
Het |
| Cdc42bpb |
T |
G |
12: 111,292,450 (GRCm39) |
S362R |
probably damaging |
Het |
| Ceacam11 |
A |
T |
7: 17,709,252 (GRCm39) |
H150L |
probably benign |
Het |
| Cfap44 |
A |
C |
16: 44,242,737 (GRCm39) |
T714P |
probably benign |
Het |
| Cpeb1 |
T |
C |
7: 81,021,867 (GRCm39) |
D92G |
probably benign |
Het |
| Cped1 |
T |
A |
6: 22,120,980 (GRCm39) |
|
probably null |
Het |
| Csf1r |
A |
G |
18: 61,263,213 (GRCm39) |
T896A |
probably damaging |
Het |
| Csf3r |
T |
C |
4: 125,936,711 (GRCm39) |
F658S |
probably damaging |
Het |
| Cts6 |
A |
T |
13: 61,349,329 (GRCm39) |
Y126* |
probably null |
Het |
| Cul7 |
T |
C |
17: 46,966,666 (GRCm39) |
L365P |
probably damaging |
Het |
| Cxcl5 |
T |
C |
5: 90,907,644 (GRCm39) |
V72A |
probably damaging |
Het |
| Cyp4v3 |
T |
A |
8: 45,759,989 (GRCm39) |
H521L |
probably benign |
Het |
| Dct |
T |
C |
14: 118,271,690 (GRCm39) |
N380S |
probably benign |
Het |
| Dnah1 |
T |
C |
14: 31,041,716 (GRCm39) |
D85G |
probably damaging |
Het |
| Dnah7a |
T |
C |
1: 53,574,637 (GRCm39) |
D1709G |
probably damaging |
Het |
| Dnai1 |
A |
T |
4: 41,625,319 (GRCm39) |
K428* |
probably null |
Het |
| Dsc1 |
A |
T |
18: 20,229,045 (GRCm39) |
V415D |
probably damaging |
Het |
| E2f8 |
T |
C |
7: 48,520,920 (GRCm39) |
H467R |
probably benign |
Het |
| Eddm3b |
T |
A |
14: 51,354,321 (GRCm39) |
I103N |
probably damaging |
Het |
| Gal3st2c |
T |
G |
1: 93,936,611 (GRCm39) |
N185K |
probably damaging |
Het |
| Ganc |
T |
C |
2: 120,276,963 (GRCm39) |
L675P |
probably damaging |
Het |
| Garin3 |
A |
T |
11: 46,297,838 (GRCm39) |
T381S |
probably benign |
Het |
| Gdf9 |
G |
A |
11: 53,327,780 (GRCm39) |
M245I |
probably benign |
Het |
| Gm21886 |
G |
A |
18: 80,132,633 (GRCm39) |
T175I |
probably damaging |
Het |
| Gria2 |
A |
G |
3: 80,629,415 (GRCm39) |
L269P |
probably damaging |
Het |
| Grm8 |
T |
C |
6: 27,429,481 (GRCm39) |
Y471C |
probably damaging |
Het |
| Gucy2g |
T |
A |
19: 55,198,669 (GRCm39) |
T825S |
probably benign |
Het |
| H2-T13 |
A |
T |
17: 36,394,845 (GRCm39) |
M16K |
probably damaging |
Het |
| Iffo2 |
T |
C |
4: 139,335,012 (GRCm39) |
S124P |
probably damaging |
Het |
| Igf1r |
T |
C |
7: 67,850,997 (GRCm39) |
Y931H |
possibly damaging |
Het |
| Il22ra1 |
A |
T |
4: 135,478,219 (GRCm39) |
Q430L |
probably damaging |
Het |
| Il23r |
A |
C |
6: 67,400,718 (GRCm39) |
D537E |
probably benign |
Het |
| Ip6k1 |
G |
A |
9: 107,918,195 (GRCm39) |
E77K |
possibly damaging |
Het |
| Itgb4 |
T |
C |
11: 115,871,564 (GRCm39) |
V179A |
probably damaging |
Het |
| Itpr2 |
T |
A |
6: 146,131,201 (GRCm39) |
H1968L |
probably damaging |
Het |
| Kdm4a |
A |
G |
4: 118,017,596 (GRCm39) |
V490A |
probably benign |
Het |
| Kif13a |
A |
T |
13: 46,941,638 (GRCm39) |
D946E |
probably benign |
Het |
| Klhl22 |
T |
A |
16: 17,589,651 (GRCm39) |
I104N |
probably damaging |
Het |
| Klk6 |
A |
C |
7: 43,475,481 (GRCm39) |
M1L |
probably benign |
Het |
| Krt78 |
A |
T |
15: 101,855,398 (GRCm39) |
C804* |
probably null |
Het |
| Larp7 |
A |
T |
3: 127,334,227 (GRCm39) |
N533K |
probably damaging |
Het |
| Lrit3 |
T |
C |
3: 129,584,895 (GRCm39) |
T288A |
probably benign |
Het |
| Lrp11 |
T |
A |
10: 7,499,544 (GRCm39) |
L245Q |
probably damaging |
Het |
| Lrp1b |
T |
C |
2: 40,750,673 (GRCm39) |
S2964G |
probably damaging |
Het |
| Lrrc66 |
C |
T |
5: 73,764,965 (GRCm39) |
V693M |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,364,958 (GRCm39) |
M3268L |
probably benign |
Het |
| Mad1l1 |
A |
G |
5: 140,289,443 (GRCm39) |
S161P |
possibly damaging |
Het |
| Mettl25 |
A |
G |
10: 105,661,948 (GRCm39) |
S341P |
probably damaging |
Het |
| Morc3 |
A |
G |
16: 93,667,385 (GRCm39) |
T588A |
probably damaging |
Het |
| Mospd3 |
A |
G |
5: 137,598,677 (GRCm39) |
S21P |
probably damaging |
Het |
| Mrpl57 |
T |
A |
14: 58,064,186 (GRCm39) |
F71L |
probably damaging |
Het |
| Mtbp |
T |
C |
15: 55,470,111 (GRCm39) |
L594S |
probably damaging |
Het |
| Mthfd2 |
T |
C |
6: 83,283,713 (GRCm39) |
N323S |
probably damaging |
Het |
| Muc5b |
G |
T |
7: 141,417,842 (GRCm39) |
S3596I |
possibly damaging |
Het |
| Mug1 |
A |
G |
6: 121,858,780 (GRCm39) |
D1166G |
probably benign |
Het |
| Nav1 |
T |
G |
1: 135,400,148 (GRCm39) |
N474T |
probably benign |
Het |
| Ncoa1 |
A |
T |
12: 4,389,049 (GRCm39) |
D75E |
possibly damaging |
Het |
| Ncor1 |
A |
C |
11: 62,228,984 (GRCm39) |
I958S |
probably damaging |
Het |
| Nefm |
T |
C |
14: 68,361,563 (GRCm39) |
S234G |
probably benign |
Het |
| Nlrp4c |
T |
C |
7: 6,068,818 (GRCm39) |
S240P |
probably damaging |
Het |
| Nox3 |
C |
T |
17: 3,720,292 (GRCm39) |
V298M |
probably damaging |
Het |
| Ntn4 |
A |
G |
10: 93,543,234 (GRCm39) |
D320G |
possibly damaging |
Het |
| Nudt13 |
C |
G |
14: 20,360,709 (GRCm39) |
T174R |
probably damaging |
Het |
| Odr4 |
T |
A |
1: 150,264,360 (GRCm39) |
|
probably null |
Het |
| Opn1sw |
T |
A |
6: 29,379,803 (GRCm39) |
N144Y |
possibly damaging |
Het |
| Or10al3 |
T |
A |
17: 38,012,312 (GRCm39) |
H250Q |
probably damaging |
Het |
| Or10g3 |
T |
G |
14: 52,610,174 (GRCm39) |
Q112P |
possibly damaging |
Het |
| Or1l8 |
T |
C |
2: 36,817,197 (GRCm39) |
I310V |
probably benign |
Het |
| Or2a52 |
T |
A |
6: 43,144,657 (GRCm39) |
|
probably null |
Het |
| Or4a72 |
A |
T |
2: 89,405,947 (GRCm39) |
L41Q |
possibly damaging |
Het |
| Or5ac25 |
A |
T |
16: 59,182,526 (GRCm39) |
D18E |
probably benign |
Het |
| Or5g25 |
T |
C |
2: 85,478,201 (GRCm39) |
S155G |
possibly damaging |
Het |
| Or6c216 |
G |
T |
10: 129,678,375 (GRCm39) |
P179T |
probably benign |
Het |
| Or6n2 |
T |
C |
1: 173,897,692 (GRCm39) |
V276A |
probably damaging |
Het |
| Or8g4 |
T |
C |
9: 39,662,102 (GRCm39) |
V140A |
probably benign |
Het |
| Osbpl5 |
T |
C |
7: 143,256,918 (GRCm39) |
D404G |
possibly damaging |
Het |
| Parp14 |
C |
T |
16: 35,673,888 (GRCm39) |
|
probably null |
Het |
| Pde3a |
C |
A |
6: 141,444,496 (GRCm39) |
N1101K |
probably benign |
Het |
| Plcb1 |
G |
A |
2: 134,655,533 (GRCm39) |
V38I |
possibly damaging |
Het |
| Plec |
T |
A |
15: 76,059,751 (GRCm39) |
E3417D |
probably damaging |
Het |
| Ppfibp2 |
C |
T |
7: 107,345,585 (GRCm39) |
P869L |
probably damaging |
Het |
| Ppp1r12a |
T |
A |
10: 108,034,752 (GRCm39) |
I99N |
probably damaging |
Het |
| Pramel5 |
G |
A |
4: 144,000,433 (GRCm39) |
Q48* |
probably null |
Het |
| Prr13 |
C |
A |
15: 102,369,133 (GRCm39) |
|
probably benign |
Het |
| Psg22 |
T |
A |
7: 18,458,363 (GRCm39) |
Y312* |
probably null |
Het |
| Ptchd4 |
A |
T |
17: 42,814,507 (GRCm39) |
I803L |
probably benign |
Het |
| Rasa4 |
A |
G |
5: 136,120,092 (GRCm39) |
D56G |
probably benign |
Het |
| Rif1 |
T |
A |
2: 52,006,685 (GRCm39) |
N2206K |
possibly damaging |
Het |
| Robo1 |
A |
G |
16: 72,757,092 (GRCm39) |
Q351R |
probably null |
Het |
| Samd4 |
T |
C |
14: 47,311,585 (GRCm39) |
F81S |
probably damaging |
Het |
| Sh3pxd2b |
T |
C |
11: 32,373,559 (GRCm39) |
*909Q |
probably null |
Het |
| Slc25a45 |
A |
G |
19: 5,934,550 (GRCm39) |
R173G |
probably damaging |
Het |
| Smarca1 |
G |
A |
X: 46,938,840 (GRCm39) |
Q723* |
probably null |
Het |
| Smoc1 |
T |
C |
12: 81,151,445 (GRCm39) |
I54T |
probably benign |
Het |
| Spef2 |
G |
T |
15: 9,607,463 (GRCm39) |
R1319S |
probably damaging |
Het |
| Steap3 |
T |
G |
1: 120,169,464 (GRCm39) |
I240L |
probably benign |
Het |
| Stmn4 |
C |
T |
14: 66,593,058 (GRCm39) |
L13F |
probably damaging |
Het |
| Stxbp5 |
C |
A |
10: 9,688,042 (GRCm39) |
V420F |
possibly damaging |
Het |
| Syt3 |
T |
C |
7: 44,039,940 (GRCm39) |
S58P |
possibly damaging |
Het |
| Tas2r125 |
T |
C |
6: 132,887,139 (GRCm39) |
F176L |
probably benign |
Het |
| Tbc1d19 |
T |
A |
5: 53,986,695 (GRCm39) |
C35S |
probably benign |
Het |
| Tcaf3 |
T |
C |
6: 42,570,486 (GRCm39) |
E422G |
possibly damaging |
Het |
| Tekt4 |
T |
A |
17: 25,690,832 (GRCm39) |
F46Y |
possibly damaging |
Het |
| Tnfaip3 |
T |
C |
10: 18,883,937 (GRCm39) |
K148E |
probably benign |
Het |
| Trrap |
T |
G |
5: 144,752,863 (GRCm39) |
I1813R |
probably damaging |
Het |
| Ttc29 |
A |
G |
8: 78,978,361 (GRCm39) |
E137G |
probably benign |
Het |
| Tubgcp6 |
C |
A |
15: 89,000,444 (GRCm39) |
R307L |
possibly damaging |
Het |
| Tyro3 |
T |
C |
2: 119,632,176 (GRCm39) |
I81T |
possibly damaging |
Het |
| Upp2 |
T |
G |
2: 58,661,464 (GRCm39) |
M71R |
probably damaging |
Het |
| Utp20 |
G |
T |
10: 88,588,888 (GRCm39) |
T2427K |
probably benign |
Het |
| Vcl |
T |
A |
14: 21,032,767 (GRCm39) |
L122Q |
probably damaging |
Het |
| Vmn1r213 |
A |
C |
13: 23,196,476 (GRCm39) |
N353T |
possibly damaging |
Het |
| Vwa5b2 |
G |
T |
16: 20,423,582 (GRCm39) |
S1165I |
possibly damaging |
Het |
| Zfp869 |
T |
C |
8: 70,160,088 (GRCm39) |
K162E |
probably benign |
Het |
|
| Other mutations in Cnot1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Cnot1
|
APN |
8 |
96,452,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01340:Cnot1
|
APN |
8 |
96,487,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01457:Cnot1
|
APN |
8 |
96,467,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01505:Cnot1
|
APN |
8 |
96,455,346 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02401:Cnot1
|
APN |
8 |
96,482,761 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02693:Cnot1
|
APN |
8 |
96,500,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Cnot1
|
APN |
8 |
96,471,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02754:Cnot1
|
APN |
8 |
96,481,706 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03092:Cnot1
|
APN |
8 |
96,496,243 (GRCm39) |
intron |
probably benign |
|
|
IGL03174:Cnot1
|
APN |
8 |
96,487,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03310:Cnot1
|
APN |
8 |
96,462,308 (GRCm39) |
splice site |
probably benign |
|
|
IGL03371:Cnot1
|
APN |
8 |
96,501,344 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Affiliate
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Barge
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
Byproduct
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
Chairman
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
cohort
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Director
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
kowloon
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Quorum
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
tugboat
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Xiao
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB001:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB003:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB011:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
BB013:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Cnot1
|
UTSW |
8 |
96,487,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Cnot1
|
UTSW |
8 |
96,489,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0335:Cnot1
|
UTSW |
8 |
96,498,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0409:Cnot1
|
UTSW |
8 |
96,475,483 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0445:Cnot1
|
UTSW |
8 |
96,486,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1505:Cnot1
|
UTSW |
8 |
96,455,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1517:Cnot1
|
UTSW |
8 |
96,469,841 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1640:Cnot1
|
UTSW |
8 |
96,496,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1737:Cnot1
|
UTSW |
8 |
96,474,904 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1755:Cnot1
|
UTSW |
8 |
96,451,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1901:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1903:Cnot1
|
UTSW |
8 |
96,469,749 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1988:Cnot1
|
UTSW |
8 |
96,468,572 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2051:Cnot1
|
UTSW |
8 |
96,451,221 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2054:Cnot1
|
UTSW |
8 |
96,466,469 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2072:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2074:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2075:Cnot1
|
UTSW |
8 |
96,466,461 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2093:Cnot1
|
UTSW |
8 |
96,501,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2116:Cnot1
|
UTSW |
8 |
96,452,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Cnot1
|
UTSW |
8 |
96,488,054 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2238:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2239:Cnot1
|
UTSW |
8 |
96,496,149 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2251:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2252:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2253:Cnot1
|
UTSW |
8 |
96,489,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2315:Cnot1
|
UTSW |
8 |
96,475,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2431:Cnot1
|
UTSW |
8 |
96,501,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2988:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2989:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3108:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3109:Cnot1
|
UTSW |
8 |
96,462,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3114:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3115:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3153:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3154:Cnot1
|
UTSW |
8 |
96,470,906 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4112:Cnot1
|
UTSW |
8 |
96,500,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Cnot1
|
UTSW |
8 |
96,466,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Cnot1
|
UTSW |
8 |
96,496,407 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4747:Cnot1
|
UTSW |
8 |
96,501,310 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4910:Cnot1
|
UTSW |
8 |
96,459,859 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4913:Cnot1
|
UTSW |
8 |
96,489,695 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4971:Cnot1
|
UTSW |
8 |
96,448,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5056:Cnot1
|
UTSW |
8 |
96,467,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5092:Cnot1
|
UTSW |
8 |
96,479,396 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5101:Cnot1
|
UTSW |
8 |
96,486,815 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5498:Cnot1
|
UTSW |
8 |
96,483,983 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5719:Cnot1
|
UTSW |
8 |
96,470,924 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5850:Cnot1
|
UTSW |
8 |
96,460,775 (GRCm39) |
nonsense |
probably null |
|
|
R5956:Cnot1
|
UTSW |
8 |
96,481,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5981:Cnot1
|
UTSW |
8 |
96,515,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6093:Cnot1
|
UTSW |
8 |
96,475,522 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6108:Cnot1
|
UTSW |
8 |
96,457,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6261:Cnot1
|
UTSW |
8 |
96,468,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6632:Cnot1
|
UTSW |
8 |
96,499,895 (GRCm39) |
intron |
probably benign |
|
|
R6882:Cnot1
|
UTSW |
8 |
96,447,054 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6966:Cnot1
|
UTSW |
8 |
96,451,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6985:Cnot1
|
UTSW |
8 |
96,460,757 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7210:Cnot1
|
UTSW |
8 |
96,515,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7410:Cnot1
|
UTSW |
8 |
96,459,787 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7623:Cnot1
|
UTSW |
8 |
96,454,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7624:Cnot1
|
UTSW |
8 |
96,478,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7695:Cnot1
|
UTSW |
8 |
96,497,260 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7703:Cnot1
|
UTSW |
8 |
96,486,726 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7771:Cnot1
|
UTSW |
8 |
96,491,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7800:Cnot1
|
UTSW |
8 |
96,491,690 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7809:Cnot1
|
UTSW |
8 |
96,478,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7857:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7914:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7924:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7926:Cnot1
|
UTSW |
8 |
96,472,275 (GRCm39) |
frame shift |
probably null |
|
|
R7981:Cnot1
|
UTSW |
8 |
96,489,797 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8004:Cnot1
|
UTSW |
8 |
96,479,380 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8061:Cnot1
|
UTSW |
8 |
96,491,655 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8185:Cnot1
|
UTSW |
8 |
96,487,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8269:Cnot1
|
UTSW |
8 |
96,478,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8306:Cnot1
|
UTSW |
8 |
96,473,649 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8322:Cnot1
|
UTSW |
8 |
96,496,472 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8427:Cnot1
|
UTSW |
8 |
96,460,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8723:Cnot1
|
UTSW |
8 |
96,462,907 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8934:Cnot1
|
UTSW |
8 |
96,491,695 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9025:Cnot1
|
UTSW |
8 |
96,475,660 (GRCm39) |
missense |
probably benign |
|
|
R9179:Cnot1
|
UTSW |
8 |
96,500,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9280:Cnot1
|
UTSW |
8 |
96,497,227 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9285:Cnot1
|
UTSW |
8 |
96,452,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9299:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9337:Cnot1
|
UTSW |
8 |
96,468,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9480:Cnot1
|
UTSW |
8 |
96,497,338 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9548:Cnot1
|
UTSW |
8 |
96,482,854 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9601:Cnot1
|
UTSW |
8 |
96,482,835 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9629:Cnot1
|
UTSW |
8 |
96,455,874 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9752:Cnot1
|
UTSW |
8 |
96,488,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9764:Cnot1
|
UTSW |
8 |
96,496,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9789:Cnot1
|
UTSW |
8 |
96,455,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Cnot1
|
UTSW |
8 |
96,469,726 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cnot1
|
UTSW |
8 |
96,474,905 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCACTGCCACAAACTAGAAG -3'
(R):5'- CTGCCCCTACTCAAGAGTTG -3'
Sequencing Primer
(F):5'- GGATCAGGATTTGATTCCCAGAACC -3'
(R):5'- ATTATCCAGCTGATTTCTTTGTTCAG -3'
|
| Posted On |
2014-06-30 |
Incidental Mutation