Incidental Mutation 'R6529:Or10ak13'
ID 522163
Institutional Source Beutler Lab
Gene Symbol Or10ak13
Ensembl Gene ENSMUSG00000111159
Gene Name olfactory receptor family 10 subfamily AK member 13
Synonyms Olfr219-ps1, GA_x6K02SYWGW3-414-3, MOR259-10, GA_x6K02T2QD9B-18767132-18768073, Olfr1337
MMRRC Submission 044655-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # R6529 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118638833-118639783 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 118638907 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 292 (V292I)
Ref Sequence ENSEMBL: ENSMUSP00000076483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077247]
AlphaFold A2ACY8
Predicted Effect probably benign
Transcript: ENSMUST00000077247
AA Change: V292I

PolyPhen 2 Score 0.148 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000076483
Gene: ENSMUSG00000111159
AA Change: V292I

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 7.8e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.5e-7 PFAM
Pfam:7tm_1 44 293 8.3e-23 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.6%
Validation Efficiency 98% (41/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A T 7: 78,739,479 (GRCm39) M296L probably benign Het
Atxn2 T C 5: 121,949,677 (GRCm39) probably null Het
B3galnt2 G T 13: 14,170,377 (GRCm39) R242S probably benign Het
Bltp3a A G 17: 28,098,750 (GRCm39) I218M possibly damaging Het
Casz1 G A 4: 149,022,646 (GRCm39) E571K probably damaging Het
Ccdc163 A G 4: 116,566,121 (GRCm39) probably null Het
Cd109 A G 9: 78,619,907 (GRCm39) D1383G probably damaging Het
Cd200r1 A G 16: 44,610,065 (GRCm39) T95A possibly damaging Het
Chd2 T C 7: 73,153,191 (GRCm39) E219G possibly damaging Het
Cibar1 A G 4: 12,168,978 (GRCm39) V175A probably damaging Het
Dnah14 T A 1: 181,494,034 (GRCm39) V1730D probably damaging Het
Eps8 G A 6: 137,491,335 (GRCm39) H348Y possibly damaging Het
Fbxo2 A T 4: 148,249,511 (GRCm39) D187V probably damaging Het
Fsip2 A T 2: 82,812,657 (GRCm39) Y2992F probably benign Het
Gle1 A T 2: 29,825,539 (GRCm39) T10S possibly damaging Het
Got2 T C 8: 96,615,013 (GRCm39) probably benign Het
Gtf3c6 T C 10: 40,127,251 (GRCm39) T34A probably benign Het
H4c11 G T 13: 21,919,476 (GRCm39) V71F possibly damaging Het
Klf15 C T 6: 90,444,394 (GRCm39) T323I probably damaging Het
Krtap5-3 C A 7: 141,756,079 (GRCm39) C305* probably null Het
Map2k6 A T 11: 110,383,388 (GRCm39) D99V probably damaging Het
Nckap5l G T 15: 99,324,475 (GRCm39) P676Q probably benign Het
Nup188 A T 2: 30,216,466 (GRCm39) T757S possibly damaging Het
Or51q1c T C 7: 103,653,133 (GRCm39) V217A probably benign Het
Peg3 C A 7: 6,711,071 (GRCm39) A1384S probably damaging Het
Plekho2 C T 9: 65,480,383 (GRCm39) R14H probably benign Het
Qsox2 A T 2: 26,107,753 (GRCm39) C247S probably damaging Het
Slc25a13 A G 6: 6,073,451 (GRCm39) V469A probably benign Het
Slitrk3 T C 3: 72,958,551 (GRCm39) T74A probably benign Het
Spmip7 T C 11: 11,465,009 (GRCm39) F120S possibly damaging Het
Sult1a1 T C 7: 126,274,310 (GRCm39) T91A probably benign Het
Sult3a2 T C 10: 33,655,733 (GRCm39) Y82C probably damaging Het
Taf1b A T 12: 24,606,650 (GRCm39) H490L possibly damaging Het
Trrap T A 5: 144,771,014 (GRCm39) H2804Q probably benign Het
Usp8 A G 2: 126,567,298 (GRCm39) I106V probably benign Het
Wdcp T A 12: 4,901,143 (GRCm39) V333D probably damaging Het
Wdr46 T A 17: 34,168,120 (GRCm39) L564Q possibly damaging Het
Wrn T C 8: 33,826,004 (GRCm39) probably null Het
Zfp664 C T 5: 124,963,352 (GRCm39) H249Y probably damaging Het
Zfp975 A C 7: 42,311,325 (GRCm39) H429Q possibly damaging Het
Other mutations in Or10ak13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02203:Or10ak13 APN 4 118,639,626 (GRCm39) missense possibly damaging 0.95
IGL02626:Or10ak13 APN 4 118,639,531 (GRCm39) missense probably damaging 0.98
IGL02699:Or10ak13 APN 4 118,639,349 (GRCm39) nonsense probably null
IGL02754:Or10ak13 APN 4 118,639,117 (GRCm39) missense possibly damaging 0.90
IGL03287:Or10ak13 APN 4 118,639,551 (GRCm39) missense possibly damaging 0.64
R1341:Or10ak13 UTSW 4 118,639,579 (GRCm39) missense probably benign 0.01
R4894:Or10ak13 UTSW 4 118,639,483 (GRCm39) missense probably damaging 1.00
R6124:Or10ak13 UTSW 4 118,639,392 (GRCm39) missense probably damaging 1.00
R6515:Or10ak13 UTSW 4 118,639,467 (GRCm39) missense probably benign 0.13
R7040:Or10ak13 UTSW 4 118,639,183 (GRCm39) missense probably benign 0.00
R7398:Or10ak13 UTSW 4 118,638,896 (GRCm39) missense possibly damaging 0.80
R7684:Or10ak13 UTSW 4 118,639,471 (GRCm39) missense probably benign 0.40
R8377:Or10ak13 UTSW 4 118,639,203 (GRCm39) missense probably benign 0.22
R8717:Or10ak13 UTSW 4 118,638,996 (GRCm39) missense probably damaging 1.00
R9369:Or10ak13 UTSW 4 118,639,077 (GRCm39) missense probably benign 0.31
R9594:Or10ak13 UTSW 4 118,638,952 (GRCm39) missense probably benign
Z1189:Or10ak13 UTSW 4 118,639,284 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- GGACAACAATGTTGGTTTCATGATG -3'
(R):5'- AGATCAAGTCCAACCAGGGC -3'

Sequencing Primer
(F):5'- AACAATGTTGGTTTCATGATGTTTTG -3'
(R):5'- GCCGTTGCAAGGCTTTC -3'
Posted On 2018-06-06