Mutagenetix > Incidental Mutation

Incidental Mutation 'R6845:Zfp207'

534725

Institutional Source

Beutler Lab

Gene Symbol

Zfp207

Ensembl Gene

ENSMUSG00000017421

Gene Name

zinc finger protein 207

Synonyms

Zep, 8430401D15Rik

MMRRC Submission

044951-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6845 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

80274105-80296559 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 80286317 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115924 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017567] [ENSMUST00000053740] [ENSMUST00000108216] [ENSMUST00000153824] [ENSMUST00000165565] [ENSMUST00000178665] [ENSMUST00000188489]

AlphaFold

Q9JMD0

Predicted Effect

unknown
Transcript: ENSMUST00000017567
AA Change: P446S

SMART Domains

Protein: ENSMUSP00000017567
Gene: ENSMUSG00000017421
AA Change: P446S

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000053740
AA Change: P477S

SMART Domains

Protein: ENSMUSP00000054168
Gene: ENSMUSG00000017421
AA Change: P477S

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	283	300	N/A	INTRINSIC
low complexity region	306	313	N/A	INTRINSIC
low complexity region	326	341	N/A	INTRINSIC
low complexity region	343	381	N/A	INTRINSIC
low complexity region	410	455	N/A	INTRINSIC
low complexity region	460	489	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108216

SMART Domains

Protein: ENSMUSP00000103851
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	283	300	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000123726
AA Change: P323S

Predicted Effect

probably benign
Transcript: ENSMUST00000153824

SMART Domains

Protein: ENSMUSP00000115924
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	3	23	1.34e2	SMART
ZnF_C2H2	24	47	2.29e0	SMART
low complexity region	87	115	N/A	INTRINSIC
low complexity region	134	173	N/A	INTRINSIC
low complexity region	189	226	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000165565
AA Change: P461S

SMART Domains

Protein: ENSMUSP00000132968
Gene: ENSMUSG00000017421
AA Change: P461S

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	221	N/A	INTRINSIC
low complexity region	236	253	N/A	INTRINSIC
low complexity region	267	284	N/A	INTRINSIC
low complexity region	290	297	N/A	INTRINSIC
low complexity region	310	325	N/A	INTRINSIC
low complexity region	327	365	N/A	INTRINSIC
low complexity region	394	439	N/A	INTRINSIC
low complexity region	444	473	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000178665
AA Change: P446S

SMART Domains

Protein: ENSMUSP00000136727
Gene: ENSMUSG00000017421
AA Change: P446S

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000188489
AA Change: P446S

SMART Domains

Protein: ENSMUSP00000139653
Gene: ENSMUSG00000017421
AA Change: P446S

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Meta Mutation Damage Score

0.0842

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.0%

Validation Efficiency

95% (53/56)

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2fm2	C	A	3: 59,659,539 (GRCm39)	P331T	probably damaging	Het
Adam6a	T	C	12: 113,507,717 (GRCm39)	L30P	possibly damaging	Het
Cabin1	G	A	10: 75,557,342 (GRCm39)	R1099W	probably damaging	Het
Cdon	C	T	9: 35,398,252 (GRCm39)	Q990*	probably null	Het
Cit	T	A	5: 116,122,947 (GRCm39)	L1421Q	probably damaging	Het
Cplane1	T	C	15: 8,251,388 (GRCm39)	S1887P	possibly damaging	Het
Ddx27	T	C	2: 166,864,016 (GRCm39)	C242R	probably damaging	Het
Dlgap5	A	T	14: 47,654,020 (GRCm39)	V3E	possibly damaging	Het
Dnah6	A	T	6: 73,110,525 (GRCm39)	F1687I	probably damaging	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Het
Duoxa1	A	T	2: 122,135,672 (GRCm39)	Y142*	probably null	Het
F3	A	G	3: 121,526,124 (GRCm39)	K229R	probably benign	Het
Fance	A	G	17: 28,536,565 (GRCm39)	R42G	probably damaging	Het
Foxs1	T	C	2: 152,774,619 (GRCm39)	K145E	probably benign	Het
Gpd1l	T	C	9: 114,762,785 (GRCm39)	M1V	probably null	Het
Gpr149	T	A	3: 62,511,942 (GRCm39)	H19L	possibly damaging	Het
Hmgcs1	T	C	13: 120,162,674 (GRCm39)	Y213H	probably damaging	Het
Htra1	C	A	7: 130,538,021 (GRCm39)		probably benign	Het
Il20ra	A	G	10: 19,635,059 (GRCm39)	I433M	probably benign	Het
Il3ra	G	C	14: 14,346,517 (GRCm38)		probably null	Het
Kif11	C	T	19: 37,392,565 (GRCm39)	L499F	probably damaging	Het
Kifc3	A	G	8: 95,835,307 (GRCm39)	M189T	probably benign	Het
Klk1b3	G	A	7: 43,851,127 (GRCm39)	A187T	probably benign	Het
Klre1	T	C	6: 129,561,202 (GRCm39)	S188P	probably damaging	Het
Krtap4-13	G	A	11: 99,700,192 (GRCm39)		probably benign	Het
Lgi4	A	T	7: 30,760,510 (GRCm39)	T22S	probably damaging	Het
Lrp10	C	T	14: 54,707,145 (GRCm39)	R661C	probably damaging	Het
Lrrtm1	A	G	6: 77,220,864 (GRCm39)	D107G	probably benign	Het
Mad1l1	C	A	5: 139,994,924 (GRCm39)	A701S	probably damaging	Het
Mia2	T	A	12: 59,231,064 (GRCm39)	Y1237*	probably null	Het
Mpp4	T	C	1: 59,183,963 (GRCm39)	D278G	probably benign	Het
Myh6	G	A	14: 55,182,206 (GRCm39)	S1734L	probably benign	Het
Nbeal1	C	T	1: 60,320,469 (GRCm39)	R2021*	probably null	Het
Nol4l	T	C	2: 153,258,582 (GRCm39)	T602A	probably benign	Het
Or5b109	T	A	19: 13,211,997 (GRCm39)	C128S	probably damaging	Het
Pcdh15	A	T	10: 74,466,465 (GRCm39)	H894L	probably benign	Het
Phldb1	A	T	9: 44,627,359 (GRCm39)	I362N	probably damaging	Het
Plcxd2	T	A	16: 45,830,223 (GRCm39)		probably benign	Het
Ppp1r13l	G	T	7: 19,105,323 (GRCm39)	R365L	probably damaging	Het
Pramel16	T	C	4: 143,676,394 (GRCm39)	T237A	probably benign	Het
Rfc1	A	T	5: 65,468,459 (GRCm39)	S85T	possibly damaging	Het
Rnf133	A	G	6: 23,649,341 (GRCm39)	V196A	possibly damaging	Het
Shank3	T	C	15: 89,432,528 (GRCm39)	V1016A	probably benign	Het
Slc22a21	T	C	11: 53,870,466 (GRCm39)	D73G	probably benign	Het
Slc34a2	T	A	5: 53,226,511 (GRCm39)	F545I	probably damaging	Het
Slc4a7	T	A	14: 14,775,000 (GRCm38)	M810K	probably damaging	Het
Ss18	A	T	18: 14,788,221 (GRCm39)	M83K	possibly damaging	Het
Tkfc	T	C	19: 10,576,696 (GRCm39)	R94G	probably damaging	Het
Tpp2	T	A	1: 44,017,668 (GRCm39)	C757*	probably null	Het
Trav13n-4	T	C	14: 53,599,856 (GRCm39)	L11P	probably damaging	Het
Trpm4	T	C	7: 44,971,753 (GRCm39)	M138V	possibly damaging	Het
Utp18	G	A	11: 93,776,582 (GRCm39)		probably benign	Het
Vps33a	A	G	5: 123,673,335 (GRCm39)	V417A	probably benign	Het

Other mutations in Zfp207

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Zfp207	APN	11	80,279,828 (GRCm39)	missense	probably benign	0.42
IGL00402:Zfp207	APN	11	80,283,911 (GRCm39)	missense	probably benign	0.07
IGL01610:Zfp207	APN	11	80,276,796 (GRCm39)	missense	probably damaging	1.00
R0440:Zfp207	UTSW	11	80,286,333 (GRCm39)	unclassified	probably benign
R1926:Zfp207	UTSW	11	80,286,253 (GRCm39)	nonsense	probably null
R4614:Zfp207	UTSW	11	80,286,016 (GRCm39)	unclassified	probably benign
R5103:Zfp207	UTSW	11	80,282,736 (GRCm39)	missense	probably damaging	1.00
R5647:Zfp207	UTSW	11	80,283,959 (GRCm39)	missense	possibly damaging	0.72
R6919:Zfp207	UTSW	11	80,286,329 (GRCm39)	unclassified	probably benign
R7131:Zfp207	UTSW	11	80,286,354 (GRCm39)	missense	unknown
R7216:Zfp207	UTSW	11	80,286,004 (GRCm39)	missense	unknown
R7672:Zfp207	UTSW	11	80,280,116 (GRCm39)	missense	probably benign	0.27
R7836:Zfp207	UTSW	11	80,282,726 (GRCm39)	missense	probably damaging	1.00
R8913:Zfp207	UTSW	11	80,276,744 (GRCm39)	missense	probably damaging	0.98
R9662:Zfp207	UTSW	11	80,286,029 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TATGATGCCACCACAGCCAG -3'
(R):5'- CCAATAGTTCCTGGTATGTGGGAAG -3'

Sequencing Primer
(F):5'- GGCAATGCGACCTCCAATG -3'
(R):5'- AGTTCCTGGTATGTGGGAAGATTATG -3'

Posted On

2018-09-12