Incidental Mutation 'R4663:Vmn2r15'
| ID |
352995 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r15
|
| Ensembl Gene |
ENSMUSG00000091375 |
| Gene Name |
vomeronasal 2, receptor 15 |
| Synonyms |
EG211223 |
| MMRRC Submission |
041921-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
R4663 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 109441940 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 164
(M164I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
| AlphaFold |
L7N2A0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167133
AA Change: M164I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: M164I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
|
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
|
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aqr |
A |
T |
2: 113,992,147 (GRCm39) |
Y76* |
probably null |
Het |
| Armc5 |
C |
A |
7: 127,837,717 (GRCm39) |
A140E |
probably benign |
Het |
| Auts2 |
T |
C |
5: 131,468,476 (GRCm39) |
H947R |
probably damaging |
Het |
| Bag2 |
T |
C |
1: 33,786,074 (GRCm39) |
T83A |
probably damaging |
Het |
| Bag4 |
C |
T |
8: 26,259,516 (GRCm39) |
A228T |
probably benign |
Het |
| Bean1 |
A |
G |
8: 104,937,799 (GRCm39) |
Y126C |
probably damaging |
Het |
| Cars1 |
T |
C |
7: 143,129,697 (GRCm39) |
E330G |
probably damaging |
Het |
| Ccdc40 |
A |
G |
11: 119,122,332 (GRCm39) |
I45V |
probably benign |
Het |
| Cd320 |
G |
A |
17: 34,067,152 (GRCm39) |
G214R |
probably null |
Het |
| Ckm |
G |
A |
7: 19,153,419 (GRCm39) |
V237M |
probably damaging |
Het |
| Cplane1 |
T |
C |
15: 8,247,939 (GRCm39) |
V1496A |
probably benign |
Het |
| Cspg4 |
T |
C |
9: 56,793,960 (GRCm39) |
V565A |
possibly damaging |
Het |
| Dnaaf10 |
T |
C |
11: 17,182,853 (GRCm39) |
V338A |
probably benign |
Het |
| Eddm13 |
T |
G |
7: 6,261,624 (GRCm39) |
I35S |
possibly damaging |
Het |
| Ephb6 |
A |
G |
6: 41,594,799 (GRCm39) |
Y638C |
probably damaging |
Het |
| Fat2 |
G |
C |
11: 55,187,039 (GRCm39) |
S1269* |
probably null |
Het |
| Fbxo3 |
T |
C |
2: 103,883,820 (GRCm39) |
V348A |
probably damaging |
Het |
| Gas6 |
G |
A |
8: 13,520,254 (GRCm39) |
P478L |
probably damaging |
Het |
| Herc1 |
T |
C |
9: 66,340,660 (GRCm39) |
S1670P |
probably damaging |
Het |
| Hnrnpk |
C |
A |
13: 58,542,331 (GRCm39) |
R281L |
probably damaging |
Het |
| Ifih1 |
C |
A |
2: 62,439,563 (GRCm39) |
C488F |
probably benign |
Het |
| Ift172 |
T |
C |
5: 31,441,559 (GRCm39) |
K192E |
probably benign |
Het |
| Ighv5-9 |
T |
A |
12: 113,625,440 (GRCm39) |
Q101L |
probably benign |
Het |
| Igkv3-2 |
G |
T |
6: 70,675,863 (GRCm39) |
M57I |
probably benign |
Het |
| Insyn2a |
A |
T |
7: 134,500,877 (GRCm39) |
Y409* |
probably null |
Het |
| Itpr2 |
A |
G |
6: 146,274,671 (GRCm39) |
F837S |
probably damaging |
Het |
| L3mbtl3 |
T |
C |
10: 26,213,715 (GRCm39) |
Y237C |
unknown |
Het |
| Lats1 |
G |
A |
10: 7,588,347 (GRCm39) |
C988Y |
probably damaging |
Het |
| Lgals3 |
T |
A |
14: 47,619,079 (GRCm39) |
|
probably null |
Het |
| Lrrc3b |
G |
T |
14: 15,358,220 (GRCm38) |
H129N |
probably benign |
Het |
| Lrriq1 |
T |
C |
10: 102,899,273 (GRCm39) |
H1656R |
possibly damaging |
Het |
| Lypd6 |
T |
G |
2: 50,063,623 (GRCm39) |
Y43* |
probably null |
Het |
| Mettl25b |
A |
G |
3: 87,835,055 (GRCm39) |
S82P |
probably damaging |
Het |
| Mical2 |
A |
G |
7: 111,927,884 (GRCm39) |
D674G |
possibly damaging |
Het |
| Msi1 |
G |
A |
5: 115,588,334 (GRCm39) |
R284Q |
probably damaging |
Het |
| Mybpc2 |
T |
C |
7: 44,155,066 (GRCm39) |
E947G |
probably damaging |
Het |
| Nat14 |
T |
A |
7: 4,927,446 (GRCm39) |
L206Q |
probably damaging |
Het |
| Nup88 |
A |
T |
11: 70,856,672 (GRCm39) |
|
probably null |
Het |
| Or11g27 |
A |
T |
14: 50,771,061 (GRCm39) |
Y64F |
probably damaging |
Het |
| Or4k15 |
A |
G |
14: 50,364,939 (GRCm39) |
R302G |
probably benign |
Het |
| Or8g19 |
A |
T |
9: 39,056,145 (GRCm39) |
I250F |
probably damaging |
Het |
| Pdcl |
T |
C |
2: 37,245,778 (GRCm39) |
E75G |
probably damaging |
Het |
| Phf14 |
A |
G |
6: 11,953,421 (GRCm39) |
I387V |
possibly damaging |
Het |
| Phf3 |
G |
A |
1: 30,860,296 (GRCm39) |
R845W |
probably damaging |
Het |
| Pm20d1 |
T |
C |
1: 131,726,340 (GRCm39) |
I59T |
probably damaging |
Het |
| Prkd1 |
C |
T |
12: 50,466,631 (GRCm39) |
|
probably null |
Het |
| Psmb2 |
T |
C |
4: 126,571,558 (GRCm39) |
L4P |
probably damaging |
Het |
| Pttg1 |
T |
A |
11: 43,315,677 (GRCm39) |
K46* |
probably null |
Het |
| Ryr2 |
T |
C |
13: 11,764,395 (GRCm39) |
H1401R |
possibly damaging |
Het |
| Septin4 |
T |
A |
11: 87,458,429 (GRCm39) |
Y268N |
probably damaging |
Het |
| Sh3d19 |
G |
A |
3: 86,030,570 (GRCm39) |
D696N |
probably benign |
Het |
| Slc16a2 |
T |
C |
X: 102,751,585 (GRCm39) |
T274A |
probably benign |
Het |
| Slc26a6 |
G |
A |
9: 108,735,106 (GRCm39) |
A335T |
probably damaging |
Het |
| Slc49a3 |
T |
C |
5: 108,590,011 (GRCm39) |
M464V |
probably benign |
Het |
| Slc6a5 |
C |
A |
7: 49,588,146 (GRCm39) |
Y493* |
probably null |
Het |
| Slf1 |
A |
T |
13: 77,274,723 (GRCm39) |
S37R |
probably damaging |
Het |
| Smoc1 |
G |
A |
12: 81,214,376 (GRCm39) |
G264S |
probably damaging |
Het |
| Snapc4 |
T |
C |
2: 26,264,193 (GRCm39) |
E280G |
possibly damaging |
Het |
| Snx25 |
G |
A |
8: 46,488,616 (GRCm39) |
T913M |
probably damaging |
Het |
| Snx7 |
T |
C |
3: 117,594,528 (GRCm39) |
T408A |
probably benign |
Het |
| Spdya |
T |
A |
17: 71,885,339 (GRCm39) |
S264R |
probably benign |
Het |
| Spg11 |
A |
T |
2: 121,928,580 (GRCm39) |
|
probably null |
Het |
| Suz12 |
T |
A |
11: 79,904,350 (GRCm39) |
L230Q |
probably damaging |
Het |
| Szt2 |
A |
G |
4: 118,234,881 (GRCm39) |
|
probably benign |
Het |
| Tenm3 |
C |
A |
8: 48,689,005 (GRCm39) |
R2194L |
probably damaging |
Het |
| Tmed8 |
T |
A |
12: 87,221,005 (GRCm39) |
I194F |
probably damaging |
Het |
| Tmem79 |
T |
A |
3: 88,240,751 (GRCm39) |
T66S |
probably damaging |
Het |
| Trappc1 |
T |
A |
11: 69,216,337 (GRCm39) |
S118T |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,569,225 (GRCm39) |
V27223I |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,606,839 (GRCm39) |
T18024A |
probably damaging |
Het |
| Vmn2r53 |
T |
A |
7: 12,334,901 (GRCm39) |
Y253F |
probably benign |
Het |
| Zfand6 |
C |
T |
7: 84,267,093 (GRCm39) |
R163H |
probably benign |
Het |
|
| Other mutations in Vmn2r15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
|
R2072:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2268:Vmn2r15
|
UTSW |
5 |
109,441,073 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9372:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9619:Vmn2r15
|
UTSW |
5 |
109,440,622 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCTCCAAGTTTTCATGTAGGC -3'
(R):5'- TGAAGAAACATTGGGACTTCTCG -3'
Sequencing Primer
(F):5'- GCTAATTGGTTAAGAGCACTGCC -3'
(R):5'- GTCTTATAGGACCATCATGGA -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation