Mutagenetix > Incidental Mutation

Incidental Mutation 'R9457:Ltbp2'

714673

Institutional Source

Beutler Lab

Gene Symbol

Ltbp2

Ensembl Gene

ENSMUSG00000002020

Gene Name

latent transforming growth factor beta binding protein 2

Synonyms

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.731) question?

Stock #

R9457 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

84783212-84876532 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 84789153 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 1335 (C1335S)

Ref Sequence

ENSEMBL: ENSMUSP00000105883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002073] [ENSMUST00000110254] [ENSMUST00000163189] [ENSMUST00000166383]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000002073
AA Change: C1358S

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000002073
Gene: ENSMUSG00000002020
AA Change: C1358S

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	546	582	3.8e-9	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	666	707	3.4e-17	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	917	1.75e-10	SMART
EGF_CA	918	957	1.53e-10	SMART
EGF_CA	958	997	3.51e-10	SMART
EGF_CA	998	1038	8.3e-12	SMART
EGF_CA	1039	1080	4.56e-9	SMART
EGF_CA	1081	1122	4.56e-9	SMART
EGF_CA	1123	1163	8.76e-11	SMART
EGF_CA	1164	1205	4.38e-11	SMART
EGF_CA	1206	1246	1.75e-10	SMART
EGF_CA	1247	1290	2.24e-8	SMART
EGF_CA	1291	1332	6.01e-9	SMART
EGF	1336	1375	1.95e1	SMART
Pfam:TB	1410	1450	1.4e-13	PFAM
EGF_CA	1473	1515	2.31e-10	SMART
EGF_CA	1516	1555	7.93e-9	SMART
Pfam:TB	1582	1623	1e-13	PFAM
low complexity region	1691	1704	N/A	INTRINSIC
EGF	1724	1761	4e-5	SMART
EGF_CA	1762	1806	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110254
AA Change: C1335S

PolyPhen 2 Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000105883
Gene: ENSMUSG00000002020
AA Change: C1335S

Domain	Start	End	E-Value	Type
low complexity region	119	128	N/A	INTRINSIC
EGF	204	233	6.55e-1	SMART
low complexity region	275	295	N/A	INTRINSIC
EGF	404	433	8.19e-2	SMART
low complexity region	535	546	N/A	INTRINSIC
Pfam:TB	565	602	4e-8	PFAM
EGF_CA	626	666	8.05e-10	SMART
Pfam:TB	685	727	3.7e-16	PFAM
EGF_CA	852	894	7.18e-7	SMART
EGF_CA	895	934	1.53e-10	SMART
EGF_CA	935	974	3.51e-10	SMART
EGF_CA	975	1015	8.3e-12	SMART
EGF_CA	1016	1057	4.56e-9	SMART
EGF_CA	1058	1099	4.56e-9	SMART
EGF_CA	1100	1140	8.76e-11	SMART
EGF_CA	1141	1182	4.38e-11	SMART
EGF_CA	1183	1223	1.75e-10	SMART
EGF_CA	1224	1267	2.24e-8	SMART
EGF_CA	1268	1309	6.01e-9	SMART
EGF	1313	1352	1.95e1	SMART
Pfam:TB	1387	1427	1.4e-11	PFAM
EGF_CA	1450	1492	2.31e-10	SMART
EGF_CA	1493	1532	7.93e-9	SMART
Pfam:TB	1558	1600	4.6e-13	PFAM
low complexity region	1668	1681	N/A	INTRINSIC
EGF	1701	1738	4e-5	SMART
EGF_CA	1739	1783	1.91e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163189
AA Change: C1315S

PolyPhen 2 Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000127693
Gene: ENSMUSG00000002020
AA Change: C1315S

Domain	Start	End	E-Value	Type
signal peptide	1	35	N/A	INTRINSIC
low complexity region	99	108	N/A	INTRINSIC
EGF	184	213	6.55e-1	SMART
low complexity region	255	275	N/A	INTRINSIC
EGF	384	413	8.19e-2	SMART
low complexity region	515	526	N/A	INTRINSIC
Pfam:TB	545	582	4e-8	PFAM
EGF_CA	606	646	8.05e-10	SMART
Pfam:TB	665	707	3.8e-16	PFAM
EGF_CA	832	874	7.18e-7	SMART
EGF_CA	875	914	1.53e-10	SMART
EGF_CA	915	954	3.51e-10	SMART
EGF_CA	955	995	8.3e-12	SMART
EGF_CA	996	1037	4.56e-9	SMART
EGF_CA	1038	1079	4.56e-9	SMART
EGF_CA	1080	1120	8.76e-11	SMART
EGF_CA	1121	1162	4.38e-11	SMART
EGF_CA	1163	1203	1.75e-10	SMART
EGF_CA	1204	1247	2.24e-8	SMART
EGF_CA	1248	1289	6.01e-9	SMART
EGF	1293	1332	1.95e1	SMART
Pfam:TB	1367	1407	1.5e-11	PFAM
EGF_CA	1430	1472	2.31e-10	SMART
EGF_CA	1473	1512	7.93e-9	SMART
Pfam:TB	1538	1580	4.7e-13	PFAM
low complexity region	1648	1661	N/A	INTRINSIC
EGF	1681	1718	4e-5	SMART
EGF_CA	1719	1763	1.91e-11	SMART

Predicted Effect

SMART Domains

Protein: ENSMUSP00000132067
Gene: ENSMUSG00000002020
AA Change: C157S

Domain	Start	End	E-Value	Type
EGF_CA	6	46	8.76e-11	SMART
EGF_CA	47	90	2.24e-8	SMART
EGF_CA	91	132	6.01e-9	SMART
EGF	136	175	1.95e1	SMART
Pfam:TB	210	250	1.5e-14	PFAM
EGF	276	307	1.5e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000165141

SMART Domains

Protein: ENSMUSP00000132690
Gene: ENSMUSG00000002020

Domain	Start	End	E-Value	Type
EGF	1	31	1.2e1	SMART
EGF_CA	32	71	3.51e-10	SMART
EGF_CA	72	112	8.3e-12	SMART
EGF_CA	113	154	4.56e-9	SMART
EGF_like	155	183	1.67e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000166383

SMART Domains

Protein: ENSMUSP00000127255
Gene: ENSMUSG00000002020

Domain	Start	End	E-Value	Type
EGF_CA	8	49	2.13e-9	SMART
Pfam:TB	75	117	1.3e-14	PFAM
low complexity region	185	198	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit early embryonic lethality prior to E6.5. Mice homozygous for a different null allele are viable, fertile, and developmentally normal but develop lens dislocations due to ciliary zonule fragmentation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3110002H16Rik	A	G	18: 12,179,246	H181R	probably benign	Het
4930404N11Rik	C	A	10: 81,365,777	V4L	probably benign	Het
4930430A15Rik	A	T	2: 111,170,286	M196K	unknown	Het
4932415D10Rik	A	G	10: 82,286,739	V3479A	probably benign	Het
A930009A15Rik	T	C	10: 115,578,331	L54P	unknown	Het
Ablim3	A	G	18: 61,845,849	S204P	probably benign	Het
Acadl	A	G	1: 66,853,241	V141A	probably benign	Het
Ace3	A	G	11: 105,994,861	D31G	probably benign	Het
Adam11	T	G	11: 102,769,898	V85G	probably benign	Het
Adarb1	A	T	10: 77,322,148	M155K	possibly damaging	Het
Arhgap10	G	A	8: 77,384,786	T376M	probably benign	Het
Bod1l	G	T	5: 41,821,967	T668K	probably damaging	Het
Ccdc87	A	G	19: 4,841,631	E717G	probably damaging	Het
Cdh17	T	A	4: 11,771,329	I37N	probably damaging	Het
Cfap99	T	G	5: 34,301,397	F45L	probably benign	Het
Chsy1	C	A	7: 66,172,400	H794Q	probably benign	Het
Clec4a3	G	A	6: 122,954,086	V45I	probably benign	Het
Clic3	G	A	2: 25,457,718	V32I	probably benign	Het
Clip2	A	T	5: 134,502,730	D740E	probably benign	Het
Col5a2	C	T	1: 45,386,844	V1062I	probably benign	Het
Col5a2	A	G	1: 45,392,813		probably null	Het
Cyp2j11	C	T	4: 96,307,359	V367I	probably damaging	Het
Ddr1	C	T	17: 35,682,758	A821T	possibly damaging	Het
Dna2	G	A	10: 62,950,793	E107K	probably benign	Het
Eif3d	A	G	15: 77,959,694	V484A	probably benign	Het
Fgfr4	A	G	13: 55,161,127	T354A	probably benign	Het
Fkbp6	T	C	5: 135,349,632	D54G	probably benign	Het
Gm4787	T	A	12: 81,379,246	E46V	probably damaging	Het
Gm47995	A	G	1: 151,198,475	T10A	possibly damaging	Het
Gm498	T	C	7: 143,883,976	V137A	possibly damaging	Het
Gnb1l	T	A	16: 18,540,995	I50N	probably damaging	Het
Gphb5	A	T	12: 75,415,749	V22D	probably damaging	Het
Gstt4	C	T	10: 75,815,125	C221Y	probably benign	Het
Hmces	T	C	6: 87,933,274	V222A	possibly damaging	Het
Kat14	T	A	2: 144,373,782	D62E	probably benign	Het
Kcnmb2	T	A	3: 32,181,869	V89E	probably benign	Het
Kif23	T	A	9: 61,944,225	N63I	probably benign	Het
Lamc2	T	C	1: 153,139,854	M578V	probably benign	Het
Lyst	A	G	13: 13,687,745	E2622G	possibly damaging	Het
Mctp1	A	T	13: 76,384,674	H47L	probably benign	Het
Micalcl	A	G	7: 112,411,458	K618R	probably damaging	Het
Mllt6	T	C	11: 97,665,760	I92T	probably benign	Het
Morc2a	A	G	11: 3,676,184	I223V	probably benign	Het
Msh3	A	T	13: 92,345,086	I306N	probably benign	Het
Myo3b	T	A	2: 70,095,209	S35T	probably benign	Het
Nfkbiz	A	T	16: 55,813,984	V700E	probably damaging	Het
Oit3	T	A	10: 59,441,683	M1L	unknown	Het
Olfr1048	A	T	2: 86,236,472	I114K	probably damaging	Het
Olfr1231	A	T	2: 89,302,731	I287N	probably damaging	Het
Olfr606	T	A	7: 103,451,411	F25I	probably benign	Het
Peg3	T	G	7: 6,707,999	D1408A	probably damaging	Het
Plaa	A	C	4: 94,586,883	S201R	possibly damaging	Het
Psmd5	A	G	2: 34,854,326	S395P	probably benign	Het
Ralgapa2	T	C	2: 146,334,554	I1701V	probably damaging	Het
Rnf32	G	A	5: 29,206,186	A157T	probably damaging	Het
Rrad	T	A	8: 104,629,727		probably null	Het
Samm50	T	A	15: 84,207,841	L339Q	probably damaging	Het
Scin	T	C	12: 40,104,958	E212G	possibly damaging	Het
Scrib	T	C	15: 76,067,299	D146G	probably damaging	Het
Slc19a1	G	A	10: 77,049,771	D502N	probably benign	Het
Slc4a4	T	C	5: 89,214,573	S839P	probably damaging	Het
Slc4a8	A	G	15: 100,806,260	D764G	probably damaging	Het
Slc6a19	G	A	13: 73,681,765	A590V	probably damaging	Het
Slfn8	G	T	11: 83,017,706	H4N	probably benign	Het
Smad9	T	A	3: 54,789,335	F274I	possibly damaging	Het
Snx4	A	G	16: 33,286,010	E271G	probably benign	Het
Thap4	G	A	1: 93,750,306	R253*	probably null	Het
Tmem65	T	A	15: 58,790,179	I144F		Het
Tnrc6a	G	A	7: 123,179,735	R1223Q	probably benign	Het
Traf7	CA	CAA	17: 24,527,763		probably benign	Het
Trpm2	T	C	10: 77,911,392	Y1424C	possibly damaging	Het
Trrap	T	A	5: 144,826,668	Y2457N	probably damaging	Het
Vmn1r7	A	G	6: 57,024,523	S251P	probably damaging	Het
Vmn2r89	A	T	14: 51,456,012	E273V	probably damaging	Het
Vps52	A	G	17: 33,962,182	D466G	probably damaging	Het
Xirp2	T	C	2: 67,515,632	V2739A	probably benign	Het
Zc3h4	C	T	7: 16,434,750	S1003F	unknown	Het
Zyg11a	A	T	4: 108,217,905	H6Q	probably damaging	Het

Other mutations in Ltbp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Ltbp2	APN	12	84791064	missense	probably damaging	1.00
IGL00938:Ltbp2	APN	12	84831799	missense	probably benign	0.03
IGL01397:Ltbp2	APN	12	84790268	missense	probably damaging	1.00
IGL01570:Ltbp2	APN	12	84794033	missense	probably benign	0.05
IGL01631:Ltbp2	APN	12	84809146	critical splice donor site	probably null
IGL01662:Ltbp2	APN	12	84809246	missense	probably benign	0.00
IGL01728:Ltbp2	APN	12	84791009	missense	probably damaging	0.99
IGL01839:Ltbp2	APN	12	84793658	missense	possibly damaging	0.48
IGL01946:Ltbp2	APN	12	84830748	missense	probably damaging	1.00
IGL01977:Ltbp2	APN	12	84830199	missense	probably damaging	1.00
IGL02220:Ltbp2	APN	12	84829309	missense	possibly damaging	0.93
IGL02340:Ltbp2	APN	12	84792955	critical splice donor site	probably null
IGL02430:Ltbp2	APN	12	84799401	missense	probably damaging	1.00
IGL02492:Ltbp2	APN	12	84809665	missense	probably damaging	1.00
IGL02517:Ltbp2	APN	12	84785317	missense	probably benign	0.42
IGL02794:Ltbp2	APN	12	84791935	missense	probably damaging	1.00
deft	UTSW	12	84853912	missense	probably damaging	0.98
masterful	UTSW	12	84791090	missense	probably benign	0.00
practiced	UTSW	12	84809348	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84809587	missense	probably damaging	1.00
R0045:Ltbp2	UTSW	12	84813288	missense	probably damaging	1.00
R0091:Ltbp2	UTSW	12	84793733	missense	probably damaging	1.00
R0094:Ltbp2	UTSW	12	84799426	missense	probably damaging	1.00
R0166:Ltbp2	UTSW	12	84786358	missense	probably benign	0.28
R0265:Ltbp2	UTSW	12	84785969	splice site	probably null
R0394:Ltbp2	UTSW	12	84806424	splice site	probably benign
R0535:Ltbp2	UTSW	12	84784858	missense	probably damaging	1.00
R0535:Ltbp2	UTSW	12	84791052	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84813300	missense	probably damaging	1.00
R1465:Ltbp2	UTSW	12	84813300	missense	probably damaging	1.00
R1513:Ltbp2	UTSW	12	84791944	missense	probably damaging	1.00
R1858:Ltbp2	UTSW	12	84830781	nonsense	probably null
R1880:Ltbp2	UTSW	12	84829271	missense	probably benign	0.45
R1894:Ltbp2	UTSW	12	84787961	missense	probably damaging	1.00
R1900:Ltbp2	UTSW	12	84830658	missense	probably damaging	1.00
R1903:Ltbp2	UTSW	12	84830105	missense	probably benign	0.01
R1912:Ltbp2	UTSW	12	84785863	missense	probably damaging	0.98
R1993:Ltbp2	UTSW	12	84808446	critical splice acceptor site	probably null
R1995:Ltbp2	UTSW	12	84808446	critical splice acceptor site	probably null
R2069:Ltbp2	UTSW	12	84793733	missense	probably damaging	1.00
R2126:Ltbp2	UTSW	12	84785709	splice site	probably null
R2139:Ltbp2	UTSW	12	84815979	missense	probably damaging	1.00
R2341:Ltbp2	UTSW	12	84809163	missense	probably benign	0.08
R2511:Ltbp2	UTSW	12	84804409	splice site	probably null
R3737:Ltbp2	UTSW	12	84804474	missense	probably damaging	1.00
R3738:Ltbp2	UTSW	12	84804474	missense	probably damaging	1.00
R3739:Ltbp2	UTSW	12	84804474	missense	probably damaging	1.00
R3889:Ltbp2	UTSW	12	84784907	unclassified	probably benign
R4034:Ltbp2	UTSW	12	84804474	missense	probably damaging	1.00
R4542:Ltbp2	UTSW	12	84831819	nonsense	probably null
R4621:Ltbp2	UTSW	12	84809348	missense	probably damaging	1.00
R4623:Ltbp2	UTSW	12	84809348	missense	probably damaging	1.00
R4831:Ltbp2	UTSW	12	84793640	missense	possibly damaging	0.55
R5080:Ltbp2	UTSW	12	84803864	missense	probably damaging	1.00
R5116:Ltbp2	UTSW	12	84809737	missense	probably damaging	1.00
R5351:Ltbp2	UTSW	12	84790358	missense	possibly damaging	0.95
R5445:Ltbp2	UTSW	12	84809654	missense	probably null	1.00
R5608:Ltbp2	UTSW	12	84787464	splice site	probably null
R5784:Ltbp2	UTSW	12	84868739	missense	probably damaging	1.00
R5838:Ltbp2	UTSW	12	84789101	missense	probably benign	0.16
R5859:Ltbp2	UTSW	12	84794063	missense	possibly damaging	0.52
R6004:Ltbp2	UTSW	12	84876149	missense	probably benign	0.00
R6028:Ltbp2	UTSW	12	84784852	missense	probably damaging	1.00
R6347:Ltbp2	UTSW	12	84853912	missense	probably damaging	0.98
R6615:Ltbp2	UTSW	12	84813317	missense	probably damaging	1.00
R6636:Ltbp2	UTSW	12	84875838	missense	probably benign	0.00
R6637:Ltbp2	UTSW	12	84875838	missense	probably benign	0.00
R6755:Ltbp2	UTSW	12	84795073	missense	probably damaging	1.00
R6759:Ltbp2	UTSW	12	84787410	missense	probably damaging	0.99
R6806:Ltbp2	UTSW	12	84809238	missense	possibly damaging	0.74
R6968:Ltbp2	UTSW	12	84789083	critical splice donor site	probably null
R7084:Ltbp2	UTSW	12	84868685	missense	probably damaging	1.00
R7250:Ltbp2	UTSW	12	84787392	nonsense	probably null
R7374:Ltbp2	UTSW	12	84830175	missense	probably damaging	1.00
R7501:Ltbp2	UTSW	12	84830645	missense	probably damaging	1.00
R7523:Ltbp2	UTSW	12	84791034	missense	probably benign	0.00
R7754:Ltbp2	UTSW	12	84813238	critical splice donor site	probably null
R7827:Ltbp2	UTSW	12	84789881	missense	probably benign	0.19
R8042:Ltbp2	UTSW	12	84791899	missense	probably damaging	0.99
R8110:Ltbp2	UTSW	12	84803902	nonsense	probably null
R8411:Ltbp2	UTSW	12	84786413	missense	probably damaging	1.00
R8688:Ltbp2	UTSW	12	84803804	missense	probably benign	0.20
R8711:Ltbp2	UTSW	12	84853741	missense	probably benign	0.00
R8712:Ltbp2	UTSW	12	84806350	missense	probably benign	0.08
R8893:Ltbp2	UTSW	12	84828542	missense	probably damaging	1.00
R8978:Ltbp2	UTSW	12	84787390	missense	probably benign	0.00
R9016:Ltbp2	UTSW	12	84809693	missense	probably benign	0.02
R9123:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9129:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9132:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9144:Ltbp2	UTSW	12	84809652	missense	probably damaging	1.00
R9150:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9152:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9156:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9157:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9158:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9159:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9160:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9199:Ltbp2	UTSW	12	84785976	missense	probably benign	0.09
R9212:Ltbp2	UTSW	12	84793050	missense	probably damaging	1.00
R9275:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9276:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9276:Ltbp2	UTSW	12	84830111	missense	possibly damaging	0.79
R9278:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9279:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9280:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9281:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9312:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9313:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9331:Ltbp2	UTSW	12	84876191	missense	probably benign
R9355:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9375:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9377:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9378:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9450:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9486:Ltbp2	UTSW	12	84831874	missense	possibly damaging	0.49
R9505:Ltbp2	UTSW	12	84853864	missense	probably damaging	1.00
R9512:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9581:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9582:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9645:Ltbp2	UTSW	12	84791090	missense	probably benign	0.00
R9747:Ltbp2	UTSW	12	84868741	missense	probably damaging	1.00
R9792:Ltbp2	UTSW	12	84829354	missense	probably damaging	0.99
R9795:Ltbp2	UTSW	12	84829354	missense	probably damaging	0.99
X0017:Ltbp2	UTSW	12	84828528	missense	probably damaging	1.00
X0026:Ltbp2	UTSW	12	84830199	missense	probably damaging	1.00
Z1176:Ltbp2	UTSW	12	84875853	missense	probably benign	0.01
Z1177:Ltbp2	UTSW	12	84829316	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- ACTGGCCCACTGAACTCTAC -3'
(R):5'- AGAGCTTGTGGACACGAGAC -3'

Sequencing Primer
(F):5'- CTGAACTCTACTAAGTAGCTGGAGC -3'
(R):5'- CTTGTGGACACGAGACACCAG -3'

Posted On

2022-06-15