Incidental Mutation 'R5126:Ly6c2'
ID393579
Institutional Source Beutler Lab
Gene Symbol Ly6c2
Ensembl Gene ENSMUSG00000022584
Gene Namelymphocyte antigen 6 complex, locus C2
Synonyms
MMRRC Submission 042714-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.241) question?
Stock #R5126 (G1)
Quality Score225
Status Not validated
Chromosome15
Chromosomal Location75108158-75111970 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 75111643 bp
ZygosityHeterozygous
Amino Acid Change Serine to Alanine at position 9 (S9A)
Ref Sequence ENSEMBL: ENSMUSP00000139556 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100542] [ENSMUST00000188214] [ENSMUST00000191451]
Predicted Effect possibly damaging
Transcript: ENSMUST00000100542
AA Change: S9A

PolyPhen 2 Score 0.748 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000098110
Gene: ENSMUSG00000022584
AA Change: S9A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187864
Predicted Effect possibly damaging
Transcript: ENSMUST00000188214
AA Change: S9A

PolyPhen 2 Score 0.748 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000140825
Gene: ENSMUSG00000022584
AA Change: S9A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000191451
AA Change: S9A

PolyPhen 2 Score 0.748 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000139556
Gene: ENSMUSG00000022584
AA Change: S9A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 G A 2: 26,996,915 probably null Het
Ahdc1 T A 4: 133,063,522 F691L probably benign Het
Ahsa2 T A 11: 23,491,036 I202F possibly damaging Het
Akap10 C T 11: 61,916,189 A72T probably damaging Het
Ccnb1 C G 13: 100,781,775 Q121H possibly damaging Het
Cep164 A G 9: 45,787,424 probably null Het
Cltc A G 11: 86,712,669 V781A probably damaging Het
Dchs1 A G 7: 105,753,517 S3273P probably damaging Het
Dnajc16 C A 4: 141,774,509 V337L probably benign Het
E130309D02Rik G T 5: 143,307,946 P259T probably benign Het
Fstl4 T C 11: 53,186,561 V715A possibly damaging Het
Grik1 C T 16: 87,947,859 G502S probably damaging Het
Ifi213 A G 1: 173,590,015 V277A possibly damaging Het
Jph3 T C 8: 121,753,048 V155A possibly damaging Het
Katnal2 T C 18: 77,017,598 E51G probably benign Het
Kcna2 T A 3: 107,104,234 F44I probably damaging Het
Kcna6 T C 6: 126,738,732 E398G probably damaging Het
Kif15 A T 9: 122,975,758 H190L probably damaging Het
Lmbrd2 A G 15: 9,194,701 R597G possibly damaging Het
Lrtm2 T A 6: 119,317,439 M244L probably benign Het
Mbd4 T A 6: 115,848,968 probably null Het
Mfsd2b A G 12: 4,866,183 I269T probably benign Het
Muc6 A T 7: 141,651,299 C218S probably damaging Het
Nlrc5 G T 8: 94,474,671 R131L possibly damaging Het
Nlrp1b A T 11: 71,181,533 C495S possibly damaging Het
Nsf C A 11: 103,882,792 E299* probably null Het
Obscn T A 11: 59,077,063 E336D probably damaging Het
Olfr112 G T 17: 37,563,828 T161K probably benign Het
Pan3 A G 5: 147,527,198 N587S probably benign Het
Plch2 T C 4: 155,000,519 D321G probably damaging Het
Plscr4 G A 9: 92,488,741 D254N probably damaging Het
Pnmal1 A C 7: 16,961,317 M366L probably benign Het
Pnpla7 G T 2: 24,980,044 C12F possibly damaging Het
Pqlc2 T C 4: 139,302,532 T63A probably benign Het
Ptprk G T 10: 28,575,644 probably null Het
Rgs22 A G 15: 36,040,644 V899A probably damaging Het
Ruvbl1 T A 6: 88,485,901 C336S probably benign Het
Slc27a5 T A 7: 12,991,320 H400L probably damaging Het
Slco1a4 A T 6: 141,815,582 V435D possibly damaging Het
Snx14 A T 9: 88,382,099 Y818N probably damaging Het
Tln2 A G 9: 67,258,535 I2098T probably damaging Het
Tlr11 T C 14: 50,360,830 L91P probably damaging Het
Tmem208 T A 8: 105,334,650 F103I probably benign Het
Tmem8 T C 17: 26,121,640 I666T probably damaging Het
Vmn2r3 C T 3: 64,259,319 C797Y probably damaging Het
Vwde T A 6: 13,187,260 M743L probably benign Het
Wdcp C A 12: 4,850,617 R158S probably damaging Het
Zfp773 T C 7: 7,136,624 T9A unknown Het
Other mutations in Ly6c2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1056:Ly6c2 UTSW 15 75111596 critical splice donor site probably null
R1386:Ly6c2 UTSW 15 75110589 missense probably benign
R1655:Ly6c2 UTSW 15 75108563 missense probably benign
R1708:Ly6c2 UTSW 15 75111620 synonymous probably null
R2149:Ly6c2 UTSW 15 75108543 makesense probably null
R3919:Ly6c2 UTSW 15 75108764 splice site probably null
Predicted Primers PCR Primer
(F):5'- TGGCAGGTTTACAGACCCAG -3'
(R):5'- AGACAGACATGTATTCCTTGGGG -3'

Sequencing Primer
(F):5'- AGTATCCCAGTACAGGAGGCTTC -3'
(R):5'- CCTTGGGGAAAGCTGTGTG -3'
Posted On2016-06-15