Incidental Mutation 'R0019:Zfp943'
| ID |
201358 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp943
|
| Ensembl Gene |
ENSMUSG00000053347 |
| Gene Name |
zinc finger prtoein 943 |
| Synonyms |
4930432O21Rik |
| MMRRC Submission |
038314-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.250)
|
| Stock # |
R0019 (G1)
|
| Quality Score |
47 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
22181540-22213347 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
C to T
at 22211070 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133735
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055349]
[ENSMUST00000153985]
[ENSMUST00000174015]
|
| AlphaFold |
Q6NZP4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055349
|
| SMART Domains |
Protein: ENSMUSP00000059554
Gene: ENSMUSG00000053347
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
72 |
2.62e-18 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
208 |
230 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
320 |
342 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
5.67e-5 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
2.15e-5 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
460 |
482 |
3.34e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153985
|
| SMART Domains |
Protein: ENSMUSP00000115817
Gene: ENSMUSG00000053347
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
73 |
3.51e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174015
|
| SMART Domains |
Protein: ENSMUSP00000133735
Gene: ENSMUSG00000053347
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
60 |
3.79e-15 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.9%
- 10x: 97.7%
- 20x: 96.0%
|
| Validation Efficiency |
98% (43/44) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsl1 |
T |
A |
8: 46,974,287 (GRCm39) |
|
probably null |
Het |
| Ankrd13a |
T |
A |
5: 114,924,142 (GRCm39) |
|
probably benign |
Het |
| D130043K22Rik |
T |
A |
13: 25,064,795 (GRCm39) |
V737D |
probably damaging |
Het |
| Dhx37 |
C |
A |
5: 125,507,098 (GRCm39) |
G133C |
probably benign |
Het |
| Espl1 |
A |
C |
15: 102,214,754 (GRCm39) |
Q765P |
probably null |
Het |
| Fasn |
A |
T |
11: 120,698,824 (GRCm39) |
|
probably benign |
Het |
| Fshb |
T |
C |
2: 106,887,690 (GRCm39) |
S110G |
probably benign |
Het |
| Gsap |
T |
C |
5: 21,475,620 (GRCm39) |
|
probably benign |
Het |
| Helz2 |
C |
A |
2: 180,874,552 (GRCm39) |
G1981C |
probably damaging |
Het |
| Herc3 |
T |
C |
6: 58,862,050 (GRCm39) |
|
probably benign |
Het |
| Il1r2 |
C |
T |
1: 40,164,210 (GRCm39) |
T359M |
probably damaging |
Het |
| Lrig1 |
T |
A |
6: 94,584,330 (GRCm39) |
R905* |
probably null |
Het |
| Myh7 |
T |
A |
14: 55,221,191 (GRCm39) |
N911Y |
possibly damaging |
Het |
| Nfatc1 |
C |
A |
18: 80,678,719 (GRCm39) |
V890L |
probably benign |
Het |
| Pcolce2 |
A |
G |
9: 95,577,017 (GRCm39) |
|
probably null |
Het |
| Pdcl |
A |
T |
2: 37,241,932 (GRCm39) |
L273M |
probably damaging |
Het |
| Pycr3 |
A |
G |
15: 75,791,155 (GRCm39) |
|
probably benign |
Het |
| Rlf |
A |
G |
4: 121,003,769 (GRCm39) |
V1737A |
possibly damaging |
Het |
| Sstr1 |
T |
C |
12: 58,259,935 (GRCm39) |
L186S |
probably damaging |
Het |
| Trim69 |
A |
T |
2: 122,004,958 (GRCm39) |
|
probably null |
Het |
| Trim80 |
T |
G |
11: 115,338,768 (GRCm39) |
Y533D |
probably damaging |
Het |
| Unc13b |
T |
C |
4: 43,096,990 (GRCm39) |
I121T |
possibly damaging |
Het |
| Vinac1 |
G |
T |
2: 128,880,946 (GRCm39) |
H327N |
probably benign |
Het |
| Ywhab |
T |
A |
2: 163,858,090 (GRCm39) |
I219N |
probably damaging |
Het |
| Zfp560 |
G |
A |
9: 20,259,656 (GRCm39) |
S402L |
probably benign |
Het |
|
| Other mutations in Zfp943 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03101:Zfp943
|
APN |
17 |
22,211,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Zfp943
|
UTSW |
17 |
22,211,071 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1824:Zfp943
|
UTSW |
17 |
22,211,361 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1958:Zfp943
|
UTSW |
17 |
22,211,979 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2174:Zfp943
|
UTSW |
17 |
22,211,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Zfp943
|
UTSW |
17 |
22,211,403 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4093:Zfp943
|
UTSW |
17 |
22,211,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4094:Zfp943
|
UTSW |
17 |
22,211,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4352:Zfp943
|
UTSW |
17 |
22,212,104 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4677:Zfp943
|
UTSW |
17 |
22,212,176 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4735:Zfp943
|
UTSW |
17 |
22,211,391 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5201:Zfp943
|
UTSW |
17 |
22,211,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5492:Zfp943
|
UTSW |
17 |
22,212,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Zfp943
|
UTSW |
17 |
22,211,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6031:Zfp943
|
UTSW |
17 |
22,212,357 (GRCm39) |
missense |
probably benign |
|
|
R6031:Zfp943
|
UTSW |
17 |
22,212,357 (GRCm39) |
missense |
probably benign |
|
|
R6667:Zfp943
|
UTSW |
17 |
22,211,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6864:Zfp943
|
UTSW |
17 |
22,211,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6976:Zfp943
|
UTSW |
17 |
22,209,922 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7837:Zfp943
|
UTSW |
17 |
22,211,346 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7934:Zfp943
|
UTSW |
17 |
22,212,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8302:Zfp943
|
UTSW |
17 |
22,211,091 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8323:Zfp943
|
UTSW |
17 |
22,211,763 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9025:Zfp943
|
UTSW |
17 |
22,211,321 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9101:Zfp943
|
UTSW |
17 |
22,212,392 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9279:Zfp943
|
UTSW |
17 |
22,209,832 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9640:Zfp943
|
UTSW |
17 |
22,209,899 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Zfp943
|
UTSW |
17 |
22,211,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Zfp943
|
UTSW |
17 |
22,207,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCACCCTTCTGCTAAGGAATGTGTTA -3'
(R):5'- TGTCAAAAGCCTTATCAAGCTCTGTGT -3'
Sequencing Primer
(F):5'- CCTCTCTTGAGATCTCTATCCTTGAG -3'
(R):5'- CTTTGGTGTTCATAGAACCATGTC -3'
|
| Posted On |
2014-06-02 |
Incidental Mutation