Incidental Mutation 'R2869:Or6c211'
ID 253457
Institutional Source Beutler Lab
Gene Symbol Or6c211
Ensembl Gene ENSMUSG00000058513
Gene Name olfactory receptor family 6 subfamily C member 211
Synonyms Olfr801, GA_x6K02T2PULF-11349138-11348182, MOR110-10
MMRRC Submission 040457-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R2869 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129505430-129506386 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 129505628 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 253 (C253*)
Ref Sequence ENSEMBL: ENSMUSP00000149555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072063] [ENSMUST00000203424] [ENSMUST00000213294] [ENSMUST00000216067]
AlphaFold Q8VEU1
Predicted Effect probably null
Transcript: ENSMUST00000072063
AA Change: C253*
SMART Domains Protein: ENSMUSP00000071941
Gene: ENSMUSG00000058513
AA Change: C253*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.2e-51 PFAM
Pfam:7tm_1 39 288 8.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203321
Predicted Effect probably benign
Transcript: ENSMUST00000203424
SMART Domains Protein: ENSMUSP00000145011
Gene: ENSMUSG00000058513

DomainStartEndE-ValueType
Pfam:7tm_4 1 96 5.9e-18 PFAM
Pfam:7tm_1 2 96 1.3e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213294
AA Change: C253*
Predicted Effect probably null
Transcript: ENSMUST00000216067
AA Change: C253*
Meta Mutation Damage Score 0.9493 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.4%
  • 10x: 93.9%
  • 20x: 77.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Als2 A G 1: 59,250,296 (GRCm39) S483P probably damaging Het
Ccl27a C T 4: 41,769,640 (GRCm39) R73Q probably benign Het
Cd6 A G 19: 10,771,990 (GRCm39) I307T possibly damaging Het
Ch25h T A 19: 34,452,210 (GRCm39) H106L probably benign Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Eef2 GCCC GCCCC 10: 81,014,601 (GRCm39) probably null Het
Eif4enif1 C T 11: 3,192,586 (GRCm39) P805S probably damaging Het
Fan1 A G 7: 64,012,938 (GRCm39) I668T probably benign Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Het
Gbp11 C T 5: 105,478,866 (GRCm39) D191N probably benign Het
Ggt6 A T 11: 72,328,187 (GRCm39) N229I probably benign Het
Gria2 G A 3: 80,609,799 (GRCm39) T670I probably damaging Het
Gsdme A T 6: 50,185,157 (GRCm39) C432* probably null Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Kcnb1 A G 2: 166,947,855 (GRCm39) L331P probably damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Het
Krt13 A G 11: 100,008,475 (GRCm39) S421P unknown Het
Lactbl1 G A 4: 136,354,097 (GRCm39) C37Y probably damaging Het
Lzts2 C A 19: 45,012,534 (GRCm39) S321* probably null Het
Meikin T C 11: 54,264,333 (GRCm39) V103A possibly damaging Het
Mki67 G A 7: 135,309,878 (GRCm39) P191L probably benign Het
Mlxip A G 5: 123,590,730 (GRCm39) M878V probably benign Het
Mpp7 G A 18: 7,461,678 (GRCm39) P65L possibly damaging Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nbn T A 4: 15,963,810 (GRCm39) D70E probably damaging Het
Nomo1 C A 7: 45,696,361 (GRCm39) T293N probably damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Nwd2 A T 5: 63,957,671 (GRCm39) I334L probably benign Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or4k2 T C 14: 50,423,811 (GRCm39) T288A probably benign Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Otud4 T A 8: 80,387,702 (GRCm39) N300K possibly damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pes1 C A 11: 3,926,834 (GRCm39) T372K probably benign Het
Plcl1 A T 1: 55,736,309 (GRCm39) D550V probably benign Het
Ppp1r7 T A 1: 93,285,585 (GRCm39) probably null Het
Prdx4 A G X: 154,123,460 (GRCm39) V15A probably benign Het
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Psmd13 A T 7: 140,466,968 (GRCm39) T116S probably damaging Het
Pzp A T 6: 128,462,519 (GRCm39) probably null Het
Serinc2 A G 4: 130,159,005 (GRCm39) S29P probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Stx3 A T 19: 11,766,938 (GRCm39) V91D probably damaging Het
Tafa2 A T 10: 123,540,270 (GRCm39) H42L possibly damaging Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Tprg1 T C 16: 25,231,590 (GRCm39) W189R probably damaging Het
Trim32 A G 4: 65,532,694 (GRCm39) D417G probably damaging Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Ybx3 G A 6: 131,347,376 (GRCm39) A253V probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Other mutations in Or6c211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Or6c211 APN 10 129,505,756 (GRCm39) missense probably damaging 1.00
IGL02400:Or6c211 APN 10 129,505,752 (GRCm39) missense probably damaging 0.99
IGL02721:Or6c211 APN 10 129,505,992 (GRCm39) missense probably benign 0.08
IGL03107:Or6c211 APN 10 129,505,809 (GRCm39) missense probably benign 0.00
R0114:Or6c211 UTSW 10 129,505,467 (GRCm39) missense probably benign
R0140:Or6c211 UTSW 10 129,505,557 (GRCm39) missense probably damaging 1.00
R0652:Or6c211 UTSW 10 129,506,248 (GRCm39) missense probably benign 0.08
R1375:Or6c211 UTSW 10 129,506,241 (GRCm39) missense probably null 0.97
R1449:Or6c211 UTSW 10 129,506,238 (GRCm39) missense probably damaging 0.99
R2026:Or6c211 UTSW 10 129,506,334 (GRCm39) missense probably damaging 1.00
R2241:Or6c211 UTSW 10 129,505,764 (GRCm39) missense probably damaging 1.00
R2516:Or6c211 UTSW 10 129,506,155 (GRCm39) missense probably damaging 1.00
R2869:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2870:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R2873:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R6562:Or6c211 UTSW 10 129,506,008 (GRCm39) missense probably damaging 1.00
R8362:Or6c211 UTSW 10 129,506,100 (GRCm39) missense possibly damaging 0.88
R8503:Or6c211 UTSW 10 129,505,512 (GRCm39) missense probably damaging 0.99
R8867:Or6c211 UTSW 10 129,505,628 (GRCm39) nonsense probably null
R9251:Or6c211 UTSW 10 129,505,980 (GRCm39) missense possibly damaging 0.61
Z1177:Or6c211 UTSW 10 129,505,663 (GRCm39) missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- ACTGTTGTGAGAATACAGTCGGTG -3'
(R):5'- GACCACTTCCTGTGTGACAC -3'

Sequencing Primer
(F):5'- TGAGAATACAGTCGGTGAAGCAC -3'
(R):5'- GACACACATTTCATGGAATTGATGGC -3'
Posted On 2014-12-04