Incidental Mutation 'R0621:Or11h7'
ID 58693
Institutional Source Beutler Lab
Gene Symbol Or11h7
Ensembl Gene ENSMUSG00000058188
Gene Name olfactory receptor family 11 subfamily H member 7
Synonyms MOR106-12, Olfr746, GA_x6K02T2PMLR-6372116-6373060
MMRRC Submission 038810-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.125) question?
Stock # R0621 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50890696-50891640 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50891419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 242 (G242R)
Ref Sequence ENSEMBL: ENSMUSP00000151399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080616] [ENSMUST00000218546]
AlphaFold E9Q840
Predicted Effect possibly damaging
Transcript: ENSMUST00000080616
AA Change: G242R

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000079451
Gene: ENSMUSG00000058188
AA Change: G242R

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-52 PFAM
Pfam:7tm_1 41 290 2.8e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000218546
AA Change: G242R

PolyPhen 2 Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abr T C 11: 76,399,898 (GRCm39) D33G probably damaging Het
Adgre1 T A 17: 57,748,359 (GRCm39) S520T probably damaging Het
Afg2a C T 3: 37,486,178 (GRCm39) T300I probably benign Het
Ankrd40 A G 11: 94,230,433 (GRCm39) probably null Het
Aph1b A T 9: 66,686,616 (GRCm39) I177K possibly damaging Het
Armc3 A T 2: 19,300,204 (GRCm39) N579I probably damaging Het
Atxn7l1 T C 12: 33,376,099 (GRCm39) V131A probably benign Het
C130073F10Rik A G 4: 101,747,992 (GRCm39) Y61H probably damaging Het
C1s2 A T 6: 124,608,071 (GRCm39) L214Q probably damaging Het
Caprin2 A T 6: 148,760,176 (GRCm39) S425T possibly damaging Het
Cdc42ep4 G A 11: 113,619,522 (GRCm39) R290C probably damaging Het
Cenpf T C 1: 189,404,825 (GRCm39) T352A probably benign Het
Col6a4 A T 9: 105,943,990 (GRCm39) F1161L probably damaging Het
Dctn2 T C 10: 127,113,809 (GRCm39) probably null Het
Ddx24 T C 12: 103,391,817 (GRCm39) probably benign Het
Dsg1c C A 18: 20,412,752 (GRCm39) A591D possibly damaging Het
Efnb3 T C 11: 69,446,798 (GRCm39) D304G probably damaging Het
Erbb3 T C 10: 128,422,094 (GRCm39) Y50C probably benign Het
Eya3 T G 4: 132,422,113 (GRCm39) D275E probably benign Het
Fam81a G T 9: 70,000,929 (GRCm39) Q272K probably benign Het
Foxf1 T C 8: 121,811,919 (GRCm39) V261A probably damaging Het
Gm9637 G A 14: 19,402,011 (GRCm38) noncoding transcript Het
Gnb4 C T 3: 32,645,356 (GRCm39) V112I probably benign Het
Gtf2h2 A T 13: 100,625,433 (GRCm39) L61Q probably damaging Het
Hey2 T A 10: 30,710,382 (GRCm39) I124F probably benign Het
Hoxb3 A T 11: 96,236,789 (GRCm39) Y289F probably damaging Het
Kctd3 C T 1: 188,713,538 (GRCm39) R399Q probably damaging Het
Kif26b C G 1: 178,743,218 (GRCm39) P1105A probably benign Het
Klhl30 C T 1: 91,285,585 (GRCm39) T369M probably damaging Het
Lipo2 C T 19: 33,708,339 (GRCm39) G225D probably damaging Het
Macf1 T C 4: 123,274,327 (GRCm39) K6350E probably damaging Het
Myh13 A C 11: 67,232,058 (GRCm39) N446T probably damaging Het
Nos1ap T C 1: 170,146,150 (GRCm39) D468G probably damaging Het
Or10j2 C T 1: 173,098,242 (GRCm39) P167S possibly damaging Het
Or4a77 C A 2: 89,487,459 (GRCm39) E109* probably null Het
Pde3a T C 6: 141,195,725 (GRCm39) L137P probably damaging Het
Ppm1f G A 16: 16,733,172 (GRCm39) R233Q probably benign Het
Rtf2 C A 2: 172,308,216 (GRCm39) A205E possibly damaging Het
Sh2d5 T C 4: 137,985,629 (GRCm39) F359S probably benign Het
Siglec1 G A 2: 130,916,188 (GRCm39) T1254M probably benign Het
Slc39a11 G A 11: 113,354,905 (GRCm39) P108L probably benign Het
Slc6a5 G A 7: 49,567,113 (GRCm39) probably null Het
Snph C T 2: 151,435,642 (GRCm39) V360M probably damaging Het
Snx29 A G 16: 11,223,651 (GRCm39) probably null Het
Sos1 A G 17: 80,759,408 (GRCm39) probably null Het
St8sia6 T A 2: 13,662,093 (GRCm39) N246I probably damaging Het
Thy1 T A 9: 43,958,030 (GRCm39) F53I probably damaging Het
Tle3 T A 9: 61,317,387 (GRCm39) Y421* probably null Het
Ttc21b C T 2: 66,056,355 (GRCm39) R677Q probably benign Het
Vmn2r107 A T 17: 20,595,252 (GRCm39) I602F probably benign Het
Wdr17 C A 8: 55,096,226 (GRCm39) G1016C probably benign Het
Wdr62 T C 7: 29,953,486 (GRCm39) E182G possibly damaging Het
Zfp597 A G 16: 3,684,228 (GRCm39) I176T probably benign Het
Other mutations in Or11h7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03288:Or11h7 APN 14 50,890,832 (GRCm39) missense possibly damaging 0.78
IGL03333:Or11h7 APN 14 50,890,855 (GRCm39) nonsense probably null
R0217:Or11h7 UTSW 14 50,891,552 (GRCm39) missense probably damaging 1.00
R1656:Or11h7 UTSW 14 50,891,465 (GRCm39) missense probably benign 0.16
R1975:Or11h7 UTSW 14 50,890,821 (GRCm39) missense probably damaging 1.00
R4281:Or11h7 UTSW 14 50,891,029 (GRCm39) missense probably benign 0.18
R5763:Or11h7 UTSW 14 50,891,525 (GRCm39) missense possibly damaging 0.84
R6236:Or11h7 UTSW 14 50,891,257 (GRCm39) missense probably damaging 1.00
R6612:Or11h7 UTSW 14 50,891,090 (GRCm39) missense probably damaging 1.00
R7112:Or11h7 UTSW 14 50,891,583 (GRCm39) missense probably benign 0.03
R7125:Or11h7 UTSW 14 50,891,041 (GRCm39) missense possibly damaging 0.92
R7221:Or11h7 UTSW 14 50,891,528 (GRCm39) missense probably damaging 0.99
R7810:Or11h7 UTSW 14 50,891,450 (GRCm39) missense probably benign 0.43
R7881:Or11h7 UTSW 14 50,890,904 (GRCm39) missense probably damaging 1.00
R8002:Or11h7 UTSW 14 50,891,314 (GRCm39) missense probably damaging 0.99
R8681:Or11h7 UTSW 14 50,890,801 (GRCm39) missense probably benign 0.00
R9518:Or11h7 UTSW 14 50,891,101 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGACCCACTAATAGCACTGTCCTG -3'
(R):5'- TGCCCTTGGAAGCATTGAGTGTC -3'

Sequencing Primer
(F):5'- ACTAATAGCACTGTCCTGTACCC -3'
(R):5'- TGGAAGCATTGAGTGTCCCATAG -3'
Posted On 2013-07-11