Mutagenetix > Incidental Mutation

Incidental Mutation 'R4755:Myo18b'

357897

Institutional Source

Beutler Lab

Gene Symbol

Myo18b

Ensembl Gene

ENSMUSG00000072720

Gene Name

myosin XVIIIb

Synonyms

4932408L24Rik, 4933411E19Rik

MMRRC Submission

042033-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4755 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

112688876-112896362 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 112874474 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 351 (Q351*)

Ref Sequence

ENSEMBL: ENSMUSP00000083810 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086617]

AlphaFold

E9PV66

Predicted Effect

probably null
Transcript: ENSMUST00000086617
AA Change: Q351*

SMART Domains

Protein: ENSMUSP00000083810
Gene: ENSMUSG00000072720
AA Change: Q351*

Domain	Start	End	E-Value	Type
low complexity region	20	28	N/A	INTRINSIC
low complexity region	43	59	N/A	INTRINSIC
low complexity region	86	100	N/A	INTRINSIC
low complexity region	185	200	N/A	INTRINSIC
low complexity region	273	290	N/A	INTRINSIC
low complexity region	291	304	N/A	INTRINSIC
low complexity region	355	372	N/A	INTRINSIC
low complexity region	377	419	N/A	INTRINSIC
MYSc	605	1374	8.78e-30	SMART
IQ	1375	1397	5.92e-4	SMART
Pfam:Myosin_tail_1	1423	1875	5e-12	PFAM
low complexity region	1965	1985	N/A	INTRINSIC
coiled coil region	2052	2126	N/A	INTRINSIC
low complexity region	2184	2199	N/A	INTRINSIC
low complexity region	2325	2336	N/A	INTRINSIC
low complexity region	2408	2424	N/A	INTRINSIC
low complexity region	2544	2558	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183029

Predicted Effect

probably benign
Transcript: ENSMUST00000183273

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.7%
10x: 97.3%
20x: 95.3%

Validation Efficiency

96% (112/117)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930449A18Rik	T	A	3: 59,825,859 (GRCm38)		noncoding transcript	Het
Accs	T	C	2: 93,841,337 (GRCm38)	E236G	probably damaging	Het
Agrn	C	T	4: 156,173,522 (GRCm38)		probably benign	Het
Ahi1	A	G	10: 21,055,047 (GRCm38)	I929V	possibly damaging	Het
Akap5	C	A	12: 76,327,807 (GRCm38)	C4*	probably null	Het
Amotl2	A	T	9: 102,720,480 (GRCm38)	H146L	probably damaging	Het
Ank1	A	G	8: 23,104,974 (GRCm38)	N666S	probably damaging	Het
Atp10d	A	T	5: 72,246,166 (GRCm38)	T373S	probably benign	Het
Bpifb9b	T	A	2: 154,319,694 (GRCm38)	M582K	probably benign	Het
Brca2	T	A	5: 150,559,987 (GRCm38)		probably null	Het
C130079G13Rik	C	T	3: 59,936,314 (GRCm38)	A143V	probably benign	Het
C330021F23Rik	A	T	8: 3,583,922 (GRCm38)	S8C	probably damaging	Het
Ccdc149	A	G	5: 52,404,151 (GRCm38)	V229A	probably damaging	Het
Cd109	CATTTATTTATTTATTTATTTATTTATTTATTTAT	CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT	9: 78,712,500 (GRCm38)		probably benign	Het
Cdk5rap2	A	G	4: 70,238,425 (GRCm38)	S1617P	probably damaging	Het
Cenpk	A	T	13: 104,249,512 (GRCm38)	H305L	probably benign	Het
Cenpk	A	T	13: 104,230,871 (GRCm38)	M37L	probably benign	Het
Ces5a	C	A	8: 93,535,677 (GRCm38)	A11S	probably benign	Het
Cfap65	T	C	1: 74,928,361 (GRCm38)	E186G	probably damaging	Het
Cfh	T	A	1: 140,088,808 (GRCm38)	I593F	probably damaging	Het
Clstn2	C	T	9: 97,445,673 (GRCm38)	V961I	probably benign	Het
Cog5	T	A	12: 31,869,406 (GRCm38)		probably null	Het
Col4a4	T	C	1: 82,541,174 (GRCm38)	D100G	unknown	Het
Cyp3a41a	T	C	5: 145,715,506 (GRCm38)	D61G	probably damaging	Het
Dnah10	A	G	5: 124,747,745 (GRCm38)	N655S	probably benign	Het
Dnaic1	C	G	4: 41,610,269 (GRCm38)	T295R	probably damaging	Het
Dnajc6	C	T	4: 101,550,799 (GRCm38)	A44V	probably damaging	Het
Eif4enif1	A	T	11: 3,244,016 (GRCm38)	D960V	probably damaging	Het
Fam167b	C	T	4: 129,578,342 (GRCm38)	G12R	probably damaging	Het
Fam20b	A	T	1: 156,687,496 (GRCm38)	Y266*	probably null	Het
Fer1l6	T	A	15: 58,640,211 (GRCm38)	V1509D	probably benign	Het
Fhad1	A	T	4: 141,928,483 (GRCm38)	I105N	probably damaging	Het
Fmo2	T	C	1: 162,888,805 (GRCm38)	D71G	probably damaging	Het
Folr2	T	C	7: 101,843,799 (GRCm38)	T6A	possibly damaging	Het
Fry	A	C	5: 150,398,254 (GRCm38)	E1018A	probably damaging	Het
Gas2l2	A	G	11: 83,429,367 (GRCm38)	I21T	probably damaging	Het
Gfra1	T	C	19: 58,453,244 (GRCm38)	Y85C	probably damaging	Het
Gm9117	T	C	3: 93,938,786 (GRCm38)		probably null	Het
Gpld1	T	A	13: 24,979,692 (GRCm38)	Y44*	probably null	Het
Gpld1	A	T	13: 24,979,688 (GRCm38)	Y43F	probably benign	Het
Grid2	A	G	6: 63,908,988 (GRCm38)	T123A	probably benign	Het
Grina	T	C	15: 76,249,242 (GRCm38)	L305P	probably damaging	Het
Gucy1a1	G	A	3: 82,094,795 (GRCm38)	A659V	probably benign	Het
H2-T10	T	A	17: 36,118,945 (GRCm38)	K319*	probably null	Het
Hey2	A	T	10: 30,834,304 (GRCm38)	V151E	probably benign	Het
Ighv1-69	G	A	12: 115,623,558 (GRCm38)	T13I	probably benign	Het
Il1rap	C	A	16: 26,722,782 (GRCm38)	A591E	probably benign	Het
Ildr1	T	C	16: 36,722,021 (GRCm38)	L261P	probably benign	Het
Jak1	A	G	4: 101,174,157 (GRCm38)	Y463H	probably damaging	Het
Lrp1b	T	C	2: 41,269,273 (GRCm38)	I1666V	probably benign	Het
Lrp1b	T	A	2: 41,471,016 (GRCm38)	T592S	probably benign	Het
Lrrc36	A	G	8: 105,452,144 (GRCm38)	T445A	possibly damaging	Het
Ly9	G	A	1: 171,607,238 (GRCm38)	S29F	probably damaging	Het
Mapk7	A	C	11: 61,490,843 (GRCm38)	C32W	probably damaging	Het
March10	C	T	11: 105,364,476 (GRCm38)		probably benign	Het
Mier2	A	T	10: 79,549,197 (GRCm38)	M119K	probably damaging	Het
Mpv17	A	T	5: 31,145,982 (GRCm38)	C59*	probably null	Het
Mrpl27	G	A	11: 94,653,833 (GRCm38)		probably benign	Het
Myo1a	A	G	10: 127,715,688 (GRCm38)	I704M	probably damaging	Het
Nadsyn1	A	G	7: 143,806,913 (GRCm38)	C373R	probably damaging	Het
Nckipsd	C	A	9: 108,814,739 (GRCm38)	A513E	probably benign	Het
Neb	T	C	2: 52,220,209 (GRCm38)	D209G	probably damaging	Het
Nkapl	T	A	13: 21,468,287 (GRCm38)	Q52L	unknown	Het
Nptx2	G	A	5: 144,546,440 (GRCm38)	S126N	probably benign	Het
Olfr13	G	A	6: 43,174,043 (GRCm38)	S19N	probably benign	Het
Olfr653	T	A	7: 104,580,061 (GRCm38)	Y138*	probably null	Het
Olfr829	A	T	9: 18,857,180 (GRCm38)	H185L	probably benign	Het
Olfr917	A	G	9: 38,665,832 (GRCm38)	V4A	probably benign	Het
Pclo	A	T	5: 14,714,348 (GRCm38)	R4278S	unknown	Het
Pcnx	T	G	12: 81,950,294 (GRCm38)	L988R	probably damaging	Het
Prl2c5	C	A	13: 13,189,385 (GRCm38)	N75K	probably benign	Het
Prpf19	T	G	19: 10,897,790 (GRCm38)		probably benign	Het
Ralgapa1	A	G	12: 55,712,748 (GRCm38)	S997P	probably damaging	Het
Rangap1	T	C	15: 81,712,917 (GRCm38)	T226A	probably benign	Het
Rimklb	G	A	6: 122,456,406 (GRCm38)	L262F	probably damaging	Het
Rnf169	A	G	7: 99,925,723 (GRCm38)	M555T	probably benign	Het
Rp1l1	A	T	14: 64,030,070 (GRCm38)	D1035V	probably benign	Het
Scd2	T	A	19: 44,301,352 (GRCm38)	L262Q	probably damaging	Het
Scgb2b12	T	A	7: 32,325,531 (GRCm38)	M84L	probably benign	Het
Shroom3	G	T	5: 92,943,086 (GRCm38)	V1151F	probably damaging	Het
Sipa1l1	G	A	12: 82,372,386 (GRCm38)	V613I	possibly damaging	Het
Slc25a23	T	A	17: 57,052,794 (GRCm38)	D67V	possibly damaging	Het
Slc25a39	C	T	11: 102,406,666 (GRCm38)		probably benign	Het
Slc4a10	T	A	2: 62,296,988 (GRCm38)	F895Y	probably damaging	Het
Slc5a4a	A	C	10: 76,186,564 (GRCm38)	K578Q	probably benign	Het
Slc6a13	G	A	6: 121,325,049 (GRCm38)	G197S	probably damaging	Het
Smarca2	A	T	19: 26,654,483 (GRCm38)	E566V	possibly damaging	Het
Sorbs3	A	T	14: 70,184,099 (GRCm38)	N594K	probably benign	Het
Spata22	A	T	11: 73,345,756 (GRCm38)	D296V	probably damaging	Het
Sphk2	G	A	7: 45,713,634 (GRCm38)	A11V	possibly damaging	Het
Spp1	A	T	5: 104,435,215 (GRCm38)		probably benign	Het
Strn3	T	A	12: 51,610,216 (GRCm38)	I760L	possibly damaging	Het
Syk	A	T	13: 52,641,986 (GRCm38)	Y539F	probably benign	Het
Thsd7b	T	A	1: 130,210,264 (GRCm38)	Y1560N	probably benign	Het
Tmod2	C	A	9: 75,597,212 (GRCm38)	E42*	probably null	Het
Tom1l1	T	C	11: 90,685,116 (GRCm38)	E30G	probably damaging	Het
Trav10	G	A	14: 53,506,061 (GRCm38)	A40T	probably benign	Het
Trav14-2	G	A	14: 53,640,780 (GRCm38)		probably benign	Het
Tril	T	A	6: 53,818,464 (GRCm38)	E591V	probably damaging	Het
Trp53bp1	T	A	2: 121,228,606 (GRCm38)	R179*	probably null	Het
Tspoap1	A	T	11: 87,771,663 (GRCm38)	D562V	possibly damaging	Het
Usp44	A	T	10: 93,846,906 (GRCm38)	H406L	probably damaging	Het
Vangl1	A	G	3: 102,158,292 (GRCm38)	I509T	probably benign	Het
Vax2	T	G	6: 83,711,397 (GRCm38)	L34W	probably damaging	Het
Vmn1r55	A	T	7: 5,147,026 (GRCm38)	C133S	probably damaging	Het
Vmn2r8	T	A	5: 108,801,700 (GRCm38)	D427V	probably benign	Het
Vwde	A	G	6: 13,205,852 (GRCm38)	I232T	possibly damaging	Het
Wnk1	C	A	6: 119,963,470 (GRCm38)	A769S	probably damaging	Het
Xpo4	A	C	14: 57,618,181 (GRCm38)	S264A	probably benign	Het
Zfp330	A	T	8: 82,769,386 (GRCm38)	C75*	probably null	Het
Zfp526	T	A	7: 25,225,639 (GRCm38)	L441Q	probably benign	Het
Zfp607b	T	G	7: 27,703,505 (GRCm38)	L462R	probably damaging	Het
Zfp719	T	A	7: 43,590,793 (GRCm38)	F602I	probably damaging	Het

Other mutations in Myo18b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Myo18b	APN	5	112,874,131 (GRCm38)	missense	probably benign	0.05
IGL00847:Myo18b	APN	5	112,830,389 (GRCm38)	splice site	probably benign
IGL00848:Myo18b	APN	5	112,871,485 (GRCm38)	missense	probably damaging	1.00
IGL00969:Myo18b	APN	5	112,875,007 (GRCm38)	unclassified	probably benign
IGL01018:Myo18b	APN	5	112,809,747 (GRCm38)	missense	probably damaging	1.00
IGL01448:Myo18b	APN	5	112,811,704 (GRCm38)	missense	probably damaging	1.00
IGL01490:Myo18b	APN	5	112,809,700 (GRCm38)	missense	possibly damaging	0.84
IGL01556:Myo18b	APN	5	112,757,449 (GRCm38)	splice site	probably benign
IGL01637:Myo18b	APN	5	112,840,629 (GRCm38)	missense	possibly damaging	0.82
IGL01819:Myo18b	APN	5	112,878,050 (GRCm38)	missense	unknown
IGL02007:Myo18b	APN	5	112,874,972 (GRCm38)	unclassified	probably benign
IGL02146:Myo18b	APN	5	112,843,285 (GRCm38)	missense	probably damaging	1.00
IGL02229:Myo18b	APN	5	112,878,110 (GRCm38)	missense	unknown
IGL02319:Myo18b	APN	5	112,791,139 (GRCm38)	missense	probably damaging	0.99
IGL02398:Myo18b	APN	5	112,830,312 (GRCm38)	missense	possibly damaging	0.92
IGL02420:Myo18b	APN	5	112,827,986 (GRCm38)	missense	possibly damaging	0.64
IGL02626:Myo18b	APN	5	112,878,085 (GRCm38)	missense	unknown
IGL02815:Myo18b	APN	5	112,809,735 (GRCm38)	missense	probably damaging	1.00
IGL02822:Myo18b	APN	5	112,775,345 (GRCm38)	missense	probably damaging	1.00
IGL02852:Myo18b	APN	5	112,715,511 (GRCm38)	missense	probably benign	0.03
IGL02995:Myo18b	APN	5	112,775,413 (GRCm38)	splice site	probably benign
IGL03019:Myo18b	APN	5	112,692,397 (GRCm38)	missense	probably benign	0.21
IGL03039:Myo18b	APN	5	112,840,771 (GRCm38)	missense	probably damaging	1.00
IGL03112:Myo18b	APN	5	112,873,990 (GRCm38)	missense	probably benign	0.02
IGL03123:Myo18b	APN	5	112,874,938 (GRCm38)	unclassified	probably benign
IGL03288:Myo18b	APN	5	112,789,997 (GRCm38)	missense	probably damaging	1.00
IGL03391:Myo18b	APN	5	112,874,479 (GRCm38)	unclassified	probably benign
klippel	UTSW	5	112,757,453 (GRCm38)	critical splice donor site	probably null
PIT4651001:Myo18b	UTSW	5	112,834,435 (GRCm38)	missense	probably benign	0.01
R0271:Myo18b	UTSW	5	112,809,685 (GRCm38)	missense	possibly damaging	0.91
R0277:Myo18b	UTSW	5	112,693,347 (GRCm38)	splice site	probably benign
R0352:Myo18b	UTSW	5	112,874,523 (GRCm38)	unclassified	probably benign
R0504:Myo18b	UTSW	5	112,873,576 (GRCm38)	unclassified	probably benign
R0539:Myo18b	UTSW	5	112,723,868 (GRCm38)	missense	probably damaging	0.99
R0599:Myo18b	UTSW	5	112,865,750 (GRCm38)	missense	probably damaging	1.00
R0627:Myo18b	UTSW	5	112,798,834 (GRCm38)	missense	probably benign	0.38
R0659:Myo18b	UTSW	5	112,760,327 (GRCm38)	missense	possibly damaging	0.66
R0671:Myo18b	UTSW	5	112,692,766 (GRCm38)	missense	probably benign	0.00
R0847:Myo18b	UTSW	5	112,874,488 (GRCm38)	unclassified	probably benign
R1082:Myo18b	UTSW	5	112,760,414 (GRCm38)	missense	probably damaging	1.00
R1116:Myo18b	UTSW	5	112,803,279 (GRCm38)	missense	probably damaging	1.00
R1264:Myo18b	UTSW	5	112,830,319 (GRCm38)	missense	probably benign	0.12
R1280:Myo18b	UTSW	5	112,723,805 (GRCm38)	critical splice donor site	probably null
R1444:Myo18b	UTSW	5	112,775,251 (GRCm38)	critical splice donor site	probably null
R1446:Myo18b	UTSW	5	112,757,559 (GRCm38)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,693,033 (GRCm38)	missense	probably damaging	1.00
R1470:Myo18b	UTSW	5	112,693,033 (GRCm38)	missense	probably damaging	1.00
R1590:Myo18b	UTSW	5	112,875,266 (GRCm38)	nonsense	probably null
R1601:Myo18b	UTSW	5	112,871,498 (GRCm38)	missense	possibly damaging	0.73
R1903:Myo18b	UTSW	5	112,692,758 (GRCm38)	missense	probably damaging	1.00
R1935:Myo18b	UTSW	5	112,760,356 (GRCm38)	missense	probably benign	0.04
R1936:Myo18b	UTSW	5	112,760,356 (GRCm38)	missense	probably benign	0.04
R2008:Myo18b	UTSW	5	112,873,557 (GRCm38)	missense	probably benign
R2127:Myo18b	UTSW	5	112,831,078 (GRCm38)	missense	probably damaging	1.00
R2129:Myo18b	UTSW	5	112,831,078 (GRCm38)	missense	probably damaging	1.00
R2141:Myo18b	UTSW	5	112,874,026 (GRCm38)	missense	probably benign	0.01
R2170:Myo18b	UTSW	5	112,723,858 (GRCm38)	missense	probably benign	0.23
R2258:Myo18b	UTSW	5	112,874,663 (GRCm38)	unclassified	probably benign
R2265:Myo18b	UTSW	5	112,782,673 (GRCm38)	missense	probably damaging	1.00
R2483:Myo18b	UTSW	5	112,858,408 (GRCm38)	missense	probably damaging	1.00
R2931:Myo18b	UTSW	5	112,693,127 (GRCm38)	missense	probably benign	0.01
R3160:Myo18b	UTSW	5	112,692,728 (GRCm38)	missense	probably damaging	0.99
R3162:Myo18b	UTSW	5	112,692,728 (GRCm38)	missense	probably damaging	0.99
R3777:Myo18b	UTSW	5	112,757,596 (GRCm38)	missense	probably damaging	0.99
R4240:Myo18b	UTSW	5	112,803,187 (GRCm38)	critical splice donor site	probably null
R4243:Myo18b	UTSW	5	112,692,395 (GRCm38)	missense	possibly damaging	0.95
R4245:Myo18b	UTSW	5	112,692,395 (GRCm38)	missense	possibly damaging	0.95
R4533:Myo18b	UTSW	5	112,693,025 (GRCm38)	missense	probably damaging	1.00
R4631:Myo18b	UTSW	5	112,846,400 (GRCm38)	missense	probably damaging	1.00
R4661:Myo18b	UTSW	5	112,875,175 (GRCm38)	unclassified	probably benign
R4771:Myo18b	UTSW	5	112,692,227 (GRCm38)	nonsense	probably null
R4812:Myo18b	UTSW	5	112,809,718 (GRCm38)	missense	possibly damaging	0.95
R4840:Myo18b	UTSW	5	112,874,029 (GRCm38)	missense	probably benign	0.02
R4888:Myo18b	UTSW	5	112,874,480 (GRCm38)	unclassified	probably benign
R4995:Myo18b	UTSW	5	112,760,392 (GRCm38)	missense	probably damaging	0.99
R5001:Myo18b	UTSW	5	112,761,340 (GRCm38)	missense	probably damaging	0.99
R5015:Myo18b	UTSW	5	112,790,057 (GRCm38)	missense	probably damaging	1.00
R5055:Myo18b	UTSW	5	112,875,217 (GRCm38)	unclassified	probably benign
R5070:Myo18b	UTSW	5	112,761,346 (GRCm38)	missense	probably damaging	1.00
R5105:Myo18b	UTSW	5	112,840,778 (GRCm38)	missense	probably damaging	1.00
R5121:Myo18b	UTSW	5	112,874,480 (GRCm38)	unclassified	probably benign
R5130:Myo18b	UTSW	5	112,873,903 (GRCm38)	missense	probably benign	0.06
R5186:Myo18b	UTSW	5	112,871,470 (GRCm38)	missense	probably damaging	1.00
R5437:Myo18b	UTSW	5	112,757,573 (GRCm38)	missense	possibly damaging	0.73
R5535:Myo18b	UTSW	5	112,790,042 (GRCm38)	missense	probably damaging	1.00
R5560:Myo18b	UTSW	5	112,868,295 (GRCm38)	missense	probably damaging	0.96
R5810:Myo18b	UTSW	5	112,834,450 (GRCm38)	missense	probably damaging	1.00
R5898:Myo18b	UTSW	5	112,802,330 (GRCm38)	splice site	probably null
R6065:Myo18b	UTSW	5	112,692,781 (GRCm38)	missense	probably benign	0.00
R6104:Myo18b	UTSW	5	112,874,291 (GRCm38)	unclassified	probably benign
R6113:Myo18b	UTSW	5	112,866,385 (GRCm38)	missense	probably damaging	1.00
R6158:Myo18b	UTSW	5	112,874,172 (GRCm38)	missense	probably benign	0.01
R6167:Myo18b	UTSW	5	112,872,507 (GRCm38)	splice site	probably null
R6220:Myo18b	UTSW	5	112,757,507 (GRCm38)	missense	possibly damaging	0.93
R6276:Myo18b	UTSW	5	112,811,642 (GRCm38)	missense	probably benign	0.31
R6290:Myo18b	UTSW	5	112,865,735 (GRCm38)	missense	possibly damaging	0.69
R6291:Myo18b	UTSW	5	112,865,735 (GRCm38)	missense	possibly damaging	0.69
R6795:Myo18b	UTSW	5	112,846,364 (GRCm38)	missense	probably damaging	0.99
R6798:Myo18b	UTSW	5	112,761,386 (GRCm38)	missense	probably damaging	0.98
R6817:Myo18b	UTSW	5	112,830,238 (GRCm38)	missense	probably benign	0.00
R6937:Myo18b	UTSW	5	112,802,392 (GRCm38)	missense	probably benign	0.12
R7034:Myo18b	UTSW	5	112,723,904 (GRCm38)	nonsense	probably null
R7097:Myo18b	UTSW	5	112,874,405 (GRCm38)	missense	unknown
R7145:Myo18b	UTSW	5	112,817,679 (GRCm38)	nonsense	probably null
R7201:Myo18b	UTSW	5	112,715,459 (GRCm38)	missense	probably damaging	1.00
R7260:Myo18b	UTSW	5	112,775,288 (GRCm38)	missense	probably benign	0.01
R7265:Myo18b	UTSW	5	112,812,072 (GRCm38)	missense	probably damaging	1.00
R7409:Myo18b	UTSW	5	112,874,105 (GRCm38)	missense	probably benign	0.25
R7466:Myo18b	UTSW	5	112,723,892 (GRCm38)	missense	probably benign	0.02
R7487:Myo18b	UTSW	5	112,834,433 (GRCm38)	missense	possibly damaging	0.93
R7571:Myo18b	UTSW	5	112,830,328 (GRCm38)	missense	probably damaging	1.00
R7600:Myo18b	UTSW	5	112,878,103 (GRCm38)	missense	unknown
R7612:Myo18b	UTSW	5	112,865,302 (GRCm38)	missense	possibly damaging	0.82
R7617:Myo18b	UTSW	5	112,757,453 (GRCm38)	critical splice donor site	probably null
R7696:Myo18b	UTSW	5	112,692,292 (GRCm38)	missense	probably damaging	1.00
R7710:Myo18b	UTSW	5	112,875,025 (GRCm38)	missense	unknown
R8047:Myo18b	UTSW	5	112,723,815 (GRCm38)	missense	possibly damaging	0.91
R8070:Myo18b	UTSW	5	112,791,120 (GRCm38)	missense	probably benign	0.01
R8088:Myo18b	UTSW	5	112,879,510 (GRCm38)	start gained	probably benign
R8247:Myo18b	UTSW	5	112,692,196 (GRCm38)	missense	probably damaging	1.00
R8276:Myo18b	UTSW	5	112,795,407 (GRCm38)	missense	possibly damaging	0.50
R8313:Myo18b	UTSW	5	112,875,179 (GRCm38)	missense	unknown
R8375:Myo18b	UTSW	5	112,760,393 (GRCm38)	missense	possibly damaging	0.85
R8432:Myo18b	UTSW	5	112,764,512 (GRCm38)	missense	probably benign	0.00
R8475:Myo18b	UTSW	5	112,873,556 (GRCm38)	nonsense	probably null
R8482:Myo18b	UTSW	5	112,871,623 (GRCm38)	nonsense	probably null
R8671:Myo18b	UTSW	5	112,874,743 (GRCm38)	missense	unknown
R8681:Myo18b	UTSW	5	112,873,563 (GRCm38)	critical splice acceptor site	probably null
R8918:Myo18b	UTSW	5	112,875,007 (GRCm38)	unclassified	probably benign
R8941:Myo18b	UTSW	5	112,874,929 (GRCm38)	unclassified	probably benign
R8962:Myo18b	UTSW	5	112,858,480 (GRCm38)	missense	probably benign	0.24
R8972:Myo18b	UTSW	5	112,693,298 (GRCm38)	missense	probably benign	0.00
R9116:Myo18b	UTSW	5	112,827,996 (GRCm38)	missense	probably damaging	1.00
R9209:Myo18b	UTSW	5	112,875,061 (GRCm38)	missense	unknown
R9358:Myo18b	UTSW	5	112,795,403 (GRCm38)	missense	possibly damaging	0.93
R9469:Myo18b	UTSW	5	112,846,381 (GRCm38)	missense	probably benign	0.15
R9607:Myo18b	UTSW	5	112,874,678 (GRCm38)	missense	unknown
R9659:Myo18b	UTSW	5	112,874,516 (GRCm38)	missense	unknown
Z1088:Myo18b	UTSW	5	112,757,484 (GRCm38)	missense	probably benign	0.25
Z1088:Myo18b	UTSW	5	112,692,943 (GRCm38)	missense	possibly damaging	0.89
Z1176:Myo18b	UTSW	5	112,831,190 (GRCm38)	missense	probably damaging	1.00
Z1176:Myo18b	UTSW	5	112,809,738 (GRCm38)	missense	possibly damaging	0.87
Z1176:Myo18b	UTSW	5	112,762,721 (GRCm38)	missense	not run
Z1177:Myo18b	UTSW	5	112,873,541 (GRCm38)	nonsense	probably null
Z1177:Myo18b	UTSW	5	112,762,721 (GRCm38)	missense	not run
Z1177:Myo18b	UTSW	5	112,692,899 (GRCm38)	missense	probably damaging	1.00
Z1177:Myo18b	UTSW	5	112,875,152 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GATTCTGAGTCTTCGCTGCC -3'
(R):5'- TGAAGTCAGACCTGTGGAACC -3'

Sequencing Primer
(F):5'- TGTCACCAGCTTTTTCTGAGG -3'
(R):5'- CCCCAGTCCCGCTAAGGAAG -3'

Posted On

2015-11-11