Incidental Mutation 'R1488:Or51a24'
ID 165503
Institutional Source Beutler Lab
Gene Symbol Or51a24
Ensembl Gene ENSMUSG00000051340
Gene Name olfactory receptor family 51 subfamily A member 24
Synonyms GA_x6K02T2PBJ9-6819097-6818150, MOR13-5, Olfr645
MMRRC Submission 039540-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1488 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103733338-103734285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103733859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 143 (I143V)
Ref Sequence ENSEMBL: ENSMUSP00000062821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057104] [ENSMUST00000138055]
AlphaFold Q7TRQ1
Predicted Effect probably benign
Transcript: ENSMUST00000057104
AA Change: I143V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000062821
Gene: ENSMUSG00000051340
AA Change: I143V

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 5.4e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 256 8e-8 PFAM
Pfam:7tm_1 43 295 5.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Meta Mutation Damage Score 0.1925 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.3%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aoc1l2 A G 6: 48,910,381 (GRCm39) N691S possibly damaging Het
Arhgap23 A G 11: 97,391,685 (GRCm39) S1401G possibly damaging Het
Art2b A C 7: 101,229,414 (GRCm39) F162V probably damaging Het
Atg4c T A 4: 99,109,479 (GRCm39) W149R probably damaging Het
Atxn1l A G 8: 110,460,049 (GRCm39) I71T probably benign Het
Axdnd1 T A 1: 156,176,530 (GRCm39) L748F probably damaging Het
Bdh2 A G 3: 135,002,602 (GRCm39) Y157C probably damaging Het
C2cd4a G T 9: 67,738,990 (GRCm39) R18S probably benign Het
Catsperb A G 12: 101,560,526 (GRCm39) H839R probably damaging Het
Ccdc24 C A 4: 117,727,765 (GRCm39) S134I possibly damaging Het
Cd55 G T 1: 130,376,115 (GRCm39) T70K probably damaging Het
Cdh10 A T 15: 19,013,349 (GRCm39) I650F probably damaging Het
Clca3a2 T A 3: 144,789,925 (GRCm39) K470N possibly damaging Het
Csn2 G A 5: 87,842,755 (GRCm39) Q91* probably null Het
Ctsh G A 9: 89,953,944 (GRCm39) D218N possibly damaging Het
Cyb5r4 C G 9: 86,911,591 (GRCm39) Y88* probably null Het
Dgkq A G 5: 108,798,743 (GRCm39) F601S probably damaging Het
Eci2 A G 13: 35,161,916 (GRCm39) V352A probably benign Het
Krt28 T C 11: 99,255,997 (GRCm39) T421A probably benign Het
Lamp5 T C 2: 135,911,011 (GRCm39) V248A probably benign Het
Lin9 T A 1: 180,515,850 (GRCm39) L483Q possibly damaging Het
Lrp1b C A 2: 41,392,036 (GRCm39) M509I probably benign Het
Lrrfip1 T C 1: 91,042,354 (GRCm39) V253A probably damaging Het
Mpdz C A 4: 81,266,945 (GRCm39) E981* probably null Het
Mpo A C 11: 87,688,256 (GRCm39) N305T probably damaging Het
Or2y1 A G 11: 49,385,945 (GRCm39) E195G probably benign Het
Or5p79 A T 7: 108,221,696 (GRCm39) I226F probably damaging Het
Papss2 T C 19: 32,614,490 (GRCm39) S69P probably benign Het
Pcdhb22 A G 18: 37,652,941 (GRCm39) T470A possibly damaging Het
Plce1 A G 19: 38,705,247 (GRCm39) D884G possibly damaging Het
Prex2 T A 1: 11,263,752 (GRCm39) I1239K probably benign Het
Prkd2 T A 7: 16,592,364 (GRCm39) F625I probably damaging Het
Rab20 A T 8: 11,504,268 (GRCm39) V144E probably benign Het
Rnf213 A G 11: 119,371,715 (GRCm39) N4840S probably benign Het
Scaf8 T G 17: 3,247,872 (GRCm39) M1065R probably damaging Het
Slco3a1 A G 7: 73,996,449 (GRCm39) L319P possibly damaging Het
Slit1 A G 19: 41,596,824 (GRCm39) C1092R probably damaging Het
Tlr4 A G 4: 66,757,786 (GRCm39) D193G probably damaging Het
Tmem145 T A 7: 25,006,860 (GRCm39) probably null Het
Tmem184a T A 5: 139,793,395 (GRCm39) K235N probably benign Het
Tnpo1 A T 13: 98,993,415 (GRCm39) D590E probably damaging Het
Trio C A 15: 27,741,053 (GRCm39) G2724V probably damaging Het
Ttc6 A T 12: 57,696,301 (GRCm39) Y34F possibly damaging Het
Tuba4a T C 1: 75,193,045 (GRCm39) T190A probably benign Het
Tubgcp4 T G 2: 121,007,031 (GRCm39) V136G possibly damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Vmn1r74 T C 7: 11,581,510 (GRCm39) I270T probably benign Het
Vmn2r103 A T 17: 20,013,922 (GRCm39) E238V probably damaging Het
Vmn2r60 T A 7: 41,786,137 (GRCm39) F313L probably benign Het
Zfp710 T C 7: 79,731,752 (GRCm39) Y310H probably damaging Het
Other mutations in Or51a24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1303:Or51a24 UTSW 7 103,733,948 (GRCm39) missense probably damaging 1.00
R1556:Or51a24 UTSW 7 103,733,468 (GRCm39) missense probably benign
R2158:Or51a24 UTSW 7 103,734,033 (GRCm39) missense probably benign
R2987:Or51a24 UTSW 7 103,734,077 (GRCm39) missense probably benign 0.01
R4437:Or51a24 UTSW 7 103,734,128 (GRCm39) missense possibly damaging 0.88
R4773:Or51a24 UTSW 7 103,733,502 (GRCm39) missense probably damaging 1.00
R5285:Or51a24 UTSW 7 103,733,340 (GRCm39) makesense probably null
R5396:Or51a24 UTSW 7 103,734,098 (GRCm39) missense probably benign 0.08
R5516:Or51a24 UTSW 7 103,733,444 (GRCm39) missense possibly damaging 0.53
R5761:Or51a24 UTSW 7 103,733,376 (GRCm39) missense probably benign 0.01
R5793:Or51a24 UTSW 7 103,734,237 (GRCm39) missense probably benign 0.10
R5960:Or51a24 UTSW 7 103,733,560 (GRCm39) missense probably damaging 1.00
R6242:Or51a24 UTSW 7 103,733,771 (GRCm39) missense possibly damaging 0.82
R6676:Or51a24 UTSW 7 103,733,661 (GRCm39) missense probably benign 0.02
R6975:Or51a24 UTSW 7 103,734,002 (GRCm39) missense probably benign
R8202:Or51a24 UTSW 7 103,734,198 (GRCm39) missense probably benign 0.20
R9402:Or51a24 UTSW 7 103,733,610 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCAACACGATGGACAACCCATAGTG -3'
(R):5'- GATCAATGCCTCTCAGGTTCCCAG -3'

Sequencing Primer
(F):5'- TGGCTATTGAGGGAAACATCAG -3'
(R):5'- TCTTACAGGCTTTCCAGGAATG -3'
Posted On 2014-03-28