Incidental Mutation 'R2509:Tnik'
| ID |
251696 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tnik
|
| Ensembl Gene |
ENSMUSG00000027692 |
| Gene Name |
TRAF2 and NCK interacting kinase |
| Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
| MMRRC Submission |
040415-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2509 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 28722064 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1310
(V1310A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124011
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000160934]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162777]
|
| AlphaFold |
P83510 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159236
AA Change: V1302A
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000124681
Gene: ENSMUSG00000027692
AA Change: V1302A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
|
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
|
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159308
AA Change: V1255A
PolyPhen 2
Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000125466
Gene: ENSMUSG00000027692
AA Change: V1255A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
|
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
|
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159680
AA Change: V1331A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000124876
Gene: ENSMUSG00000027692
AA Change: V1331A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
|
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
|
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159733
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160307
AA Change: V1339A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000125081
Gene: ENSMUSG00000027692
AA Change: V1339A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
|
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
|
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160518
AA Change: V1310A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124011
Gene: ENSMUSG00000027692
AA Change: V1310A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
|
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
|
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
| SMART Domains |
Protein: ENSMUSP00000123859
Gene: ENSMUSG00000027692
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
|
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192205
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: V1247A
|
| SMART Domains |
Protein: ENSMUSP00000125411
Gene: ENSMUSG00000027692
AA Change: V1247A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
|
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162485
AA Change: V1284A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000124387
Gene: ENSMUSG00000027692
AA Change: V1284A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
|
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
|
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: V1276A
|
| SMART Domains |
Protein: ENSMUSP00000124726
Gene: ENSMUSG00000027692
AA Change: V1276A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
|
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
|
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
| Meta Mutation Damage Score |
0.1020 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
96% (105/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
T |
C |
3: 124,200,102 (GRCm39) |
I497V |
probably benign |
Het |
| 4930571K23Rik |
C |
A |
7: 124,968,311 (GRCm39) |
|
noncoding transcript |
Het |
| Abca17 |
G |
T |
17: 24,508,587 (GRCm39) |
|
probably benign |
Het |
| Ablim1 |
C |
T |
19: 57,140,791 (GRCm39) |
R196Q |
probably damaging |
Het |
| Acot11 |
T |
C |
4: 106,612,516 (GRCm39) |
I379V |
possibly damaging |
Het |
| Acot4 |
G |
A |
12: 84,088,647 (GRCm39) |
G165D |
probably damaging |
Het |
| Agrn |
A |
T |
4: 156,250,881 (GRCm39) |
|
probably null |
Het |
| Ahctf1 |
T |
C |
1: 179,598,258 (GRCm39) |
S945G |
possibly damaging |
Het |
| Akr1c13 |
C |
T |
13: 4,248,583 (GRCm39) |
R263C |
probably damaging |
Het |
| Arfgap1 |
T |
A |
2: 180,615,846 (GRCm39) |
|
probably benign |
Het |
| Arhgef3 |
A |
G |
14: 27,101,633 (GRCm39) |
K103R |
probably damaging |
Het |
| Cabp1 |
A |
T |
5: 115,310,843 (GRCm39) |
N211K |
probably damaging |
Het |
| Cacna1c |
T |
A |
6: 118,711,943 (GRCm39) |
D261V |
probably damaging |
Het |
| Car11 |
G |
A |
7: 45,350,783 (GRCm39) |
G93E |
probably damaging |
Het |
| Card10 |
A |
G |
15: 78,664,473 (GRCm39) |
I821T |
probably benign |
Het |
| Cast |
T |
C |
13: 74,885,735 (GRCm39) |
I277V |
probably benign |
Het |
| Cenpj |
T |
C |
14: 56,769,694 (GRCm39) |
K1165R |
probably null |
Het |
| Cenpk |
A |
G |
13: 104,370,675 (GRCm39) |
|
probably null |
Het |
| Cfap251 |
A |
G |
5: 123,394,169 (GRCm39) |
K353E |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,230,066 (GRCm39) |
Q1674R |
probably benign |
Het |
| Cnnm1 |
T |
A |
19: 43,430,325 (GRCm39) |
V481D |
probably damaging |
Het |
| Cracdl |
T |
C |
1: 37,664,381 (GRCm39) |
M506V |
probably benign |
Het |
| Csmd3 |
CCTTTGCGCTT |
CCTT |
15: 47,604,632 (GRCm39) |
|
probably null |
Het |
| Cyp2c50 |
G |
A |
19: 40,079,013 (GRCm39) |
V119I |
probably benign |
Het |
| Dnah7b |
A |
G |
1: 46,234,447 (GRCm39) |
T1460A |
probably damaging |
Het |
| Dnah8 |
G |
A |
17: 30,994,019 (GRCm39) |
D3379N |
probably benign |
Het |
| Dnajc4 |
C |
T |
19: 6,968,111 (GRCm39) |
R55H |
probably damaging |
Het |
| Ebf4 |
C |
T |
2: 130,148,482 (GRCm39) |
R98* |
probably null |
Het |
| Epha4 |
G |
A |
1: 77,488,339 (GRCm39) |
A47V |
possibly damaging |
Het |
| Ercc8 |
T |
C |
13: 108,320,251 (GRCm39) |
|
probably benign |
Het |
| Exo1 |
T |
C |
1: 175,733,399 (GRCm39) |
F75S |
probably damaging |
Het |
| Fam168a |
G |
T |
7: 100,483,391 (GRCm39) |
|
probably null |
Het |
| Fat3 |
G |
A |
9: 15,836,310 (GRCm39) |
R4065W |
possibly damaging |
Het |
| Gm5431 |
T |
A |
11: 48,779,536 (GRCm39) |
N740I |
probably benign |
Het |
| Gm5900 |
T |
A |
7: 104,599,571 (GRCm39) |
|
noncoding transcript |
Het |
| Gpi1 |
A |
G |
7: 33,905,348 (GRCm39) |
S359P |
probably damaging |
Het |
| Gpr156 |
A |
G |
16: 37,768,149 (GRCm39) |
R22G |
probably benign |
Het |
| Greb1 |
A |
G |
12: 16,774,923 (GRCm39) |
V158A |
probably damaging |
Het |
| Grin2c |
T |
A |
11: 115,141,894 (GRCm39) |
K842* |
probably null |
Het |
| Gsta5 |
T |
A |
9: 78,202,089 (GRCm39) |
M1K |
probably null |
Het |
| Hnf4a |
T |
A |
2: 163,408,161 (GRCm39) |
L329Q |
probably damaging |
Het |
| Hsp90ab1 |
A |
G |
17: 45,880,267 (GRCm39) |
L92P |
probably damaging |
Het |
| Ido1 |
T |
A |
8: 25,074,501 (GRCm39) |
R290* |
probably null |
Het |
| Ifnlr1 |
G |
T |
4: 135,432,559 (GRCm39) |
D332Y |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,420,312 (GRCm39) |
N1108S |
probably benign |
Het |
| Igkv3-9 |
T |
A |
6: 70,565,728 (GRCm39) |
M109K |
probably benign |
Het |
| Igsf10 |
T |
C |
3: 59,239,287 (GRCm39) |
D298G |
probably damaging |
Het |
| Iqck |
T |
G |
7: 118,475,505 (GRCm39) |
M98R |
probably benign |
Het |
| Klk1b1 |
T |
C |
7: 43,618,803 (GRCm39) |
V60A |
probably damaging |
Het |
| Krtap1-3 |
C |
T |
11: 99,481,653 (GRCm39) |
E165K |
unknown |
Het |
| Lair1 |
A |
G |
7: 4,013,782 (GRCm39) |
L155P |
probably damaging |
Het |
| Maco1 |
A |
G |
4: 134,531,699 (GRCm39) |
S657P |
probably damaging |
Het |
| Mast4 |
G |
T |
13: 102,990,350 (GRCm39) |
S57Y |
probably damaging |
Het |
| Mical3 |
T |
C |
6: 121,011,118 (GRCm39) |
H360R |
probably damaging |
Het |
| Muc5b |
A |
T |
7: 141,412,798 (GRCm39) |
N1915Y |
unknown |
Het |
| Myh1 |
A |
G |
11: 67,096,423 (GRCm39) |
I301V |
probably benign |
Het |
| Nck2 |
T |
A |
1: 43,593,393 (GRCm39) |
V200E |
probably damaging |
Het |
| Odad4 |
T |
G |
11: 100,444,361 (GRCm39) |
L222R |
probably damaging |
Het |
| Or2y1b |
T |
G |
11: 49,209,048 (GRCm39) |
L225R |
probably damaging |
Het |
| Or4b12 |
T |
C |
2: 90,096,030 (GRCm39) |
Y248C |
possibly damaging |
Het |
| Or4c109 |
T |
G |
2: 88,817,775 (GRCm39) |
Y257S |
probably damaging |
Het |
| Or4f60 |
T |
A |
2: 111,902,837 (GRCm39) |
L30F |
probably benign |
Het |
| Or4k38 |
C |
T |
2: 111,166,076 (GRCm39) |
V116I |
probably damaging |
Het |
| Or52n2c |
G |
A |
7: 104,574,894 (GRCm39) |
H26Y |
probably benign |
Het |
| Or5b101 |
T |
A |
19: 13,005,058 (GRCm39) |
I212F |
probably damaging |
Het |
| Or8b12i |
A |
G |
9: 20,082,525 (GRCm39) |
L114P |
probably damaging |
Het |
| Otoa |
C |
T |
7: 120,759,695 (GRCm39) |
T1099I |
probably benign |
Het |
| Pask |
T |
A |
1: 93,258,485 (GRCm39) |
I288F |
possibly damaging |
Het |
| Pcnx4 |
T |
C |
12: 72,613,746 (GRCm39) |
W564R |
probably damaging |
Het |
| Pip4p1 |
A |
T |
14: 51,167,115 (GRCm39) |
Y129* |
probably null |
Het |
| Pitpnm2 |
T |
C |
5: 124,274,389 (GRCm39) |
E240G |
probably damaging |
Het |
| Ppp1r16b |
A |
G |
2: 158,603,383 (GRCm39) |
Y436C |
possibly damaging |
Het |
| Pramel27 |
G |
A |
4: 143,578,561 (GRCm39) |
V274I |
probably benign |
Het |
| Prkca |
T |
C |
11: 107,870,032 (GRCm39) |
Y37C |
probably damaging |
Het |
| Rad18 |
T |
G |
6: 112,652,883 (GRCm39) |
H238P |
possibly damaging |
Het |
| Rap1b |
T |
A |
10: 117,654,444 (GRCm39) |
Q1L |
probably damaging |
Het |
| Rgs9 |
T |
C |
11: 109,159,798 (GRCm39) |
Y178C |
probably benign |
Het |
| Rpl3l |
A |
T |
17: 24,951,360 (GRCm39) |
D87V |
possibly damaging |
Het |
| Scrn2 |
T |
C |
11: 96,923,992 (GRCm39) |
V292A |
possibly damaging |
Het |
| Sdad1 |
A |
G |
5: 92,453,684 (GRCm39) |
Y35H |
probably benign |
Het |
| Sez6l2 |
T |
C |
7: 126,552,944 (GRCm39) |
S177P |
probably benign |
Het |
| Sh3bp1 |
C |
T |
15: 78,795,706 (GRCm39) |
P612S |
probably damaging |
Het |
| Shank1 |
T |
C |
7: 44,001,148 (GRCm39) |
S956P |
unknown |
Het |
| Shank1 |
G |
A |
7: 44,001,547 (GRCm39) |
A1089T |
unknown |
Het |
| Shprh |
G |
A |
10: 11,042,468 (GRCm39) |
C817Y |
probably damaging |
Het |
| Spata22 |
C |
T |
11: 73,236,593 (GRCm39) |
P300S |
probably damaging |
Het |
| Sstr2 |
A |
T |
11: 113,515,749 (GRCm39) |
I223F |
probably damaging |
Het |
| Stom |
C |
T |
2: 35,210,354 (GRCm39) |
A217T |
probably damaging |
Het |
| Stpg1 |
T |
C |
4: 135,263,960 (GRCm39) |
V341A |
probably benign |
Het |
| Tagap |
A |
G |
17: 8,147,586 (GRCm39) |
T99A |
probably benign |
Het |
| Tas1r2 |
A |
G |
4: 139,387,162 (GRCm39) |
N207S |
probably damaging |
Het |
| Thbs2 |
A |
G |
17: 14,906,105 (GRCm39) |
V265A |
probably benign |
Het |
| Thyn1 |
A |
G |
9: 26,911,316 (GRCm39) |
R3G |
possibly damaging |
Het |
| Tia1 |
T |
A |
6: 86,401,312 (GRCm39) |
|
probably null |
Het |
| Tktl2 |
A |
G |
8: 66,965,504 (GRCm39) |
E354G |
probably benign |
Het |
| Tmc8 |
A |
G |
11: 117,683,511 (GRCm39) |
T689A |
possibly damaging |
Het |
| Tmem11 |
A |
T |
11: 60,755,807 (GRCm39) |
|
probably null |
Het |
| Trappc10 |
A |
G |
10: 78,047,357 (GRCm39) |
S380P |
possibly damaging |
Het |
| Trim8 |
C |
T |
19: 46,503,734 (GRCm39) |
P429S |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,687,756 (GRCm39) |
|
probably benign |
Het |
| Ulk2 |
T |
C |
11: 61,678,340 (GRCm39) |
Y793C |
probably benign |
Het |
| Vill |
G |
A |
9: 118,899,370 (GRCm39) |
V337M |
possibly damaging |
Het |
| Vps53 |
C |
A |
11: 75,957,661 (GRCm39) |
V364F |
possibly damaging |
Het |
| Zan |
A |
T |
5: 137,454,848 (GRCm39) |
I1396N |
unknown |
Het |
| Zfa-ps |
A |
C |
10: 52,420,339 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp426 |
T |
C |
9: 20,381,977 (GRCm39) |
T337A |
possibly damaging |
Het |
| Zfp536 |
T |
C |
7: 37,267,403 (GRCm39) |
E671G |
possibly damaging |
Het |
| Zfp985 |
A |
G |
4: 147,667,443 (GRCm39) |
T104A |
possibly damaging |
Het |
|
| Other mutations in Tnik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
|
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6244:Tnik
|
UTSW |
3 |
28,704,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTATCTCCCTTGGCCTGGG -3'
(R):5'- TGTTCAACCAGGCCTTCTG -3'
Sequencing Primer
(F):5'- TCTGCTAGCATCAGCAGAGAGC -3'
(R):5'- AACCAGGCCTTCTGATTCTG -3'
|
| Posted On |
2014-12-04 |
Incidental Mutation