Mutagenetix > Incidental Mutation

Incidental Mutation 'R8711:Ltbp2'

669596

Institutional Source

Beutler Lab

Gene Symbol

Ltbp2

Ensembl Gene

ENSMUSG00000002020

Gene Name

latent transforming growth factor beta binding protein 2

Synonyms

MMRRC Submission

068565-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.794) question?

Stock #

R8711 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

84829986-84923306 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 84900515 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 269 (S269N)

Ref Sequence

ENSEMBL: ENSMUSP00000105883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002073] [ENSMUST00000110254] [ENSMUST00000163189]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000002073
AA Change: S249N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000002073
Gene: ENSMUSG00000002020
AA Change: S249N

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	546	582	3.8e-9	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	666	707	3.4e-17	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	917	1.75e-10	SMART
EGF_CA	918	957	1.53e-10	SMART
EGF_CA	958	997	3.51e-10	SMART
EGF_CA	998	1038	8.3e-12	SMART
EGF_CA	1039	1080	4.56e-9	SMART
EGF_CA	1081	1122	4.56e-9	SMART
EGF_CA	1123	1163	8.76e-11	SMART
EGF_CA	1164	1205	4.38e-11	SMART
EGF_CA	1206	1246	1.75e-10	SMART
EGF_CA	1247	1290	2.24e-8	SMART
EGF_CA	1291	1332	6.01e-9	SMART
EGF	1336	1375	1.95e1	SMART
Pfam:TB	1410	1450	1.4e-13	PFAM
EGF_CA	1473	1515	2.31e-10	SMART
EGF_CA	1516	1555	7.93e-9	SMART
Pfam:TB	1582	1623	1e-13	PFAM
low complexity region	1691	1704	N/A	INTRINSIC
EGF	1724	1761	4e-5	SMART
EGF_CA	1762	1806	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110254
AA Change: S269N

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000105883
Gene: ENSMUSG00000002020
AA Change: S269N

Domain	Start	End	E-Value	Type
low complexity region	119	128	N/A	INTRINSIC
EGF	204	233	6.55e-1	SMART
low complexity region	275	295	N/A	INTRINSIC
EGF	404	433	8.19e-2	SMART
low complexity region	535	546	N/A	INTRINSIC
Pfam:TB	565	602	4e-8	PFAM
EGF_CA	626	666	8.05e-10	SMART
Pfam:TB	685	727	3.7e-16	PFAM
EGF_CA	852	894	7.18e-7	SMART
EGF_CA	895	934	1.53e-10	SMART
EGF_CA	935	974	3.51e-10	SMART
EGF_CA	975	1015	8.3e-12	SMART
EGF_CA	1016	1057	4.56e-9	SMART
EGF_CA	1058	1099	4.56e-9	SMART
EGF_CA	1100	1140	8.76e-11	SMART
EGF_CA	1141	1182	4.38e-11	SMART
EGF_CA	1183	1223	1.75e-10	SMART
EGF_CA	1224	1267	2.24e-8	SMART
EGF_CA	1268	1309	6.01e-9	SMART
EGF	1313	1352	1.95e1	SMART
Pfam:TB	1387	1427	1.4e-11	PFAM
EGF_CA	1450	1492	2.31e-10	SMART
EGF_CA	1493	1532	7.93e-9	SMART
Pfam:TB	1558	1600	4.6e-13	PFAM
low complexity region	1668	1681	N/A	INTRINSIC
EGF	1701	1738	4e-5	SMART
EGF_CA	1739	1783	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163189
AA Change: S249N

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000127693
Gene: ENSMUSG00000002020
AA Change: S249N

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	545	582	4e-8	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	665	707	3.8e-16	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	914	1.53e-10	SMART
EGF_CA	915	954	3.51e-10	SMART
EGF_CA	955	995	8.3e-12	SMART
EGF_CA	996	1037	4.56e-9	SMART
EGF_CA	1038	1079	4.56e-9	SMART
EGF_CA	1080	1120	8.76e-11	SMART
EGF_CA	1121	1162	4.38e-11	SMART
EGF_CA	1163	1203	1.75e-10	SMART
EGF_CA	1204	1247	2.24e-8	SMART
EGF_CA	1248	1289	6.01e-9	SMART
EGF	1293	1332	1.95e1	SMART
Pfam:TB	1367	1407	1.5e-11	PFAM
EGF_CA	1430	1472	2.31e-10	SMART
EGF_CA	1473	1512	7.93e-9	SMART
Pfam:TB	1538	1580	4.7e-13	PFAM
low complexity region	1648	1661	N/A	INTRINSIC
EGF	1681	1718	4e-5	SMART
EGF_CA	1719	1763	1.91e-11	SMART

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (70/71)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit early embryonic lethality prior to E6.5. Mice homozygous for a different null allele are viable, fertile, and developmentally normal but develop lens dislocations due to ciliary zonule fragmentation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadat	T	A	8: 60,969,120 (GRCm39)	S122T	probably benign	Het
Abcb11	G	A	2: 69,095,856 (GRCm39)	T828I	probably damaging	Het
Atp5f1b	T	A	10: 127,921,369 (GRCm39)	N222K	probably damaging	Het
C1qbp	T	C	11: 70,869,313 (GRCm39)	T211A	probably benign	Het
Ccdc85a	A	T	11: 28,384,146 (GRCm39)	S410T	possibly damaging	Het
Chd4	T	A	6: 125,100,485 (GRCm39)		probably benign	Het
Col10a1	G	T	10: 34,270,824 (GRCm39)	K265N	probably damaging	Het
Cyp2j5	A	T	4: 96,529,660 (GRCm39)	M237K	possibly damaging	Het
Cyp4f40	T	C	17: 32,894,962 (GRCm39)		probably benign	Het
Cytip	A	T	2: 58,041,135 (GRCm39)	F90L	probably damaging	Het
Dnah7b	A	G	1: 46,214,598 (GRCm39)	D1121G	probably damaging	Het
Dohh	G	T	10: 81,221,859 (GRCm39)	E84D	probably benign	Het
Efcab3	A	G	11: 104,743,371 (GRCm39)	I2187V	probably benign	Het
Eif1ad19	T	A	12: 87,740,130 (GRCm39)	D143V	unknown	Het
Eif4g2	T	C	7: 110,673,127 (GRCm39)	Y855C	probably damaging	Het
Ell	T	A	8: 71,034,331 (GRCm39)		probably benign	Het
Ermap	T	C	4: 119,044,355 (GRCm39)	Y147C	probably damaging	Het
Fasn	T	C	11: 120,709,944 (GRCm39)	D371G	possibly damaging	Het
Fat2	A	G	11: 55,159,129 (GRCm39)	S3348P	probably benign	Het
Fhad1	T	A	4: 141,684,924 (GRCm39)	N472Y	probably benign	Het
Flad1	A	G	3: 89,316,415 (GRCm39)	V49A	probably damaging	Het
Fpr-rs3	T	C	17: 20,844,554 (GRCm39)	T196A	probably benign	Het
Fsip2	A	G	2: 82,815,246 (GRCm39)	N3660D	possibly damaging	Het
Gabrp	T	A	11: 33,505,023 (GRCm39)	L259F	probably damaging	Het
Gm16686	A	T	4: 88,673,473 (GRCm39)	W119R	unknown	Het
Gng2	C	T	14: 19,941,438 (GRCm39)	M1I	probably null	Het
Hmgxb3	T	C	18: 61,290,721 (GRCm39)	N384S	probably benign	Het
Ibtk	T	C	9: 85,606,208 (GRCm39)	I440V	probably benign	Het
Il11ra1	A	G	4: 41,767,539 (GRCm39)	D297G	probably damaging	Het
Irf2bpl	T	C	12: 86,928,496 (GRCm39)	I726V	probably benign	Het
Klk1b5	A	G	7: 43,867,996 (GRCm39)	N56S	probably benign	Het
Laptm4b	T	A	15: 34,277,648 (GRCm39)	V193E	probably damaging	Het
Lrrc37a	A	T	11: 103,388,350 (GRCm39)	C2358*	probably null	Het
Morc2a	T	G	11: 3,630,013 (GRCm39)	Y450D	probably damaging	Het
Mycbp2	A	T	14: 103,407,430 (GRCm39)	I2740K	probably benign	Het
Naif1	T	A	2: 32,344,848 (GRCm39)	V184E	probably damaging	Het
Neurl1b	T	C	17: 26,660,747 (GRCm39)	V540A	probably damaging	Het
Nt5c1b	T	A	12: 10,431,450 (GRCm39)	F451Y	probably damaging	Het
Obox3	A	G	7: 15,360,148 (GRCm39)	S174P	probably benign	Het
Obscn	T	C	11: 58,951,894 (GRCm39)	E3953G	probably damaging	Het
Or4a74	A	C	2: 89,440,291 (GRCm39)	S52A	probably benign	Het
Or4p19	A	T	2: 88,242,595 (GRCm39)	C136S	probably damaging	Het
Pkd1l1	G	A	11: 8,815,550 (GRCm39)	H1904Y		Het
Plec	C	T	15: 76,059,531 (GRCm39)	D3469N	probably benign	Het
Polr1b	A	G	2: 128,943,064 (GRCm39)	T20A	probably damaging	Het
Ppp1r16b	G	A	2: 158,603,286 (GRCm39)	E404K	possibly damaging	Het
Prkce	T	A	17: 86,795,625 (GRCm39)	N287K	probably damaging	Het
Rchy1	C	A	5: 92,105,397 (GRCm39)	C108F	probably damaging	Het
Scpppq1	G	A	5: 104,219,956 (GRCm39)	T78I	unknown	Het
Sema6d	A	G	2: 124,502,232 (GRCm39)	Y572C	possibly damaging	Het
Sh3rf1	T	A	8: 61,783,030 (GRCm39)	I248K	probably damaging	Het
Sin3b	T	C	8: 73,450,026 (GRCm39)	L30P	probably damaging	Het
Slc25a47	G	A	12: 108,820,313 (GRCm39)	G106S	probably damaging	Het
Slc43a2	A	C	11: 75,457,879 (GRCm39)	M385L	probably benign	Het
Slc43a3	A	G	2: 84,768,671 (GRCm39)	T97A	probably damaging	Het
Slc9b2	T	A	3: 135,030,351 (GRCm39)	S223T	probably benign	Het
Smc5	A	T	19: 23,243,058 (GRCm39)	C118S	probably damaging	Het
Smpdl3b	T	C	4: 132,472,491 (GRCm39)	D94G	probably damaging	Het
Spred3	A	G	7: 28,866,086 (GRCm39)	V71A	possibly damaging	Het
Srsf5	T	A	12: 80,994,328 (GRCm39)	S86T	possibly damaging	Het
Sycp2	A	G	2: 177,990,088 (GRCm39)	V1386A	probably benign	Het
Syne2	T	C	12: 76,104,258 (GRCm39)	L743P	probably damaging	Het
Synj1	A	G	16: 90,806,971 (GRCm39)	V62A	probably damaging	Het
Tbc1d9b	T	C	11: 50,047,578 (GRCm39)	L637P	probably damaging	Het
Tcf12	T	G	9: 71,757,097 (GRCm39)	S697R	possibly damaging	Het
Tnfrsf11b	T	A	15: 54,123,508 (GRCm39)	Y31F	possibly damaging	Het
Trav5n-4	T	C	14: 53,550,362 (GRCm39)	M1T	probably null	Het
Trbv13-2	A	G	6: 41,098,716 (GRCm39)	E97G	probably benign	Het
Trpa1	G	A	1: 14,980,998 (GRCm39)	P135S	probably damaging	Het
Ugt1a6a	A	C	1: 88,066,590 (GRCm39)	D132A	possibly damaging	Het
Vmn2r8	A	T	5: 108,945,962 (GRCm39)	D548E	possibly damaging	Het
Zbtb39	A	T	10: 127,578,815 (GRCm39)	D463V	probably damaging	Het
Zc3h12c	C	T	9: 52,037,858 (GRCm39)		probably benign	Het
Zfp952	C	T	17: 33,222,004 (GRCm39)	P161L	possibly damaging	Het

Other mutations in Ltbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Ltbp2	APN	12	84,837,838 (GRCm39)	missense	probably damaging	1.00
IGL00938:Ltbp2	APN	12	84,878,573 (GRCm39)	missense	probably benign	0.03
IGL01397:Ltbp2	APN	12	84,837,042 (GRCm39)	missense	probably damaging	1.00
IGL01570:Ltbp2	APN	12	84,840,807 (GRCm39)	missense	probably benign	0.05
IGL01631:Ltbp2	APN	12	84,855,920 (GRCm39)	critical splice donor site	probably null
IGL01662:Ltbp2	APN	12	84,856,020 (GRCm39)	missense	probably benign	0.00
IGL01728:Ltbp2	APN	12	84,837,783 (GRCm39)	missense	probably damaging	0.99
IGL01839:Ltbp2	APN	12	84,840,432 (GRCm39)	missense	possibly damaging	0.48
IGL01946:Ltbp2	APN	12	84,877,522 (GRCm39)	missense	probably damaging	1.00
IGL01977:Ltbp2	APN	12	84,876,973 (GRCm39)	missense	probably damaging	1.00
IGL02220:Ltbp2	APN	12	84,876,083 (GRCm39)	missense	possibly damaging	0.93
IGL02340:Ltbp2	APN	12	84,839,729 (GRCm39)	critical splice donor site	probably null
IGL02430:Ltbp2	APN	12	84,846,175 (GRCm39)	missense	probably damaging	1.00
IGL02492:Ltbp2	APN	12	84,856,439 (GRCm39)	missense	probably damaging	1.00
IGL02517:Ltbp2	APN	12	84,832,091 (GRCm39)	missense	probably benign	0.42
IGL02794:Ltbp2	APN	12	84,838,709 (GRCm39)	missense	probably damaging	1.00
deft	UTSW	12	84,900,686 (GRCm39)	missense	probably damaging	0.98
masterful	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
practiced	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84,860,062 (GRCm39)	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84,856,361 (GRCm39)	missense	probably damaging	1.00
R0091:Ltbp2	UTSW	12	84,840,507 (GRCm39)	missense	probably damaging	1.00
R0094:Ltbp2	UTSW	12	84,846,200 (GRCm39)	missense	probably damaging	1.00
R0166:Ltbp2	UTSW	12	84,833,132 (GRCm39)	missense	probably benign	0.28
R0265:Ltbp2	UTSW	12	84,832,743 (GRCm39)	splice site	probably null
R0394:Ltbp2	UTSW	12	84,853,198 (GRCm39)	splice site	probably benign
R0535:Ltbp2	UTSW	12	84,837,826 (GRCm39)	missense	probably damaging	1.00
R0535:Ltbp2	UTSW	12	84,831,632 (GRCm39)	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84,860,074 (GRCm39)	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84,860,074 (GRCm39)	missense	probably damaging	1.00
R1513:Ltbp2	UTSW	12	84,838,718 (GRCm39)	missense	probably damaging	1.00
R1858:Ltbp2	UTSW	12	84,877,555 (GRCm39)	nonsense	probably null
R1880:Ltbp2	UTSW	12	84,876,045 (GRCm39)	missense	probably benign	0.45
R1894:Ltbp2	UTSW	12	84,834,735 (GRCm39)	missense	probably damaging	1.00
R1900:Ltbp2	UTSW	12	84,877,432 (GRCm39)	missense	probably damaging	1.00
R1903:Ltbp2	UTSW	12	84,876,879 (GRCm39)	missense	probably benign	0.01
R1912:Ltbp2	UTSW	12	84,832,637 (GRCm39)	missense	probably damaging	0.98
R1993:Ltbp2	UTSW	12	84,855,220 (GRCm39)	critical splice acceptor site	probably null
R1995:Ltbp2	UTSW	12	84,855,220 (GRCm39)	critical splice acceptor site	probably null
R2069:Ltbp2	UTSW	12	84,840,507 (GRCm39)	missense	probably damaging	1.00
R2126:Ltbp2	UTSW	12	84,832,483 (GRCm39)	splice site	probably null
R2139:Ltbp2	UTSW	12	84,862,753 (GRCm39)	missense	probably damaging	1.00
R2341:Ltbp2	UTSW	12	84,855,937 (GRCm39)	missense	probably benign	0.08
R2511:Ltbp2	UTSW	12	84,851,183 (GRCm39)	splice site	probably null
R3737:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3738:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3739:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R3889:Ltbp2	UTSW	12	84,831,681 (GRCm39)	unclassified	probably benign
R4034:Ltbp2	UTSW	12	84,851,248 (GRCm39)	missense	probably damaging	1.00
R4542:Ltbp2	UTSW	12	84,878,593 (GRCm39)	nonsense	probably null
R4621:Ltbp2	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R4623:Ltbp2	UTSW	12	84,856,122 (GRCm39)	missense	probably damaging	1.00
R4831:Ltbp2	UTSW	12	84,840,414 (GRCm39)	missense	possibly damaging	0.55
R5080:Ltbp2	UTSW	12	84,850,638 (GRCm39)	missense	probably damaging	1.00
R5116:Ltbp2	UTSW	12	84,856,511 (GRCm39)	missense	probably damaging	1.00
R5351:Ltbp2	UTSW	12	84,837,132 (GRCm39)	missense	possibly damaging	0.95
R5445:Ltbp2	UTSW	12	84,856,428 (GRCm39)	missense	probably null	1.00
R5608:Ltbp2	UTSW	12	84,834,238 (GRCm39)	splice site	probably null
R5784:Ltbp2	UTSW	12	84,915,513 (GRCm39)	missense	probably damaging	1.00
R5838:Ltbp2	UTSW	12	84,835,875 (GRCm39)	missense	probably benign	0.16
R5859:Ltbp2	UTSW	12	84,840,837 (GRCm39)	missense	possibly damaging	0.52
R6004:Ltbp2	UTSW	12	84,922,923 (GRCm39)	missense	probably benign	0.00
R6028:Ltbp2	UTSW	12	84,831,626 (GRCm39)	missense	probably damaging	1.00
R6347:Ltbp2	UTSW	12	84,900,686 (GRCm39)	missense	probably damaging	0.98
R6615:Ltbp2	UTSW	12	84,860,091 (GRCm39)	missense	probably damaging	1.00
R6636:Ltbp2	UTSW	12	84,922,612 (GRCm39)	missense	probably benign	0.00
R6637:Ltbp2	UTSW	12	84,922,612 (GRCm39)	missense	probably benign	0.00
R6755:Ltbp2	UTSW	12	84,841,847 (GRCm39)	missense	probably damaging	1.00
R6759:Ltbp2	UTSW	12	84,834,184 (GRCm39)	missense	probably damaging	0.99
R6806:Ltbp2	UTSW	12	84,856,012 (GRCm39)	missense	possibly damaging	0.74
R6968:Ltbp2	UTSW	12	84,835,857 (GRCm39)	critical splice donor site	probably null
R7084:Ltbp2	UTSW	12	84,915,459 (GRCm39)	missense	probably damaging	1.00
R7250:Ltbp2	UTSW	12	84,834,166 (GRCm39)	nonsense	probably null
R7374:Ltbp2	UTSW	12	84,876,949 (GRCm39)	missense	probably damaging	1.00
R7501:Ltbp2	UTSW	12	84,877,419 (GRCm39)	missense	probably damaging	1.00
R7523:Ltbp2	UTSW	12	84,837,808 (GRCm39)	missense	probably benign	0.00
R7754:Ltbp2	UTSW	12	84,860,012 (GRCm39)	critical splice donor site	probably null
R7827:Ltbp2	UTSW	12	84,836,655 (GRCm39)	missense	probably benign	0.19
R8042:Ltbp2	UTSW	12	84,838,673 (GRCm39)	missense	probably damaging	0.99
R8110:Ltbp2	UTSW	12	84,850,676 (GRCm39)	nonsense	probably null
R8411:Ltbp2	UTSW	12	84,833,187 (GRCm39)	missense	probably damaging	1.00
R8688:Ltbp2	UTSW	12	84,850,578 (GRCm39)	missense	probably benign	0.20
R8712:Ltbp2	UTSW	12	84,853,124 (GRCm39)	missense	probably benign	0.08
R8893:Ltbp2	UTSW	12	84,875,316 (GRCm39)	missense	probably damaging	1.00
R8978:Ltbp2	UTSW	12	84,834,164 (GRCm39)	missense	probably benign	0.00
R9016:Ltbp2	UTSW	12	84,856,467 (GRCm39)	missense	probably benign	0.02
R9123:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9129:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9132:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9144:Ltbp2	UTSW	12	84,856,426 (GRCm39)	missense	probably damaging	1.00
R9150:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9152:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9156:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9157:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9158:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9159:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9160:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9199:Ltbp2	UTSW	12	84,832,750 (GRCm39)	missense	probably benign	0.09
R9212:Ltbp2	UTSW	12	84,839,824 (GRCm39)	missense	probably damaging	1.00
R9275:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9276:Ltbp2	UTSW	12	84,876,885 (GRCm39)	missense	possibly damaging	0.79
R9276:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9278:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9279:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9280:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9281:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9312:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9313:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9331:Ltbp2	UTSW	12	84,922,965 (GRCm39)	missense	probably benign
R9355:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9375:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9377:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9378:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9450:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9457:Ltbp2	UTSW	12	84,835,927 (GRCm39)	missense	probably benign	0.19
R9486:Ltbp2	UTSW	12	84,878,648 (GRCm39)	missense	possibly damaging	0.49
R9505:Ltbp2	UTSW	12	84,900,638 (GRCm39)	missense	probably damaging	1.00
R9512:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9581:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9582:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9645:Ltbp2	UTSW	12	84,837,864 (GRCm39)	missense	probably benign	0.00
R9747:Ltbp2	UTSW	12	84,915,515 (GRCm39)	missense	probably damaging	1.00
R9792:Ltbp2	UTSW	12	84,876,128 (GRCm39)	missense	probably damaging	0.99
R9795:Ltbp2	UTSW	12	84,876,128 (GRCm39)	missense	probably damaging	0.99
X0017:Ltbp2	UTSW	12	84,875,302 (GRCm39)	missense	probably damaging	1.00
X0026:Ltbp2	UTSW	12	84,876,973 (GRCm39)	missense	probably damaging	1.00
Z1176:Ltbp2	UTSW	12	84,922,627 (GRCm39)	missense	probably benign	0.01
Z1177:Ltbp2	UTSW	12	84,876,090 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- TACTTGCACTCCGGATGCTG -3'
(R):5'- GACGCCTCTAGTGTGTAGTC -3'

Sequencing Primer
(F):5'- ATGCTGCAGTCCTCTCAGG -3'
(R):5'- TCATAGGACTTGGCCCTGC -3'

Posted On

2021-04-30