Incidental Mutation 'R3767:Mgl2'
ID 273073
Institutional Source Beutler Lab
Gene Symbol Mgl2
Ensembl Gene ENSMUSG00000040950
Gene Name macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms CD301b
MMRRC Submission 040744-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3767 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 70021155-70028376 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 70026659 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 128 (L128P)
Ref Sequence ENSEMBL: ENSMUSP00000131344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041550] [ENSMUST00000108584] [ENSMUST00000165951]
AlphaFold A9XX86
Predicted Effect probably damaging
Transcript: ENSMUST00000041550
AA Change: L127P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048568
Gene: ENSMUSG00000040950
AA Change: L127P

DomainStartEndE-ValueType
Pfam:Lectin_N 6 179 4.6e-56 PFAM
CLECT 189 313 2.37e-35 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000108584
AA Change: L121P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104225
Gene: ENSMUSG00000040950
AA Change: L121P

DomainStartEndE-ValueType
Pfam:Lectin_N 8 173 8.6e-56 PFAM
CLECT 183 355 5.76e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132645
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147502
Predicted Effect probably damaging
Transcript: ENSMUST00000165951
AA Change: L128P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131344
Gene: ENSMUSG00000040950
AA Change: L128P

DomainStartEndE-ValueType
Pfam:Lectin_N 21 133 2.1e-35 PFAM
Pfam:Lectin_N 129 180 5.4e-19 PFAM
CLECT 190 362 5.76e-25 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipoq T A 16: 22,975,938 (GRCm39) V134E possibly damaging Het
Agmat A G 4: 141,483,273 (GRCm39) T236A probably benign Het
Anxa9 T C 3: 95,208,425 (GRCm39) N197S probably benign Het
Arhgap23 A T 11: 97,366,932 (GRCm39) D1071V probably damaging Het
Axdnd1 G A 1: 156,208,428 (GRCm39) T470M probably damaging Het
C3 C T 17: 57,512,303 (GRCm39) D1542N possibly damaging Het
Cdh3 A T 8: 107,263,606 (GRCm39) probably null Het
Cep85l A T 10: 53,167,906 (GRCm39) I624K probably benign Het
Cplx4 T C 18: 66,102,998 (GRCm39) T41A probably benign Het
Dchs1 A T 7: 105,406,292 (GRCm39) D2313E possibly damaging Het
Dock7 T C 4: 98,859,066 (GRCm39) T1409A probably benign Het
Exo1 C T 1: 175,714,312 (GRCm39) P73L probably damaging Het
Fgfrl1 C A 5: 108,853,242 (GRCm39) H197Q possibly damaging Het
Fsbp G A 4: 11,583,706 (GRCm39) G135D probably damaging Het
Herc3 G A 6: 58,839,973 (GRCm39) R362H probably benign Het
Herc3 T C 6: 58,853,587 (GRCm39) F583L probably benign Het
Ifna7 T C 4: 88,734,964 (GRCm39) V167A probably damaging Het
Ighv1-54 A G 12: 115,157,596 (GRCm39) V17A possibly damaging Het
Kcnh5 A G 12: 75,134,350 (GRCm39) Y400H possibly damaging Het
Kcnk16 T A 14: 20,319,230 (GRCm39) M1L possibly damaging Het
Kctd19 T C 8: 106,123,112 (GRCm39) T101A probably benign Het
Klf3 A G 5: 64,984,560 (GRCm39) probably null Het
Krtap12-1 G T 10: 77,556,729 (GRCm39) V91L probably benign Het
Lonp1 T C 17: 56,928,952 (GRCm39) E270G possibly damaging Het
Mrc1 A G 2: 14,323,981 (GRCm39) Y1106C probably damaging Het
Mybpc1 G T 10: 88,406,521 (GRCm39) probably null Het
Mypn C A 10: 62,961,486 (GRCm39) L1035F possibly damaging Het
Neurl1a T C 19: 47,228,328 (GRCm39) L58P probably damaging Het
Nlrp4e G T 7: 23,039,988 (GRCm39) L770F probably damaging Het
Npas3 A G 12: 54,115,857 (GRCm39) *895W probably null Het
Nphs2 T C 1: 156,140,608 (GRCm39) I115T probably damaging Het
Or1ad6 A G 11: 50,860,385 (GRCm39) D180G probably damaging Het
Or8g22 T A 9: 38,958,707 (GRCm39) H47L unknown Het
Patj A T 4: 98,569,456 (GRCm39) K1128* probably null Het
Pla2g5 C G 4: 138,528,746 (GRCm39) C70S probably damaging Het
Pole4 G A 6: 82,599,095 (GRCm39) R119C possibly damaging Het
Ppm1h G T 10: 122,740,027 (GRCm39) L367F probably damaging Het
Ppp1r13b G T 12: 111,812,851 (GRCm39) R123S probably damaging Het
Ptpru C T 4: 131,535,735 (GRCm39) C414Y probably damaging Het
Pum2 T A 12: 8,769,076 (GRCm39) Y323* probably null Het
Rhot2 T C 17: 26,059,521 (GRCm39) D407G probably benign Het
Rreb1 C T 13: 38,113,579 (GRCm39) R313W possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Scn11a T A 9: 119,613,115 (GRCm39) D825V probably damaging Het
Selenoi A G 5: 30,461,187 (GRCm39) Y141C probably damaging Het
Smcr8 A G 11: 60,670,330 (GRCm39) T493A probably benign Het
Tjp2 A T 19: 24,078,190 (GRCm39) I901N probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Ttc23l T A 15: 10,530,781 (GRCm39) Y277F possibly damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Wdr1 C T 5: 38,697,882 (GRCm39) G228R probably damaging Het
Xab2 T C 8: 3,669,053 (GRCm39) N31S probably damaging Het
Other mutations in Mgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Mgl2 APN 11 70,027,932 (GRCm39) missense probably benign 0.33
IGL00757:Mgl2 APN 11 70,025,976 (GRCm39) missense probably damaging 1.00
IGL00838:Mgl2 APN 11 70,025,038 (GRCm39) missense probably benign 0.00
IGL01118:Mgl2 APN 11 70,025,015 (GRCm39) missense probably benign 0.00
IGL01613:Mgl2 APN 11 70,024,984 (GRCm39) missense probably benign 0.08
IGL02094:Mgl2 APN 11 70,027,923 (GRCm39) missense possibly damaging 0.73
IGL03000:Mgl2 APN 11 70,025,026 (GRCm39) nonsense probably null
R1893:Mgl2 UTSW 11 70,024,993 (GRCm39) splice site probably null
R3768:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3769:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R5467:Mgl2 UTSW 11 70,025,878 (GRCm39) missense possibly damaging 0.46
R5742:Mgl2 UTSW 11 70,027,510 (GRCm39) missense probably benign 0.00
R6018:Mgl2 UTSW 11 70,027,937 (GRCm39) makesense probably null
R7189:Mgl2 UTSW 11 70,027,869 (GRCm39) missense probably damaging 1.00
R7270:Mgl2 UTSW 11 70,026,506 (GRCm39) missense probably damaging 1.00
R7536:Mgl2 UTSW 11 70,027,833 (GRCm39) missense probably benign 0.02
R8330:Mgl2 UTSW 11 70,026,785 (GRCm39) missense probably benign 0.03
R9174:Mgl2 UTSW 11 70,026,606 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCAGATTCCCAGTTAAGGAGGG -3'
(R):5'- GCCTCACCTGTTTTGAGAGC -3'

Sequencing Primer
(F):5'- TAGGCACCCTAAGAGCCATTTTAG -3'
(R):5'- ACCTGTTTTGAGAGCCTGCTC -3'
Posted On 2015-03-25