Incidental Mutation 'R4829:Tnik'
| ID |
372647 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
042445-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4829 (G1)
|
| Quality Score |
150 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to T
at 28593690 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000162777]
[ENSMUST00000162485]
[ENSMUST00000161964]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159236
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159308
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159680
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160307
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160518
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161423
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193721
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162777
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162485
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161964
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.4%
- 20x: 92.8%
|
| Validation Efficiency |
98% (109/111) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
T |
C |
3: 137,774,780 (GRCm39) |
V1323A |
probably damaging |
Het |
| Abcb1a |
T |
C |
5: 8,773,214 (GRCm39) |
L814P |
probably damaging |
Het |
| Acat1 |
C |
A |
9: 53,502,756 (GRCm39) |
G191V |
probably damaging |
Het |
| Acsbg3 |
A |
G |
17: 57,190,500 (GRCm39) |
|
probably null |
Het |
| Adamts20 |
A |
T |
15: 94,224,277 (GRCm39) |
D1184E |
probably benign |
Het |
| Adss1 |
T |
C |
12: 112,601,147 (GRCm39) |
L283P |
probably damaging |
Het |
| Arid4a |
A |
G |
12: 71,070,272 (GRCm39) |
|
probably null |
Het |
| Arid4b |
T |
A |
13: 14,359,023 (GRCm39) |
D599E |
probably benign |
Het |
| AW146154 |
T |
C |
7: 41,130,057 (GRCm39) |
K353R |
possibly damaging |
Het |
| Axdnd1 |
G |
T |
1: 156,204,216 (GRCm39) |
R547S |
possibly damaging |
Het |
| Bcat1 |
A |
T |
6: 144,961,201 (GRCm39) |
F134Y |
probably damaging |
Het |
| Camk2d |
C |
A |
3: 126,573,646 (GRCm39) |
|
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,400,550 (GRCm39) |
K268T |
probably damaging |
Het |
| Ccar1 |
A |
C |
10: 62,581,114 (GRCm39) |
F1103L |
unknown |
Het |
| Ccdc141 |
T |
A |
2: 76,905,260 (GRCm39) |
E395D |
probably damaging |
Het |
| Cdc37l1 |
A |
G |
19: 28,967,983 (GRCm39) |
T16A |
probably benign |
Het |
| Cdca2 |
T |
A |
14: 67,931,202 (GRCm39) |
|
probably null |
Het |
| Cfap96 |
T |
C |
8: 46,420,952 (GRCm39) |
I159V |
probably damaging |
Het |
| Cntn5 |
T |
G |
9: 9,976,288 (GRCm39) |
K219Q |
probably damaging |
Het |
| Col23a1 |
C |
A |
11: 51,448,413 (GRCm39) |
A202E |
unknown |
Het |
| Csmd1 |
G |
A |
8: 16,177,310 (GRCm39) |
L1318F |
probably damaging |
Het |
| Csnk1g3 |
C |
T |
18: 54,028,895 (GRCm39) |
A16V |
possibly damaging |
Het |
| Cspg4b |
A |
G |
13: 113,504,696 (GRCm39) |
I1942V |
probably benign |
Het |
| Dab2 |
A |
G |
15: 6,454,162 (GRCm39) |
D224G |
probably damaging |
Het |
| Ddr1 |
A |
T |
17: 35,996,005 (GRCm39) |
C625S |
probably damaging |
Het |
| Dennd4a |
T |
C |
9: 64,796,338 (GRCm39) |
V788A |
probably damaging |
Het |
| Dgcr2 |
T |
C |
16: 17,660,617 (GRCm39) |
E402G |
possibly damaging |
Het |
| Dhcr7 |
T |
G |
7: 143,391,654 (GRCm39) |
I81S |
probably damaging |
Het |
| Exd1 |
C |
T |
2: 119,350,807 (GRCm39) |
A485T |
probably benign |
Het |
| Fat1 |
C |
T |
8: 45,489,199 (GRCm39) |
T3467I |
probably damaging |
Het |
| Fblim1 |
T |
C |
4: 141,312,020 (GRCm39) |
E235G |
probably damaging |
Het |
| Fbxo38 |
T |
A |
18: 62,651,662 (GRCm39) |
M548L |
probably benign |
Het |
| Fstl5 |
T |
C |
3: 76,229,489 (GRCm39) |
Y97H |
probably damaging |
Het |
| Glb1l |
A |
T |
1: 75,176,994 (GRCm39) |
S481T |
probably damaging |
Het |
| Gp2 |
A |
T |
7: 119,056,407 (GRCm39) |
V22E |
possibly damaging |
Het |
| Grin1 |
A |
G |
2: 25,208,736 (GRCm39) |
S55P |
possibly damaging |
Het |
| Herc2 |
A |
G |
7: 55,756,240 (GRCm39) |
D760G |
probably benign |
Het |
| Hpn |
A |
G |
7: 30,798,300 (GRCm39) |
|
probably benign |
Het |
| Hsf2 |
T |
C |
10: 57,372,266 (GRCm39) |
V73A |
probably damaging |
Het |
| Ighv1-42 |
T |
C |
12: 114,900,788 (GRCm39) |
Y80C |
probably benign |
Het |
| Ighv1-64 |
T |
C |
12: 115,471,346 (GRCm39) |
K57R |
probably benign |
Het |
| Klc1 |
T |
C |
12: 111,762,037 (GRCm39) |
I569T |
probably damaging |
Het |
| Klra3 |
T |
G |
6: 130,300,579 (GRCm39) |
K263N |
probably benign |
Het |
| Lrcol1 |
C |
A |
5: 110,502,393 (GRCm39) |
H90N |
probably benign |
Het |
| Mamdc4 |
T |
C |
2: 25,455,368 (GRCm39) |
E921G |
possibly damaging |
Het |
| Mark1 |
G |
A |
1: 184,637,724 (GRCm39) |
R622W |
possibly damaging |
Het |
| Mdga1 |
A |
G |
17: 30,065,343 (GRCm39) |
S696P |
possibly damaging |
Het |
| Mmp1b |
C |
T |
9: 7,370,729 (GRCm39) |
|
probably null |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Mtnr1a |
T |
C |
8: 45,538,652 (GRCm39) |
|
probably benign |
Het |
| Myo5a |
T |
C |
9: 75,043,689 (GRCm39) |
I226T |
probably damaging |
Het |
| Ncoa6 |
G |
T |
2: 155,257,147 (GRCm39) |
P799T |
probably damaging |
Het |
| Npc1l1 |
C |
T |
11: 6,164,010 (GRCm39) |
|
probably null |
Het |
| Nxph3 |
T |
C |
11: 95,402,321 (GRCm39) |
E31G |
probably benign |
Het |
| Obscn |
T |
C |
11: 58,945,072 (GRCm39) |
I4649V |
probably null |
Het |
| Or10d4b |
A |
T |
9: 39,534,734 (GRCm39) |
H103L |
probably damaging |
Het |
| Or8b12b |
G |
T |
9: 37,684,243 (GRCm39) |
C96F |
probably damaging |
Het |
| Or8g35 |
A |
T |
9: 39,381,663 (GRCm39) |
Y120N |
probably damaging |
Het |
| Or8h10 |
G |
A |
2: 86,808,918 (GRCm39) |
S74L |
probably damaging |
Het |
| P3h3 |
G |
A |
6: 124,818,601 (GRCm39) |
|
probably benign |
Het |
| Pcnx2 |
A |
T |
8: 126,587,797 (GRCm39) |
|
probably null |
Het |
| Pirb |
C |
T |
7: 3,720,602 (GRCm39) |
G299S |
probably benign |
Het |
| Pla2g4d |
A |
G |
2: 120,097,224 (GRCm39) |
S792P |
probably damaging |
Het |
| Plppr4 |
A |
T |
3: 117,129,240 (GRCm39) |
L76M |
possibly damaging |
Het |
| Ppp2r3d |
A |
T |
9: 101,089,709 (GRCm39) |
S205T |
possibly damaging |
Het |
| Prkdc |
G |
A |
16: 15,519,939 (GRCm39) |
D1126N |
possibly damaging |
Het |
| Prrt4 |
G |
A |
6: 29,177,181 (GRCm39) |
S196L |
probably benign |
Het |
| Ptpn21 |
A |
C |
12: 98,655,555 (GRCm39) |
S471A |
probably damaging |
Het |
| Ptprk |
C |
A |
10: 28,456,480 (GRCm39) |
S9* |
probably null |
Het |
| Rassf4 |
A |
T |
6: 116,622,103 (GRCm39) |
I163K |
possibly damaging |
Het |
| Rgs22 |
C |
A |
15: 36,104,034 (GRCm39) |
R142S |
probably damaging |
Het |
| Rit2 |
C |
A |
18: 31,345,726 (GRCm39) |
L73F |
probably damaging |
Het |
| Rrbp1 |
A |
C |
2: 143,831,607 (GRCm39) |
S187A |
probably benign |
Het |
| Rspo2 |
A |
T |
15: 42,956,583 (GRCm39) |
Y83* |
probably null |
Het |
| Scn5a |
C |
T |
9: 119,363,773 (GRCm39) |
V456M |
probably benign |
Het |
| Scn9a |
T |
A |
2: 66,382,057 (GRCm39) |
H290L |
probably benign |
Het |
| Smarca4 |
T |
C |
9: 21,550,623 (GRCm39) |
I452T |
probably damaging |
Het |
| Smc2 |
T |
A |
4: 52,449,612 (GRCm39) |
I198K |
probably damaging |
Het |
| Smim14 |
G |
A |
5: 65,617,946 (GRCm39) |
|
probably benign |
Het |
| Spg11 |
A |
C |
2: 121,938,936 (GRCm39) |
N339K |
probably benign |
Het |
| Spta1 |
A |
G |
1: 174,065,493 (GRCm39) |
E2014G |
probably benign |
Het |
| Stk4 |
T |
C |
2: 163,941,747 (GRCm39) |
|
probably null |
Het |
| Sypl1 |
C |
T |
12: 33,017,645 (GRCm39) |
T121M |
probably damaging |
Het |
| Tas2r120 |
T |
A |
6: 132,634,331 (GRCm39) |
F138I |
probably benign |
Het |
| Tcstv4 |
G |
A |
13: 120,769,926 (GRCm39) |
C82Y |
possibly damaging |
Het |
| Tet2 |
A |
C |
3: 133,182,381 (GRCm39) |
C1194W |
possibly damaging |
Het |
| Tex29 |
T |
C |
8: 11,905,668 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf22 |
T |
A |
7: 143,197,067 (GRCm39) |
T91S |
possibly damaging |
Het |
| Tnr |
A |
T |
1: 159,685,974 (GRCm39) |
I402F |
probably benign |
Het |
| Unc93b1 |
A |
T |
19: 3,994,293 (GRCm39) |
S475C |
probably damaging |
Het |
| Utrn |
T |
A |
10: 12,539,205 (GRCm39) |
E1937D |
probably benign |
Het |
| Vmn1r227 |
A |
T |
17: 20,955,927 (GRCm39) |
|
noncoding transcript |
Het |
| Vmn2r101 |
G |
A |
17: 19,832,229 (GRCm39) |
V742I |
probably benign |
Het |
| Vmn2r81 |
T |
C |
10: 79,083,635 (GRCm39) |
L3P |
possibly damaging |
Het |
| Zfp882 |
T |
G |
8: 72,668,233 (GRCm39) |
H353Q |
probably damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTACAAGTATCTCTGGGTGAGTTG -3'
(R):5'- TGTAGGCTTCTAGTCACCACAC -3'
Sequencing Primer
(F):5'- TCAAAAGTGTGTTTCCATCTTCG -3'
(R):5'- TTTGGGGAAATGCCCCA -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation