Incidental Mutation 'IGL03068:Vmn2r96'
ID409756
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r96
Ensembl Gene ENSMUSG00000091679
Gene Namevomeronasal 2, receptor 96
SynonymsEG433070
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.185) question?
Stock #IGL03068
Quality Score
Status
Chromosome17
Chromosomal Location18573151-18616003 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 18582875 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 349 (I349N)
Ref Sequence ENSEMBL: ENSMUSP00000156012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]
Predicted Effect probably benign
Transcript: ENSMUST00000165692
AA Change: I157N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: I157N

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 257 8.6e-20 PFAM
Pfam:NCD3G 317 370 3.7e-22 PFAM
Pfam:7tm_3 402 638 3.9e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177244
AA Change: I349N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: I349N

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 245 4.2e-19 PFAM
Pfam:NCD3G 317 370 6.9e-21 PFAM
Pfam:7tm_3 400 639 3.4e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231261
Predicted Effect probably benign
Transcript: ENSMUST00000231286
AA Change: I349N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago3 A G 4: 126,417,378 L14P probably damaging Het
Ak2 G T 4: 129,008,026 probably benign Het
Appbp2 T C 11: 85,201,420 Y311C probably damaging Het
Arl9 C A 5: 77,007,378 L119I possibly damaging Het
Atp1a1 T C 3: 101,583,859 H620R probably benign Het
Cfap52 T C 11: 67,935,856 D381G probably benign Het
Cngb3 T C 4: 19,375,246 F292S possibly damaging Het
Comtd1 G A 14: 21,847,643 R203C probably damaging Het
Crmp1 G T 5: 37,265,289 A147S possibly damaging Het
Csmd3 T A 15: 47,847,121 H1586L possibly damaging Het
Ctnna1 G A 18: 35,249,732 E644K possibly damaging Het
Dock3 T C 9: 106,964,759 D957G possibly damaging Het
Ear1 G T 14: 43,819,045 S122* probably null Het
Eefsec G T 6: 88,258,227 Q576K probably benign Het
Efcab5 T A 11: 77,104,101 I1215L probably benign Het
Etfa A T 9: 55,487,482 D160E probably benign Het
Exoc7 G A 11: 116,301,134 R197C possibly damaging Het
G6pc A G 11: 101,370,750 D92G probably benign Het
Gm3182 T A 14: 4,483,921 probably null Het
Gm4952 A G 19: 12,623,704 N96S probably damaging Het
Gpr156 G A 16: 37,992,129 V276M probably damaging Het
Irs2 A G 8: 11,004,974 S1153P probably damaging Het
Kif21b T C 1: 136,158,355 probably benign Het
Lmo7 A T 14: 101,875,492 probably benign Het
Mapk4 G T 18: 73,970,344 N31K probably damaging Het
Mccc2 T C 13: 99,963,811 T357A probably damaging Het
Mpeg1 A G 19: 12,462,206 T343A probably benign Het
Myo3b G T 2: 70,426,816 probably benign Het
Pald1 T C 10: 61,321,184 E829G possibly damaging Het
Pde11a A G 2: 76,017,864 I873T probably damaging Het
Samd9l T A 6: 3,375,348 K638* probably null Het
Sema4d A G 13: 51,708,886 S479P probably damaging Het
Slc12a2 T C 18: 57,904,335 probably benign Het
Slc47a2 T C 11: 61,303,943 N470S probably damaging Het
Spag17 C T 3: 100,080,205 P1604S probably benign Het
Taf8 C A 17: 47,501,365 V39L probably damaging Het
Tlr11 A G 14: 50,361,484 E309G probably benign Het
Tmem260 A G 14: 48,486,914 probably benign Het
Tsc1 A T 2: 28,681,258 K816M probably damaging Het
Ttc29 A G 8: 78,325,551 I354V probably benign Het
Ttll3 A T 6: 113,409,197 N665Y probably damaging Het
Ubr4 A G 4: 139,409,730 T971A probably benign Het
Vwa5a A G 9: 38,734,847 T504A probably benign Het
Ythdf3 T A 3: 16,204,718 V354E possibly damaging Het
Zan C A 5: 137,476,415 G13V probably damaging Het
Other mutations in Vmn2r96
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Vmn2r96 APN 17 18583815 missense probably benign 0.00
IGL00563:Vmn2r96 APN 17 18583815 missense probably benign 0.00
IGL00769:Vmn2r96 APN 17 18583819 missense probably benign 0.00
IGL01314:Vmn2r96 APN 17 18582964 missense probably benign 0.00
IGL01983:Vmn2r96 APN 17 18597265 missense probably damaging 0.99
IGL02314:Vmn2r96 APN 17 18583959 missense probably benign 0.01
IGL02600:Vmn2r96 APN 17 18597567 missense probably benign
IGL02672:Vmn2r96 APN 17 18598114 missense probably benign 0.02
IGL02750:Vmn2r96 APN 17 18582589 missense probably benign 0.01
IGL03411:Vmn2r96 APN 17 18586372 missense possibly damaging 0.88
R0316:Vmn2r96 UTSW 17 18582565 missense probably damaging 1.00
R0502:Vmn2r96 UTSW 17 18584000 missense probably benign
R0580:Vmn2r96 UTSW 17 18582638 missense probably damaging 1.00
R0652:Vmn2r96 UTSW 17 18597568 missense probably benign 0.05
R0789:Vmn2r96 UTSW 17 18582476 missense possibly damaging 0.81
R1462:Vmn2r96 UTSW 17 18597398 missense possibly damaging 0.94
R1462:Vmn2r96 UTSW 17 18597398 missense possibly damaging 0.94
R1660:Vmn2r96 UTSW 17 18597726 missense probably benign 0.00
R1755:Vmn2r96 UTSW 17 18582653 missense possibly damaging 0.50
R1843:Vmn2r96 UTSW 17 18597921 missense probably benign 0.14
R1943:Vmn2r96 UTSW 17 18586402 missense probably benign 0.09
R1993:Vmn2r96 UTSW 17 18583876 missense probably damaging 1.00
R2018:Vmn2r96 UTSW 17 18584001 missense probably benign
R2405:Vmn2r96 UTSW 17 18597840 missense probably damaging 0.96
R3977:Vmn2r96 UTSW 17 18597679 missense probably damaging 1.00
R3979:Vmn2r96 UTSW 17 18597679 missense probably damaging 1.00
R4059:Vmn2r96 UTSW 17 18598077 missense probably benign 0.20
R4693:Vmn2r96 UTSW 17 18583008 missense probably benign 0.03
R4709:Vmn2r96 UTSW 17 18582826 missense probably benign 0.36
R4776:Vmn2r96 UTSW 17 18597508 missense probably damaging 1.00
R4882:Vmn2r96 UTSW 17 18597604 missense probably damaging 1.00
R4920:Vmn2r96 UTSW 17 18582656 missense probably benign 0.07
R5143:Vmn2r96 UTSW 17 18583858 missense possibly damaging 0.65
R5301:Vmn2r96 UTSW 17 18597688 missense probably damaging 0.98
R5507:Vmn2r96 UTSW 17 18597829 missense probably damaging 1.00
R6151:Vmn2r96 UTSW 17 18583959 missense probably benign 0.01
R6181:Vmn2r96 UTSW 17 18583864 missense probably benign
R6339:Vmn2r96 UTSW 17 18583862 missense possibly damaging 0.84
R6404:Vmn2r96 UTSW 17 18597531 missense probably damaging 1.00
R6452:Vmn2r96 UTSW 17 18583855 missense probably benign 0.07
R6749:Vmn2r96 UTSW 17 18598090 missense probably damaging 0.99
R6813:Vmn2r96 UTSW 17 18581854 missense probably benign 0.04
R6851:Vmn2r96 UTSW 17 18582538 missense possibly damaging 0.95
R6944:Vmn2r96 UTSW 17 18597629 missense probably benign 0.16
R6949:Vmn2r96 UTSW 17 18597838 missense probably damaging 1.00
R6962:Vmn2r96 UTSW 17 18598021 missense probably damaging 0.99
R6990:Vmn2r96 UTSW 17 18583820 missense probably benign
R7149:Vmn2r96 UTSW 17 18597727 missense possibly damaging 0.89
Z1088:Vmn2r96 UTSW 17 18597366 missense possibly damaging 0.86
Posted On2016-08-02