Incidental Mutation 'IGL01134:Fut9'
ID 50962
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fut9
Ensembl Gene ENSMUSG00000055373
Gene Name fucosyltransferase 9
Synonyms mFUT9, mFuc-TIX
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01134
Quality Score
Chromosome 4
Chromosomal Location 25609333-25800003 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 25620446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 123 (Q123K)
Ref Sequence ENSEMBL: ENSMUSP00000103834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084770] [ENSMUST00000108199]
AlphaFold O88819
Predicted Effect probably benign
Transcript: ENSMUST00000084770
AA Change: Q123K

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000081826
Gene: ENSMUSG00000055373
AA Change: Q123K

Pfam:Glyco_transf_10 6 358 2.9e-140 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108199
AA Change: Q123K

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000103834
Gene: ENSMUSG00000055373
AA Change: Q123K

transmembrane domain 7 29 N/A INTRINSIC
Pfam:Glyco_tran_10_N 61 169 1.4e-43 PFAM
Pfam:Glyco_transf_10 185 357 4.8e-69 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased number of neuronal stem cells with increased self-renewal capacity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Acaca T G 11: 84,142,105 (GRCm39) H637Q probably benign Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Akap6 C A 12: 52,984,000 (GRCm39) A848E probably damaging Het
Cxxc4 A G 3: 133,946,420 (GRCm39) I334V probably null Het
Cyp2b13 T A 7: 25,781,125 (GRCm39) I179N probably damaging Het
Cyp2d40 C A 15: 82,645,102 (GRCm39) A183S unknown Het
Cyp2g1 A G 7: 26,509,256 (GRCm39) N110S probably benign Het
F5 A T 1: 164,019,548 (GRCm39) R674S possibly damaging Het
Fnip2 G T 3: 79,419,810 (GRCm39) Y155* probably null Het
Gda A G 19: 21,394,429 (GRCm39) S143P probably damaging Het
Gpr162 T C 6: 124,835,820 (GRCm39) probably null Het
Hsf2bp A G 17: 32,206,378 (GRCm39) L251S probably damaging Het
Hsh2d A T 8: 72,947,375 (GRCm39) D24V probably damaging Het
Htr1f T A 16: 64,746,501 (GRCm39) T264S probably benign Het
Med12l G A 3: 58,949,696 (GRCm39) E151K possibly damaging Het
Mgat3 C A 15: 80,096,377 (GRCm39) N401K probably benign Het
Mmp27 T G 9: 7,573,298 (GRCm39) M130R probably benign Het
Mroh2b T A 15: 4,944,634 (GRCm39) S412T probably benign Het
Mrps9 A G 1: 42,942,557 (GRCm39) I338M probably damaging Het
Mtmr4 C T 11: 87,494,893 (GRCm39) T395M probably damaging Het
Nlrp9b A G 7: 19,757,112 (GRCm39) I116M probably benign Het
Nqo1 T C 8: 108,115,587 (GRCm39) D230G probably benign Het
Pcnx2 C T 8: 126,589,889 (GRCm39) V795I probably benign Het
Pde8a G A 7: 80,968,826 (GRCm39) R449Q possibly damaging Het
Scn9a A G 2: 66,335,312 (GRCm39) Y1226H probably damaging Het
Sema3e A G 5: 14,302,784 (GRCm39) R770G probably damaging Het
Smr2 T C 5: 88,256,378 (GRCm39) S19P probably damaging Het
Trank1 T C 9: 111,220,849 (GRCm39) S2529P probably benign Het
Uspl1 T A 5: 149,141,103 (GRCm39) F367L probably damaging Het
Vps41 A G 13: 19,050,320 (GRCm39) S838G probably benign Het
Ythdf2 A T 4: 131,932,789 (GRCm39) F124I probably damaging Het
Other mutations in Fut9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00919:Fut9 APN 4 25,620,316 (GRCm39) missense possibly damaging 0.71
IGL01330:Fut9 APN 4 25,619,791 (GRCm39) missense possibly damaging 0.95
IGL01732:Fut9 APN 4 25,619,867 (GRCm39) missense possibly damaging 0.58
IGL02824:Fut9 APN 4 25,620,037 (GRCm39) missense probably damaging 1.00
ANU74:Fut9 UTSW 4 25,620,802 (GRCm39) missense probably benign 0.25
R0280:Fut9 UTSW 4 25,619,852 (GRCm39) missense probably benign 0.00
R0408:Fut9 UTSW 4 25,620,319 (GRCm39) missense possibly damaging 0.69
R0594:Fut9 UTSW 4 25,620,526 (GRCm39) missense possibly damaging 0.94
R0609:Fut9 UTSW 4 25,620,811 (GRCm39) start codon destroyed probably null 0.98
R0709:Fut9 UTSW 4 25,620,359 (GRCm39) missense probably damaging 1.00
R1567:Fut9 UTSW 4 25,620,344 (GRCm39) missense probably damaging 0.99
R1719:Fut9 UTSW 4 25,619,744 (GRCm39) missense possibly damaging 0.62
R1856:Fut9 UTSW 4 25,620,352 (GRCm39) missense probably damaging 1.00
R2036:Fut9 UTSW 4 25,620,322 (GRCm39) missense probably damaging 1.00
R2165:Fut9 UTSW 4 25,619,734 (GRCm39) makesense probably null
R2165:Fut9 UTSW 4 25,619,733 (GRCm39) makesense probably null
R2332:Fut9 UTSW 4 25,619,823 (GRCm39) nonsense probably null
R4539:Fut9 UTSW 4 25,619,793 (GRCm39) missense probably damaging 1.00
R4722:Fut9 UTSW 4 25,799,734 (GRCm39) utr 5 prime probably benign
R4766:Fut9 UTSW 4 25,799,191 (GRCm39) intron probably benign
R4937:Fut9 UTSW 4 25,799,591 (GRCm39) splice site probably benign
R5025:Fut9 UTSW 4 25,620,502 (GRCm39) missense probably damaging 1.00
R5032:Fut9 UTSW 4 25,799,245 (GRCm39) intron probably benign
R5158:Fut9 UTSW 4 25,620,731 (GRCm39) missense probably benign 0.01
R5601:Fut9 UTSW 4 25,620,299 (GRCm39) missense probably benign 0.00
R5974:Fut9 UTSW 4 25,620,090 (GRCm39) nonsense probably null
R6315:Fut9 UTSW 4 25,619,774 (GRCm39) missense probably damaging 1.00
R6385:Fut9 UTSW 4 25,620,328 (GRCm39) missense probably damaging 1.00
R6652:Fut9 UTSW 4 25,620,619 (GRCm39) missense probably benign 0.44
R6809:Fut9 UTSW 4 25,620,647 (GRCm39) missense probably benign
R6825:Fut9 UTSW 4 25,619,925 (GRCm39) missense probably benign
R7145:Fut9 UTSW 4 25,620,507 (GRCm39) missense probably damaging 0.96
R7573:Fut9 UTSW 4 25,620,691 (GRCm39) missense probably benign 0.04
R8933:Fut9 UTSW 4 25,619,861 (GRCm39) missense probably damaging 1.00
R9715:Fut9 UTSW 4 25,620,679 (GRCm39) missense probably benign 0.00
X0057:Fut9 UTSW 4 25,799,686 (GRCm39) start gained probably benign
Posted On 2013-06-21