Incidental Mutation 'RF053:Zfp69'
ID 605180
Institutional Source Beutler Lab
Gene Symbol Zfp69
Ensembl Gene ENSMUSG00000064141
Gene Name zinc finger protein 69
Synonyms Zfp63, KRAB2, LOC381549
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # RF053 (G1)
Quality Score 214.458
Status Not validated
Chromosome 4
Chromosomal Location 120787334-120808896 bp(-) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) GTGCCAGGGGTCTCTCCATCATGGGATCCTGCTGCAGGGATGCCAGGGGTCTCTCCATCATGGGATCCTGCTGCAGGGGTGCCAGGGGTCGCTTCATCATGGGATCCTGTTGCAGTGGTGCCAGGGGTCGCTCCATCATGGGATCCTGCTGCAGGGGTGCCAGGGGTC to GTGCCAGGGGTCTCTCCATCATGGGATCCTGCTGCAGGGGTGCCAGGGGTCGCTTCATCATGGGATCCTGTTGCAGTGGTGCCAGGGGTCGCTCCATCATGGGATCCTGCTGCAGGGGTGCCAGGGGTC at 120804544 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106280] [ENSMUST00000106281] [ENSMUST00000130702]
AlphaFold A2A761
Predicted Effect probably benign
Transcript: ENSMUST00000106280
SMART Domains Protein: ENSMUSP00000101887
Gene: ENSMUSG00000064141

DomainStartEndE-ValueType
internal_repeat_1 32 80 1.53e-8 PROSPERO
KRAB 131 192 1.15e-32 SMART
ZnF_C2H2 324 346 1.13e-4 SMART
ZnF_C2H2 352 374 2.79e-4 SMART
ZnF_C2H2 380 402 1.04e-3 SMART
ZnF_C2H2 408 430 1.12e-3 SMART
ZnF_C2H2 436 458 1.82e-3 SMART
ZnF_C2H2 464 486 3.29e-1 SMART
ZnF_C2H2 492 514 1.38e-3 SMART
ZnF_C2H2 520 542 3.29e-1 SMART
ZnF_C2H2 548 570 2.12e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106281
SMART Domains Protein: ENSMUSP00000101888
Gene: ENSMUSG00000064141

DomainStartEndE-ValueType
internal_repeat_1 32 80 1.53e-8 PROSPERO
KRAB 131 192 1.15e-32 SMART
ZnF_C2H2 324 346 1.13e-4 SMART
ZnF_C2H2 352 374 2.79e-4 SMART
ZnF_C2H2 380 402 1.04e-3 SMART
ZnF_C2H2 408 430 1.12e-3 SMART
ZnF_C2H2 436 458 1.82e-3 SMART
ZnF_C2H2 464 486 3.29e-1 SMART
ZnF_C2H2 492 514 1.38e-3 SMART
ZnF_C2H2 520 542 3.29e-1 SMART
ZnF_C2H2 548 570 2.12e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000130702
SMART Domains Protein: ENSMUSP00000133312
Gene: ENSMUSG00000064141

DomainStartEndE-ValueType
KRAB 1 32 2.6e-2 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A030005L19Rik TGGCTGCTG TGGCTGCTGGGGCTGCTG 1: 82,891,294 (GRCm39) probably benign Het
Abra TGGC T 15: 41,729,695 (GRCm39) probably benign Het
Blm CTCCTCCTCCTC CTCCTCCTCCTCATCCTCCTCCTC 7: 80,162,669 (GRCm39) probably benign Het
Bmp5 TGAGGAG T 9: 75,683,656 (GRCm39) probably benign Het
Cngb1 GGCTCTGGCTCTGGCTCTGGCTCTG GG 8: 96,030,276 (GRCm39) probably null Het
Cyb5r4 GGATGTGACAGACACACTGCCCAG GGATGTGACAGACACACTGCCCAGCGATGTGACAGACACACTGCCCAG 9: 86,922,475 (GRCm39) probably benign Het
Ehbp1l1 TCACACCACC T 19: 5,766,030 (GRCm39) probably benign Het
Kdm3a TTTTT TTTTTT 6: 71,609,033 (GRCm39) probably benign Het
Krtap28-10 CAGCCACCACAGC CAGCCACCACAGCCAAAGCCACCACAGC 1: 83,019,999 (GRCm39) probably benign Het
Mamld1 CA CAGAA X: 70,162,458 (GRCm39) probably benign Het
Map1a CTCCAGCTCCAGCTCCAGCTCCAGCTCCA CTCCAGCTCCAGCTCCAGCTCCAGCTCCAGATCCAGCTCCAGCTCCAGCTCCAGCTCCA 2: 121,136,771 (GRCm39) probably benign Het
Med12l CAG CAGAAG 3: 59,183,414 (GRCm39) probably benign Het
Nefh GACTTGGCCTCACCT GACTTGGCCTCACCTCACCACTTGGCCTCACCT 11: 4,891,014 (GRCm39) probably null Het
Polr1has CACCAC CACCACCACCACCACCACCTCTACCAC 17: 37,275,958 (GRCm39) probably benign Het
Rap1gds1 TCATTTATTATGACCATAC TC 3: 138,647,418 (GRCm39) probably null Het
Tcof1 C CAGA 18: 60,968,819 (GRCm39) probably benign Het
Tfeb AGC AGCCGC 17: 48,097,039 (GRCm39) probably benign Het
Trappc9 TGCT TGCTGCTGCTGCTGCGGCT 15: 72,673,177 (GRCm39) probably benign Het
Usp2 C CTCATGTGACCTGTTCTTCACTTAA 9: 44,000,426 (GRCm39) probably benign Het
Zfp598 CCCACCACCACAACCACCACCACCACCACCAC CCCACCACCACCACCACAACCACCACCACCACCACCAC 17: 24,899,735 (GRCm39) probably benign Het
Other mutations in Zfp69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Zfp69 APN 4 120,788,697 (GRCm39) missense probably damaging 1.00
IGL02604:Zfp69 APN 4 120,788,660 (GRCm39) missense probably benign 0.10
IGL03406:Zfp69 APN 4 120,788,281 (GRCm39) missense probably benign
R0505:Zfp69 UTSW 4 120,788,292 (GRCm39) missense probably damaging 1.00
R0613:Zfp69 UTSW 4 120,791,544 (GRCm39) missense probably benign
R0628:Zfp69 UTSW 4 120,806,622 (GRCm39) nonsense probably null
R0838:Zfp69 UTSW 4 120,788,478 (GRCm39) missense probably benign 0.09
R1669:Zfp69 UTSW 4 120,804,695 (GRCm39) utr 5 prime probably benign
R2060:Zfp69 UTSW 4 120,788,029 (GRCm39) missense probably damaging 0.98
R3740:Zfp69 UTSW 4 120,788,071 (GRCm39) splice site probably null
R4242:Zfp69 UTSW 4 120,791,672 (GRCm39) intron probably benign
R4770:Zfp69 UTSW 4 120,791,614 (GRCm39) missense probably damaging 0.99
R4998:Zfp69 UTSW 4 120,804,522 (GRCm39) missense possibly damaging 0.52
R5620:Zfp69 UTSW 4 120,787,719 (GRCm39) missense probably damaging 1.00
R6312:Zfp69 UTSW 4 120,806,714 (GRCm39) unclassified probably benign
R6534:Zfp69 UTSW 4 120,788,394 (GRCm39) missense probably benign 0.05
R7056:Zfp69 UTSW 4 120,788,295 (GRCm39) missense probably benign 0.01
R7061:Zfp69 UTSW 4 120,788,598 (GRCm39) missense possibly damaging 0.69
R7663:Zfp69 UTSW 4 120,792,323 (GRCm39) missense probably benign 0.17
R8169:Zfp69 UTSW 4 120,787,731 (GRCm39) missense probably damaging 1.00
R8348:Zfp69 UTSW 4 120,787,834 (GRCm39) missense probably damaging 1.00
R8389:Zfp69 UTSW 4 120,806,549 (GRCm39) missense possibly damaging 0.93
R9182:Zfp69 UTSW 4 120,792,308 (GRCm39) missense probably damaging 1.00
R9340:Zfp69 UTSW 4 120,788,013 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGTAACTTGCCTGGACTCC -3'
(R):5'- AGCTCTGCTATCCCATGATGC -3'

Sequencing Primer
(F):5'- GGACTCCCTCCATATTGAATTATTGG -3'
(R):5'- TGCTATCCCATGATGCTAATGG -3'
Posted On 2019-12-04