Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01560:Zfp282'

90823

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp282

Ensembl Gene

ENSMUSG00000025821

Gene Name

zinc finger protein 282

Synonyms

HUB1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01560

Quality Score

Status

Chromosome

Chromosomal Location

47854138-47885419 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 47857211 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 148 (E148V)

Ref Sequence

ENSEMBL: ENSMUSP00000053643 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061890]

AlphaFold

E9PVC2

Predicted Effect

probably damaging
Transcript: ENSMUST00000061890
AA Change: E148V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000053643
Gene: ENSMUSG00000025821
AA Change: E148V

Domain	Start	End	E-Value	Type
low complexity region	11	20	N/A	INTRINSIC
low complexity region	66	75	N/A	INTRINSIC
Pfam:DUF3669	98	168	1.8e-12	PFAM
KRAB	198	260	1.04e-21	SMART
internal_repeat_1	317	372	1.1e-13	PROSPERO
low complexity region	387	399	N/A	INTRINSIC
low complexity region	403	420	N/A	INTRINSIC
low complexity region	457	499	N/A	INTRINSIC
ZnF_C2H2	514	536	8.94e-3	SMART
ZnF_C2H2	542	564	4.72e-2	SMART
ZnF_C2H2	570	592	1.04e-3	SMART
ZnF_C2H2	598	620	4.24e-4	SMART
ZnF_C2H2	626	648	1.06e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125957

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap28	A	T	17: 68,203,066 (GRCm39)	I129N	probably damaging	Het
Arsb	A	G	13: 93,944,106 (GRCm39)	I266V	probably benign	Het
Atp6v1b1	A	G	6: 83,726,897 (GRCm39)		probably benign	Het
Cacna1d	C	T	14: 29,821,163 (GRCm39)	V1118I	probably benign	Het
Cadps	A	T	14: 12,491,792 (GRCm38)	V791D	probably damaging	Het
Cdh2	T	C	18: 16,783,495 (GRCm39)	D78G	probably benign	Het
Fem1al	A	T	11: 29,774,643 (GRCm39)	Y271*	probably null	Het
Flnb	T	G	14: 7,893,829 (GRCm38)	I714S	probably benign	Het
Fzd1	A	G	5: 4,806,037 (GRCm39)	M515T	probably benign	Het
Lrpprc	A	T	17: 85,015,547 (GRCm39)	F1288Y	probably benign	Het
Lrrk2	A	G	15: 91,659,191 (GRCm39)	I1868V	probably benign	Het
Mmel1	A	G	4: 154,976,967 (GRCm39)	D561G	probably null	Het
Mypn	A	T	10: 62,970,743 (GRCm39)	V887E	probably benign	Het
Or4c118	C	T	2: 88,974,947 (GRCm39)	C140Y	probably damaging	Het
Or6p1	A	T	1: 174,258,467 (GRCm39)	M158L	probably benign	Het
Or7g28	T	C	9: 19,271,842 (GRCm39)	T270A	probably benign	Het
Osbpl5	C	A	7: 143,269,430 (GRCm39)	E49*	probably null	Het
Prpf8	A	G	11: 75,381,232 (GRCm39)	Q189R	possibly damaging	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Six6	T	A	12: 72,986,831 (GRCm39)	M1K	probably null	Het
Slc13a4	A	G	6: 35,248,538 (GRCm39)		probably benign	Het
Slc17a1	T	A	13: 24,058,612 (GRCm39)	I22N	probably damaging	Het
Thsd7b	C	T	1: 130,145,918 (GRCm39)		probably benign	Het
Thumpd3	A	G	6: 113,040,120 (GRCm39)	I335V	possibly damaging	Het
Ttn	T	C	2: 76,602,016 (GRCm39)	T18549A	possibly damaging	Het
Ugt2b37	G	T	5: 87,399,698 (GRCm39)	P270Q	probably damaging	Het
Wdfy3	A	T	5: 102,105,352 (GRCm39)	Y158*	probably null	Het

Other mutations in Zfp282

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00732:Zfp282	APN	6	47,857,324 (GRCm39)	missense	probably damaging	1.00
IGL00755:Zfp282	APN	6	47,857,324 (GRCm39)	missense	probably damaging	1.00
IGL01402:Zfp282	APN	6	47,874,770 (GRCm39)	missense	probably damaging	0.99
IGL01404:Zfp282	APN	6	47,874,770 (GRCm39)	missense	probably damaging	0.99
IGL01484:Zfp282	APN	6	47,867,054 (GRCm39)	missense	possibly damaging	0.76
IGL02949:Zfp282	APN	6	47,874,848 (GRCm39)	missense	probably damaging	1.00
FR4304:Zfp282	UTSW	6	47,881,731 (GRCm39)	small insertion	probably benign
FR4589:Zfp282	UTSW	6	47,881,725 (GRCm39)	small insertion	probably benign
FR4737:Zfp282	UTSW	6	47,881,733 (GRCm39)	small insertion	probably benign
FR4737:Zfp282	UTSW	6	47,881,724 (GRCm39)	small insertion	probably benign
FR4976:Zfp282	UTSW	6	47,881,724 (GRCm39)	small insertion	probably benign
R0020:Zfp282	UTSW	6	47,856,943 (GRCm39)	missense	probably damaging	1.00
R0020:Zfp282	UTSW	6	47,856,943 (GRCm39)	missense	probably damaging	1.00
R0118:Zfp282	UTSW	6	47,869,866 (GRCm39)	missense	probably benign	0.34
R0415:Zfp282	UTSW	6	47,881,987 (GRCm39)	missense	possibly damaging	0.88
R0415:Zfp282	UTSW	6	47,874,815 (GRCm39)	missense	probably damaging	0.99
R0607:Zfp282	UTSW	6	47,857,303 (GRCm39)	missense	probably damaging	1.00
R0710:Zfp282	UTSW	6	47,857,318 (GRCm39)	missense	probably damaging	1.00
R0946:Zfp282	UTSW	6	47,856,943 (GRCm39)	missense	probably damaging	1.00
R1054:Zfp282	UTSW	6	47,881,533 (GRCm39)	missense	probably benign	0.00
R1401:Zfp282	UTSW	6	47,867,108 (GRCm39)	nonsense	probably null
R1572:Zfp282	UTSW	6	47,869,801 (GRCm39)	missense	probably damaging	1.00
R2016:Zfp282	UTSW	6	47,874,721 (GRCm39)	splice site	probably null
R2971:Zfp282	UTSW	6	47,874,866 (GRCm39)	splice site	probably null
R4064:Zfp282	UTSW	6	47,857,028 (GRCm39)	missense	probably damaging	0.99
R4478:Zfp282	UTSW	6	47,867,630 (GRCm39)	nonsense	probably null
R4530:Zfp282	UTSW	6	47,867,567 (GRCm39)	missense	probably benign	0.00
R4532:Zfp282	UTSW	6	47,867,567 (GRCm39)	missense	probably benign	0.00
R5068:Zfp282	UTSW	6	47,854,637 (GRCm39)	missense	probably benign	0.01
R5261:Zfp282	UTSW	6	47,874,824 (GRCm39)	missense	probably damaging	0.99
R5326:Zfp282	UTSW	6	47,882,261 (GRCm39)	missense	probably benign
R5551:Zfp282	UTSW	6	47,867,579 (GRCm39)	missense	possibly damaging	0.59
R6046:Zfp282	UTSW	6	47,857,102 (GRCm39)	missense	probably damaging	1.00
R6408:Zfp282	UTSW	6	47,857,319 (GRCm39)	missense	probably damaging	1.00
R7535:Zfp282	UTSW	6	47,881,878 (GRCm39)	missense	probably benign	0.03
R8098:Zfp282	UTSW	6	47,867,652 (GRCm39)	missense	probably benign	0.00
R8158:Zfp282	UTSW	6	47,867,626 (GRCm39)	missense	possibly damaging	0.61
R8304:Zfp282	UTSW	6	47,881,722 (GRCm39)	small deletion	probably benign
R8385:Zfp282	UTSW	6	47,882,023 (GRCm39)	missense	possibly damaging	0.88
R8543:Zfp282	UTSW	6	47,881,561 (GRCm39)	missense	probably benign	0.40
R8817:Zfp282	UTSW	6	47,881,760 (GRCm39)	missense	probably benign	0.00
S24628:Zfp282	UTSW	6	47,881,987 (GRCm39)	missense	possibly damaging	0.88
S24628:Zfp282	UTSW	6	47,874,815 (GRCm39)	missense	probably damaging	0.99
Z1177:Zfp282	UTSW	6	47,867,571 (GRCm39)	missense	probably benign	0.00

Posted On

2013-12-09