Incidental Mutation 'R7156:Vmn2r79'
| ID |
557309 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| MMRRC Submission |
045257-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R7156 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86686851 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 744
(V744A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164462
AA Change: V744A
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: V744A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (81/81) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
T |
C |
7: 40,643,282 (GRCm39) |
I317T |
possibly damaging |
Het |
| Acsl5 |
G |
A |
19: 55,257,260 (GRCm39) |
|
probably null |
Het |
| Ahrr |
G |
A |
13: 74,378,035 (GRCm39) |
T136I |
probably damaging |
Het |
| AI597479 |
G |
A |
1: 43,150,261 (GRCm39) |
D124N |
probably damaging |
Het |
| Arap2 |
G |
T |
5: 62,761,914 (GRCm39) |
A1604D |
probably damaging |
Het |
| Bcl6 |
G |
A |
16: 23,784,976 (GRCm39) |
R675* |
probably null |
Het |
| Cadps2 |
T |
C |
6: 23,688,955 (GRCm39) |
N118S |
probably benign |
Het |
| Caskin1 |
T |
A |
17: 24,719,657 (GRCm39) |
|
probably null |
Het |
| Cc2d1a |
C |
T |
8: 84,862,389 (GRCm39) |
V684M |
possibly damaging |
Het |
| Ccdc91 |
T |
C |
6: 147,435,676 (GRCm39) |
S87P |
possibly damaging |
Het |
| Cdr2l |
A |
G |
11: 115,281,792 (GRCm39) |
Q99R |
probably benign |
Het |
| Celsr3 |
T |
C |
9: 108,715,203 (GRCm39) |
L2066P |
possibly damaging |
Het |
| Cep95 |
A |
C |
11: 106,700,050 (GRCm39) |
L313F |
possibly damaging |
Het |
| Chst10 |
G |
A |
1: 38,913,088 (GRCm39) |
T63M |
probably damaging |
Het |
| Clrn2 |
G |
A |
5: 45,611,258 (GRCm39) |
G36R |
probably damaging |
Het |
| Cnn2 |
T |
G |
10: 79,830,349 (GRCm39) |
Y273* |
probably null |
Het |
| Crtap |
T |
C |
9: 114,207,164 (GRCm39) |
T365A |
probably benign |
Het |
| D630045J12Rik |
T |
C |
6: 38,171,964 (GRCm39) |
T735A |
possibly damaging |
Het |
| Disp2 |
C |
T |
2: 118,622,292 (GRCm39) |
A1008V |
probably damaging |
Het |
| Dmrt3 |
A |
G |
19: 25,588,317 (GRCm39) |
D52G |
probably damaging |
Het |
| Dmrta1 |
T |
G |
4: 89,576,700 (GRCm39) |
L52R |
probably damaging |
Het |
| Dmrta2 |
A |
G |
4: 109,839,185 (GRCm39) |
T311A |
probably damaging |
Het |
| Dnm1 |
T |
A |
2: 32,230,479 (GRCm39) |
N112Y |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,064,858 (GRCm39) |
|
probably null |
Het |
| Ep400 |
A |
G |
5: 110,833,229 (GRCm39) |
F2034L |
unknown |
Het |
| F12 |
G |
A |
13: 55,566,310 (GRCm39) |
A494V |
probably damaging |
Het |
| Fbp2 |
A |
T |
13: 62,989,675 (GRCm39) |
F210L |
probably benign |
Het |
| Fbxo31 |
T |
A |
8: 122,281,060 (GRCm39) |
Q362L |
possibly damaging |
Het |
| Fkbp4 |
C |
T |
6: 128,412,787 (GRCm39) |
A95T |
probably benign |
Het |
| Frmd6 |
T |
G |
12: 70,923,983 (GRCm39) |
C80W |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,813,085 (GRCm39) |
I3135V |
probably benign |
Het |
| Garre1 |
G |
T |
7: 33,945,133 (GRCm39) |
N582K |
possibly damaging |
Het |
| Guca2b |
T |
A |
4: 119,514,887 (GRCm39) |
E34V |
probably damaging |
Het |
| Hdlbp |
G |
A |
1: 93,341,637 (GRCm39) |
T974I |
probably damaging |
Het |
| Hsdl2 |
T |
A |
4: 59,617,653 (GRCm39) |
M460K |
possibly damaging |
Het |
| Ift172 |
C |
T |
5: 31,429,419 (GRCm39) |
V581M |
probably damaging |
Het |
| Ift74 |
A |
G |
4: 94,549,189 (GRCm39) |
K313R |
possibly damaging |
Het |
| Ints4 |
T |
A |
7: 97,184,493 (GRCm39) |
|
probably null |
Het |
| Iqca1l |
C |
T |
5: 24,757,648 (GRCm39) |
E150K |
probably benign |
Het |
| Kif21b |
A |
C |
1: 136,075,562 (GRCm39) |
T230P |
probably damaging |
Het |
| Kit |
A |
T |
5: 75,776,034 (GRCm39) |
Y272F |
probably benign |
Het |
| Krt77 |
G |
A |
15: 101,773,931 (GRCm39) |
T241M |
probably benign |
Het |
| Lce1j |
T |
A |
3: 92,696,491 (GRCm39) |
S96C |
unknown |
Het |
| Marveld3 |
T |
A |
8: 110,674,820 (GRCm39) |
D332V |
probably damaging |
Het |
| Matr3 |
G |
T |
18: 35,705,974 (GRCm39) |
V300F |
probably damaging |
Het |
| Mical1 |
T |
A |
10: 41,361,253 (GRCm39) |
|
probably null |
Het |
| Mslnl |
T |
A |
17: 25,962,184 (GRCm39) |
V194E |
probably benign |
Het |
| Mug1 |
C |
A |
6: 121,857,864 (GRCm39) |
T1119K |
probably damaging |
Het |
| Mug1 |
C |
T |
6: 121,861,302 (GRCm39) |
P1308S |
probably damaging |
Het |
| Neb |
C |
A |
2: 52,195,295 (GRCm39) |
|
probably null |
Het |
| Neo1 |
T |
A |
9: 58,810,206 (GRCm39) |
T1082S |
probably damaging |
Het |
| Nkx6-2 |
C |
T |
7: 139,162,045 (GRCm39) |
|
probably null |
Het |
| Or10g6 |
T |
C |
9: 39,934,526 (GRCm39) |
I279T |
probably benign |
Het |
| Or8k27 |
T |
A |
2: 86,275,652 (GRCm39) |
I225L |
probably damaging |
Het |
| Orc1 |
A |
T |
4: 108,452,656 (GRCm39) |
E177V |
probably benign |
Het |
| Parp1 |
G |
A |
1: 180,426,629 (GRCm39) |
V924I |
possibly damaging |
Het |
| Pax2 |
A |
T |
19: 44,777,298 (GRCm39) |
I165F |
probably benign |
Het |
| Pnma2 |
C |
T |
14: 67,153,980 (GRCm39) |
P135S |
probably benign |
Het |
| Ranbp17 |
A |
G |
11: 33,247,420 (GRCm39) |
I718T |
probably damaging |
Het |
| Rbm25 |
T |
A |
12: 83,710,965 (GRCm39) |
D359E |
unknown |
Het |
| Rgs3 |
T |
C |
4: 62,535,363 (GRCm39) |
L194P |
probably damaging |
Het |
| Serpinb6b |
A |
G |
13: 33,155,598 (GRCm39) |
I104V |
probably benign |
Het |
| Smg9 |
A |
G |
7: 24,120,286 (GRCm39) |
D420G |
probably benign |
Het |
| Smpd1 |
C |
T |
7: 105,203,693 (GRCm39) |
|
probably benign |
Het |
| Snx17 |
T |
A |
5: 31,354,692 (GRCm39) |
M318K |
probably damaging |
Het |
| Spata31e5 |
A |
T |
1: 28,815,848 (GRCm39) |
M728K |
possibly damaging |
Het |
| Stard10 |
G |
A |
7: 100,995,258 (GRCm39) |
D337N |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,375,545 (GRCm39) |
T103A |
probably damaging |
Het |
| Tle1 |
A |
G |
4: 72,088,953 (GRCm39) |
S97P |
probably benign |
Het |
| Tnfrsf8 |
T |
A |
4: 145,041,654 (GRCm39) |
M1L |
unknown |
Het |
| Traf3ip2 |
T |
C |
10: 39,502,173 (GRCm39) |
L107P |
possibly damaging |
Het |
| Trpc7 |
A |
T |
13: 56,937,579 (GRCm39) |
S626T |
possibly damaging |
Het |
| Ubl7 |
T |
A |
9: 57,837,039 (GRCm39) |
I350N |
probably damaging |
Het |
| Ubr3 |
T |
A |
2: 69,851,967 (GRCm39) |
I1878N |
probably damaging |
Het |
| Usp24 |
G |
T |
4: 106,245,116 (GRCm39) |
|
probably null |
Het |
| Vcan |
A |
T |
13: 89,837,229 (GRCm39) |
S2772T |
possibly damaging |
Het |
| Wbp2nl |
T |
C |
15: 82,189,903 (GRCm39) |
S32P |
probably damaging |
Het |
| Wwc1 |
A |
G |
11: 35,788,201 (GRCm39) |
|
probably null |
Het |
| Zfp629 |
C |
T |
7: 127,211,463 (GRCm39) |
W115* |
probably null |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6260:Vmn2r79
|
UTSW |
7 |
86,686,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6374:Vmn2r79
|
UTSW |
7 |
86,651,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8073:Vmn2r79
|
UTSW |
7 |
86,651,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8145:Vmn2r79
|
UTSW |
7 |
86,686,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9276:Vmn2r79
|
UTSW |
7 |
86,687,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAAGACTGAGGTGGCTGCTAC -3'
(R):5'- TGCACTGGAGGCCAAGATAC -3'
Sequencing Primer
(F):5'- GCTACTTTCAGGAGCACCTAATTAC -3'
(R):5'- GAGGCCAAGATACAGAAGACCTC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation