Mutagenetix > Incidental Mutations

Incidental Mutation 'R3836:Olfr191'

275666

Institutional Source

Beutler Lab

Gene Symbol

Olfr191

Ensembl Gene

ENSMUSG00000094539

Gene Name

olfactory receptor 191

Synonyms

GA_x54KRFPKG5P-55314632-55313703, MOR183-5P

MMRRC Submission

040891-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R3836 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

59082829-59089822 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 59086223 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 87 (S87P)

Ref Sequence

ENSEMBL: ENSMUSP00000150473 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078517] [ENSMUST00000205471] [ENSMUST00000215647]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000078517
AA Change: S87P

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000077604
Gene: ENSMUSG00000094539
AA Change: S87P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4e-47	PFAM
Pfam:7tm_1	41	290	6.2e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205471
AA Change: S87P

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215647
AA Change: S87P

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

100% (61/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700028I16Rik	A	G	10: 82,812,385		noncoding transcript	Het
Aasdh	A	G	5: 76,878,468	V903A	probably benign	Het
Ankrd6	T	A	4: 32,817,531	D271V	probably damaging	Het
Ano10	C	T	9: 122,263,763	V167M	possibly damaging	Het
Arhgef25	T	C	10: 127,189,736	T12A	probably benign	Het
AW551984	T	C	9: 39,597,908		probably benign	Het
Bub1	G	T	2: 127,814,886	P442Q	probably damaging	Het
Clstn1	A	G	4: 149,638,333	E476G	probably damaging	Het
Comp	A	G	8: 70,373,859	D28G	probably benign	Het
Crym	A	G	7: 120,201,216	V61A	probably benign	Het
Dock4	G	T	12: 40,794,624		probably null	Het
Dtna	A	T	18: 23,625,102	Q488L	probably damaging	Het
Ecel1	A	C	1: 87,150,656	L565R	probably damaging	Het
Extl2	T	C	3: 116,024,357	I106T	probably benign	Het
Fam13c	C	T	10: 70,542,648	S336L	probably damaging	Het
Fnbp4	A	G	2: 90,746,785	T154A	probably damaging	Het
Fsip2	T	C	2: 82,950,946	L32P	probably damaging	Het
Gldc	T	A	19: 30,118,675		probably benign	Het
Gm12695	T	G	4: 96,762,097	T171P	probably damaging	Het
Gm4868	A	C	5: 125,847,950		noncoding transcript	Het
Gpam	T	C	19: 55,080,458	N450S	probably benign	Het
Gstm5	T	C	3: 107,896,362	I37T	probably benign	Het
Hivep2	C	A	10: 14,128,969	T437K	probably benign	Het
Itga11	G	T	9: 62,769,283	V918L	probably benign	Het
Itgb2l	T	A	16: 96,426,167	M559L	probably benign	Het
Itih1	T	A	14: 30,935,828	N429Y	probably damaging	Het
Madd	A	T	2: 91,154,643		probably null	Het
Map3k11	A	G	19: 5,690,803	E186G	possibly damaging	Het
Mbl2	T	C	19: 30,239,514	F242S	probably damaging	Het
Mcph1	A	G	8: 18,622,659	T102A	possibly damaging	Het
Mid1ip1	T	C	X: 10,718,381	V51A	possibly damaging	Het
Mkln1	A	G	6: 31,468,336	D389G	probably damaging	Het
Mmrn1	G	A	6: 60,944,847	S96N	probably benign	Het
Myd88	A	G	9: 119,338,193		probably benign	Het
Nap1l1	T	A	10: 111,495,322		probably null	Het
Nprl3	C	T	11: 32,233,082	E502K	probably damaging	Het
Nudt5	T	A	2: 5,866,347		probably null	Het
Olfr1045	A	G	2: 86,198,662	V30A	probably benign	Het
Olfr691	G	A	7: 105,337,210	P169S	probably benign	Het
Olfr810	C	T	10: 129,791,170	V140M	probably benign	Het
Plaa	T	C	4: 94,586,922		probably null	Het
Ptk2b	A	G	14: 66,156,342	L894P	probably damaging	Het
Rab8b	A	G	9: 66,847,796	S183P	probably benign	Het
Reln	A	G	5: 21,911,014	Y2999H	probably damaging	Het
Rims4	A	G	2: 163,918,653	S11P	possibly damaging	Het
Scel	A	G	14: 103,592,386	K448R	possibly damaging	Het
Serpinb10	A	T	1: 107,536,086	T33S	probably benign	Het
Sgip1	A	G	4: 102,867,700		probably null	Het
Spata5	T	A	3: 37,433,643	Y428N	possibly damaging	Het
Sv2b	A	T	7: 75,157,428	M158K	probably damaging	Het
Tmem132d	A	T	5: 127,784,885	I724N	probably damaging	Het
Tnrc6c	A	G	11: 117,723,229	T738A	probably benign	Het
Tpbg	T	C	9: 85,843,114		probably benign	Het
Tubb2a	G	T	13: 34,075,311	N165K	probably benign	Het
Ubtfl1	A	T	9: 18,409,237	E20D	possibly damaging	Het
Usp14	A	G	18: 10,024,532		probably null	Het
Vmn2r25	C	A	6: 123,853,085	D36Y	probably damaging	Het
Wdhd1	A	G	14: 47,245,054	V946A	probably benign	Het
Wnk1	T	C	6: 119,950,043	E1265G	probably damaging	Het
Zmynd8	G	A	2: 165,858,099	T14I	probably benign	Het

Other mutations in Olfr191

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00951:Olfr191	APN	16	59086393	missense	possibly damaging	0.86
IGL01553:Olfr191	APN	16	59086322	missense	probably benign	0.35
R0233:Olfr191	UTSW	16	59085675	missense	probably benign	0.01
R0233:Olfr191	UTSW	16	59085675	missense	probably benign	0.01
R1367:Olfr191	UTSW	16	59086343	missense	probably benign	0.00
R1631:Olfr191	UTSW	16	59086045	missense	probably benign
R1660:Olfr191	UTSW	16	59086343	missense	probably benign	0.00
R2166:Olfr191	UTSW	16	59085586	missense	probably benign	0.07
R2167:Olfr191	UTSW	16	59085586	missense	probably benign	0.07
R2168:Olfr191	UTSW	16	59085586	missense	probably benign	0.07
R2191:Olfr191	UTSW	16	59085675	missense	probably benign	0.01
R4999:Olfr191	UTSW	16	59086402	missense	probably damaging	1.00
R5386:Olfr191	UTSW	16	59085890	missense	probably benign
R5589:Olfr191	UTSW	16	59085971	missense	probably benign	0.03
R5590:Olfr191	UTSW	16	59085997	missense	probably benign	0.06
R5609:Olfr191	UTSW	16	59086076	missense	possibly damaging	0.96
R5965:Olfr191	UTSW	16	59086303	missense	probably damaging	1.00
R5989:Olfr191	UTSW	16	59086334	missense	probably benign	0.00
R6049:Olfr191	UTSW	16	59086146	nonsense	probably null
R6058:Olfr191	UTSW	16	59085910	missense	probably damaging	0.99
R6058:Olfr191	UTSW	16	59086429	missense	probably benign
R6250:Olfr191	UTSW	16	59085832	missense	probably damaging	1.00
R6319:Olfr191	UTSW	16	59086021	missense	probably benign	0.08
R6473:Olfr191	UTSW	16	59086043	missense	probably benign	0.09
R6524:Olfr191	UTSW	16	59086277	missense	possibly damaging	0.76
R6748:Olfr191	UTSW	16	59085890	missense	probably benign
R6874:Olfr191	UTSW	16	59085949	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GCCTTCGTGAATTAAAGCATGAATG -3'
(R):5'- ATCTGCCCCAGTGGAAAATCC -3'

Sequencing Primer
(F):5'- GCATGAATGAATCCACCTAAAAAGG -3'
(R):5'- AGTGGAAAATCCCCCTGTTC -3'

Posted On

2015-04-06