Mutagenetix > Incidental Mutation

Incidental Mutation 'R9645:Ltbp2'

726233

Institutional Source

Beutler Lab

Gene Symbol

Ltbp2

Ensembl Gene

ENSMUSG00000002020

Gene Name

latent transforming growth factor beta binding protein 2

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably essential (E-score: 0.794) question?

Stock #

R9645 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84829986-84923306 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 84837864 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 1192 (P1192L)

Ref Sequence

ENSEMBL: ENSMUSP00000105883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002073] [ENSMUST00000110254] [ENSMUST00000163189] [ENSMUST00000166383]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000002073
AA Change: P1215L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000002073
Gene: ENSMUSG00000002020
AA Change: P1215L

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	546	582	3.8e-9	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	666	707	3.4e-17	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	917	1.75e-10	SMART
EGF_CA	918	957	1.53e-10	SMART
EGF_CA	958	997	3.51e-10	SMART
EGF_CA	998	1038	8.3e-12	SMART
EGF_CA	1039	1080	4.56e-9	SMART
EGF_CA	1081	1122	4.56e-9	SMART
EGF_CA	1123	1163	8.76e-11	SMART
EGF_CA	1164	1205	4.38e-11	SMART
EGF_CA	1206	1246	1.75e-10	SMART
EGF_CA	1247	1290	2.24e-8	SMART
EGF_CA	1291	1332	6.01e-9	SMART
EGF	1336	1375	1.95e1	SMART
Pfam:TB	1410	1450	1.4e-13	PFAM
EGF_CA	1473	1515	2.31e-10	SMART
EGF_CA	1516	1555	7.93e-9	SMART
Pfam:TB	1582	1623	1e-13	PFAM
low complexity region	1691	1704	N/A	INTRINSIC
EGF	1724	1761	4e-5	SMART
EGF_CA	1762	1806	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110254
AA Change: P1192L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000105883
Gene: ENSMUSG00000002020
AA Change: P1192L

Domain	Start	End	E-Value	Type
low complexity region	119	128	N/A	INTRINSIC
EGF	204	233	6.55e-1	SMART
low complexity region	275	295	N/A	INTRINSIC
EGF	404	433	8.19e-2	SMART
low complexity region	535	546	N/A	INTRINSIC
Pfam:TB	565	602	4e-8	PFAM
EGF_CA	626	666	8.05e-10	SMART
Pfam:TB	685	727	3.7e-16	PFAM
EGF_CA	852	894	7.18e-7	SMART
EGF_CA	895	934	1.53e-10	SMART
EGF_CA	935	974	3.51e-10	SMART
EGF_CA	975	1015	8.3e-12	SMART
EGF_CA	1016	1057	4.56e-9	SMART
EGF_CA	1058	1099	4.56e-9	SMART
EGF_CA	1100	1140	8.76e-11	SMART
EGF_CA	1141	1182	4.38e-11	SMART
EGF_CA	1183	1223	1.75e-10	SMART
EGF_CA	1224	1267	2.24e-8	SMART
EGF_CA	1268	1309	6.01e-9	SMART
EGF	1313	1352	1.95e1	SMART
Pfam:TB	1387	1427	1.4e-11	PFAM
EGF_CA	1450	1492	2.31e-10	SMART
EGF_CA	1493	1532	7.93e-9	SMART
Pfam:TB	1558	1600	4.6e-13	PFAM
low complexity region	1668	1681	N/A	INTRINSIC
EGF	1701	1738	4e-5	SMART
EGF_CA	1739	1783	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163189
AA Change: P1172L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000127693
Gene: ENSMUSG00000002020
AA Change: P1172L

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	545	582	4e-8	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	665	707	3.8e-16	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	914	1.53e-10	SMART
EGF_CA	915	954	3.51e-10	SMART
EGF_CA	955	995	8.3e-12	SMART
EGF_CA	996	1037	4.56e-9	SMART
EGF_CA	1038	1079	4.56e-9	SMART
EGF_CA	1080	1120	8.76e-11	SMART
EGF_CA	1121	1162	4.38e-11	SMART
EGF_CA	1163	1203	1.75e-10	SMART
EGF_CA	1204	1247	2.24e-8	SMART
EGF_CA	1248	1289	6.01e-9	SMART
EGF	1293	1332	1.95e1	SMART
Pfam:TB	1367	1407	1.5e-11	PFAM
EGF_CA	1430	1472	2.31e-10	SMART
EGF_CA	1473	1512	7.93e-9	SMART
Pfam:TB	1538	1580	4.7e-13	PFAM
low complexity region	1648	1661	N/A	INTRINSIC
EGF	1681	1718	4e-5	SMART
EGF_CA	1719	1763	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163214

SMART Domains

Protein: ENSMUSP00000132067
Gene: ENSMUSG00000002020

Domain	Start	End	E-Value	Type
EGF_CA	6	46	8.76e-11	SMART
EGF_CA	47	90	2.24e-8	SMART
EGF_CA	91	132	6.01e-9	SMART
EGF	136	175	1.95e1	SMART
Pfam:TB	210	250	1.5e-14	PFAM
EGF	276	307	1.5e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000165141

SMART Domains

Protein: ENSMUSP00000132690
Gene: ENSMUSG00000002020

Domain	Start	End	E-Value	Type
EGF	1	31	1.2e1	SMART
EGF_CA	32	71	3.51e-10	SMART
EGF_CA	72	112	8.3e-12	SMART
EGF_CA	113	154	4.56e-9	SMART
EGF_like	155	183	1.67e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000166383

SMART Domains

Protein: ENSMUSP00000127255
Gene: ENSMUSG00000002020

Domain	Start	End	E-Value	Type
EGF_CA	8	49	2.13e-9	SMART
Pfam:TB	75	117	1.3e-14	PFAM
low complexity region	185	198	N/A	INTRINSIC

Meta Mutation Damage Score

0.0892

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit early embryonic lethality prior to E6.5. Mice homozygous for a different null allele are viable, fertile, and developmentally normal but develop lens dislocations due to ciliary zonule fragmentation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430033K04Rik	T	C	5: 138,644,793 (GRCm39)	V226A	probably benign	Het
Acan	G	T	7: 78,749,653 (GRCm39)	V1475F	probably benign	Het
Acin1	T	A	14: 54,901,913 (GRCm39)	R626S	probably benign	Het
Aff3	T	C	1: 38,249,121 (GRCm39)	K662R	probably damaging	Het
Ankrd11	C	T	8: 123,617,682 (GRCm39)	A2057T	probably benign	Het
Ano9	T	G	7: 140,687,388 (GRCm39)	N309T	probably benign	Het
Ap3d1	G	A	10: 80,545,062 (GRCm39)	S1092L	probably benign	Het
B4galt7	C	T	13: 55,756,556 (GRCm39)	H257Y	probably damaging	Het
BC051665	G	T	13: 60,932,545 (GRCm39)	Q47K	possibly damaging	Het
Brip1	A	G	11: 85,952,512 (GRCm39)	F1090L	probably benign	Het
Cabin1	A	G	10: 75,494,543 (GRCm39)	V1612A	probably benign	Het
Ccar1	A	T	10: 62,602,369 (GRCm39)	D434E	probably benign	Het
Ccdc15	T	C	9: 37,227,083 (GRCm39)	D297G	probably benign	Het
Celsr3	C	A	9: 108,704,691 (GRCm39)	Y391*	probably null	Het
Cfap52	A	G	11: 67,837,179 (GRCm39)	I194T	possibly damaging	Het
Ctif	T	C	18: 75,757,352 (GRCm39)	E67G	probably benign	Het
Cxcr6	T	C	9: 123,639,151 (GRCm39)	F58L	possibly damaging	Het
Cyp2c69	T	C	19: 39,869,593 (GRCm39)	E142G	probably damaging	Het
Dnah6	T	A	6: 73,115,750 (GRCm39)	R1549S	possibly damaging	Het
Duxf3	A	T	10: 58,066,803 (GRCm39)	H75Q	probably benign	Het
Ehbp1	A	T	11: 22,051,052 (GRCm39)	I500N	probably damaging	Het
F13a1	A	T	13: 37,082,154 (GRCm39)	S517T	probably benign	Het
Fbln7	C	T	2: 128,719,316 (GRCm39)	R38C	probably damaging	Het
Fn1	T	C	1: 71,667,629 (GRCm39)	N788S	probably benign	Het
Foxc1	A	T	13: 31,991,882 (GRCm39)	E231V	probably damaging	Het
Gal3st2b	T	C	1: 93,866,328 (GRCm39)	S10P	probably damaging	Het
Gm6899	G	A	11: 26,543,592 (GRCm39)	C53Y	unknown	Het
Hps3	T	C	3: 20,084,831 (GRCm39)	E119G	probably benign	Het
Impg2	A	G	16: 56,038,767 (GRCm39)	E135G	probably damaging	Het
Kalrn	G	A	16: 34,032,583 (GRCm39)	T1155M	probably benign	Het
Kcna6	G	A	6: 126,716,022 (GRCm39)	A289V	probably benign	Het
Kcnh5	T	C	12: 75,134,191 (GRCm39)	M453V	probably benign	Het
Krt222	A	G	11: 99,131,320 (GRCm39)	V75A	possibly damaging	Het
Lmtk3	A	T	7: 45,450,431 (GRCm39)	T1432S	unknown	Het
Ltbp3	C	G	19: 5,802,099 (GRCm39)	N758K	probably damaging	Het
Map6d1	T	A	16: 20,055,377 (GRCm39)	H153L	possibly damaging	Het
Mefv	A	G	16: 3,528,782 (GRCm39)	L583P	probably damaging	Het
Mrps28	T	C	3: 8,867,389 (GRCm39)	T160A	probably damaging	Het
Mtcl2	T	C	2: 156,869,390 (GRCm39)	K1082E	probably damaging	Het
Muc6	T	C	7: 141,217,783 (GRCm39)	T2297A	possibly damaging	Het
Mx1	G	T	16: 97,253,409 (GRCm39)	D338E	probably benign	Het
Myom1	G	A	17: 71,399,204 (GRCm39)	R1120H	probably benign	Het
Nif3l1	T	C	1: 58,487,074 (GRCm39)	F87L	probably benign	Het
Or1e35	T	A	11: 73,797,713 (GRCm39)	M202L	probably benign	Het
Or4p22	T	C	2: 88,317,373 (GRCm39)	V99A	possibly damaging	Het
Pex10	T	A	4: 155,153,264 (GRCm39)	L111Q	probably damaging	Het
Phf1	T	C	17: 27,154,130 (GRCm39)		probably null	Het
Pigp	A	T	16: 94,166,278 (GRCm39)	Y143*	probably null	Het
Pou2af2	A	G	9: 51,229,579 (GRCm39)		probably null	Het
Prrc2a	A	G	17: 35,381,176 (GRCm39)		probably null	Het
Psd	GCC	GC	19: 46,301,841 (GRCm39)		probably null	Het
Pum3	A	G	19: 27,403,412 (GRCm39)	S30P	probably benign	Het
Rab12	A	G	17: 66,826,421 (GRCm39)	S97P	probably damaging	Het
Rigi	T	C	4: 40,220,437 (GRCm39)	E482G	possibly damaging	Het
Ros1	A	G	10: 51,948,148 (GRCm39)		probably null	Het
Scp2	A	T	4: 107,948,519 (GRCm39)	Y197N	probably benign	Het
Serpinb10	T	C	1: 107,474,488 (GRCm39)	F217L	possibly damaging	Het
Shank3	T	G	15: 89,409,453 (GRCm39)	M604R	possibly damaging	Het
Slc22a29	A	G	19: 8,184,488 (GRCm39)	S238P	probably benign	Het
Smarcc1	A	G	9: 109,986,410 (GRCm39)	D237G	probably damaging	Het
Stag3	T	C	5: 138,299,701 (GRCm39)	S871P	possibly damaging	Het
Tmem132d	A	G	5: 128,346,075 (GRCm39)	F149S	probably damaging	Het
Tmem25	C	T	9: 44,706,515 (GRCm39)	E333K		Het
Togaram1	T	A	12: 65,066,082 (GRCm39)	Y1695*	probably null	Het
Tox3	G	A	8: 90,984,574 (GRCm39)	P202S	probably damaging	Het
Trim34b	T	A	7: 103,980,474 (GRCm39)	N187K	probably benign	Het
Vcan	A	G	13: 89,841,081 (GRCm39)	S1488P	probably benign	Het
Vps26a	A	C	10: 62,305,791 (GRCm39)	V124G	probably benign	Het
Vps50	T	G	6: 3,516,706 (GRCm39)	S63A	possibly damaging	Het
Wbp4	T	A	14: 79,707,553 (GRCm39)	E186V	possibly damaging	Het
Zfp52	A	G	17: 21,781,937 (GRCm39)	D595G	possibly damaging	Het
Zfr2	C	A	10: 81,084,252 (GRCm39)	S1*	probably null	Het

Other mutations in Ltbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Ltbp2	APN	12	84,837,838 (GRCm39)	missense	probably damaging	1.00
IGL00938:Ltbp2	APN	12	84,878,573 (GRCm39)	missense	probably benign	0.03
IGL01397:Ltbp2	APN	12	84,837,042 (GRCm39)	missense	probably damaging	1.00
IGL01570:Ltbp2	APN	12	84,840,807 (GRCm39)	missense	probably benign	0.05
IGL01631:Ltbp2	APN	12	84,855,920 (GRCm39)	critical splice donor site	probably null
IGL01662:Ltbp2	APN	12	84,856,020 (GRCm39)	missense	probably benign	0.00
IGL01728:Ltbp2	APN	12	84,837,783 (GRCm39)	missense	probably damaging	0.99
IGL01839:Ltbp2	APN	12	84,840,432 (GRCm39)	missense	possibly damaging	0.48
IGL01946:Ltbp2	APN	12	84,877,522 (GRCm39)	missense	probably damaging	1.00
IGL01977:Ltbp2	APN	12	84,876,973 (GRCm39)	missense	probably damaging	1.00
IGL02220:Ltbp2	APN	12	84,876,083 (GRCm39)	missense	possibly damaging	0.93
IGL02340:Ltbp2	APN	12	84,839,729 (GRCm39)	critical splice donor site	probably null
IGL02430:Ltbp2	APN	12	84,846,175 (GRCm39)	missense	probably damaging	1.00
IGL02492:Ltbp2	APN	12	84,856,439 (GRCm39)	missense	probably damaging	1.00
IGL02517:Ltbp2	APN	12	84,832,091 (GRCm39)	missense	probably benign	0.42
IGL02794:Ltbp2	APN	12	84,838,709 (GRCm39)	missense	probably damaging	1.00
deft	UTSW	12	84,900,686 (GRCm39)	missense	probably damaging	0.98
masterful	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
practiced	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84,860,062 (GRCm39)	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84,856,361 (GRCm39)	missense	probably damaging	1.00
R0091:Ltbp2	UTSW	12	84,840,507 (GRCm39)	missense	probably damaging	1.00
R0094:Ltbp2	UTSW	12	84,846,200 (GRCm39)	missense	probably damaging	1.00
R0166:Ltbp2	UTSW	12	84,833,132 (GRCm39)	missense	probably benign	0.28
R0265:Ltbp2	UTSW	12	84,832,743 (GRCm39)	splice site	probably null
R0394:Ltbp2	UTSW	12	84,853,198 (GRCm39)	splice site	probably benign
R0535:Ltbp2	UTSW	12	84,837,826 (GRCm39)	missense	probably damaging	1.00
R0535:Ltbp2	UTSW	12	84,831,632 (GRCm39)	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84,860,074 (GRCm39)	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84,860,074 (GRCm39)	missense	probably damaging	1.00
R1513:Ltbp2	UTSW	12	84,838,718 (GRCm39)	missense	probably damaging	1.00
R1858:Ltbp2	UTSW	12	84,877,555 (GRCm39)	nonsense	probably null
R1880:Ltbp2	UTSW	12	84,876,045 (GRCm39)	missense	probably benign	0.45
R1894:Ltbp2	UTSW	12	84,834,735 (GRCm39)	missense	probably damaging	1.00
R1900:Ltbp2	UTSW	12	84,877,432 (GRCm39)	missense	probably damaging	1.00
R1903:Ltbp2	UTSW	12	84,876,879 (GRCm39)	missense	probably benign	0.01
R1912:Ltbp2	UTSW	12	84,832,637 (GRCm39)	missense	probably damaging	0.98
R1993:Ltbp2	UTSW	12	84,855,220 (GRCm39)	critical splice acceptor site	probably null
R1995:Ltbp2	UTSW	12	84,855,220 (GRCm39)	critical splice acceptor site	probably null
R2069:Ltbp2	UTSW	12	84,840,507 (GRCm39)	missense	probably damaging	1.00
R2126:Ltbp2	UTSW	12	84,832,483 (GRCm39)	splice site	probably null
R2139:Ltbp2	UTSW	12	84,862,753 (GRCm39)	missense	probably damaging	1.00
R2341:Ltbp2	UTSW	12	84,855,937 (GRCm39)	missense	probably benign	0.08
R2511:Ltbp2	UTSW	12	84,851,183 (GRCm39)	splice site	probably null
R3737:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3738:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3739:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3889:Ltbp2	UTSW	12	84,831,681 (GRCm39)	unclassified	probably benign
R4034:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R4542:Ltbp2	UTSW	12	84,878,593 (GRCm39)	nonsense	probably null
R4621:Ltbp2	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R4623:Ltbp2	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R4831:Ltbp2	UTSW	12	84,840,414 (GRCm39)	missense	possibly damaging	0.55
R5080:Ltbp2	UTSW	12	84,850,638 (GRCm39)	missense	probably damaging	1.00
R5116:Ltbp2	UTSW	12	84,856,511 (GRCm39)	missense	probably damaging	1.00
R5351:Ltbp2	UTSW	12	84,837,132 (GRCm39)	missense	possibly damaging	0.95
R5445:Ltbp2	UTSW	12	84,856,428 (GRCm39)	missense	probably null	1.00
R5608:Ltbp2	UTSW	12	84,834,238 (GRCm39)	splice site	probably null
R5784:Ltbp2	UTSW	12	84,915,513 (GRCm39)	missense	probably damaging	1.00
R5838:Ltbp2	UTSW	12	84,835,875 (GRCm39)	missense	probably benign	0.16
R5859:Ltbp2	UTSW	12	84,840,837 (GRCm39)	missense	possibly damaging	0.52
R6004:Ltbp2	UTSW	12	84,922,923 (GRCm39)	missense	probably benign	0.00
R6028:Ltbp2	UTSW	12	84,831,626 (GRCm39)	missense	probably damaging	1.00
R6347:Ltbp2	UTSW	12	84,900,686 (GRCm39)	missense	probably damaging	0.98
R6615:Ltbp2	UTSW	12	84,860,091 (GRCm39)	missense	probably damaging	1.00
R6636:Ltbp2	UTSW	12	84,922,612 (GRCm39)	missense	probably benign	0.00
R6637:Ltbp2	UTSW	12	84,922,612 (GRCm39)	missense	probably benign	0.00
R6755:Ltbp2	UTSW	12	84,841,847 (GRCm39)	missense	probably damaging	1.00
R6759:Ltbp2	UTSW	12	84,834,184 (GRCm39)	missense	probably damaging	0.99
R6806:Ltbp2	UTSW	12	84,856,012 (GRCm39)	missense	possibly damaging	0.74
R6968:Ltbp2	UTSW	12	84,835,857 (GRCm39)	critical splice donor site	probably null
R7084:Ltbp2	UTSW	12	84,915,459 (GRCm39)	missense	probably damaging	1.00
R7250:Ltbp2	UTSW	12	84,834,166 (GRCm39)	nonsense	probably null
R7374:Ltbp2	UTSW	12	84,876,949 (GRCm39)	missense	probably damaging	1.00
R7501:Ltbp2	UTSW	12	84,877,419 (GRCm39)	missense	probably damaging	1.00
R7523:Ltbp2	UTSW	12	84,837,808 (GRCm39)	missense	probably benign	0.00
R7754:Ltbp2	UTSW	12	84,860,012 (GRCm39)	critical splice donor site	probably null
R7827:Ltbp2	UTSW	12	84,836,655 (GRCm39)	missense	probably benign	0.19
R8042:Ltbp2	UTSW	12	84,838,673 (GRCm39)	missense	probably damaging	0.99
R8110:Ltbp2	UTSW	12	84,850,676 (GRCm39)	nonsense	probably null
R8411:Ltbp2	UTSW	12	84,833,187 (GRCm39)	missense	probably damaging	1.00
R8688:Ltbp2	UTSW	12	84,850,578 (GRCm39)	missense	probably benign	0.20
R8711:Ltbp2	UTSW	12	84,900,515 (GRCm39)	missense	probably benign	0.00
R8712:Ltbp2	UTSW	12	84,853,124 (GRCm39)	missense	probably benign	0.08
R8893:Ltbp2	UTSW	12	84,875,316 (GRCm39)	missense	probably damaging	1.00
R8978:Ltbp2	UTSW	12	84,834,164 (GRCm39)	missense	probably benign	0.00
R9016:Ltbp2	UTSW	12	84,856,467 (GRCm39)	missense	probably benign	0.02
R9123:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9129:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9132:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9144:Ltbp2	UTSW	12	84,856,426 (GRCm39)	missense	probably damaging	1.00
R9150:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9152:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9156:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9157:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9158:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9159:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9160:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9199:Ltbp2	UTSW	12	84,832,750 (GRCm39)	missense	probably benign	0.09
R9212:Ltbp2	UTSW	12	84,839,824 (GRCm39)	missense	probably damaging	1.00
R9275:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9276:Ltbp2	UTSW	12	84,876,885 (GRCm39)	missense	possibly damaging	0.79
R9276:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9278:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9279:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9280:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9281:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9312:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9313:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9331:Ltbp2	UTSW	12	84,922,965 (GRCm39)	missense	probably benign
R9355:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9375:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9377:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9378:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9450:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9457:Ltbp2	UTSW	12	84,835,927 (GRCm39)	missense	probably benign	0.19
R9486:Ltbp2	UTSW	12	84,878,648 (GRCm39)	missense	possibly damaging	0.49
R9505:Ltbp2	UTSW	12	84,900,638 (GRCm39)	missense	probably damaging	1.00
R9512:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9581:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9582:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9747:Ltbp2	UTSW	12	84,915,515 (GRCm39)	missense	probably damaging	1.00
R9792:Ltbp2	UTSW	12	84,876,128 (GRCm39)	missense	probably damaging	0.99
R9795:Ltbp2	UTSW	12	84,876,128 (GRCm39)	missense	probably damaging	0.99
X0017:Ltbp2	UTSW	12	84,875,302 (GRCm39)	missense	probably damaging	1.00
X0026:Ltbp2	UTSW	12	84,876,973 (GRCm39)	missense	probably damaging	1.00
Z1176:Ltbp2	UTSW	12	84,922,627 (GRCm39)	missense	probably benign	0.01
Z1177:Ltbp2	UTSW	12	84,876,090 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- CGTTCCAGGGAGCTAAGAAG -3'
(R):5'- TCTCCAGGGTCTCAGTGTTC -3'

Sequencing Primer
(F):5'- TTCCAGGGAGCTAAGAAGGACATG -3'
(R):5'- CTCAGGTTCCTGGCACTG -3'

Posted On

2022-09-12