Incidental Mutation 'IGL01134:Htr1f'
| ID |
52961 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Htr1f
|
| Ensembl Gene |
ENSMUSG00000050783 |
| Gene Name |
5-hydroxytryptamine (serotonin) receptor 1F |
| Synonyms |
Htr1eb |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01134
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
64745092-64926147 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 64746501 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 264
(T264S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063136
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063076]
|
| AlphaFold |
Q02284 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063076
AA Change: T264S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000063136
Gene: ENSMUSG00000050783
AA Change: T264S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
32 |
230 |
4.8e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
34 |
362 |
2.4e-10 |
PFAM |
|
Pfam:7tm_1
|
40 |
347 |
4.1e-74 |
PFAM |
|
Pfam:7TM_GPCR_Srv
|
54 |
249 |
5.2e-7 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,834,475 (GRCm39) |
V124I |
probably damaging |
Het |
| Acaca |
T |
G |
11: 84,142,105 (GRCm39) |
H637Q |
probably benign |
Het |
| Aen |
G |
A |
7: 78,557,050 (GRCm39) |
M299I |
probably damaging |
Het |
| Akap6 |
C |
A |
12: 52,984,000 (GRCm39) |
A848E |
probably damaging |
Het |
| Cxxc4 |
A |
G |
3: 133,946,420 (GRCm39) |
I334V |
probably null |
Het |
| Cyp2b13 |
T |
A |
7: 25,781,125 (GRCm39) |
I179N |
probably damaging |
Het |
| Cyp2d40 |
C |
A |
15: 82,645,102 (GRCm39) |
A183S |
unknown |
Het |
| Cyp2g1 |
A |
G |
7: 26,509,256 (GRCm39) |
N110S |
probably benign |
Het |
| F5 |
A |
T |
1: 164,019,548 (GRCm39) |
R674S |
possibly damaging |
Het |
| Fnip2 |
G |
T |
3: 79,419,810 (GRCm39) |
Y155* |
probably null |
Het |
| Fut9 |
G |
T |
4: 25,620,446 (GRCm39) |
Q123K |
probably benign |
Het |
| Gda |
A |
G |
19: 21,394,429 (GRCm39) |
S143P |
probably damaging |
Het |
| Gpr162 |
T |
C |
6: 124,835,820 (GRCm39) |
|
probably null |
Het |
| Hsf2bp |
A |
G |
17: 32,206,378 (GRCm39) |
L251S |
probably damaging |
Het |
| Hsh2d |
A |
T |
8: 72,947,375 (GRCm39) |
D24V |
probably damaging |
Het |
| Med12l |
G |
A |
3: 58,949,696 (GRCm39) |
E151K |
possibly damaging |
Het |
| Mgat3 |
C |
A |
15: 80,096,377 (GRCm39) |
N401K |
probably benign |
Het |
| Mmp27 |
T |
G |
9: 7,573,298 (GRCm39) |
M130R |
probably benign |
Het |
| Mroh2b |
T |
A |
15: 4,944,634 (GRCm39) |
S412T |
probably benign |
Het |
| Mrps9 |
A |
G |
1: 42,942,557 (GRCm39) |
I338M |
probably damaging |
Het |
| Mtmr4 |
C |
T |
11: 87,494,893 (GRCm39) |
T395M |
probably damaging |
Het |
| Nlrp9b |
A |
G |
7: 19,757,112 (GRCm39) |
I116M |
probably benign |
Het |
| Nqo1 |
T |
C |
8: 108,115,587 (GRCm39) |
D230G |
probably benign |
Het |
| Pcnx2 |
C |
T |
8: 126,589,889 (GRCm39) |
V795I |
probably benign |
Het |
| Pde8a |
G |
A |
7: 80,968,826 (GRCm39) |
R449Q |
possibly damaging |
Het |
| Scn9a |
A |
G |
2: 66,335,312 (GRCm39) |
Y1226H |
probably damaging |
Het |
| Sema3e |
A |
G |
5: 14,302,784 (GRCm39) |
R770G |
probably damaging |
Het |
| Smr2 |
T |
C |
5: 88,256,378 (GRCm39) |
S19P |
probably damaging |
Het |
| Trank1 |
T |
C |
9: 111,220,849 (GRCm39) |
S2529P |
probably benign |
Het |
| Uspl1 |
T |
A |
5: 149,141,103 (GRCm39) |
F367L |
probably damaging |
Het |
| Vps41 |
A |
G |
13: 19,050,320 (GRCm39) |
S838G |
probably benign |
Het |
| Ythdf2 |
A |
T |
4: 131,932,789 (GRCm39) |
F124I |
probably damaging |
Het |
|
| Other mutations in Htr1f |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Htr1f
|
APN |
16 |
64,746,469 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01455:Htr1f
|
APN |
16 |
64,746,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01580:Htr1f
|
APN |
16 |
64,746,198 (GRCm39) |
nonsense |
probably null |
|
|
IGL01865:Htr1f
|
APN |
16 |
64,746,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02027:Htr1f
|
APN |
16 |
64,746,684 (GRCm39) |
nonsense |
probably null |
|
|
IGL02234:Htr1f
|
APN |
16 |
64,746,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02567:Htr1f
|
APN |
16 |
64,746,611 (GRCm39) |
missense |
probably benign |
0.45 |
|
R0035:Htr1f
|
UTSW |
16 |
64,746,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Htr1f
|
UTSW |
16 |
64,747,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0523:Htr1f
|
UTSW |
16 |
64,746,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Htr1f
|
UTSW |
16 |
64,746,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2055:Htr1f
|
UTSW |
16 |
64,746,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Htr1f
|
UTSW |
16 |
64,746,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4090:Htr1f
|
UTSW |
16 |
64,746,324 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4320:Htr1f
|
UTSW |
16 |
64,747,050 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5037:Htr1f
|
UTSW |
16 |
64,746,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6004:Htr1f
|
UTSW |
16 |
64,746,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7383:Htr1f
|
UTSW |
16 |
64,747,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7462:Htr1f
|
UTSW |
16 |
64,746,383 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7864:Htr1f
|
UTSW |
16 |
64,747,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8677:Htr1f
|
UTSW |
16 |
64,746,414 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8816:Htr1f
|
UTSW |
16 |
64,746,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8836:Htr1f
|
UTSW |
16 |
64,747,196 (GRCm39) |
missense |
probably benign |
|
|
R9106:Htr1f
|
UTSW |
16 |
64,746,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Htr1f
|
UTSW |
16 |
64,746,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Htr1f
|
UTSW |
16 |
64,746,825 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9244:Htr1f
|
UTSW |
16 |
64,746,857 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9430:Htr1f
|
UTSW |
16 |
64,746,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Htr1f
|
UTSW |
16 |
64,747,237 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Htr1f
|
UTSW |
16 |
64,746,440 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-06-21 |
Incidental Mutation