Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01060:Taar6'

52028

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar6

Ensembl Gene

ENSMUSG00000045111

Gene Name

trace amine-associated receptor 6

Synonyms

LOC215855

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.224) question?

Stock #

IGL01060

Quality Score

Status

Chromosome

Chromosomal Location

23984609-23985646 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23985072 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 192 (V192A)

Ref Sequence

ENSEMBL: ENSMUSP00000097603 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057080]

Predicted Effect

probably benign
Transcript: ENSMUST00000057080
AA Change: V192A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097603
Gene: ENSMUSG00000045111
AA Change: V192A

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	43	326	5.5e-13	PFAM
Pfam:7tm_1	49	311	5.9e-58	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Anks4b	A	G	7: 120,173,925	T3A	possibly damaging	Het
Arhgef26	T	A	3: 62,340,121	S209T	probably benign	Het
Ccdc78	A	G	17: 25,788,832	D281G	probably damaging	Het
Ccnb3	A	T	X: 6,980,274	N1362K	probably benign	Het
Dnah2	T	C	11: 69,478,092	N1662S	possibly damaging	Het
Ern2	T	A	7: 122,170,092	R904W	probably damaging	Het
Fam120c	C	T	X: 151,469,587	P1045S	probably benign	Het
Gm12887	C	T	4: 121,616,413		probably benign	Het
Gpld1	G	A	13: 24,982,566	G627S	probably damaging	Het
Ikbkap	C	T	4: 56,784,537		probably null	Het
Krt77	T	A	15: 101,860,880		probably benign	Het
Ltf	A	T	9: 111,022,882		probably null	Het
Map3k6	G	T	4: 133,247,302		probably null	Het
Nsd1	G	A	13: 55,263,429	G1431D	probably damaging	Het
Plekhm2	C	T	4: 141,642,645		probably null	Het
Popdc2	T	A	16: 38,373,965	N249K	probably damaging	Het
Ppm1h	A	G	10: 122,907,571	D400G	possibly damaging	Het
Rps6ka1	A	T	4: 133,860,870	S320T	probably damaging	Het
Rsph6a	C	T	7: 19,054,868	R42*	probably null	Het
Sap130	T	C	18: 31,715,443	L967P	probably damaging	Het
Smyd2	T	C	1: 189,897,470	E121G	possibly damaging	Het
Sspo	G	A	6: 48,449,479	W144*	probably null	Het
Tbc1d24	A	T	17: 24,185,828	V114E	probably damaging	Het
Trim16	T	C	11: 62,820,704	I67T	probably benign	Het
Ttll7	A	G	3: 146,909,582	D267G	possibly damaging	Het
Ttn	T	C	2: 76,889,729		probably benign	Het
Vmn2r56	T	A	7: 12,713,089	I379F	probably damaging	Het
Zfp14	T	C	7: 30,038,085	T492A	probably damaging	Het

Other mutations in Taar6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00648:Taar6	APN	10	23985508	missense	probably benign	0.15
IGL00918:Taar6	APN	10	23985582	missense	probably damaging	1.00
IGL02608:Taar6	APN	10	23985183	missense	probably benign	0.01
R0042:Taar6	UTSW	10	23985123	missense	probably benign	0.36
R0042:Taar6	UTSW	10	23985123	missense	probably benign	0.36
R0360:Taar6	UTSW	10	23985148	missense	probably benign	0.01
R0364:Taar6	UTSW	10	23985148	missense	probably benign	0.01
R0746:Taar6	UTSW	10	23985360	missense	probably benign	0.43
R1637:Taar6	UTSW	10	23985181	missense	probably benign	0.12
R4893:Taar6	UTSW	10	23985400	missense	probably benign
R4944:Taar6	UTSW	10	23984715	missense	probably damaging	1.00
R4951:Taar6	UTSW	10	23985208	missense	probably benign	0.09
R5173:Taar6	UTSW	10	23985352	missense	probably damaging	1.00
R5181:Taar6	UTSW	10	23984785	missense	possibly damaging	0.76
R5919:Taar6	UTSW	10	23985270	missense	probably damaging	1.00
R5988:Taar6	UTSW	10	23985256	missense	probably damaging	0.98
R6327:Taar6	UTSW	10	23985279	missense	probably damaging	1.00
R6493:Taar6	UTSW	10	23985123	missense	probably benign	0.36
R7595:Taar6	UTSW	10	23985070	missense	probably benign
R7802:Taar6	UTSW	10	23985253	missense	probably benign	0.02
R8053:Taar6	UTSW	10	23985246	missense	possibly damaging	0.59
R8506:Taar6	UTSW	10	23985631	missense	probably benign	0.01

Posted On

2013-06-21