Mutagenetix > Incidental Mutation

Incidental Mutation 'R8014:Or13c7'

617056

Institutional Source

Beutler Lab

Gene Symbol

Or13c7

Ensembl Gene

ENSMUSG00000071000

Gene Name

olfactory receptor family 13 subfamily C member 7

Synonyms

MOR262-14, mOR37a, OR37A, GA_x6K02T2N78B-16092200-16091241, Olfr37a, Olfr155

MMRRC Submission

067454-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R8014 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

43854292-43855463 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 43854958 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 216 (F216L)

Ref Sequence

ENSEMBL: ENSMUSP00000103492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095108] [ENSMUST00000107860]

AlphaFold

Q9QZ22

Predicted Effect

probably benign
Transcript: ENSMUST00000095108
AA Change: F216L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000092726
Gene: ENSMUSG00000071000
AA Change: F216L

Domain	Start	End	E-Value	Type
Pfam:7tm_1	42	297	2.8e-35	PFAM
Pfam:7tm_4	140	290	1.4e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000107860
AA Change: F216L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000103492
Gene: ENSMUSG00000071000
AA Change: F216L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	315	9.7e-59	PFAM
Pfam:7tm_1	42	297	3.5e-25	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6030458C11Rik	C	A	15: 12,824,615 (GRCm39)	D7Y	probably benign	Het
Aff1	A	G	5: 103,981,735 (GRCm39)	T625A	possibly damaging	Het
Aldh8a1	T	C	10: 21,265,201 (GRCm39)	V276A	probably benign	Het
Alkbh3	T	C	2: 93,831,858 (GRCm39)	D124G	probably benign	Het
Apob	T	A	12: 8,060,798 (GRCm39)	N3093K	possibly damaging	Het
Atp13a1	C	T	8: 70,252,429 (GRCm39)	R608*	probably null	Het
Bbs7	A	T	3: 36,648,536 (GRCm39)	I404K	probably damaging	Het
Cacna2d1	A	T	5: 16,547,689 (GRCm39)	T647S	possibly damaging	Het
Carmil1	T	C	13: 24,220,304 (GRCm39)	E1140G	possibly damaging	Het
Ccdc158	C	A	5: 92,796,889 (GRCm39)	E482D	probably damaging	Het
Ccdc92	A	T	5: 124,913,090 (GRCm39)	H146Q	probably damaging	Het
Cntnap4	T	A	8: 113,480,577 (GRCm39)	N341K	probably damaging	Het
Cog1	A	G	11: 113,546,990 (GRCm39)	D528G	probably damaging	Het
Cttnbp2	G	C	6: 18,426,092 (GRCm39)	A762G	possibly damaging	Het
D130043K22Rik	A	T	13: 25,040,685 (GRCm39)	I36F	probably damaging	Het
Dis3	T	A	14: 99,314,835 (GRCm39)	R954W	possibly damaging	Het
Eef1ece2	A	T	16: 20,461,067 (GRCm39)	T618S	probably benign	Het
Ext1	T	C	15: 52,939,283 (GRCm39)	I589V	possibly damaging	Het
Fam20a	T	A	11: 109,576,332 (GRCm39)	E142D	possibly damaging	Het
Fars2	C	T	13: 36,389,068 (GRCm39)	Q186*	probably null	Het
Fcgbpl1	G	A	7: 27,836,966 (GRCm39)	R295H	probably benign	Het
Fhdc1	A	T	3: 84,381,946 (GRCm39)	M1K	probably null	Het
Gars1	T	A	6: 55,050,392 (GRCm39)	F551Y	probably benign	Het
Gm28363	A	G	1: 117,654,534 (GRCm39)	R58G	probably benign	Het
Gm8356	A	T	14: 17,692,450 (GRCm39)	N58K	probably damaging	Het
Gm9758	A	G	5: 14,961,454 (GRCm39)	V175A	possibly damaging	Het
Gpr182	T	C	10: 127,586,874 (GRCm39)	T26A	possibly damaging	Het
Gpr19	A	G	6: 134,846,436 (GRCm39)	Y416H	probably damaging	Het
Hrob	A	G	11: 102,148,725 (GRCm39)	N379D	probably benign	Het
Itgb7	T	A	15: 102,131,087 (GRCm39)	S322C	probably damaging	Het
Kcnma1	T	A	14: 23,423,211 (GRCm39)	I831F	probably benign	Het
Lrba	A	T	3: 86,325,278 (GRCm39)	D1912V	probably damaging	Het
Macf1	T	A	4: 123,420,619 (GRCm39)	T212S	probably benign	Het
Map3k4	A	T	17: 12,489,918 (GRCm39)	C504*	probably null	Het
Morc2a	T	C	11: 3,627,419 (GRCm39)	S281P	probably damaging	Het
Muc16	T	C	9: 18,566,171 (GRCm39)	H2116R	unknown	Het
Nrp2	C	T	1: 62,784,567 (GRCm39)	R239C	probably damaging	Het
Omg	T	C	11: 79,393,729 (GRCm39)	D43G	possibly damaging	Het
Or2ag15	C	T	7: 106,340,824 (GRCm39)	V106I	probably benign	Het
Or4c122	T	A	2: 89,079,343 (GRCm39)	I220F	probably damaging	Het
Or4c3	C	A	2: 89,852,087 (GRCm39)	V108F	possibly damaging	Het
Or5b3	A	T	19: 13,388,175 (GRCm39)	T81S	not run	Het
Or5w22	A	T	2: 87,362,508 (GRCm39)	M44L	probably benign	Het
Pdia6	T	C	12: 17,323,966 (GRCm39)	L66S	probably damaging	Het
Pds5a	A	G	5: 65,785,082 (GRCm39)	I930T	possibly damaging	Het
Piezo2	C	T	18: 63,216,271 (GRCm39)	G1169S	probably benign	Het
Pkhd1	A	G	1: 20,579,115 (GRCm39)		probably null	Het
Plekhg1	A	T	10: 3,907,758 (GRCm39)	R947W		Het
Ptprs	A	C	17: 56,742,994 (GRCm39)	S383A	probably damaging	Het
Rin3	T	A	12: 102,327,630 (GRCm39)	L193*	probably null	Het
Sgsh	A	G	11: 119,243,521 (GRCm39)	V67A	probably damaging	Het
Slc16a4	A	G	3: 107,218,794 (GRCm39)	Y465C	probably damaging	Het
Stab2	C	A	10: 86,686,767 (GRCm39)	S2259I	possibly damaging	Het
Tbc1d24	G	A	17: 24,401,795 (GRCm39)	P385S	possibly damaging	Het
Tm4sf1	T	C	3: 57,200,319 (GRCm39)	I99V	probably benign	Het
Tmem108	A	T	9: 103,376,606 (GRCm39)	I281N	probably benign	Het
Usp31	T	C	7: 121,248,480 (GRCm39)	S988G	probably damaging	Het
Usp44	G	T	10: 93,688,571 (GRCm39)		probably null	Het
Zbtb26	T	A	2: 37,327,013 (GRCm39)		probably null	Het
Zfp599	A	G	9: 22,160,777 (GRCm39)	Y463H	probably benign	Het
Zfp750	T	A	11: 121,403,843 (GRCm39)	D344V	possibly damaging	Het
Zmym5	T	A	14: 57,031,883 (GRCm39)	K408N	possibly damaging	Het

Other mutations in Or13c7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02729:Or13c7	APN	4	43,854,439 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0285:Or13c7	UTSW	4	43,854,398 (GRCm39)	missense	possibly damaging	0.46
R0427:Or13c7	UTSW	4	43,854,417 (GRCm39)	missense	probably damaging	1.00
R4468:Or13c7	UTSW	4	43,854,737 (GRCm39)	missense	probably benign	0.08
R4548:Or13c7	UTSW	4	43,854,834 (GRCm39)	missense	probably damaging	1.00
R4583:Or13c7	UTSW	4	43,855,262 (GRCm39)	missense	probably benign
R4793:Or13c7	UTSW	4	43,854,323 (GRCm39)	missense	probably benign	0.37
R4884:Or13c7	UTSW	4	43,854,890 (GRCm39)	missense	probably damaging	1.00
R5016:Or13c7	UTSW	4	43,854,596 (GRCm39)	missense	probably benign	0.02
R5220:Or13c7	UTSW	4	43,854,624 (GRCm39)	missense	possibly damaging	0.89
R5613:Or13c7	UTSW	4	43,854,528 (GRCm39)	missense	probably damaging	0.99
R5805:Or13c7	UTSW	4	43,855,152 (GRCm39)	missense	probably benign	0.15
R5955:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R6250:Or13c7	UTSW	4	43,854,363 (GRCm39)	missense	possibly damaging	0.58
R6768:Or13c7	UTSW	4	43,854,351 (GRCm39)	missense	probably benign	0.01
R6801:Or13c7	UTSW	4	43,855,206 (GRCm39)	nonsense	probably null
R6835:Or13c7	UTSW	4	43,854,912 (GRCm39)	missense	probably benign	0.00
R7510:Or13c7	UTSW	4	43,854,482 (GRCm39)	missense	probably benign	0.20
R8013:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8312:Or13c7	UTSW	4	43,854,461 (GRCm39)	missense	probably benign	0.04
R9116:Or13c7	UTSW	4	43,854,602 (GRCm39)	missense	probably damaging	1.00
R9636:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R9643:Or13c7	UTSW	4	43,855,183 (GRCm39)	missense	probably benign	0.31
W0251:Or13c7	UTSW	4	43,855,058 (GRCm39)	missense	probably benign	0.42

Predicted Primers

PCR Primer
(F):5'- AGACATCTTTGGCAATGCGG -3'
(R):5'- CTCAAGCTGTAGATGATGGGG -3'

Sequencing Primer
(F):5'- AATGCGGCTGCCCTTCTG -3'
(R):5'- TTTAGCATGGGGGTCACCACTC -3'

Posted On

2020-01-23