Incidental Mutation 'R8749:Zfp961'
ID 663714
Institutional Source Beutler Lab
Gene Symbol Zfp961
Ensembl Gene ENSMUSG00000052446
Gene Name zinc finger protein 961
Synonyms A230105L22Rik, BC049349
MMRRC Submission 068592-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8749 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 72704910-72724177 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 72719686 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 39 (W39R)
Ref Sequence ENSEMBL: ENSMUSP00000105623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109997] [ENSMUST00000131237] [ENSMUST00000132848] [ENSMUST00000136516] [ENSMUST00000138304] [ENSMUST00000145256]
AlphaFold E9Q4R5
Predicted Effect probably damaging
Transcript: ENSMUST00000109997
AA Change: W39R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: W39R

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
ZnF_C2H2 226 248 3.29e-1 SMART
ZnF_C2H2 254 276 3.34e-2 SMART
ZnF_C2H2 282 304 9.58e-3 SMART
ZnF_C2H2 310 332 2.17e-1 SMART
ZnF_C2H2 338 360 1.04e-3 SMART
ZnF_C2H2 366 388 2.24e-3 SMART
ZnF_C2H2 394 416 2.24e-3 SMART
ZnF_C2H2 421 443 4.61e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000131237
AA Change: W20R

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: W20R

DomainStartEndE-ValueType
KRAB 6 63 1.14e-18 SMART
ZnF_C2H2 125 147 1.69e-3 SMART
ZnF_C2H2 153 175 3.07e-1 SMART
ZnF_C2H2 180 202 1.36e-2 SMART
ZnF_C2H2 207 229 3.29e-1 SMART
ZnF_C2H2 235 257 3.34e-2 SMART
ZnF_C2H2 263 285 9.58e-3 SMART
ZnF_C2H2 291 313 2.17e-1 SMART
ZnF_C2H2 319 341 1.04e-3 SMART
ZnF_C2H2 347 369 2.24e-3 SMART
ZnF_C2H2 375 397 2.24e-3 SMART
ZnF_C2H2 402 424 4.61e-5 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000132848
AA Change: W39R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
AA Change: W39R

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
Predicted Effect
SMART Domains Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
AA Change: W39R

DomainStartEndE-ValueType
KRAB 25 82 1.14e-18 SMART
ZnF_C2H2 144 166 1.69e-3 SMART
ZnF_C2H2 172 194 3.07e-1 SMART
ZnF_C2H2 199 221 1.36e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000138304
AA Change: W39R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000145256
AA Change: W39R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.7%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 C T 13: 4,320,155 (GRCm39) probably benign Het
Ap3b1 T A 13: 94,664,725 (GRCm39) M888K unknown Het
Arhgap23 T A 11: 97,391,641 (GRCm39) V223E probably damaging Het
Atm C T 9: 53,410,497 (GRCm39) W1028* probably null Het
Atp7b A G 8: 22,518,334 (GRCm39) V168A probably damaging Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Caskin1 C T 17: 24,723,774 (GRCm39) A854V probably benign Het
Cdcp1 T C 9: 123,019,027 (GRCm39) N84S probably benign Het
Cdh20 T A 1: 110,027,009 (GRCm39) I475N probably damaging Het
Ciz1 A T 2: 32,255,848 (GRCm39) Y107F probably benign Het
Creb3l4 T C 3: 90,145,199 (GRCm39) N318D probably benign Het
Dmrt3 G A 19: 25,588,550 (GRCm39) A130T probably benign Het
Dmxl1 A T 18: 50,088,937 (GRCm39) K2805N probably damaging Het
Dusp15 T A 2: 152,788,209 (GRCm39) I63F probably damaging Het
Dync2h1 T C 9: 7,035,063 (GRCm39) Q3462R probably benign Het
Evpl A G 11: 116,120,232 (GRCm39) C569R probably benign Het
Fmnl3 A T 15: 99,219,322 (GRCm39) M766K possibly damaging Het
G6pc2 A G 2: 69,057,140 (GRCm39) N262S probably damaging Het
Galk1 A T 11: 115,899,762 (GRCm39) L325Q probably damaging Het
H3c3 T C 13: 23,929,108 (GRCm39) I125V probably benign Het
Hr G A 14: 70,795,510 (GRCm39) G352R probably damaging Het
Il12b A T 11: 44,294,864 (GRCm39) M1L not run Het
Lpar6 A T 14: 73,476,950 (GRCm39) M304L probably benign Het
Mpeg1 G A 19: 12,439,291 (GRCm39) A250T probably benign Het
Mtcl3 T C 10: 29,072,721 (GRCm39) I671T possibly damaging Het
Neb T C 2: 52,180,863 (GRCm39) K1221R probably benign Het
Ogfrl1 T A 1: 23,409,399 (GRCm39) I276F probably damaging Het
Or4f62 A G 2: 111,986,869 (GRCm39) D191G possibly damaging Het
Or4k37 T C 2: 111,158,817 (GRCm39) C18R possibly damaging Het
Or4x12-ps1 T C 2: 89,916,631 (GRCm39) Y58C probably damaging Het
Oxr1 A G 15: 41,574,260 (GRCm39) N2S probably benign Het
P3h3 G A 6: 124,822,940 (GRCm39) R505C probably damaging Het
Pcdhb16 A T 18: 37,612,392 (GRCm39) I451F possibly damaging Het
Pet117 C A 2: 144,215,122 (GRCm39) D36E probably benign Het
Prf1 T C 10: 61,138,948 (GRCm39) V302A probably damaging Het
Prkdc G A 16: 15,601,029 (GRCm39) A2897T possibly damaging Het
Prkra A G 2: 76,460,879 (GRCm39) L273P probably damaging Het
Prr30 T A 14: 101,436,365 (GRCm39) T66S probably benign Het
Slc29a4 A G 5: 142,700,819 (GRCm39) Y188C probably damaging Het
Spink5 A T 18: 44,122,425 (GRCm39) K297* probably null Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tmem100 G A 11: 89,926,574 (GRCm39) A134T probably damaging Het
Tmem132c A G 5: 127,437,003 (GRCm39) D164G possibly damaging Het
Tnfsf18 A G 1: 161,331,047 (GRCm39) T66A possibly damaging Het
Ubr4 C T 4: 139,129,935 (GRCm39) T685I probably damaging Het
Uck1 T C 2: 32,146,524 (GRCm39) Y185C Het
Umod T A 7: 119,070,639 (GRCm39) I418F probably benign Het
Upp1 A T 11: 9,079,561 (GRCm39) S41C probably damaging Het
Vmn1r168 A T 7: 23,240,428 (GRCm39) Y95F probably benign Het
Vmn1r180 G T 7: 23,652,415 (GRCm39) D193Y probably damaging Het
Vmn2r11 A G 5: 109,195,319 (GRCm39) V669A probably damaging Het
Vmn2r55 T A 7: 12,385,796 (GRCm39) Y728F probably damaging Het
Vmn2r78 A G 7: 86,603,513 (GRCm39) T564A possibly damaging Het
Vps13d T A 4: 144,865,183 (GRCm39) N2057I Het
Wdfy3 C T 5: 102,030,446 (GRCm39) R2354Q probably damaging Het
Wdr77 T A 3: 105,866,975 (GRCm39) C26S probably damaging Het
Yif1b C T 7: 28,946,690 (GRCm39) A267V probably benign Het
Zfp316 A G 5: 143,248,565 (GRCm39) V227A unknown Het
Zfp600 T A 4: 146,133,151 (GRCm39) H606Q unknown Het
Zfp804a T C 2: 82,087,919 (GRCm39) W583R probably benign Het
Zfp990 T A 4: 145,264,156 (GRCm39) C385S probably damaging Het
Other mutations in Zfp961
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Zfp961 APN 8 72,722,272 (GRCm39) missense probably damaging 1.00
IGL00801:Zfp961 APN 8 72,719,732 (GRCm39) missense probably damaging 1.00
IGL00825:Zfp961 APN 8 72,721,888 (GRCm39) missense possibly damaging 0.91
IGL01405:Zfp961 APN 8 72,721,778 (GRCm39) missense possibly damaging 0.53
IGL03100:Zfp961 APN 8 72,721,754 (GRCm39) makesense probably null
R0969:Zfp961 UTSW 8 72,722,139 (GRCm39) missense probably damaging 1.00
R4851:Zfp961 UTSW 8 72,722,847 (GRCm39) unclassified probably benign
R5502:Zfp961 UTSW 8 72,721,903 (GRCm39) missense probably damaging 0.99
R5813:Zfp961 UTSW 8 72,722,070 (GRCm39) missense probably damaging 1.00
R6762:Zfp961 UTSW 8 72,719,958 (GRCm39) missense possibly damaging 0.53
R6902:Zfp961 UTSW 8 72,722,522 (GRCm39) missense probably damaging 1.00
R7858:Zfp961 UTSW 8 72,704,949 (GRCm39) missense unknown
R9718:Zfp961 UTSW 8 72,721,933 (GRCm39) missense possibly damaging 0.81
X0027:Zfp961 UTSW 8 72,721,793 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CTGATTACCTGGTCCTGGAACTG -3'
(R):5'- CAGCATTCCCAGTTTATGCC -3'

Sequencing Primer
(F):5'- GTCCTGGAACTGACTGAAGTC -3'
(R):5'- GACGTTTAGTGCAACCATTAGATG -3'
Posted On 2021-03-08