Incidental Mutation 'R7206:Vmn2r73'
ID |
560619 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r73
|
Ensembl Gene |
ENSMUSG00000070458 |
Gene Name |
vomeronasal 2, receptor 73 |
Synonyms |
EG620928 |
MMRRC Submission |
045284-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.172)
|
Stock # |
R7206 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 85522075 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Serine
at position 88
(N88S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
AlphaFold |
D3Z7M3 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000077478
AA Change: N88S
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
SMART Domains |
Protein: ENSMUSP00000076687 Gene: ENSMUSG00000070458 AA Change: N88S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
Validation Efficiency |
99% (87/88) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 87 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aadacl2 |
G |
A |
3: 59,932,662 (GRCm39) |
M392I |
probably benign |
Het |
Aadacl4fm2 |
T |
A |
4: 144,285,211 (GRCm39) |
D142V |
probably damaging |
Het |
Acr |
T |
C |
15: 89,458,374 (GRCm39) |
S352P |
probably benign |
Het |
Adam6a |
T |
C |
12: 113,509,654 (GRCm39) |
C676R |
probably damaging |
Het |
Adgra3 |
T |
C |
5: 50,164,238 (GRCm39) |
D247G |
probably damaging |
Het |
Agxt2 |
A |
T |
15: 10,377,542 (GRCm39) |
E147D |
probably damaging |
Het |
Atp2a1 |
T |
C |
7: 126,047,144 (GRCm39) |
T805A |
probably benign |
Het |
Atp8b4 |
T |
C |
2: 126,300,212 (GRCm39) |
S106G |
probably damaging |
Het |
Ccdc170 |
T |
A |
10: 4,464,120 (GRCm39) |
M87K |
possibly damaging |
Het |
Ccnl2 |
T |
G |
4: 155,905,431 (GRCm39) |
V287G |
possibly damaging |
Het |
Ccr6 |
A |
T |
17: 8,475,781 (GRCm39) |
M329L |
probably benign |
Het |
Cflar |
G |
T |
1: 58,780,150 (GRCm39) |
M248I |
|
Het |
Cib4 |
A |
T |
5: 30,703,110 (GRCm39) |
L5* |
probably null |
Het |
Col27a1 |
A |
T |
4: 63,153,583 (GRCm39) |
Y645F |
probably benign |
Het |
Cxcr2 |
A |
G |
1: 74,198,213 (GRCm39) |
T236A |
possibly damaging |
Het |
Dnah12 |
G |
A |
14: 26,500,869 (GRCm39) |
|
probably null |
Het |
Dnah7a |
A |
T |
1: 53,737,792 (GRCm39) |
L47* |
probably null |
Het |
Dnajb6 |
A |
C |
5: 29,986,335 (GRCm39) |
K301T |
possibly damaging |
Het |
Dpf2 |
T |
A |
19: 5,954,571 (GRCm39) |
I157F |
possibly damaging |
Het |
Drd4 |
G |
A |
7: 140,872,032 (GRCm39) |
G28R |
probably damaging |
Het |
Dus3l |
A |
T |
17: 57,074,807 (GRCm39) |
I310F |
probably damaging |
Het |
Dusp29 |
A |
G |
14: 21,727,102 (GRCm39) |
V182A |
probably damaging |
Het |
Eef1akmt3 |
A |
G |
10: 126,876,862 (GRCm39) |
L95P |
probably damaging |
Het |
Fabp7 |
C |
T |
10: 57,661,087 (GRCm39) |
|
probably benign |
Het |
Fam135a |
T |
C |
1: 24,069,354 (GRCm39) |
N505S |
probably benign |
Het |
Fam216b |
C |
A |
14: 78,322,567 (GRCm39) |
D46Y |
probably damaging |
Het |
Gata6 |
C |
T |
18: 11,054,850 (GRCm39) |
R260C |
probably damaging |
Het |
Gm10800 |
A |
AC |
2: 98,497,378 (GRCm39) |
|
probably null |
Het |
Golgb1 |
A |
G |
16: 36,734,111 (GRCm39) |
I1160M |
probably benign |
Het |
Hjv |
A |
T |
3: 96,435,444 (GRCm39) |
D234V |
probably damaging |
Het |
Kiss1 |
A |
G |
1: 133,255,063 (GRCm39) |
K26E |
probably benign |
Het |
Knl1 |
T |
A |
2: 118,899,780 (GRCm39) |
F494I |
probably benign |
Het |
Ktn1 |
T |
C |
14: 47,932,985 (GRCm39) |
L713S |
probably damaging |
Het |
Loxhd1 |
A |
G |
18: 77,529,513 (GRCm39) |
D2052G |
probably damaging |
Het |
Lpo |
A |
C |
11: 87,698,249 (GRCm39) |
L582R |
probably damaging |
Het |
Map2k3 |
A |
G |
11: 60,834,406 (GRCm39) |
T125A |
|
Het |
Matn3 |
T |
A |
12: 9,011,170 (GRCm39) |
N360K |
probably benign |
Het |
Mlip |
A |
T |
9: 77,072,144 (GRCm39) |
V237E |
probably damaging |
Het |
Mms22l |
T |
C |
4: 24,591,146 (GRCm39) |
V999A |
probably benign |
Het |
Mn1 |
A |
G |
5: 111,568,378 (GRCm39) |
K783E |
possibly damaging |
Het |
Myo1h |
A |
T |
5: 114,457,836 (GRCm39) |
K132* |
probably null |
Het |
Nle1 |
A |
G |
11: 82,795,757 (GRCm39) |
V230A |
probably benign |
Het |
Or1ak2 |
T |
A |
2: 36,827,784 (GRCm39) |
Y218N |
probably damaging |
Het |
Or1e1b-ps1 |
A |
T |
11: 73,845,647 (GRCm39) |
I44F |
probably benign |
Het |
Or4a68 |
T |
C |
2: 89,270,801 (GRCm39) |
|
probably benign |
Het |
Or4f62 |
T |
G |
2: 111,986,804 (GRCm39) |
C169W |
probably damaging |
Het |
Or51f23 |
T |
C |
7: 102,452,891 (GRCm39) |
S69P |
probably damaging |
Het |
Or7e169 |
C |
T |
9: 19,757,856 (GRCm39) |
D20N |
probably damaging |
Het |
Ormdl2 |
T |
A |
10: 128,656,284 (GRCm39) |
H7L |
possibly damaging |
Het |
Pam |
A |
G |
1: 97,823,757 (GRCm39) |
S225P |
probably damaging |
Het |
Pan2 |
C |
A |
10: 128,150,414 (GRCm39) |
Y719* |
probably null |
Het |
Ppfia4 |
T |
C |
1: 134,255,127 (GRCm39) |
S243G |
probably benign |
Het |
Ppig |
T |
G |
2: 69,571,910 (GRCm39) |
S210A |
unknown |
Het |
Ppwd1 |
A |
T |
13: 104,350,106 (GRCm39) |
N426K |
probably damaging |
Het |
Prxl2a |
T |
A |
14: 40,726,142 (GRCm39) |
M12L |
probably benign |
Het |
Rnf10 |
T |
G |
5: 115,382,180 (GRCm39) |
D675A |
probably benign |
Het |
Rrp12 |
A |
T |
19: 41,866,478 (GRCm39) |
L619H |
probably damaging |
Het |
Rsph10b |
C |
T |
5: 143,898,010 (GRCm39) |
T497I |
possibly damaging |
Het |
Scnm1 |
A |
T |
3: 95,041,205 (GRCm39) |
M1K |
probably null |
Het |
Scp2 |
G |
T |
4: 107,931,638 (GRCm39) |
D332E |
probably benign |
Het |
Senp3 |
T |
C |
11: 69,569,557 (GRCm39) |
I314V |
probably benign |
Het |
Sfmbt1 |
T |
A |
14: 30,533,330 (GRCm39) |
|
probably null |
Het |
Slc44a2 |
T |
C |
9: 21,258,103 (GRCm39) |
F451S |
probably damaging |
Het |
Slfn1 |
A |
T |
11: 83,012,837 (GRCm39) |
M318L |
probably benign |
Het |
Syne2 |
C |
T |
12: 76,051,531 (GRCm39) |
S4087L |
probably benign |
Het |
Syt7 |
A |
G |
19: 10,395,337 (GRCm39) |
Y49C |
probably damaging |
Het |
Tas2r134 |
T |
C |
2: 51,518,120 (GRCm39) |
Y200H |
probably benign |
Het |
Tgfbr1 |
A |
T |
4: 47,402,941 (GRCm39) |
H315L |
probably damaging |
Het |
Tmem184c |
A |
G |
8: 78,323,206 (GRCm39) |
V552A |
possibly damaging |
Het |
Tnxb |
A |
G |
17: 34,923,075 (GRCm39) |
R2553G |
possibly damaging |
Het |
Tomm40 |
C |
G |
7: 19,444,861 (GRCm39) |
R173S |
probably benign |
Het |
Tonsl |
T |
C |
15: 76,517,851 (GRCm39) |
D650G |
probably damaging |
Het |
Tpo |
G |
C |
12: 30,153,133 (GRCm39) |
S407W |
possibly damaging |
Het |
Trank1 |
T |
C |
9: 111,174,583 (GRCm39) |
|
probably null |
Het |
Trp53tg5 |
T |
C |
2: 164,313,378 (GRCm39) |
E99G |
probably damaging |
Het |
Tubb2a |
C |
A |
13: 34,259,505 (GRCm39) |
S95I |
possibly damaging |
Het |
Vav2 |
C |
A |
2: 27,226,731 (GRCm39) |
R114L |
probably benign |
Het |
Vmn1r172 |
A |
T |
7: 23,359,582 (GRCm39) |
I156L |
possibly damaging |
Het |
Vmn1r238 |
A |
G |
18: 3,122,623 (GRCm39) |
Y264H |
possibly damaging |
Het |
Vmn2r26 |
T |
A |
6: 124,016,727 (GRCm39) |
M397K |
probably benign |
Het |
Vps13a |
T |
C |
19: 16,731,662 (GRCm39) |
N150S |
probably damaging |
Het |
Vps35 |
A |
T |
8: 86,014,350 (GRCm39) |
Y100N |
probably damaging |
Het |
Vps8 |
A |
C |
16: 21,276,171 (GRCm39) |
I235L |
probably damaging |
Het |
Yipf2 |
T |
A |
9: 21,501,657 (GRCm39) |
H157L |
probably damaging |
Het |
Zfp354a |
A |
T |
11: 50,961,073 (GRCm39) |
H426L |
probably damaging |
Het |
Zfp503 |
G |
T |
14: 22,035,553 (GRCm39) |
S454R |
possibly damaging |
Het |
Zfp619 |
C |
T |
7: 39,184,824 (GRCm39) |
R285C |
probably benign |
Het |
|
Other mutations in Vmn2r73 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
R9159:Vmn2r73
|
UTSW |
7 |
85,521,931 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCTGGACATGAACAGGAATGGTC -3'
(R):5'- CCCTTTCCTGTAAGTTAAAACCAGTAC -3'
Sequencing Primer
(F):5'- GGTCCTAGTTTTGTAGATACTGCCC -3'
(R):5'- AGTACATAACTGTGGGATTTTTGTG -3'
|
Posted On |
2019-06-26 |