Mutagenetix > Incidental Mutation

Incidental Mutation 'R8126:Vmn2r-ps117'

631784

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r-ps117

Ensembl Gene

ENSMUSG00000093531

Gene Name

vomeronasal 2, receptor, pseudogene 117

Synonyms

EG665303

MMRRC Submission

067555-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.168) question?

Stock #

R8126 (G1)

Quality Score

202.009

Status

Validated

Chromosome

Chromosomal Location

19042822-19059004 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19042814 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 74 (Y74F)

Ref Sequence

ENSEMBL: ENSMUSP00000156026 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176899]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000176899
AA Change: Y74F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.0%
20x: 97.3%

Validation Efficiency

95% (42/44)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	T	13: 81,588,344 (GRCm39)	V4414E	possibly damaging	Het
Aplp1	T	A	7: 30,141,164 (GRCm39)	D299V	probably damaging	Het
Atad2	T	C	15: 57,968,987 (GRCm39)	I841M	probably benign	Het
Bdp1	T	C	13: 100,192,790 (GRCm39)	E1348G	probably damaging	Het
Cacna1a	A	G	8: 85,359,881 (GRCm39)	T1948A	probably benign	Het
Cdh12	T	C	15: 21,558,393 (GRCm39)	Y431H	probably benign	Het
Cfap74	C	A	4: 155,511,831 (GRCm39)	D446E		Het
Clpsl2	G	A	17: 28,769,702 (GRCm39)	G55R	probably damaging	Het
Col4a4	T	C	1: 82,431,007 (GRCm39)	T1632A	unknown	Het
Csnk2a2	G	A	8: 96,182,575 (GRCm39)	P296L		Het
Cspg4b	T	A	13: 113,504,697 (GRCm39)	I1942N		Het
Cstl1	A	G	2: 148,596,591 (GRCm39)	E98G	probably benign	Het
Ddx49	A	T	8: 70,748,246 (GRCm39)	I303N	probably damaging	Het
Ddx60	C	T	8: 62,436,945 (GRCm39)	A965V	probably benign	Het
Evl	C	T	12: 108,647,783 (GRCm39)	R295*	probably null	Het
Gm14295	A	G	2: 176,502,658 (GRCm39)	D716G	probably benign	Het
Gsap	T	A	5: 21,475,010 (GRCm39)	H556Q	probably benign	Het
Hsp90b1	T	C	10: 86,530,246 (GRCm39)	I538V	probably damaging	Het
Ighv1-49	C	T	12: 115,019,230 (GRCm39)		probably benign	Het
Lrrk1	T	C	7: 65,942,063 (GRCm39)	N725S	probably damaging	Het
Mfsd4b2	A	G	10: 39,797,984 (GRCm39)	S124P	probably benign	Het
Ncoa1	A	T	12: 4,340,951 (GRCm39)	L827Q	probably damaging	Het
Ncor2	T	C	5: 125,183,268 (GRCm39)	N59D	unknown	Het
Nfkbid	T	A	7: 30,123,799 (GRCm39)	S120T	probably benign	Het
Nktr	T	C	9: 121,575,514 (GRCm39)	Y341H	probably damaging	Het
Npat	T	C	9: 53,463,634 (GRCm39)	V139A	probably benign	Het
Or5ae1	T	A	7: 84,565,114 (GRCm39)	N42K	probably damaging	Het
Plxnb2	T	C	15: 89,047,506 (GRCm39)	D721G	probably benign	Het
Ppl	C	T	16: 4,906,725 (GRCm39)	R1190H	probably damaging	Het
Ppp3ca	T	A	3: 136,608,952 (GRCm39)	D348E	probably damaging	Het
Pramel21	T	A	4: 143,343,635 (GRCm39)	C312S	possibly damaging	Het
Rnf146	T	C	10: 29,223,372 (GRCm39)	I171M	probably damaging	Het
Snrpa	G	T	7: 26,892,373 (GRCm39)	F62L	possibly damaging	Het
Spata3	C	T	1: 85,952,075 (GRCm39)	R110C	unknown	Het
Tbc1d2b	T	C	9: 90,104,369 (GRCm39)	H591R	probably benign	Het
Tnfsf8	T	G	4: 63,752,423 (GRCm39)	D214A	possibly damaging	Het
Trdmt1	C	T	2: 13,524,816 (GRCm39)	R213H	probably benign	Het
Uspl1	C	T	5: 149,151,430 (GRCm39)	L877F	probably damaging	Het
Vmn1r22	C	A	6: 57,877,669 (GRCm39)	V103F	possibly damaging	Het
Vmn2r102	T	C	17: 19,880,712 (GRCm39)	S18P	probably benign	Het
Wdr90	A	G	17: 26,067,951 (GRCm39)	F1429S	possibly damaging	Het
Zdhhc20	C	A	14: 58,084,402 (GRCm39)	V238F	probably damaging	Het

Other mutations in Vmn2r-ps117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6903:Vmn2r-ps117	UTSW	17	19,058,552 (GRCm39)	missense	possibly damaging	0.94
R6912:Vmn2r-ps117	UTSW	17	19,047,464 (GRCm39)	missense	probably damaging	1.00
R6934:Vmn2r-ps117	UTSW	17	19,044,967 (GRCm39)	nonsense	probably null
R6953:Vmn2r-ps117	UTSW	17	19,045,095 (GRCm39)	missense	probably benign
R6974:Vmn2r-ps117	UTSW	17	19,058,495 (GRCm39)	missense	probably benign	0.15
R7373:Vmn2r-ps117	UTSW	17	19,044,948 (GRCm39)	missense	probably benign
R7630:Vmn2r-ps117	UTSW	17	19,044,909 (GRCm39)	missense	probably benign	0.01
R7776:Vmn2r-ps117	UTSW	17	19,043,934 (GRCm39)	missense	probably damaging	0.96
R8060:Vmn2r-ps117	UTSW	17	19,058,124 (GRCm39)	missense	possibly damaging	0.85
R8751:Vmn2r-ps117	UTSW	17	19,044,021 (GRCm39)	missense	probably benign
R8986:Vmn2r-ps117	UTSW	17	19,044,943 (GRCm39)	nonsense	probably null
R9324:Vmn2r-ps117	UTSW	17	19,042,911 (GRCm39)	missense	probably benign	0.20
R9417:Vmn2r-ps117	UTSW	17	19,044,037 (GRCm39)	nonsense	probably null
R9607:Vmn2r-ps117	UTSW	17	19,043,940 (GRCm39)	missense	probably benign	0.03
Z1177:Vmn2r-ps117	UTSW	17	19,058,338 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GTAAAGGAGCTTGCTTAAACCTAAC -3'
(R):5'- GAGTGCAGCAGTGAAATTTCTC -3'

Sequencing Primer
(F):5'- TCTGTTCATGGGAAGGCA -3'
(R):5'- ATGATTTCCGTCACCAAGAGCTG -3'

Posted On

2020-06-30