Incidental Mutation 'R0504:Myo18b'
| ID |
47325 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo18b
|
| Ensembl Gene |
ENSMUSG00000072720 |
| Gene Name |
myosin XVIIIb |
| Synonyms |
4932408L24Rik, 4933411E19Rik |
| MMRRC Submission |
038699-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0504 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
112836742-113044228 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to G
at 113021442 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086617]
|
| AlphaFold |
E9PV66 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086617
|
| SMART Domains |
Protein: ENSMUSP00000083810
Gene: ENSMUSG00000072720
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
20 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
200 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
355 |
372 |
N/A |
INTRINSIC |
|
low complexity region
|
377 |
419 |
N/A |
INTRINSIC |
|
MYSc
|
605 |
1374 |
8.78e-30 |
SMART |
|
IQ
|
1375 |
1397 |
5.92e-4 |
SMART |
|
Pfam:Myosin_tail_1
|
1423 |
1875 |
5e-12 |
PFAM |
|
low complexity region
|
1965 |
1985 |
N/A |
INTRINSIC |
|
coiled coil region
|
2052 |
2126 |
N/A |
INTRINSIC |
|
low complexity region
|
2184 |
2199 |
N/A |
INTRINSIC |
|
low complexity region
|
2325 |
2336 |
N/A |
INTRINSIC |
|
low complexity region
|
2408 |
2424 |
N/A |
INTRINSIC |
|
low complexity region
|
2544 |
2558 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183029
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183273
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
99% (145/147) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 145 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921539E11Rik |
A |
G |
4: 103,128,057 (GRCm39) |
|
probably benign |
Het |
| Adamts6 |
T |
C |
13: 104,563,438 (GRCm39) |
|
probably benign |
Het |
| Adamts9 |
T |
A |
6: 92,889,626 (GRCm39) |
Y316F |
probably damaging |
Het |
| Agl |
A |
T |
3: 116,580,433 (GRCm39) |
F374I |
probably damaging |
Het |
| Akr1c19 |
A |
G |
13: 4,286,250 (GRCm39) |
T83A |
possibly damaging |
Het |
| Ankrd36 |
T |
A |
11: 5,579,274 (GRCm39) |
S179R |
probably damaging |
Het |
| Appbp2 |
A |
G |
11: 85,082,513 (GRCm39) |
S573P |
probably benign |
Het |
| Arid4a |
T |
A |
12: 71,093,988 (GRCm39) |
F254I |
probably damaging |
Het |
| Bin3 |
T |
C |
14: 70,361,336 (GRCm39) |
|
probably null |
Het |
| Bmi1 |
T |
C |
2: 18,688,883 (GRCm39) |
|
probably null |
Het |
| Bmper |
G |
T |
9: 23,317,983 (GRCm39) |
C534F |
probably damaging |
Het |
| Bora |
T |
A |
14: 99,299,059 (GRCm39) |
C205* |
probably null |
Het |
| Btnl2 |
A |
G |
17: 34,577,091 (GRCm39) |
E82G |
probably benign |
Het |
| Ccdc8 |
A |
T |
7: 16,729,939 (GRCm39) |
D476V |
unknown |
Het |
| Ccr3 |
C |
A |
9: 123,829,478 (GRCm39) |
T271K |
possibly damaging |
Het |
| Cd276 |
A |
G |
9: 58,447,961 (GRCm39) |
L23P |
possibly damaging |
Het |
| Cd3e |
T |
C |
9: 44,913,552 (GRCm39) |
Q61R |
probably benign |
Het |
| Cep97 |
A |
G |
16: 55,726,142 (GRCm39) |
S582P |
probably benign |
Het |
| Chml |
A |
T |
1: 175,514,748 (GRCm39) |
M391K |
probably damaging |
Het |
| Chst1 |
A |
G |
2: 92,444,169 (GRCm39) |
N214D |
probably benign |
Het |
| Chuk |
T |
C |
19: 44,070,377 (GRCm39) |
|
probably benign |
Het |
| Col12a1 |
G |
A |
9: 79,588,750 (GRCm39) |
H1122Y |
possibly damaging |
Het |
| Cpne6 |
A |
G |
14: 55,752,059 (GRCm39) |
K272R |
probably damaging |
Het |
| Cpsf2 |
T |
A |
12: 101,956,262 (GRCm39) |
L355Q |
probably damaging |
Het |
| Cyp2c29 |
T |
A |
19: 39,298,224 (GRCm39) |
D256E |
probably benign |
Het |
| Daglb |
G |
A |
5: 143,479,952 (GRCm39) |
V420I |
probably benign |
Het |
| Ddx42 |
G |
T |
11: 106,138,675 (GRCm39) |
G825C |
probably benign |
Het |
| Dis3 |
T |
C |
14: 99,318,826 (GRCm39) |
|
probably benign |
Het |
| Dkk4 |
C |
T |
8: 23,115,359 (GRCm39) |
R70C |
probably damaging |
Het |
| Dock6 |
G |
T |
9: 21,713,732 (GRCm39) |
Q1933K |
probably damaging |
Het |
| Dpep2 |
T |
G |
8: 106,716,620 (GRCm39) |
Q186H |
probably benign |
Het |
| Dzip3 |
A |
C |
16: 48,780,006 (GRCm39) |
|
probably benign |
Het |
| Egflam |
T |
A |
15: 7,252,239 (GRCm39) |
I853F |
probably damaging |
Het |
| Fastkd5 |
A |
G |
2: 130,457,837 (GRCm39) |
I251T |
probably benign |
Het |
| Fbn2 |
T |
A |
18: 58,172,532 (GRCm39) |
D2091V |
possibly damaging |
Het |
| Fem1al |
T |
C |
11: 29,774,990 (GRCm39) |
I156V |
probably damaging |
Het |
| Fer1l4 |
C |
A |
2: 155,894,115 (GRCm39) |
V63L |
probably benign |
Het |
| Frem1 |
T |
A |
4: 82,830,874 (GRCm39) |
D2062V |
probably benign |
Het |
| Galnt6 |
A |
C |
15: 100,594,538 (GRCm39) |
|
probably benign |
Het |
| Get3 |
A |
C |
8: 85,745,236 (GRCm39) |
V277G |
probably damaging |
Het |
| Gm10972 |
A |
T |
3: 94,550,440 (GRCm39) |
|
probably benign |
Het |
| Gm4846 |
G |
A |
1: 166,319,114 (GRCm39) |
T208I |
probably benign |
Het |
| Gorab |
A |
G |
1: 163,214,174 (GRCm39) |
L252P |
probably damaging |
Het |
| Gtsf2 |
A |
G |
15: 103,352,988 (GRCm39) |
C63R |
probably damaging |
Het |
| Hal |
T |
C |
10: 93,325,036 (GRCm39) |
V15A |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,752,170 (GRCm39) |
|
probably benign |
Het |
| Hormad2 |
A |
T |
11: 4,358,833 (GRCm39) |
H191Q |
possibly damaging |
Het |
| Hspa2 |
A |
T |
12: 76,451,990 (GRCm39) |
D228V |
probably damaging |
Het |
| Igfn1 |
A |
T |
1: 135,896,267 (GRCm39) |
M1433K |
probably benign |
Het |
| Il18 |
A |
G |
9: 50,486,628 (GRCm39) |
D19G |
probably damaging |
Het |
| Il1rl2 |
G |
A |
1: 40,368,216 (GRCm39) |
V129I |
probably benign |
Het |
| Inpp5b |
C |
A |
4: 124,676,201 (GRCm39) |
Y352* |
probably null |
Het |
| Insrr |
A |
T |
3: 87,720,463 (GRCm39) |
M1034L |
possibly damaging |
Het |
| Jmjd1c |
T |
C |
10: 67,061,534 (GRCm39) |
S1296P |
probably damaging |
Het |
| Kdm5b |
G |
T |
1: 134,548,761 (GRCm39) |
|
probably null |
Het |
| Krba1 |
C |
T |
6: 48,393,188 (GRCm39) |
T998I |
probably benign |
Het |
| L3mbtl4 |
A |
G |
17: 69,084,907 (GRCm39) |
N606S |
probably benign |
Het |
| Lonrf1 |
T |
A |
8: 36,698,313 (GRCm39) |
N395I |
possibly damaging |
Het |
| Lpp |
A |
G |
16: 24,790,720 (GRCm39) |
D393G |
probably damaging |
Het |
| Lrrc17 |
A |
G |
5: 21,765,528 (GRCm39) |
I3M |
probably benign |
Het |
| Lrrtm4 |
A |
T |
6: 79,999,029 (GRCm39) |
Q147L |
probably damaging |
Het |
| Map1a |
A |
G |
2: 121,133,422 (GRCm39) |
M1413V |
probably benign |
Het |
| Mapk8ip2 |
A |
G |
15: 89,340,861 (GRCm39) |
E102G |
possibly damaging |
Het |
| Marf1 |
C |
T |
16: 13,960,398 (GRCm39) |
A549T |
probably damaging |
Het |
| Mdn1 |
T |
C |
4: 32,698,916 (GRCm39) |
|
probably benign |
Het |
| Mfng |
A |
C |
15: 78,641,514 (GRCm39) |
H294Q |
probably benign |
Het |
| Mical2 |
T |
A |
7: 111,870,524 (GRCm39) |
N4K |
probably benign |
Het |
| Mov10l1 |
T |
A |
15: 88,883,042 (GRCm39) |
V384E |
probably damaging |
Het |
| Nlrp1b |
T |
G |
11: 71,073,241 (GRCm39) |
I201L |
probably damaging |
Het |
| Nos2 |
C |
T |
11: 78,830,903 (GRCm39) |
P249L |
probably damaging |
Het |
| Notch4 |
A |
G |
17: 34,794,065 (GRCm39) |
T681A |
probably damaging |
Het |
| Nr1i3 |
C |
T |
1: 171,044,805 (GRCm39) |
|
probably benign |
Het |
| Obscn |
A |
G |
11: 58,899,333 (GRCm39) |
|
probably null |
Het |
| Onecut2 |
A |
T |
18: 64,473,820 (GRCm39) |
I124F |
possibly damaging |
Het |
| Or10a49 |
C |
T |
7: 108,468,057 (GRCm39) |
M101I |
possibly damaging |
Het |
| Or2a14 |
A |
T |
6: 43,130,395 (GRCm39) |
H52L |
probably benign |
Het |
| Or2ag1 |
T |
A |
7: 106,313,908 (GRCm39) |
|
probably benign |
Het |
| Or2f2 |
C |
T |
6: 42,767,530 (GRCm39) |
R186* |
probably null |
Het |
| Or2t47 |
C |
A |
11: 58,442,462 (GRCm39) |
C201F |
probably damaging |
Het |
| Or4a75 |
A |
T |
2: 89,448,438 (GRCm39) |
Y33N |
probably damaging |
Het |
| Or4c123 |
C |
T |
2: 89,127,083 (GRCm39) |
C177Y |
probably damaging |
Het |
| Or52u1 |
C |
T |
7: 104,237,682 (GRCm39) |
R224* |
probably null |
Het |
| Or5m12 |
T |
A |
2: 85,735,030 (GRCm39) |
M123L |
possibly damaging |
Het |
| Or8b35 |
A |
G |
9: 37,904,438 (GRCm39) |
T217A |
probably benign |
Het |
| Otol1 |
G |
A |
3: 69,934,937 (GRCm39) |
G310R |
probably damaging |
Het |
| Oxct2b |
T |
A |
4: 123,010,633 (GRCm39) |
S184R |
possibly damaging |
Het |
| Oxct2b |
ACTG |
A |
4: 123,010,705 (GRCm39) |
|
probably benign |
Het |
| P2rx6 |
A |
G |
16: 17,385,291 (GRCm39) |
|
probably benign |
Het |
| Pde4a |
A |
G |
9: 21,115,699 (GRCm39) |
N411S |
probably damaging |
Het |
| Phkb |
A |
T |
8: 86,783,153 (GRCm39) |
D983V |
probably benign |
Het |
| Piezo2 |
G |
A |
18: 63,157,522 (GRCm39) |
T2396I |
probably damaging |
Het |
| Pik3ap1 |
T |
A |
19: 41,275,929 (GRCm39) |
D717V |
probably damaging |
Het |
| Plce1 |
T |
A |
19: 38,766,465 (GRCm39) |
|
probably benign |
Het |
| Plekhg1 |
A |
G |
10: 3,887,853 (GRCm39) |
I261V |
probably damaging |
Het |
| Ppfia4 |
T |
C |
1: 134,251,851 (GRCm39) |
H441R |
probably damaging |
Het |
| Prpf8 |
T |
A |
11: 75,392,768 (GRCm39) |
|
probably benign |
Het |
| Ptn |
T |
A |
6: 36,718,388 (GRCm39) |
|
probably benign |
Het |
| Ptpn13 |
A |
G |
5: 103,649,362 (GRCm39) |
Y255C |
possibly damaging |
Het |
| Ptpn4 |
A |
G |
1: 119,693,645 (GRCm39) |
Y126H |
probably damaging |
Het |
| Ptprc |
T |
C |
1: 138,016,435 (GRCm39) |
N505D |
probably damaging |
Het |
| Ptprs |
T |
A |
17: 56,761,220 (GRCm39) |
I116F |
possibly damaging |
Het |
| Rab1a |
T |
G |
11: 20,173,169 (GRCm39) |
V90G |
probably damaging |
Het |
| Rcor1 |
T |
C |
12: 111,068,102 (GRCm39) |
V267A |
probably benign |
Het |
| Reep4 |
A |
G |
14: 70,784,678 (GRCm39) |
|
probably null |
Het |
| Rere |
T |
A |
4: 150,699,779 (GRCm39) |
|
probably benign |
Het |
| Rin3 |
T |
A |
12: 102,353,823 (GRCm39) |
Y743* |
probably null |
Het |
| Rprm |
A |
G |
2: 53,975,067 (GRCm39) |
S84P |
probably damaging |
Het |
| Sdhaf2 |
C |
T |
19: 10,494,383 (GRCm39) |
E109K |
probably damaging |
Het |
| Sec31b |
G |
T |
19: 44,523,225 (GRCm39) |
Q24K |
probably damaging |
Het |
| Sema5a |
T |
C |
15: 32,574,949 (GRCm39) |
|
probably benign |
Het |
| Sh3pxd2a |
T |
C |
19: 47,256,186 (GRCm39) |
Y844C |
probably damaging |
Het |
| Shmt2 |
A |
C |
10: 127,355,941 (GRCm39) |
N134K |
probably damaging |
Het |
| Slc9a8 |
C |
T |
2: 167,266,125 (GRCm39) |
A34V |
probably benign |
Het |
| Spidr |
A |
C |
16: 15,957,936 (GRCm39) |
S64A |
possibly damaging |
Het |
| Stk10 |
A |
G |
11: 32,567,882 (GRCm39) |
T895A |
probably benign |
Het |
| Syne2 |
A |
T |
12: 76,080,365 (GRCm39) |
|
probably benign |
Het |
| Szt2 |
T |
C |
4: 118,230,149 (GRCm39) |
|
probably null |
Het |
| Tecpr1 |
A |
T |
5: 144,150,899 (GRCm39) |
V303D |
probably damaging |
Het |
| Tet3 |
A |
G |
6: 83,350,776 (GRCm39) |
Y1048H |
probably damaging |
Het |
| Tfb2m |
A |
G |
1: 179,373,396 (GRCm39) |
C101R |
probably damaging |
Het |
| Tg |
T |
C |
15: 66,554,253 (GRCm39) |
V556A |
probably damaging |
Het |
| Thbs4 |
A |
C |
13: 92,903,692 (GRCm39) |
I441M |
probably benign |
Het |
| Thsd7a |
A |
T |
6: 12,379,593 (GRCm39) |
Y944N |
probably damaging |
Het |
| Tm9sf3 |
C |
A |
19: 41,236,331 (GRCm39) |
|
probably benign |
Het |
| Tmem145 |
T |
C |
7: 25,010,787 (GRCm39) |
F359S |
probably damaging |
Het |
| Ttc21b |
C |
T |
2: 66,053,142 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
G |
2: 76,579,880 (GRCm39) |
V23671A |
probably damaging |
Het |
| Txnl4b |
T |
C |
8: 110,298,103 (GRCm39) |
I78T |
probably benign |
Het |
| Ubr4 |
C |
A |
4: 139,133,889 (GRCm39) |
L762I |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,208,149 (GRCm39) |
|
probably null |
Het |
| Ugt1a8 |
C |
T |
1: 88,016,079 (GRCm39) |
P164L |
probably damaging |
Het |
| Unc13b |
T |
C |
4: 43,263,559 (GRCm39) |
S1594P |
probably damaging |
Het |
| Utrn |
A |
T |
10: 12,278,639 (GRCm39) |
F912I |
probably benign |
Het |
| Vat1l |
T |
C |
8: 114,963,319 (GRCm39) |
|
probably benign |
Het |
| Vmn1r50 |
T |
A |
6: 90,084,863 (GRCm39) |
S203T |
probably damaging |
Het |
| Vmn2r4 |
A |
T |
3: 64,296,784 (GRCm39) |
L667Q |
probably damaging |
Het |
| Vmn2r66 |
T |
G |
7: 84,656,023 (GRCm39) |
Q331P |
probably damaging |
Het |
| Wdsub1 |
A |
T |
2: 59,708,669 (GRCm39) |
V68D |
possibly damaging |
Het |
| Wnk2 |
C |
G |
13: 49,238,870 (GRCm39) |
A564P |
possibly damaging |
Het |
| Wnk2 |
T |
A |
13: 49,238,872 (GRCm39) |
K563M |
probably damaging |
Het |
| Zan |
T |
A |
5: 137,468,580 (GRCm39) |
H297L |
probably damaging |
Het |
| Zfp426 |
A |
T |
9: 20,381,327 (GRCm39) |
H539Q |
probably damaging |
Het |
| Zfp488 |
T |
A |
14: 33,692,497 (GRCm39) |
N222I |
probably damaging |
Het |
| Zfp536 |
T |
A |
7: 37,268,243 (GRCm39) |
H391L |
probably damaging |
Het |
| Zp1 |
T |
A |
19: 10,893,571 (GRCm39) |
N31I |
probably damaging |
Het |
|
| Other mutations in Myo18b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Myo18b
|
APN |
5 |
113,021,997 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00847:Myo18b
|
APN |
5 |
112,978,255 (GRCm39) |
splice site |
probably benign |
|
|
IGL00848:Myo18b
|
APN |
5 |
113,019,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00969:Myo18b
|
APN |
5 |
113,022,873 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01018:Myo18b
|
APN |
5 |
112,957,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01448:Myo18b
|
APN |
5 |
112,959,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01490:Myo18b
|
APN |
5 |
112,957,566 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01556:Myo18b
|
APN |
5 |
112,905,315 (GRCm39) |
splice site |
probably benign |
|
|
IGL01637:Myo18b
|
APN |
5 |
112,988,495 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01819:Myo18b
|
APN |
5 |
113,025,916 (GRCm39) |
missense |
unknown |
|
|
IGL02007:Myo18b
|
APN |
5 |
113,022,838 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02146:Myo18b
|
APN |
5 |
112,991,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02229:Myo18b
|
APN |
5 |
113,025,976 (GRCm39) |
missense |
unknown |
|
|
IGL02319:Myo18b
|
APN |
5 |
112,939,005 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02398:Myo18b
|
APN |
5 |
112,978,178 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02420:Myo18b
|
APN |
5 |
112,975,852 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02626:Myo18b
|
APN |
5 |
113,025,951 (GRCm39) |
missense |
unknown |
|
|
IGL02815:Myo18b
|
APN |
5 |
112,957,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02822:Myo18b
|
APN |
5 |
112,923,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Myo18b
|
APN |
5 |
112,863,377 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02995:Myo18b
|
APN |
5 |
112,923,279 (GRCm39) |
splice site |
probably benign |
|
|
IGL03019:Myo18b
|
APN |
5 |
112,840,263 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL03039:Myo18b
|
APN |
5 |
112,988,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03112:Myo18b
|
APN |
5 |
113,021,856 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03123:Myo18b
|
APN |
5 |
113,022,804 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03288:Myo18b
|
APN |
5 |
112,937,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03391:Myo18b
|
APN |
5 |
113,022,345 (GRCm39) |
unclassified |
probably benign |
|
|
klippel
|
UTSW |
5 |
112,905,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4651001:Myo18b
|
UTSW |
5 |
112,982,301 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0271:Myo18b
|
UTSW |
5 |
112,957,551 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0277:Myo18b
|
UTSW |
5 |
112,841,213 (GRCm39) |
splice site |
probably benign |
|
|
R0352:Myo18b
|
UTSW |
5 |
113,022,389 (GRCm39) |
unclassified |
probably benign |
|
|
R0539:Myo18b
|
UTSW |
5 |
112,871,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0599:Myo18b
|
UTSW |
5 |
113,013,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Myo18b
|
UTSW |
5 |
112,946,700 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0659:Myo18b
|
UTSW |
5 |
112,908,193 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0671:Myo18b
|
UTSW |
5 |
112,840,632 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0847:Myo18b
|
UTSW |
5 |
113,022,354 (GRCm39) |
unclassified |
probably benign |
|
|
R1082:Myo18b
|
UTSW |
5 |
112,908,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1116:Myo18b
|
UTSW |
5 |
112,951,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Myo18b
|
UTSW |
5 |
112,978,185 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1280:Myo18b
|
UTSW |
5 |
112,871,671 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1444:Myo18b
|
UTSW |
5 |
112,923,117 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1446:Myo18b
|
UTSW |
5 |
112,905,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Myo18b
|
UTSW |
5 |
112,840,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1470:Myo18b
|
UTSW |
5 |
112,840,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1590:Myo18b
|
UTSW |
5 |
113,023,132 (GRCm39) |
nonsense |
probably null |
|
|
R1601:Myo18b
|
UTSW |
5 |
113,019,364 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1903:Myo18b
|
UTSW |
5 |
112,840,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Myo18b
|
UTSW |
5 |
112,908,222 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1936:Myo18b
|
UTSW |
5 |
112,908,222 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2008:Myo18b
|
UTSW |
5 |
113,021,423 (GRCm39) |
missense |
probably benign |
|
|
R2127:Myo18b
|
UTSW |
5 |
112,978,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Myo18b
|
UTSW |
5 |
112,978,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2141:Myo18b
|
UTSW |
5 |
113,021,892 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2170:Myo18b
|
UTSW |
5 |
112,871,724 (GRCm39) |
missense |
probably benign |
0.23 |
|
R2258:Myo18b
|
UTSW |
5 |
113,022,529 (GRCm39) |
unclassified |
probably benign |
|
|
R2265:Myo18b
|
UTSW |
5 |
112,930,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2483:Myo18b
|
UTSW |
5 |
113,006,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2931:Myo18b
|
UTSW |
5 |
112,840,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3160:Myo18b
|
UTSW |
5 |
112,840,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Myo18b
|
UTSW |
5 |
112,840,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3777:Myo18b
|
UTSW |
5 |
112,905,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4240:Myo18b
|
UTSW |
5 |
112,951,053 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4243:Myo18b
|
UTSW |
5 |
112,840,261 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4245:Myo18b
|
UTSW |
5 |
112,840,261 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4533:Myo18b
|
UTSW |
5 |
112,840,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4631:Myo18b
|
UTSW |
5 |
112,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Myo18b
|
UTSW |
5 |
113,023,041 (GRCm39) |
unclassified |
probably benign |
|
|
R4755:Myo18b
|
UTSW |
5 |
113,022,340 (GRCm39) |
nonsense |
probably null |
|
|
R4771:Myo18b
|
UTSW |
5 |
112,840,093 (GRCm39) |
nonsense |
probably null |
|
|
R4812:Myo18b
|
UTSW |
5 |
112,957,584 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4840:Myo18b
|
UTSW |
5 |
113,021,895 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4888:Myo18b
|
UTSW |
5 |
113,022,346 (GRCm39) |
unclassified |
probably benign |
|
|
R4995:Myo18b
|
UTSW |
5 |
112,908,258 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5001:Myo18b
|
UTSW |
5 |
112,909,206 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5015:Myo18b
|
UTSW |
5 |
112,937,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5055:Myo18b
|
UTSW |
5 |
113,023,083 (GRCm39) |
unclassified |
probably benign |
|
|
R5070:Myo18b
|
UTSW |
5 |
112,909,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5105:Myo18b
|
UTSW |
5 |
112,988,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5121:Myo18b
|
UTSW |
5 |
113,022,346 (GRCm39) |
unclassified |
probably benign |
|
|
R5130:Myo18b
|
UTSW |
5 |
113,021,769 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5186:Myo18b
|
UTSW |
5 |
113,019,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5437:Myo18b
|
UTSW |
5 |
112,905,439 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5535:Myo18b
|
UTSW |
5 |
112,937,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5560:Myo18b
|
UTSW |
5 |
113,016,161 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5810:Myo18b
|
UTSW |
5 |
112,982,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5898:Myo18b
|
UTSW |
5 |
112,950,196 (GRCm39) |
splice site |
probably null |
|
|
R6065:Myo18b
|
UTSW |
5 |
112,840,647 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6104:Myo18b
|
UTSW |
5 |
113,022,157 (GRCm39) |
unclassified |
probably benign |
|
|
R6113:Myo18b
|
UTSW |
5 |
113,014,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6158:Myo18b
|
UTSW |
5 |
113,022,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6167:Myo18b
|
UTSW |
5 |
113,020,373 (GRCm39) |
splice site |
probably null |
|
|
R6220:Myo18b
|
UTSW |
5 |
112,905,373 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6276:Myo18b
|
UTSW |
5 |
112,959,508 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6290:Myo18b
|
UTSW |
5 |
113,013,601 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6291:Myo18b
|
UTSW |
5 |
113,013,601 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6795:Myo18b
|
UTSW |
5 |
112,994,230 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6798:Myo18b
|
UTSW |
5 |
112,909,252 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6817:Myo18b
|
UTSW |
5 |
112,978,104 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6937:Myo18b
|
UTSW |
5 |
112,950,258 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7034:Myo18b
|
UTSW |
5 |
112,871,770 (GRCm39) |
nonsense |
probably null |
|
|
R7097:Myo18b
|
UTSW |
5 |
113,022,271 (GRCm39) |
missense |
unknown |
|
|
R7145:Myo18b
|
UTSW |
5 |
112,965,545 (GRCm39) |
nonsense |
probably null |
|
|
R7201:Myo18b
|
UTSW |
5 |
112,863,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7260:Myo18b
|
UTSW |
5 |
112,923,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7265:Myo18b
|
UTSW |
5 |
112,959,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Myo18b
|
UTSW |
5 |
113,021,971 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7466:Myo18b
|
UTSW |
5 |
112,871,758 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7487:Myo18b
|
UTSW |
5 |
112,982,299 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7571:Myo18b
|
UTSW |
5 |
112,978,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7600:Myo18b
|
UTSW |
5 |
113,025,969 (GRCm39) |
missense |
unknown |
|
|
R7612:Myo18b
|
UTSW |
5 |
113,013,168 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7617:Myo18b
|
UTSW |
5 |
112,905,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7696:Myo18b
|
UTSW |
5 |
112,840,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7710:Myo18b
|
UTSW |
5 |
113,022,891 (GRCm39) |
missense |
unknown |
|
|
R8047:Myo18b
|
UTSW |
5 |
112,871,681 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8070:Myo18b
|
UTSW |
5 |
112,938,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8088:Myo18b
|
UTSW |
5 |
113,027,376 (GRCm39) |
start gained |
probably benign |
|
|
R8247:Myo18b
|
UTSW |
5 |
112,840,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8276:Myo18b
|
UTSW |
5 |
112,943,273 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8313:Myo18b
|
UTSW |
5 |
113,023,045 (GRCm39) |
missense |
unknown |
|
|
R8375:Myo18b
|
UTSW |
5 |
112,908,259 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8432:Myo18b
|
UTSW |
5 |
112,912,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8475:Myo18b
|
UTSW |
5 |
113,021,422 (GRCm39) |
nonsense |
probably null |
|
|
R8482:Myo18b
|
UTSW |
5 |
113,019,489 (GRCm39) |
nonsense |
probably null |
|
|
R8671:Myo18b
|
UTSW |
5 |
113,022,609 (GRCm39) |
missense |
unknown |
|
|
R8681:Myo18b
|
UTSW |
5 |
113,021,429 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8918:Myo18b
|
UTSW |
5 |
113,022,873 (GRCm39) |
unclassified |
probably benign |
|
|
R8941:Myo18b
|
UTSW |
5 |
113,022,795 (GRCm39) |
unclassified |
probably benign |
|
|
R8962:Myo18b
|
UTSW |
5 |
113,006,346 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8972:Myo18b
|
UTSW |
5 |
112,841,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9116:Myo18b
|
UTSW |
5 |
112,975,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9209:Myo18b
|
UTSW |
5 |
113,022,927 (GRCm39) |
missense |
unknown |
|
|
R9358:Myo18b
|
UTSW |
5 |
112,943,269 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Myo18b
|
UTSW |
5 |
112,994,247 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9607:Myo18b
|
UTSW |
5 |
113,022,544 (GRCm39) |
missense |
unknown |
|
|
R9659:Myo18b
|
UTSW |
5 |
113,022,382 (GRCm39) |
missense |
unknown |
|
|
Z1088:Myo18b
|
UTSW |
5 |
112,905,350 (GRCm39) |
missense |
probably benign |
0.25 |
|
Z1088:Myo18b
|
UTSW |
5 |
112,840,809 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,979,056 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,957,604 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Myo18b
|
UTSW |
5 |
112,910,587 (GRCm39) |
missense |
not run |
|
|
Z1177:Myo18b
|
UTSW |
5 |
113,021,407 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Myo18b
|
UTSW |
5 |
112,910,587 (GRCm39) |
missense |
not run |
|
|
Z1177:Myo18b
|
UTSW |
5 |
112,840,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Myo18b
|
UTSW |
5 |
113,023,018 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCTTTTGAGACAAAGGTTAGCAC -3'
(R):5'- ACTTAGTGGTTACCGCGTCCCTTG -3'
Sequencing Primer
(F):5'- GAAGTCCACCGACCTGTTC -3'
(R):5'- GTTACCCACAATTCTCTGTGC -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation