Incidental Mutation 'IGL01833:Lmtk2'
ID154849
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lmtk2
Ensembl Gene ENSMUSG00000038970
Gene Namelemur tyrosine kinase 2
SynonymsAATYK2, A330101P12Rik, KPI2, cprk, KPI-2, 2900041G10Rik, BREK
Accession Numbers

Genbank: NM_001081109; MGI: 3036247

Is this an essential gene? Possibly non essential (E-score: 0.446) question?
Stock #IGL01833
Quality Score
Status
Chromosome5
Chromosomal Location144100436-144188204 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 144175935 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 1158 (R1158*)
Ref Sequence ENSEMBL: ENSMUSP00000048238 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041804]
Predicted Effect probably null
Transcript: ENSMUST00000041804
AA Change: R1158*
SMART Domains Protein: ENSMUSP00000048238
Gene: ENSMUSG00000038970
AA Change: R1158*

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
transmembrane domain 42 61 N/A INTRINSIC
low complexity region 72 88 N/A INTRINSIC
STYKc 136 406 3.4e-39 SMART
low complexity region 924 953 N/A INTRINSIC
low complexity region 1019 1035 N/A INTRINSIC
low complexity region 1104 1117 N/A INTRINSIC
low complexity region 1168 1180 N/A INTRINSIC
low complexity region 1252 1266 N/A INTRINSIC
low complexity region 1354 1367 N/A INTRINSIC
low complexity region 1380 1392 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a null mutation in this gene display partial prenatal lethality, male infertility, and azoospermia. [provided by MGI curators]
Allele List at MGI

All alleles(31) : Targeted, knock-out(1) Gene trapped(30)

Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700061G19Rik A G 17: 56,881,062 N190S probably benign Het
Adamts18 T A 8: 113,743,096 Y658F probably benign Het
Camsap3 T A 8: 3,608,508 L1151Q probably damaging Het
Casp14 T A 10: 78,715,403 Y16F probably damaging Het
Clip2 A T 5: 134,498,084 probably benign Het
Clip4 G A 17: 71,827,790 probably benign Het
Cyb5r4 G A 9: 87,059,452 probably null Het
Ep400 A T 5: 110,680,008 N2329K unknown Het
Fam163a T A 1: 156,079,996 I17F probably damaging Het
Fam213b G T 4: 154,896,602 probably benign Het
Galnt1 T A 18: 24,267,560 I241N probably damaging Het
Galnt14 T G 17: 73,504,904 I441L probably benign Het
Gpr45 T C 1: 43,032,242 L15P probably benign Het
Hivep1 A T 13: 42,154,988 K235* probably null Het
Kcnip2 T C 19: 45,794,307 probably null Het
Kpna3 T C 14: 61,370,445 N437S possibly damaging Het
Lpo A G 11: 87,807,333 V612A possibly damaging Het
Myh15 T C 16: 49,114,058 C663R probably damaging Het
Nacad G A 11: 6,605,700 R17C unknown Het
Olfr1351 A T 10: 79,017,936 M205L probably benign Het
Pcsk2 A G 2: 143,687,580 Q99R possibly damaging Het
Pkd1l2 T C 8: 117,060,525 N593S probably benign Het
Plce1 G A 19: 38,720,981 S1093N probably damaging Het
Rhpn2 T A 7: 35,376,171 Y258N probably benign Het
Serpinb9d T C 13: 33,200,705 Y222H probably damaging Het
Shprh T C 10: 11,191,062 L1401P probably damaging Het
Slc5a7 A G 17: 54,281,833 L262P probably damaging Het
Stat2 T G 10: 128,281,176 F293V probably benign Het
Stpg4 T A 17: 87,395,157 probably null Het
Styk1 G T 6: 131,302,366 probably benign Het
Sult2a2 T A 7: 13,734,796 D62E probably damaging Het
Sytl2 G A 7: 90,396,537 V632M probably damaging Het
Themis C T 10: 28,782,311 Q445* probably null Het
Tmem225 A T 9: 40,148,429 E35V probably damaging Het
Vmn1r48 T A 6: 90,036,283 T187S probably damaging Het
Xpnpep1 A G 19: 53,000,393 Y463H probably damaging Het
Other mutations in Lmtk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Lmtk2 APN 5 144134155 missense probably damaging 1.00
IGL00496:Lmtk2 APN 5 144174694 missense probably benign
IGL00848:Lmtk2 APN 5 144176398 missense probably benign
IGL01450:Lmtk2 APN 5 144174702 missense probably benign 0.03
IGL01967:Lmtk2 APN 5 144182779 missense probably benign
IGL01998:Lmtk2 APN 5 144176065 missense probably damaging 1.00
IGL02106:Lmtk2 APN 5 144175951 missense probably benign 0.03
IGL02147:Lmtk2 APN 5 144156936 missense possibly damaging 0.78
IGL02581:Lmtk2 APN 5 144148348 missense probably damaging 1.00
madagascar UTSW 5 144174919 missense probably benign 0.02
A4554:Lmtk2 UTSW 5 144166317 missense possibly damaging 0.82
R0039:Lmtk2 UTSW 5 144166387 missense probably damaging 1.00
R0039:Lmtk2 UTSW 5 144166387 missense probably damaging 1.00
R0108:Lmtk2 UTSW 5 144174285 missense possibly damaging 0.78
R0367:Lmtk2 UTSW 5 144174285 missense possibly damaging 0.78
R0515:Lmtk2 UTSW 5 144174991 missense possibly damaging 0.77
R1434:Lmtk2 UTSW 5 144174589 missense probably damaging 1.00
R1617:Lmtk2 UTSW 5 144173862 missense probably damaging 1.00
R1760:Lmtk2 UTSW 5 144174175 missense probably damaging 0.99
R1785:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R1786:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R1907:Lmtk2 UTSW 5 144175110 missense probably benign 0.00
R2130:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R2131:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R2132:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R2133:Lmtk2 UTSW 5 144174988 missense possibly damaging 0.61
R2140:Lmtk2 UTSW 5 144147615 missense probably damaging 1.00
R2141:Lmtk2 UTSW 5 144147615 missense probably damaging 1.00
R2210:Lmtk2 UTSW 5 144147609 missense probably damaging 1.00
R2289:Lmtk2 UTSW 5 144176106 missense possibly damaging 0.80
R2312:Lmtk2 UTSW 5 144173626 missense probably damaging 1.00
R2352:Lmtk2 UTSW 5 144173911 missense probably benign 0.05
R3870:Lmtk2 UTSW 5 144166427 splice site probably benign
R4011:Lmtk2 UTSW 5 144175879 missense probably benign 0.01
R4272:Lmtk2 UTSW 5 144183226 missense probably benign 0.05
R4361:Lmtk2 UTSW 5 144147664 missense probably damaging 1.00
R4580:Lmtk2 UTSW 5 144174781 missense possibly damaging 0.56
R4621:Lmtk2 UTSW 5 144174934 missense probably benign 0.02
R4981:Lmtk2 UTSW 5 144176447 missense probably damaging 1.00
R5818:Lmtk2 UTSW 5 144156900 missense probably benign 0.07
R5984:Lmtk2 UTSW 5 144174838 missense probably benign
R6083:Lmtk2 UTSW 5 144182756 missense probably damaging 1.00
R6180:Lmtk2 UTSW 5 144175342 missense probably damaging 1.00
R6411:Lmtk2 UTSW 5 144174586 missense probably damaging 0.99
R6544:Lmtk2 UTSW 5 144173806 missense possibly damaging 0.68
R6628:Lmtk2 UTSW 5 144174685 missense probably benign 0.03
R6698:Lmtk2 UTSW 5 144174919 missense probably benign 0.02
R6742:Lmtk2 UTSW 5 144148357 missense probably damaging 1.00
R6763:Lmtk2 UTSW 5 144173797 missense probably damaging 1.00
R7286:Lmtk2 UTSW 5 144174360 nonsense probably null
R7390:Lmtk2 UTSW 5 144129443 missense possibly damaging 0.79
R7594:Lmtk2 UTSW 5 144173746 missense probably damaging 1.00
R7660:Lmtk2 UTSW 5 144148340 missense probably damaging 1.00
R7785:Lmtk2 UTSW 5 144174753 missense probably benign 0.00
X0024:Lmtk2 UTSW 5 144174250 missense probably benign 0.22
Z1088:Lmtk2 UTSW 5 144182851 missense probably benign 0.12
Posted On2014-02-04