Incidental Mutation 'R8055:Wnt8b'
ID 619346
Institutional Source Beutler Lab
Gene Symbol Wnt8b
Ensembl Gene ENSMUSG00000036961
Gene Name wingless-type MMTV integration site family, member 8B
Synonyms
MMRRC Submission 067492-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8055 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 44481912-44502712 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to G at 44481952 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000042867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041163]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000041163
SMART Domains Protein: ENSMUSP00000042867
Gene: ENSMUSG00000036961

DomainStartEndE-ValueType
WNT1 38 351 1.02e-185 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adrm1b C A 3: 92,336,139 (GRCm39) G188W unknown Het
Ahcyl1 A T 3: 107,576,047 (GRCm39) D353E probably benign Het
Alk G T 17: 72,206,252 (GRCm39) P1033T probably benign Het
Asb15 G T 6: 24,556,565 (GRCm39) C20F probably benign Het
BC049715 A G 6: 136,816,913 (GRCm39) N51S possibly damaging Het
Ccser1 G A 6: 61,290,757 (GRCm39) V480M possibly damaging Het
Cep295 T C 9: 15,244,905 (GRCm39) N1184D probably benign Het
Cers6 C T 2: 68,777,625 (GRCm39) R111W probably damaging Het
Clybl T A 14: 122,615,273 (GRCm39) D204E probably damaging Het
Cxcl13 T C 5: 96,107,763 (GRCm39) V73A probably benign Het
Dchs2 A G 3: 83,037,032 (GRCm39) N593S probably benign Het
Esco2 A T 14: 66,069,168 (GRCm39) N47K probably benign Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fmo4 T C 1: 162,636,015 (GRCm39) T46A probably benign Het
Gm15217 T C 14: 46,616,911 (GRCm39) probably benign Het
Gnb5 G T 9: 75,250,826 (GRCm39) A317S probably benign Het
Klf14 A G 6: 30,934,722 (GRCm39) V304A probably benign Het
Klrc2 A T 6: 129,633,424 (GRCm39) C209* probably null Het
Kmt2a A T 9: 44,732,378 (GRCm39) N2646K unknown Het
Krt14 C G 11: 100,095,584 (GRCm39) V274L possibly damaging Het
Myo16 A T 8: 10,612,186 (GRCm39) D1277V unknown Het
Myo9a A T 9: 59,814,743 (GRCm39) E2226D probably damaging Het
Osbpl8 T C 10: 111,120,255 (GRCm39) V631A possibly damaging Het
Piezo2 G A 18: 63,175,882 (GRCm39) S1833L probably damaging Het
Pkp4 T C 2: 59,138,359 (GRCm39) V203A probably benign Het
Primpol T C 8: 47,032,197 (GRCm39) D459G probably benign Het
Prkdc G T 16: 15,634,749 (GRCm39) R3631S probably benign Het
Rbbp8nl T C 2: 179,920,001 (GRCm39) T558A probably benign Het
Rcc2 G A 4: 140,429,586 (GRCm39) C40Y probably benign Het
Rdx G A 9: 51,997,724 (GRCm39) R566Q probably damaging Het
Rhbdf2 A C 11: 116,498,191 (GRCm39) S3A probably benign Het
Rpap1 A T 2: 119,595,284 (GRCm39) I1319N probably benign Het
Sbno2 T A 10: 79,905,265 (GRCm39) I206F possibly damaging Het
Scn1a A G 2: 66,149,845 (GRCm39) V944A probably damaging Het
Scube1 C T 15: 83,543,226 (GRCm39) probably null Het
Slc22a20 G A 19: 6,021,439 (GRCm39) A521V probably benign Het
Slc6a4 C A 11: 76,901,424 (GRCm39) T53K probably benign Het
Snapc2 G A 8: 4,304,322 (GRCm39) R75Q probably damaging Het
Sptan1 A T 2: 29,884,351 (GRCm39) K662I probably benign Het
Sycp3 T C 10: 88,298,438 (GRCm39) S55P probably damaging Het
Tet2 A T 3: 133,173,753 (GRCm39) V1503D possibly damaging Het
Tfrc T A 16: 32,437,474 (GRCm39) N277K probably benign Het
Tlx3 A T 11: 33,151,283 (GRCm39) V291E probably damaging Het
Tnk1 A T 11: 69,747,327 (GRCm39) H101Q probably benign Het
Tns3 A T 11: 8,495,343 (GRCm39) D70E probably damaging Het
Trip11 C A 12: 101,803,924 (GRCm39) G1938C probably damaging Het
Tubg1 T C 11: 101,014,828 (GRCm39) L190P probably damaging Het
Vmn2r79 A T 7: 86,686,541 (GRCm39) S641C possibly damaging Het
Other mutations in Wnt8b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:Wnt8b APN 19 44,499,704 (GRCm39) missense probably damaging 1.00
Manorborne UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
Prospero UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R0601:Wnt8b UTSW 19 44,482,106 (GRCm39) missense probably benign 0.01
R0948:Wnt8b UTSW 19 44,498,968 (GRCm39) missense possibly damaging 0.69
R1315:Wnt8b UTSW 19 44,500,462 (GRCm39) missense probably damaging 1.00
R1672:Wnt8b UTSW 19 44,499,715 (GRCm39) missense probably damaging 1.00
R1864:Wnt8b UTSW 19 44,482,029 (GRCm39) missense probably benign 0.08
R5728:Wnt8b UTSW 19 44,499,757 (GRCm39) missense possibly damaging 0.69
R6180:Wnt8b UTSW 19 44,500,082 (GRCm39) missense probably benign 0.01
R6997:Wnt8b UTSW 19 44,500,280 (GRCm39) missense probably damaging 1.00
R7187:Wnt8b UTSW 19 44,500,121 (GRCm39) missense probably benign 0.04
R7216:Wnt8b UTSW 19 44,500,511 (GRCm39) missense probably benign
R7469:Wnt8b UTSW 19 44,500,001 (GRCm39) missense possibly damaging 0.83
R7673:Wnt8b UTSW 19 44,500,127 (GRCm39) missense possibly damaging 0.73
R8003:Wnt8b UTSW 19 44,500,396 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAGGACCCTGGAGTGTTC -3'
(R):5'- ACAGAATGGCTTTTCCCAAGAC -3'

Sequencing Primer
(F):5'- GAGTGTTCTTTTGATCAGCTCAATC -3'
(R):5'- GGCTTTTCCCAAGACAGAGCTTAAG -3'
Posted On 2020-01-23