Incidental Mutation 'IGL03230:Olfr1031'
ID413855
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1031
Ensembl Gene ENSMUSG00000043267
Gene Nameolfactory receptor 1031
SynonymsGA_x6K02T2Q125-47470765-47471775, MOR200-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL03230
Quality Score
Status
Chromosome2
Chromosomal Location85990304-85993704 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 85992239 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 141 (T141S)
Ref Sequence ENSEMBL: ENSMUSP00000149225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050942] [ENSMUST00000056849] [ENSMUST00000216807]
Predicted Effect probably benign
Transcript: ENSMUST00000050942
AA Change: T141S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000059256
Gene: ENSMUSG00000043267
AA Change: T141S

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 1.1e-55 PFAM
Pfam:7tm_1 40 289 6.6e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000056849
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216807
AA Change: T141S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C A 11: 9,294,313 Q2059K probably benign Het
Abcc1 A T 16: 14,457,947 T902S probably benign Het
Acly A T 11: 100,494,059 C623S probably damaging Het
Ak8 A G 2: 28,709,923 probably benign Het
Birc6 A G 17: 74,611,070 D1811G probably damaging Het
Bms1 T A 6: 118,418,561 K8N possibly damaging Het
Cdc25b T C 2: 131,188,140 F79L probably benign Het
Cdh13 T A 8: 119,242,317 V471D probably damaging Het
Cnot4 T C 6: 35,051,409 D424G probably damaging Het
Cyp2a12 A T 7: 27,029,592 I70F possibly damaging Het
Cyp2c66 A T 19: 39,183,858 R406W possibly damaging Het
Cyp2g1 C A 7: 26,819,403 P408Q probably damaging Het
Defa26 A G 8: 21,618,298 D39G probably damaging Het
Dnah1 A T 14: 31,270,066 S3020T probably damaging Het
Dst A T 1: 34,184,052 K1119* probably null Het
Gm10110 A C 14: 89,898,297 noncoding transcript Het
Grk2 C T 19: 4,287,829 E508K probably benign Het
Hpx A T 7: 105,599,312 I94N probably benign Het
Il23r C T 6: 67,423,964 A461T probably benign Het
Iqca A G 1: 90,145,002 I52T probably damaging Het
Kif21b T A 1: 136,162,812 M1146K probably benign Het
Kifap3 C A 1: 163,825,724 T293K probably benign Het
Luzp1 G A 4: 136,542,878 S804N probably benign Het
Mcmdc2 C T 1: 9,931,996 probably benign Het
Mctp1 G T 13: 76,824,857 A403S possibly damaging Het
Mtnr1a T C 8: 45,087,398 I132T probably damaging Het
Musk T A 4: 58,296,710 N103K probably damaging Het
Nipal2 T A 15: 34,575,556 D352V probably damaging Het
Oas1a T A 5: 120,898,356 K336I probably benign Het
Oasl1 T C 5: 114,937,056 S392P probably damaging Het
Olfr1222 A G 2: 89,125,548 F61S probably damaging Het
Olfr1225 A T 2: 89,171,089 M41K possibly damaging Het
Olfr402 A G 11: 74,155,273 T40A probably benign Het
Olfr48 T C 2: 89,844,113 T287A probably benign Het
Olfr699 A G 7: 106,790,704 L99P probably damaging Het
Pate3 T G 9: 35,646,106 T85P probably benign Het
Piezo2 T C 18: 63,041,720 N1988D probably damaging Het
Plcxd3 T A 15: 4,516,790 I92N probably damaging Het
Ptprd T A 4: 76,050,417 R213* probably null Het
Slit1 T C 19: 41,729,085 D80G probably damaging Het
Sorcs1 A G 19: 50,242,093 V472A probably damaging Het
Trp63 T A 16: 25,889,010 D485E probably damaging Het
Tsr1 T C 11: 74,900,471 V292A probably benign Het
Ttc37 T A 13: 76,155,647 probably benign Het
Ush2a G T 1: 188,466,193 A1485S probably benign Het
Vmn1r49 T A 6: 90,072,668 R117S probably damaging Het
Vmn2r97 C A 17: 18,929,406 P352H probably benign Het
Zxdc C T 6: 90,373,803 T412I probably damaging Het
Other mutations in Olfr1031
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02104:Olfr1031 APN 2 85992386 missense probably damaging 1.00
IGL02475:Olfr1031 APN 2 85992032 missense probably benign 0.19
IGL03405:Olfr1031 APN 2 85991886 missense possibly damaging 0.84
PIT4151001:Olfr1031 UTSW 2 85992194 missense probably damaging 0.96
PIT4366001:Olfr1031 UTSW 2 85992041 missense probably damaging 1.00
R0344:Olfr1031 UTSW 2 85992382 nonsense probably null
R1168:Olfr1031 UTSW 2 85992684 missense probably damaging 1.00
R1170:Olfr1031 UTSW 2 85992696 missense probably damaging 1.00
R2345:Olfr1031 UTSW 2 85991822 missense probably benign 0.01
R2915:Olfr1031 UTSW 2 85992045 missense probably damaging 1.00
R3498:Olfr1031 UTSW 2 85992430 missense probably benign 0.43
R4058:Olfr1031 UTSW 2 85992232 missense possibly damaging 0.87
R4747:Olfr1031 UTSW 2 85991927 missense probably damaging 1.00
R4859:Olfr1031 UTSW 2 85992731 missense probably damaging 0.96
R4991:Olfr1031 UTSW 2 85992287 missense probably damaging 0.99
R5438:Olfr1031 UTSW 2 85992581 missense probably damaging 1.00
R6362:Olfr1031 UTSW 2 85991941 missense probably damaging 1.00
R7458:Olfr1031 UTSW 2 85992650 missense probably damaging 1.00
R7535:Olfr1031 UTSW 2 85991901 missense probably benign 0.37
Posted On2016-08-02