Mutagenetix > Incidental Mutations

Incidental Mutation 'R0019:Zfp943'

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201358

Institutional Source

Beutler Lab

Gene Symbol

Zfp943

Ensembl Gene

ENSMUSG00000053347

Gene Name

zinc finger prtoein 943

Synonyms

MMRRC Submission

038314-MU

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.258) question?

Stock #

R0019 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

21962552-22071168 bp(+) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

C to T at 21992089 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000133735 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055349] [ENSMUST00000153985] [ENSMUST00000174015]

Predicted Effect

probably benign
Transcript: ENSMUST00000055349

SMART Domains

Protein: ENSMUSP00000059554
Gene: ENSMUSG00000053347

Domain	Start	End	E-Value	Type
KRAB	13	72	2.62e-18	SMART
ZnF_C2H2	180	202	1.6e-4	SMART
ZnF_C2H2	208	230	1.38e-3	SMART
ZnF_C2H2	236	258	1.13e-4	SMART
ZnF_C2H2	264	286	1.03e-2	SMART
ZnF_C2H2	292	314	2.24e-3	SMART
ZnF_C2H2	320	342	9.58e-3	SMART
ZnF_C2H2	348	370	5.67e-5	SMART
ZnF_C2H2	376	398	4.54e-4	SMART
ZnF_C2H2	404	426	2.15e-5	SMART
ZnF_C2H2	432	454	5.59e-4	SMART
ZnF_C2H2	460	482	3.34e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000153985

SMART Domains

Protein: ENSMUSP00000115817
Gene: ENSMUSG00000053347

Domain	Start	End	E-Value	Type
KRAB	13	73	3.51e-19	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000174015

SMART Domains

Protein: ENSMUSP00000133735
Gene: ENSMUSG00000053347

Domain	Start	End	E-Value	Type
KRAB	13	60	3.79e-15	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.9%
10x: 97.7%
20x: 96.0%

Validation Efficiency

98% (43/44)

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl1	T	A	8: 46,521,250		probably null	Het
Ankrd13a	T	A	5: 114,786,081		probably benign	Het
D130043K22Rik	T	A	13: 24,880,812	V737D	probably damaging	Het
Dhx37	C	A	5: 125,430,034	G133C	probably benign	Het
Espl1	A	C	15: 102,306,319	Q765P	probably null	Het
Fasn	A	T	11: 120,807,998		probably benign	Het
Fshb	T	C	2: 107,057,345	S110G	probably benign	Het
Gm14025	G	T	2: 129,039,026	H327N	probably benign	Het
Gsap	T	C	5: 21,270,622		probably benign	Het
Helz2	C	A	2: 181,232,759	G1981C	probably damaging	Het
Herc3	T	C	6: 58,885,065		probably benign	Het
Il1r2	C	T	1: 40,125,050	T359M	probably damaging	Het
Lrig1	T	A	6: 94,607,349	R905*	probably null	Het
Myh7	T	A	14: 54,983,734	N911Y	possibly damaging	Het
Nfatc1	C	A	18: 80,635,504	V890L	probably benign	Het
Pcolce2	A	G	9: 95,694,964		probably null	Het
Pdcl	A	T	2: 37,351,920	L273M	probably damaging	Het
Pycrl	A	G	15: 75,919,306		probably benign	Het
Rlf	A	G	4: 121,146,572	V1737A	possibly damaging	Het
Sstr1	T	C	12: 58,213,149	L186S	probably damaging	Het
Trim69	A	T	2: 122,174,477		probably null	Het
Trim80	T	G	11: 115,447,942	Y533D	probably damaging	Het
Unc13b	T	C	4: 43,096,990	I121T	possibly damaging	Het
Ywhab	T	A	2: 164,016,170	I219N	probably damaging	Het
Zfp560	G	A	9: 20,348,360	S402L	probably benign	Het

Other mutations in Zfp943

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03101:Zfp943	APN	17	21992175	missense	probably damaging	1.00
R0827:Zfp943	UTSW	17	21992090	critical splice acceptor site	probably null
R1824:Zfp943	UTSW	17	21992380	missense	probably benign	0.32
R1958:Zfp943	UTSW	17	21992998	missense	probably damaging	0.99
R2174:Zfp943	UTSW	17	21992823	missense	probably damaging	1.00
R3790:Zfp943	UTSW	17	21992422	missense	possibly damaging	0.81
R4093:Zfp943	UTSW	17	21992982	missense	probably damaging	1.00
R4094:Zfp943	UTSW	17	21992982	missense	probably damaging	1.00
R4352:Zfp943	UTSW	17	21993123	missense	probably damaging	0.98
R4677:Zfp943	UTSW	17	21993195	missense	probably benign	0.17
R4735:Zfp943	UTSW	17	21992410	missense	probably benign	0.03
R5201:Zfp943	UTSW	17	21992813	missense	probably damaging	1.00
R5492:Zfp943	UTSW	17	21993075	missense	probably damaging	1.00
R5642:Zfp943	UTSW	17	21992832	missense	probably damaging	1.00
R6031:Zfp943	UTSW	17	21993376	missense	probably benign
R6031:Zfp943	UTSW	17	21993376	missense	probably benign
R6667:Zfp943	UTSW	17	21992908	missense	probably damaging	1.00
R6864:Zfp943	UTSW	17	21992612	missense	probably damaging	1.00
R6976:Zfp943	UTSW	17	21990941	missense	possibly damaging	0.47

Predicted Primers

PCR Primer
(F):5'- TCCACCCTTCTGCTAAGGAATGTGTTA -3'
(R):5'- TGTCAAAAGCCTTATCAAGCTCTGTGT -3'

Sequencing Primer
(F):5'- CCTCTCTTGAGATCTCTATCCTTGAG -3'
(R):5'- CTTTGGTGTTCATAGAACCATGTC -3'

Posted On

2014-06-02