Incidental Mutation 'R8147:Or2y14'
ID 632873
Institutional Source Beutler Lab
Gene Symbol Or2y14
Ensembl Gene ENSMUSG00000044170
Gene Name olfactory receptor family 2 subfamily Y member 14
Synonyms Olfr1384, MOR256-23, GA_x6K02T2QP88-5922712-5921756
MMRRC Submission 067575-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R8147 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 49404445-49405478 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 49405050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 195 (T195I)
Ref Sequence ENSEMBL: ENSMUSP00000149183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060434] [ENSMUST00000213776]
AlphaFold Q8VFA8
Predicted Effect probably benign
Transcript: ENSMUST00000060434
AA Change: T195I

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000051954
Gene: ENSMUSG00000044170
AA Change: T195I

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 6.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 34 161 4.3e-6 PFAM
Pfam:7tm_1 40 313 2.7e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213776
AA Change: T195I

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 98.5%
  • 20x: 94.3%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg7 T C 16: 56,562,876 (GRCm39) E487G probably damaging Het
Aldh9a1 T A 1: 167,184,949 (GRCm39) I287N probably damaging Het
Aox1 T A 1: 58,339,821 (GRCm39) N371K probably benign Het
Atr T A 9: 95,781,113 (GRCm39) F1392L probably damaging Het
Bicra G A 7: 15,722,395 (GRCm39) P374L possibly damaging Het
Cacna1b C T 2: 24,569,188 (GRCm39) R912Q probably damaging Het
Cdhr1 T C 14: 36,801,609 (GRCm39) N778S probably benign Het
Cert1 C T 13: 96,679,736 (GRCm39) P22L probably benign Het
Dgat2 C T 7: 98,806,187 (GRCm39) V337I possibly damaging Het
Dlg5 T C 14: 24,208,395 (GRCm39) D937G probably benign Het
Dqx1 T C 6: 83,037,222 (GRCm39) V295A probably benign Het
Dsg3 A G 18: 20,673,130 (GRCm39) T934A probably benign Het
Fam81b A C 13: 76,383,140 (GRCm39) V243G probably damaging Het
Gen1 A T 12: 11,305,051 (GRCm39) probably null Het
Glrx3 G A 7: 137,064,736 (GRCm39) S275N probably benign Het
Igdcc4 A T 9: 65,031,253 (GRCm39) Q397L probably benign Het
Ints6 C T 14: 62,951,186 (GRCm39) G281D probably damaging Het
Kalrn A T 16: 33,875,414 (GRCm39) S1722T probably benign Het
Lrrc4b A G 7: 44,111,829 (GRCm39) D567G probably damaging Het
Macf1 A G 4: 123,385,491 (GRCm39) L1200S probably damaging Het
Mad1l1 G A 5: 140,129,734 (GRCm39) R434C probably damaging Het
Mia3 A T 1: 183,109,062 (GRCm39) F358I Het
Ncapd3 C T 9: 26,942,014 (GRCm39) probably benign Het
Nfkb2 A G 19: 46,295,873 (GRCm39) R156G possibly damaging Het
Nus1 T C 10: 52,305,416 (GRCm39) probably null Het
Or4a79 T A 2: 89,552,186 (GRCm39) I90F probably damaging Het
Or4c31 T C 2: 88,292,427 (GRCm39) F267L possibly damaging Het
Or5aq1b T A 2: 86,902,017 (GRCm39) I154F probably benign Het
Pafah1b2 A G 9: 45,895,147 (GRCm39) probably null Het
Pold2 T C 11: 5,826,842 (GRCm39) T31A probably benign Het
Ppp1r12b T C 1: 134,801,680 (GRCm39) N512S possibly damaging Het
Prl8a8 A T 13: 27,695,564 (GRCm39) L23Q probably damaging Het
Ptprb T C 10: 116,153,283 (GRCm39) V293A probably damaging Het
Rpl18a G T 8: 71,348,069 (GRCm39) T174N probably damaging Het
Senp5 A T 16: 31,808,128 (GRCm39) H375Q probably benign Het
Setbp1 A T 18: 78,900,015 (GRCm39) F1217L probably damaging Het
Skint4 A G 4: 111,993,218 (GRCm39) I314V probably benign Het
Slc28a2 A G 2: 122,288,682 (GRCm39) D596G probably benign Het
Stat5b A G 11: 100,688,607 (GRCm39) I285T probably benign Het
Sycp3 T C 10: 88,298,467 (GRCm39) probably null Het
Sympk T C 7: 18,770,718 (GRCm39) F270L probably damaging Het
Taar5 T C 10: 23,846,749 (GRCm39) V49A probably damaging Het
Tbx18 C T 9: 87,606,411 (GRCm39) V245I probably damaging Het
Tet1 A G 10: 62,714,586 (GRCm39) M403T probably benign Het
Tmprss11f A T 5: 86,677,769 (GRCm39) F333L probably damaging Het
Tnpo3 T C 6: 29,589,213 (GRCm39) I46V probably benign Het
Traf5 G T 1: 191,746,984 (GRCm39) N112K probably damaging Het
Trim12c A T 7: 103,991,165 (GRCm39) M263K unknown Het
Trim55 A G 3: 19,727,011 (GRCm39) I359M probably benign Het
Utp20 A T 10: 88,594,306 (GRCm39) W2140R probably benign Het
Vgll3 T C 16: 65,624,964 (GRCm39) V104A probably damaging Het
Vmn2r74 C A 7: 85,605,227 (GRCm39) G474* probably null Het
Vps18 G A 2: 119,123,237 (GRCm39) A98T probably benign Het
Zfand4 T A 6: 116,291,169 (GRCm39) S387T probably damaging Het
Zfp808 A G 13: 62,320,934 (GRCm39) Y721C probably damaging Het
Other mutations in Or2y14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02212:Or2y14 APN 11 49,404,737 (GRCm39) missense probably damaging 0.98
IGL02972:Or2y14 APN 11 49,404,918 (GRCm39) missense probably damaging 1.00
R0157:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R1106:Or2y14 UTSW 11 49,404,519 (GRCm39) missense probably damaging 1.00
R1213:Or2y14 UTSW 11 49,405,421 (GRCm39) makesense probably null
R3768:Or2y14 UTSW 11 49,404,600 (GRCm39) missense probably damaging 1.00
R4191:Or2y14 UTSW 11 49,404,639 (GRCm39) missense probably damaging 1.00
R4708:Or2y14 UTSW 11 49,405,216 (GRCm39) nonsense probably null
R5443:Or2y14 UTSW 11 49,405,262 (GRCm39) missense probably damaging 0.98
R5770:Or2y14 UTSW 11 49,405,419 (GRCm39) missense unknown
R6245:Or2y14 UTSW 11 49,404,992 (GRCm39) missense possibly damaging 0.94
R6336:Or2y14 UTSW 11 49,405,369 (GRCm39) missense probably damaging 0.99
R7652:Or2y14 UTSW 11 49,404,512 (GRCm39) missense probably damaging 1.00
R8070:Or2y14 UTSW 11 49,404,941 (GRCm39) missense probably damaging 1.00
R9289:Or2y14 UTSW 11 49,404,635 (GRCm39) missense probably damaging 1.00
R9551:Or2y14 UTSW 11 49,404,942 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTGTGTCGTCCACTACACTAC -3'
(R):5'- ATACGTGTACATGGCTGAGC -3'

Sequencing Primer
(F):5'- GTGTCGTCCACTACACTACACCAG -3'
(R):5'- CTTCAACACTGCATGAGC -3'
Posted On 2020-06-30