Incidental Mutation 'R4051:Ier5l'
ID 314144
Institutional Source Beutler Lab
Gene Symbol Ier5l
Ensembl Gene ENSMUSG00000089762
Gene Name immediate early response 5-like
Synonyms 2610524G09Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.616) question?
Stock # R4051 ()
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 30362643-30364211 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 30363324 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 234 (S234A)
Ref Sequence ENSEMBL: ENSMUSP00000132594 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065134]
AlphaFold Q99J55
Predicted Effect probably benign
Transcript: ENSMUST00000065134
AA Change: S234A

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000132594
Gene: ENSMUSG00000089762
AA Change: S234A

DomainStartEndE-ValueType
Pfam:IER 1 406 8.1e-141 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A C 7: 45,635,987 (GRCm39) L1020R probably damaging Het
Ahnak A C 19: 8,991,691 (GRCm39) D4325A probably damaging Het
Chtf18 A G 17: 25,938,168 (GRCm39) V955A probably damaging Het
Dclk2 A G 3: 86,738,129 (GRCm39) probably null Het
Disc1 A G 8: 125,875,164 (GRCm39) T547A possibly damaging Het
Eif4b A G 15: 101,995,039 (GRCm39) Y211C probably benign Het
Fli1 T G 9: 32,363,458 (GRCm39) D176A probably benign Het
Hcn2 A C 10: 79,569,521 (GRCm39) probably null Het
Ice1 A G 13: 70,751,646 (GRCm39) V1480A probably damaging Het
Ino80b G C 6: 83,099,314 (GRCm39) P178R probably damaging Het
Itga11 C T 9: 62,662,933 (GRCm39) Q550* probably null Het
Kdr T A 5: 76,129,068 (GRCm39) M193L probably benign Het
Kif3b G A 2: 153,165,477 (GRCm39) R628Q probably damaging Het
Ldlrad3 C T 2: 101,783,507 (GRCm39) D240N probably damaging Het
Met T C 6: 17,548,728 (GRCm39) V924A possibly damaging Het
Or52m1 T C 7: 102,290,233 (GRCm39) V260A possibly damaging Het
Peg10 T C 6: 4,754,534 (GRCm39) L105P probably benign Het
Phtf1 A G 3: 103,912,824 (GRCm39) T717A possibly damaging Het
Ptafr T C 4: 132,307,305 (GRCm39) W232R probably benign Het
Rnase4 A G 14: 51,342,462 (GRCm39) K62R probably benign Het
Slamf7 T C 1: 171,464,951 (GRCm39) K261E possibly damaging Het
Slc9c1 T A 16: 45,363,593 (GRCm39) Y120N probably damaging Het
Sstr2 A C 11: 113,515,482 (GRCm39) T134P probably damaging Het
Steap4 A G 5: 8,030,404 (GRCm39) Y420C probably damaging Het
Tbc1d9b T C 11: 50,062,070 (GRCm39) C1210R probably benign Het
Tnfsf10 T A 3: 27,389,503 (GRCm39) I188N probably damaging Het
Trav7-3 A G 14: 53,681,203 (GRCm39) T82A probably benign Het
Usp46 T C 5: 74,163,416 (GRCm39) N283S probably benign Het
Vmn2r84 T G 10: 130,226,767 (GRCm39) N357T probably damaging Het
Zfp217 T C 2: 169,954,536 (GRCm39) probably null Het
Other mutations in Ier5l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01610:Ier5l APN 2 30,363,966 (GRCm39) missense probably damaging 1.00
IGL03209:Ier5l APN 2 30,363,067 (GRCm39) missense possibly damaging 0.84
R2073:Ier5l UTSW 2 30,363,068 (GRCm39) missense probably damaging 0.99
R5727:Ier5l UTSW 2 30,363,171 (GRCm39) missense possibly damaging 0.86
R8329:Ier5l UTSW 2 30,362,861 (GRCm39) missense possibly damaging 0.86
R8400:Ier5l UTSW 2 30,363,105 (GRCm39) missense possibly damaging 0.93
R8542:Ier5l UTSW 2 30,362,948 (GRCm39) missense possibly damaging 0.52
RF035:Ier5l UTSW 2 30,363,832 (GRCm39) small deletion probably benign
X0021:Ier5l UTSW 2 30,363,832 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- GGGTAATACTTGCGCTTGC -3'
(R):5'- TCTACCTGAGCGAGCGTTAC -3'

Sequencing Primer
(F):5'- GACGCCAGACCGGGTCC -3'
(R):5'- TGCACCTCCAGCAGCAG -3'
Posted On 2015-04-30