Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02881:Myh15'

362802

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myh15

Ensembl Gene

ENSMUSG00000092009

Gene Name

myosin, heavy chain 15

Synonyms

EG667772

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.156) question?

Stock #

IGL02881

Quality Score

Status

Chromosome

Chromosomal Location

49057486-49199104 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 49117265 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 743 (D743A)

Ref Sequence

ENSEMBL: ENSMUSP00000127539 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168680]

AlphaFold

E9Q264

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168680
AA Change: D743A

PolyPhen 2 Score 0.513 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: D743A

Domain	Start	End	E-Value	Type
Pfam:Myosin_N	30	70	5.2e-12	PFAM
MYSc	76	770	N/A	SMART
Pfam:Myosin_tail_1	836	1915	9.5e-118	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700029H14Rik	C	A	8: 13,555,999		probably benign	Het
Aatf	A	G	11: 84,471,289		probably benign	Het
Asap3	A	T	4: 136,239,237	H542L	probably benign	Het
Cyp4v3	A	T	8: 45,308,716	L389H	probably damaging	Het
Dnah17	C	T	11: 118,042,118	E3605K	probably damaging	Het
Fry	C	T	5: 150,359,051	T347M	probably damaging	Het
Glul	C	A	1: 153,907,116	T191K	probably benign	Het
Gm6614	T	C	6: 141,972,243	R636G	probably benign	Het
Grsf1	A	T	5: 88,673,830	L125Q	probably damaging	Het
Hfm1	A	G	5: 106,874,252	I976T	probably damaging	Het
Itgb5	A	G	16: 33,919,905	T462A	probably benign	Het
Lmna	G	T	3: 88,502,926	R60S	possibly damaging	Het
Mrpl10	T	A	11: 97,047,073	V89D	probably damaging	Het
Muc5b	C	T	7: 141,857,712	T1465I	unknown	Het
Noxo1	C	A	17: 24,699,435	L190I	probably damaging	Het
Noxo1	T	A	17: 24,699,436	L190Q	probably damaging	Het
Nrn1	C	A	13: 36,730,106		probably null	Het
Olfr1025-ps1	A	G	2: 85,918,116	S64G	probably benign	Het
Olfr1098	A	G	2: 86,922,713	V273A	possibly damaging	Het
Olfr1226	T	A	2: 89,193,641	Y131F	probably damaging	Het
Olfr170	A	T	16: 19,606,300	Y123N	probably damaging	Het
Pfkfb4	A	G	9: 109,007,296	T131A	probably null	Het
Phf20l1	T	C	15: 66,594,980		probably null	Het
Pnliprp2	A	G	19: 58,771,446	D363G	probably benign	Het
Prpf6	C	T	2: 181,632,071	T336I	probably benign	Het
Rcc1	C	T	4: 132,337,756	R139H	probably benign	Het
Sae1	T	G	7: 16,359,118	K221N	probably damaging	Het
Slc45a1	T	C	4: 150,638,530	K299R	probably benign	Het
Smad2	C	A	18: 76,299,780		probably null	Het
Tmem117	T	C	15: 94,879,425	F152S	probably damaging	Het
Tmem232	C	T	17: 65,450,370	C276Y	probably damaging	Het
Tor1b	A	T	2: 30,953,853	K47*	probably null	Het
Ttn	A	G	2: 76,909,803	V3464A	probably benign	Het
Ube3b	A	G	5: 114,412,884	T870A	possibly damaging	Het
Zscan25	T	G	5: 145,290,486	L320R	probably benign	Het

Other mutations in Myh15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00943:Myh15	APN	16	49,165,813 (GRCm38)	missense	probably damaging	0.98
IGL01095:Myh15	APN	16	49,132,015 (GRCm38)	missense	probably damaging	1.00
IGL01343:Myh15	APN	16	49,155,677 (GRCm38)	missense	probably benign	0.09
IGL01474:Myh15	APN	16	49,132,098 (GRCm38)	missense	probably damaging	1.00
IGL01572:Myh15	APN	16	49,100,222 (GRCm38)	missense	possibly damaging	0.55
IGL01595:Myh15	APN	16	49,172,949 (GRCm38)	missense	probably damaging	1.00
IGL01632:Myh15	APN	16	49,061,511 (GRCm38)	missense	probably benign	0.00
IGL01638:Myh15	APN	16	49,069,480 (GRCm38)	missense	probably damaging	1.00
IGL01667:Myh15	APN	16	49,195,579 (GRCm38)	missense	probably benign	0.20
IGL01715:Myh15	APN	16	49,057,484 (GRCm38)	unclassified	probably benign
IGL01833:Myh15	APN	16	49,114,058 (GRCm38)	missense	probably damaging	1.00
IGL02004:Myh15	APN	16	49,110,529 (GRCm38)	splice site	probably benign
IGL02033:Myh15	APN	16	49,145,344 (GRCm38)	missense	probably benign	0.05
IGL02148:Myh15	APN	16	49,116,315 (GRCm38)	missense	probably damaging	1.00
IGL02225:Myh15	APN	16	49,091,163 (GRCm38)	missense	probably benign	0.14
IGL02249:Myh15	APN	16	49,110,484 (GRCm38)	missense	probably damaging	0.99
IGL02505:Myh15	APN	16	49,117,263 (GRCm38)	missense	possibly damaging	0.90
IGL02622:Myh15	APN	16	49,176,954 (GRCm38)	missense	probably benign	0.02
IGL02814:Myh15	APN	16	49,145,438 (GRCm38)	splice site	probably benign
IGL02869:Myh15	APN	16	49,145,404 (GRCm38)	missense	probably benign
IGL02879:Myh15	APN	16	49,173,059 (GRCm38)	missense	possibly damaging	0.68
IGL03077:Myh15	APN	16	49,096,538 (GRCm38)	missense	probably benign	0.10
IGL03354:Myh15	APN	16	49,172,010 (GRCm38)	missense	probably benign	0.01
IGL03411:Myh15	APN	16	49,159,967 (GRCm38)	missense	possibly damaging	0.58
ANU74:Myh15	UTSW	16	49,172,932 (GRCm38)	missense	possibly damaging	0.58
P0027:Myh15	UTSW	16	49,081,208 (GRCm38)	missense	possibly damaging	0.77
PIT1430001:Myh15	UTSW	16	49,196,891 (GRCm38)	critical splice donor site	probably null
R0017:Myh15	UTSW	16	49,163,060 (GRCm38)	missense	probably damaging	0.97
R0038:Myh15	UTSW	16	49,071,141 (GRCm38)	splice site	probably benign
R0149:Myh15	UTSW	16	49,114,005 (GRCm38)	missense	probably benign	0.01
R0361:Myh15	UTSW	16	49,114,005 (GRCm38)	missense	probably benign	0.01
R0373:Myh15	UTSW	16	49,182,959 (GRCm38)	missense	possibly damaging	0.86
R0433:Myh15	UTSW	16	49,145,236 (GRCm38)	missense	probably damaging	1.00
R0525:Myh15	UTSW	16	49,132,051 (GRCm38)	missense	probably benign	0.03
R0586:Myh15	UTSW	16	49,171,887 (GRCm38)	splice site	probably benign
R0601:Myh15	UTSW	16	49,061,581 (GRCm38)	missense	probably damaging	1.00
R0717:Myh15	UTSW	16	49,142,993 (GRCm38)	missense	probably benign	0.03
R0963:Myh15	UTSW	16	49,132,149 (GRCm38)	missense	probably damaging	0.97
R1075:Myh15	UTSW	16	49,120,054 (GRCm38)	missense	possibly damaging	0.63
R1143:Myh15	UTSW	16	49,065,086 (GRCm38)	missense	probably benign	0.02
R1200:Myh15	UTSW	16	49,096,519 (GRCm38)	missense	probably damaging	1.00
R1644:Myh15	UTSW	16	49,132,203 (GRCm38)	missense	probably benign	0.12
R1646:Myh15	UTSW	16	49,195,568 (GRCm38)	missense	probably damaging	1.00
R1720:Myh15	UTSW	16	49,092,782 (GRCm38)	missense	probably damaging	1.00
R1768:Myh15	UTSW	16	49,163,135 (GRCm38)	missense	probably benign	0.27
R1881:Myh15	UTSW	16	49,071,083 (GRCm38)	missense	probably damaging	0.98
R2048:Myh15	UTSW	16	49,155,565 (GRCm38)	missense	probably damaging	0.99
R2064:Myh15	UTSW	16	49,155,621 (GRCm38)	missense	possibly damaging	0.50
R2184:Myh15	UTSW	16	49,137,511 (GRCm38)	missense	probably damaging	0.99
R2212:Myh15	UTSW	16	49,138,732 (GRCm38)	missense	probably benign	0.02
R2216:Myh15	UTSW	16	49,165,838 (GRCm38)	nonsense	probably null
R2321:Myh15	UTSW	16	49,113,073 (GRCm38)	missense	possibly damaging	0.93
R2327:Myh15	UTSW	16	49,142,950 (GRCm38)	missense	probably benign	0.01
R2395:Myh15	UTSW	16	49,069,514 (GRCm38)	missense	probably benign	0.04
R2399:Myh15	UTSW	16	49,137,589 (GRCm38)	missense	probably damaging	0.97
R3413:Myh15	UTSW	16	49,138,732 (GRCm38)	missense	probably benign	0.02
R4234:Myh15	UTSW	16	49,163,042 (GRCm38)	missense	probably benign	0.04
R4382:Myh15	UTSW	16	49,142,943 (GRCm38)	missense	probably benign	0.03
R4421:Myh15	UTSW	16	49,109,344 (GRCm38)	missense	probably damaging	0.99
R4580:Myh15	UTSW	16	49,065,025 (GRCm38)	missense	possibly damaging	0.93
R4657:Myh15	UTSW	16	49,172,058 (GRCm38)	nonsense	probably null
R4780:Myh15	UTSW	16	49,120,057 (GRCm38)	missense	probably benign	0.13
R5004:Myh15	UTSW	16	49,132,048 (GRCm38)	missense	probably damaging	0.99
R5175:Myh15	UTSW	16	49,069,426 (GRCm38)	missense	possibly damaging	0.85
R5189:Myh15	UTSW	16	49,101,507 (GRCm38)	missense	probably benign	0.20
R5311:Myh15	UTSW	16	49,165,841 (GRCm38)	missense	possibly damaging	0.94
R5318:Myh15	UTSW	16	49,110,471 (GRCm38)	missense	probably damaging	0.99
R5404:Myh15	UTSW	16	49,159,978 (GRCm38)	missense	probably benign	0.15
R5415:Myh15	UTSW	16	49,117,295 (GRCm38)	missense	probably null	1.00
R5558:Myh15	UTSW	16	49,069,537 (GRCm38)	missense	probably benign	0.32
R5977:Myh15	UTSW	16	49,153,503 (GRCm38)	missense	probably damaging	1.00
R6004:Myh15	UTSW	16	49,159,699 (GRCm38)	missense	probably benign	0.00
R6275:Myh15	UTSW	16	49,145,247 (GRCm38)	missense	probably benign	0.00
R6381:Myh15	UTSW	16	49,101,481 (GRCm38)	missense	probably damaging	1.00
R6448:Myh15	UTSW	16	49,171,932 (GRCm38)	missense	probably damaging	0.99
R6516:Myh15	UTSW	16	49,137,633 (GRCm38)	missense	probably benign	0.19
R6752:Myh15	UTSW	16	49,182,927 (GRCm38)	missense	probably damaging	1.00
R6847:Myh15	UTSW	16	49,145,088 (GRCm38)	missense	possibly damaging	0.70
R6868:Myh15	UTSW	16	49,069,403 (GRCm38)	missense	probably damaging	1.00
R6889:Myh15	UTSW	16	49,153,111 (GRCm38)	missense	possibly damaging	0.75
R6896:Myh15	UTSW	16	49,113,071 (GRCm38)	missense	probably benign	0.44
R6955:Myh15	UTSW	16	49,081,235 (GRCm38)	critical splice donor site	probably null
R6984:Myh15	UTSW	16	49,110,412 (GRCm38)	missense	probably damaging	1.00
R7046:Myh15	UTSW	16	49,109,299 (GRCm38)	nonsense	probably null
R7095:Myh15	UTSW	16	49,171,909 (GRCm38)	missense	possibly damaging	0.90
R7098:Myh15	UTSW	16	49,177,057 (GRCm38)	missense	possibly damaging	0.53
R7134:Myh15	UTSW	16	49,081,342 (GRCm38)	missense	possibly damaging	0.86
R7159:Myh15	UTSW	16	49,061,574 (GRCm38)	missense	probably damaging	0.97
R7244:Myh15	UTSW	16	49,196,786 (GRCm38)	missense	probably damaging	1.00
R7278:Myh15	UTSW	16	49,091,105 (GRCm38)	missense	probably damaging	0.98
R7309:Myh15	UTSW	16	49,096,465 (GRCm38)	missense	probably benign	0.34
R7327:Myh15	UTSW	16	49,173,006 (GRCm38)	missense	possibly damaging	0.88
R7418:Myh15	UTSW	16	49,155,537 (GRCm38)	missense	possibly damaging	0.69
R7937:Myh15	UTSW	16	49,155,646 (GRCm38)	missense	probably benign	0.00
R8053:Myh15	UTSW	16	49,142,939 (GRCm38)	missense	possibly damaging	0.89
R8313:Myh15	UTSW	16	49,120,018 (GRCm38)	missense	probably damaging	0.99
R8315:Myh15	UTSW	16	49,120,018 (GRCm38)	missense	probably damaging	0.99
R8316:Myh15	UTSW	16	49,120,018 (GRCm38)	missense	probably damaging	0.99
R8317:Myh15	UTSW	16	49,120,018 (GRCm38)	missense	probably damaging	0.99
R8342:Myh15	UTSW	16	49,092,757 (GRCm38)	missense	probably benign
R8379:Myh15	UTSW	16	49,081,188 (GRCm38)	missense	probably benign
R8445:Myh15	UTSW	16	49,120,018 (GRCm38)	missense	probably damaging	0.99
R8707:Myh15	UTSW	16	49,153,087 (GRCm38)	missense	probably damaging	1.00
R8729:Myh15	UTSW	16	49,061,488 (GRCm38)	missense	probably damaging	0.97
R8773:Myh15	UTSW	16	49,195,537 (GRCm38)	missense	possibly damaging	0.89
R8869:Myh15	UTSW	16	49,177,003 (GRCm38)	missense	probably benign
R8890:Myh15	UTSW	16	49,138,767 (GRCm38)	missense	probably damaging	1.00
R9026:Myh15	UTSW	16	49,187,070 (GRCm38)	missense	probably damaging	1.00
R9063:Myh15	UTSW	16	49,092,755 (GRCm38)	missense	probably benign	0.00
R9290:Myh15	UTSW	16	49,177,012 (GRCm38)	missense	probably damaging	1.00
R9630:Myh15	UTSW	16	49,159,978 (GRCm38)	missense	probably benign	0.15
R9710:Myh15	UTSW	16	49,138,681 (GRCm38)	missense	probably damaging	1.00
X0012:Myh15	UTSW	16	49,142,978 (GRCm38)	missense	probably damaging	1.00
X0020:Myh15	UTSW	16	49,165,874 (GRCm38)	missense	probably damaging	1.00
Z1176:Myh15	UTSW	16	49,096,531 (GRCm38)	missense	probably damaging	0.98
Z1177:Myh15	UTSW	16	49,159,826 (GRCm38)	missense	probably benign	0.09
Z1177:Myh15	UTSW	16	49,155,618 (GRCm38)	missense	probably damaging	0.97
Z1177:Myh15	UTSW	16	49,081,228 (GRCm38)	missense	probably benign	0.02

Posted On

2015-12-18