Mutagenetix > Incidental Mutation

Incidental Mutation 'R8312:Or13c7'

641427

Institutional Source

Beutler Lab

Gene Symbol

Or13c7

Ensembl Gene

ENSMUSG00000071000

Gene Name

olfactory receptor family 13 subfamily C member 7

Synonyms

MOR262-14, mOR37a, OR37A, GA_x6K02T2N78B-16092200-16091241, Olfr37a, Olfr155

MMRRC Submission

067718-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R8312 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

43854292-43855463 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 43854461 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 51 (I51F)

Ref Sequence

ENSEMBL: ENSMUSP00000103492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095108] [ENSMUST00000107860]

AlphaFold

Q9QZ22

Predicted Effect

probably benign
Transcript: ENSMUST00000095108
AA Change: I51F

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000092726
Gene: ENSMUSG00000071000
AA Change: I51F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	42	297	2.8e-35	PFAM
Pfam:7tm_4	140	290	1.4e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107860
AA Change: I51F

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000103492
Gene: ENSMUSG00000071000
AA Change: I51F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	315	9.7e-59	PFAM
Pfam:7tm_1	42	297	3.5e-25	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (68/68)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd4	T	C	12: 84,662,190 (GRCm39)	R23G	probably damaging	Het
Abraxas2	A	G	7: 132,478,329 (GRCm39)	Y163C	probably damaging	Het
Acnat1	A	T	4: 49,449,142 (GRCm39)	L208*	probably null	Het
Agbl5	A	G	5: 31,051,850 (GRCm39)	E556G	probably damaging	Het
Ampd2	C	A	3: 107,987,432 (GRCm39)	V134L	probably benign	Het
Arih2	A	G	9: 108,521,473 (GRCm39)	S2P	probably damaging	Het
C87436	T	A	6: 86,434,813 (GRCm39)	L387Q	probably damaging	Het
Card9	A	T	2: 26,247,801 (GRCm39)	Y183*	probably null	Het
Cdk14	T	C	5: 4,944,141 (GRCm39)	D394G	probably benign	Het
Cep135	C	T	5: 76,784,746 (GRCm39)	S947L	probably damaging	Het
Cfb	T	C	17: 35,077,121 (GRCm39)	K505E	probably benign	Het
Cnot4	T	A	6: 35,000,076 (GRCm39)	D708V	probably damaging	Het
Col16a1	T	A	4: 129,948,244 (GRCm39)	L281M	unknown	Het
Col6a3	G	T	1: 90,741,412 (GRCm39)	D673E	possibly damaging	Het
Ctdnep1	G	A	11: 69,879,527 (GRCm39)	S150N	probably benign	Het
Fanca	T	A	8: 123,996,549 (GRCm39)		probably benign	Het
Fras1	T	A	5: 96,736,050 (GRCm39)	N548K	probably benign	Het
Gbp2b	A	G	3: 142,304,812 (GRCm39)	M83V	probably benign	Het
Gbp2b	C	A	3: 142,304,815 (GRCm39)	P84T	probably damaging	Het
Gli2	A	T	1: 118,795,842 (GRCm39)		probably benign	Het
Greb1l	A	G	18: 10,511,587 (GRCm39)		probably benign	Het
Grn	A	C	11: 102,327,073 (GRCm39)	K557T	probably damaging	Het
Hapln1	C	T	13: 89,749,563 (GRCm39)	A36V	probably benign	Het
Heg1	C	T	16: 33,547,045 (GRCm39)	R635W	probably benign	Het
Hivep1	C	A	13: 42,308,653 (GRCm39)	Q298K	possibly damaging	Het
Hmcn1	A	G	1: 150,614,515 (GRCm39)	I1297T	probably damaging	Het
Hp1bp3	T	A	4: 137,950,750 (GRCm39)		probably benign	Het
Htr4	C	G	18: 62,570,549 (GRCm39)	F201L	probably damaging	Het
Insrr	C	G	3: 87,707,791 (GRCm39)	Q78E	possibly damaging	Het
Itga6	A	T	2: 71,686,297 (GRCm39)	M1072L	probably benign	Het
Kdsr	A	G	1: 106,675,216 (GRCm39)		probably null	Het
Klhl7	T	C	5: 24,339,965 (GRCm39)	I149T	probably damaging	Het
Lce1l	G	C	3: 92,757,766 (GRCm39)	P31A	unknown	Het
Mag	T	C	7: 30,610,894 (GRCm39)	Y116C	probably damaging	Het
Mast2	A	G	4: 116,287,683 (GRCm39)	S131P	probably benign	Het
Mlec	C	A	5: 115,288,266 (GRCm39)		probably null	Het
Mrap2	G	A	9: 87,051,712 (GRCm39)		probably null	Het
Myo5b	A	G	18: 74,867,033 (GRCm39)	K1395E	probably damaging	Het
Nipa2	G	A	7: 55,583,050 (GRCm39)	Q232*	probably null	Het
Nsd3	C	T	8: 26,153,268 (GRCm39)	T536M	probably damaging	Het
Oit3	T	C	10: 59,274,632 (GRCm39)	N56S	probably benign	Het
Or10p22	A	G	10: 128,826,347 (GRCm39)	T189A	probably benign	Het
Or2m13	T	C	16: 19,225,987 (GRCm39)	M260V	probably benign	Het
Pax3	C	T	1: 78,172,006 (GRCm39)	R68Q	probably damaging	Het
Pcnx2	G	T	8: 126,489,589 (GRCm39)	H1668Q	possibly damaging	Het
Peg10	GC	GCTCC	6: 4,756,452 (GRCm39)		probably benign	Het
Pkd1	A	G	17: 24,786,102 (GRCm39)	S463G	probably benign	Het
Plb1	C	T	5: 32,485,829 (GRCm39)	T871M	probably damaging	Het
Prdx1	A	G	4: 116,556,398 (GRCm39)	D182G	possibly damaging	Het
Prkch	T	A	12: 73,807,358 (GRCm39)	F593I	noncoding transcript	Het
Psrc1	C	T	3: 108,293,673 (GRCm39)	P194L	probably benign	Het
Ptp4a2	A	T	4: 129,733,427 (GRCm39)	I18L	probably benign	Het
Samd10	A	T	2: 181,238,668 (GRCm39)	L153H	probably damaging	Het
Shc3	T	G	13: 51,596,754 (GRCm39)	H423P	probably damaging	Het
Siae	A	T	9: 37,557,593 (GRCm39)	I467F		Het
Slc27a5	C	T	7: 12,725,214 (GRCm39)	R411Q	probably damaging	Het
Spata24	A	G	18: 35,793,861 (GRCm39)	I56T	probably benign	Het
Spns3	G	A	11: 72,390,534 (GRCm39)	T407M	probably damaging	Het
Spta1	G	A	1: 174,067,777 (GRCm39)	C2068Y	probably damaging	Het
Svs5	C	A	2: 164,080,091 (GRCm39)	G25W	probably damaging	Het
Thsd7a	T	C	6: 12,471,181 (GRCm39)	D479G		Het
Trhde	T	C	10: 114,249,192 (GRCm39)	Y858C	probably damaging	Het
Ttn	G	A	2: 76,781,992 (GRCm39)	R1057C	unknown	Het
Tulp4	G	T	17: 6,257,333 (GRCm39)		probably null	Het
Tyk2	T	C	9: 21,026,945 (GRCm39)	T613A	possibly damaging	Het
Ugt2b37	T	C	5: 87,390,799 (GRCm39)	K356R	probably benign	Het
Vmn1r39	A	G	6: 66,781,841 (GRCm39)	V159A	noncoding transcript	Het
Vps35	A	G	8: 86,001,498 (GRCm39)	V440A	possibly damaging	Het
Zmym6	A	G	4: 127,017,627 (GRCm39)	N1136S	probably damaging	Het

Other mutations in Or13c7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02729:Or13c7	APN	4	43,854,439 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0285:Or13c7	UTSW	4	43,854,398 (GRCm39)	missense	possibly damaging	0.46
R0427:Or13c7	UTSW	4	43,854,417 (GRCm39)	missense	probably damaging	1.00
R4468:Or13c7	UTSW	4	43,854,737 (GRCm39)	missense	probably benign	0.08
R4548:Or13c7	UTSW	4	43,854,834 (GRCm39)	missense	probably damaging	1.00
R4583:Or13c7	UTSW	4	43,855,262 (GRCm39)	missense	probably benign
R4793:Or13c7	UTSW	4	43,854,323 (GRCm39)	missense	probably benign	0.37
R4884:Or13c7	UTSW	4	43,854,890 (GRCm39)	missense	probably damaging	1.00
R5016:Or13c7	UTSW	4	43,854,596 (GRCm39)	missense	probably benign	0.02
R5220:Or13c7	UTSW	4	43,854,624 (GRCm39)	missense	possibly damaging	0.89
R5613:Or13c7	UTSW	4	43,854,528 (GRCm39)	missense	probably damaging	0.99
R5805:Or13c7	UTSW	4	43,855,152 (GRCm39)	missense	probably benign	0.15
R5955:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R6250:Or13c7	UTSW	4	43,854,363 (GRCm39)	missense	possibly damaging	0.58
R6768:Or13c7	UTSW	4	43,854,351 (GRCm39)	missense	probably benign	0.01
R6801:Or13c7	UTSW	4	43,855,206 (GRCm39)	nonsense	probably null
R6835:Or13c7	UTSW	4	43,854,912 (GRCm39)	missense	probably benign	0.00
R7510:Or13c7	UTSW	4	43,854,482 (GRCm39)	missense	probably benign	0.20
R8013:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8014:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R9116:Or13c7	UTSW	4	43,854,602 (GRCm39)	missense	probably damaging	1.00
R9636:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R9643:Or13c7	UTSW	4	43,855,183 (GRCm39)	missense	probably benign	0.31
W0251:Or13c7	UTSW	4	43,855,058 (GRCm39)	missense	probably benign	0.42

Predicted Primers

PCR Primer
(F):5'- ATGCTGATTGCTGAGTTCCTGC -3'
(R):5'- ACGCCATCATACTCAGGAGC -3'

Sequencing Primer
(F):5'- GAGTTCCTGCAGGTTTCAAAC -3'
(R):5'- ACACTCCGTGGCTCCCATG -3'

Posted On

2020-07-28