Incidental Mutation 'R3779:Tex26'
ID 271959
Institutional Source Beutler Lab
Gene Symbol Tex26
Ensembl Gene ENSMUSG00000029660
Gene Name testis expressed 26
Synonyms 4930588N13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R3779 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 149363125-149394444 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 149369316 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 48 (I48T)
Ref Sequence ENSEMBL: ENSMUSP00000143851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031667] [ENSMUST00000200985] [ENSMUST00000201610] [ENSMUST00000201683] [ENSMUST00000202677] [ENSMUST00000202920]
AlphaFold Q0VB26
Predicted Effect probably damaging
Transcript: ENSMUST00000031667
AA Change: I47T

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000200985
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201035
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201454
Predicted Effect possibly damaging
Transcript: ENSMUST00000201610
AA Change: I48T

PolyPhen 2 Score 0.462 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably damaging
Transcript: ENSMUST00000201683
AA Change: I48T

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000202677
AA Change: I48T

PolyPhen 2 Score 0.462 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000202920
Meta Mutation Damage Score 0.2382 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310079G19Rik A G 16: 88,424,273 (GRCm39) C73R probably damaging Het
Acot10 A G 15: 20,665,628 (GRCm39) V371A probably damaging Het
Ambn C A 5: 88,613,201 (GRCm39) probably benign Het
Ankrd34a T C 3: 96,506,247 (GRCm39) F484L possibly damaging Het
Bcl11a A G 11: 24,114,568 (GRCm39) K637R probably damaging Het
Cenpe T C 3: 134,962,337 (GRCm39) S1968P possibly damaging Het
Cfap61 T C 2: 145,792,714 (GRCm39) I52T probably damaging Het
Cit A T 5: 115,997,400 (GRCm39) M128L probably benign Het
Cnga1 G T 5: 72,762,126 (GRCm39) L463I probably damaging Het
Dnah11 C T 12: 118,094,448 (GRCm39) probably benign Het
Elovl4 ACT A 9: 83,667,201 (GRCm39) probably null Het
Ep400 A G 5: 110,839,515 (GRCm39) I1853T unknown Het
Flg2 C T 3: 93,109,730 (GRCm39) S586L unknown Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably benign Het
Gm21886 G T 18: 80,132,649 (GRCm39) Q170K possibly damaging Het
Gm5819 A G 18: 8,694,429 (GRCm39) E118G probably damaging Het
Gm9376 T C 14: 118,504,727 (GRCm39) V53A probably benign Het
H2-T3 T C 17: 36,500,574 (GRCm39) T90A probably damaging Het
Hif1an A G 19: 44,557,847 (GRCm39) D243G probably damaging Het
Hmgcs2 C T 3: 98,206,428 (GRCm39) probably benign Het
Ighv1-72 A T 12: 115,721,636 (GRCm39) S107T probably damaging Het
Jak1 G A 4: 101,013,687 (GRCm39) H1014Y probably benign Het
Klrb1c T C 6: 128,757,306 (GRCm39) D253G probably damaging Het
Lpin1 G A 12: 16,614,569 (GRCm39) T404M probably damaging Het
Map3k9 A T 12: 81,790,565 (GRCm39) probably benign Het
Mtrex A T 13: 113,039,926 (GRCm39) probably benign Het
Myl12a G T 17: 71,301,631 (GRCm39) H165Q possibly damaging Het
Or6c38 A G 10: 128,929,165 (GRCm39) F226S possibly damaging Het
Pdgfrb T A 18: 61,205,738 (GRCm39) S575T probably damaging Het
Phldb2 T C 16: 45,569,118 (GRCm39) Y1247C probably damaging Het
Pinlyp T A 7: 24,241,260 (GRCm39) T181S probably benign Het
Pkn2 A G 3: 142,499,741 (GRCm39) V928A possibly damaging Het
Skint5 C T 4: 113,636,237 (GRCm39) probably benign Het
Slc24a1 A G 9: 64,855,579 (GRCm39) Y443H unknown Het
Sp8 G T 12: 118,812,750 (GRCm39) V202L possibly damaging Het
Svil A G 18: 5,090,855 (GRCm39) N915S probably damaging Het
Syncrip A C 9: 88,358,992 (GRCm39) D172E probably damaging Het
Trpm6 A C 19: 18,853,403 (GRCm39) I1808L possibly damaging Het
Uba2 T C 7: 33,854,071 (GRCm39) probably null Het
Vwa8 T A 14: 79,339,762 (GRCm39) probably benign Het
Wfs1 C A 5: 37,125,968 (GRCm39) V308L probably benign Het
Wrn T A 8: 33,731,048 (GRCm39) R1095W probably damaging Het
Zfp808 T A 13: 62,319,717 (GRCm39) N315K probably damaging Het
Other mutations in Tex26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02527:Tex26 APN 5 149,380,407 (GRCm39) missense probably damaging 1.00
R0401:Tex26 UTSW 5 149,384,323 (GRCm39) missense probably benign 0.01
R2063:Tex26 UTSW 5 149,363,204 (GRCm39) missense probably damaging 0.98
R2424:Tex26 UTSW 5 149,393,913 (GRCm39) utr 3 prime probably benign
R4361:Tex26 UTSW 5 149,384,388 (GRCm39) missense probably benign 0.01
R4434:Tex26 UTSW 5 149,376,820 (GRCm39) missense probably benign 0.08
R5791:Tex26 UTSW 5 149,363,240 (GRCm39) splice site probably null
R5804:Tex26 UTSW 5 149,386,612 (GRCm39) missense possibly damaging 0.92
R8898:Tex26 UTSW 5 149,380,369 (GRCm39) missense probably benign
R9007:Tex26 UTSW 5 149,376,884 (GRCm39) missense probably damaging 1.00
R9063:Tex26 UTSW 5 149,393,826 (GRCm39) missense probably damaging 1.00
R9766:Tex26 UTSW 5 149,386,642 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGTCATCATAGCTAATTGGACC -3'
(R):5'- CTTATAGCAAGTCTGGCCTTGAAG -3'

Sequencing Primer
(F):5'- GGACCCTAAGATGAAATCATTGTGC -3'
(R):5'- AAGTCTGGCCTTGAAGTTTGCAAG -3'
Posted On 2015-03-25