Mutagenetix > Incidental Mutation

Incidental Mutation 'R7965:Or1n2'

650301

Institutional Source

Beutler Lab

Gene Symbol

Or1n2

Ensembl Gene

ENSMUSG00000055088

Gene Name

olfactory receptor family 1 subfamily N member 2

Synonyms

GA_x6K02T2NLDC-33601476-33602429, MOR127-4, Olfr354

MMRRC Submission

046008-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.172) question?

Stock #

R7965 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

36796960-36797913 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 36796953 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149298 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]

AlphaFold

Q8VGJ8

Predicted Effect

probably benign
Transcript: ENSMUST00000068475

SMART Domains

Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	310	2.1e-62	PFAM
Pfam:7tm_1	44	293	2.9e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217479

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (45/45)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankhd1	A	G	18: 36,791,465 (GRCm39)	T154A		Het
Arhgap21	A	G	2: 20,854,007 (GRCm39)	I1795T	probably damaging	Het
Arhgef4	T	C	1: 34,850,762 (GRCm39)	V436A	probably benign	Het
Bche	A	T	3: 73,609,149 (GRCm39)	N92K	probably damaging	Het
Bmp2	C	T	2: 133,403,105 (GRCm39)	H219Y	probably benign	Het
Cables1	T	G	18: 11,973,269 (GRCm39)	V136G	probably benign	Het
Cacna1d	G	A	14: 29,769,270 (GRCm39)	R1887*	probably null	Het
Chrd	A	G	16: 20,557,903 (GRCm39)	E774G	probably benign	Het
Chrna2	A	G	14: 66,388,525 (GRCm39)	*513W	probably null	Het
Cracr2b	T	C	7: 141,044,161 (GRCm39)	F131S	probably damaging	Het
Ctsf	T	G	19: 4,906,567 (GRCm39)	F165V	probably damaging	Het
Cyfip1	T	A	7: 55,546,523 (GRCm39)	I545N	possibly damaging	Het
Enpp3	T	A	10: 24,654,717 (GRCm39)	T654S	possibly damaging	Het
Glce	A	G	9: 61,968,228 (GRCm39)	S308P	probably damaging	Het
H3c13	C	A	3: 96,176,309 (GRCm39)	Y100*	probably null	Het
Hmmr	A	C	11: 40,606,256 (GRCm39)		probably null	Het
Hoxb9	A	G	11: 96,165,464 (GRCm39)	N178D	probably benign	Het
Igkv10-94	A	T	6: 68,681,595 (GRCm39)	F82I	probably damaging	Het
Igkv1-133	A	T	6: 67,702,578 (GRCm39)	K99*	probably null	Het
Il4i1	A	G	7: 44,489,819 (GRCm39)	Q528R	probably benign	Het
Inhba	G	T	13: 16,201,572 (GRCm39)	G378V	possibly damaging	Het
Katna1	T	C	10: 7,614,623 (GRCm39)	S44P	probably benign	Het
Ldlrad1	G	A	4: 107,066,688 (GRCm39)	A8T	probably benign	Het
Mgat4d	T	C	8: 84,084,722 (GRCm39)	V155A	possibly damaging	Het
Morc2b	C	T	17: 33,354,746 (GRCm39)	E1009K	possibly damaging	Het
Myo9a	T	A	9: 59,695,721 (GRCm39)	L341H	probably damaging	Het
Nell2	C	T	15: 95,129,216 (GRCm39)	D716N	probably damaging	Het
Or5t16	A	G	2: 86,818,707 (GRCm39)	V271A	probably benign	Het
Or8g36	C	T	9: 39,422,810 (GRCm39)	V69I	probably benign	Het
Or8k30	A	G	2: 86,338,815 (GRCm39)	H4R	probably benign	Het
Ppp1r37	T	C	7: 19,265,868 (GRCm39)	T633A	probably damaging	Het
Prdm10	A	G	9: 31,258,302 (GRCm39)	K576E	probably damaging	Het
Prl2c5	G	T	13: 13,360,469 (GRCm39)	M45I	probably benign	Het
Rigi	C	A	4: 40,223,824 (GRCm39)	G397*	probably null	Het
Rnf44	A	G	13: 54,830,667 (GRCm39)	S247P	probably benign	Het
Scn3a	A	G	2: 65,336,555 (GRCm39)	F684L	probably damaging	Het
Skint2	T	A	4: 112,502,648 (GRCm39)	M286K	probably benign	Het
Slc39a9	G	A	12: 80,713,450 (GRCm39)	G116D	probably damaging	Het
Smchd1	G	A	17: 71,762,621 (GRCm39)	T206I	possibly damaging	Het
Tmem161a	C	T	8: 70,630,154 (GRCm39)		probably benign	Het
Trpm6	T	A	19: 18,853,474 (GRCm39)	H1831Q	probably damaging	Het
Trpm7	A	T	2: 126,667,614 (GRCm39)	H792Q	probably damaging	Het
Ttc6	A	G	12: 57,720,542 (GRCm39)	Q936R	possibly damaging	Het
Usp53	A	T	3: 122,756,531 (GRCm39)		probably null	Het
Vmn1r236	T	A	17: 21,507,696 (GRCm39)	C271*	probably null	Het
Vmn2r70	T	A	7: 85,211,071 (GRCm39)	M547L	probably damaging	Het
Vwa5b1	G	A	4: 138,332,800 (GRCm39)	T254M	probably damaging	Het
Zc3h4	T	C	7: 16,163,770 (GRCm39)	F655S	unknown	Het
Zfp605	G	A	5: 110,275,316 (GRCm39)	G145S	probably benign	Het

Other mutations in Or1n2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01942:Or1n2	APN	2	36,797,869 (GRCm39)	missense	probably benign
IGL02573:Or1n2	APN	2	36,797,566 (GRCm39)	missense	probably damaging	1.00
P0027:Or1n2	UTSW	2	36,797,582 (GRCm39)	missense	probably benign	0.00
R0040:Or1n2	UTSW	2	36,797,470 (GRCm39)	missense	probably damaging	1.00
R0610:Or1n2	UTSW	2	36,797,671 (GRCm39)	missense	probably damaging	1.00
R0760:Or1n2	UTSW	2	36,797,233 (GRCm39)	missense	probably benign	0.25
R1727:Or1n2	UTSW	2	36,797,405 (GRCm39)	missense	probably benign	0.00
R2972:Or1n2	UTSW	2	36,797,416 (GRCm39)	missense	probably benign	0.03
R4671:Or1n2	UTSW	2	36,797,405 (GRCm39)	missense	probably benign	0.00
R4750:Or1n2	UTSW	2	36,797,728 (GRCm39)	missense	probably benign	0.13
R5043:Or1n2	UTSW	2	36,796,977 (GRCm39)	missense	probably benign	0.01
R5400:Or1n2	UTSW	2	36,797,833 (GRCm39)	missense	probably damaging	1.00
R5543:Or1n2	UTSW	2	36,797,369 (GRCm39)	missense	possibly damaging	0.75
R5792:Or1n2	UTSW	2	36,797,113 (GRCm39)	missense	probably benign	0.00
R6639:Or1n2	UTSW	2	36,797,690 (GRCm39)	missense	probably damaging	1.00
R6876:Or1n2	UTSW	2	36,797,834 (GRCm39)	missense	probably damaging	1.00
R8351:Or1n2	UTSW	2	36,797,149 (GRCm39)	missense	probably benign	0.00
R8859:Or1n2	UTSW	2	36,797,516 (GRCm39)	missense	possibly damaging	0.63
T0722:Or1n2	UTSW	2	36,797,582 (GRCm39)	missense	probably benign	0.00
Z1176:Or1n2	UTSW	2	36,797,713 (GRCm39)	missense	possibly damaging	0.95

Predicted Primers

PCR Primer
(F):5'- GCATCACAGAAAGGAACATTTGC -3'
(R):5'- TGTAGGTGTGCATCAGAACTG -3'

Sequencing Primer
(F):5'- CACAGAAAGGAACATTTGCATTTGC -3'
(R):5'- GATGACAAAGATGATGAGTAGGTTCC -3'

Posted On

2020-09-15