Incidental Mutation 'R5057:Nrxn3'
| ID |
390971 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrxn3
|
| Ensembl Gene |
ENSMUSG00000066392 |
| Gene Name |
neurexin III |
| Synonyms |
4933401A11Rik, D12Bwg0831e, neurexin III alpha, neurexin III alpha, neurexin III beta, neurexin III beta, 9330112C09Rik |
| MMRRC Submission |
042647-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5057 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
88689646-90301709 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 89221804 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 528
(I528F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129678
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057634]
[ENSMUST00000163134]
[ENSMUST00000167103]
[ENSMUST00000167887]
[ENSMUST00000190626]
|
| AlphaFold |
Q6P9K9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000057634
AA Change: I155F
PolyPhen 2
Score 0.898 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000050075
Gene: ENSMUSG00000066392
AA Change: I155F
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
3.28e-41 |
SMART |
|
EGF
|
273 |
307 |
4.1e-2 |
SMART |
|
LamG
|
332 |
470 |
4.87e-26 |
SMART |
|
LamG
|
518 |
654 |
7.08e-37 |
SMART |
|
EGF
|
688 |
722 |
1.99e1 |
SMART |
|
LamG
|
750 |
907 |
1.14e-17 |
SMART |
|
low complexity region
|
948 |
964 |
N/A |
INTRINSIC |
|
low complexity region
|
1028 |
1043 |
N/A |
INTRINSIC |
|
4.1m
|
1046 |
1064 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163134
AA Change: I528F
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129678
Gene: ENSMUSG00000066392
AA Change: I528F
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
47 |
184 |
9.8e-31 |
SMART |
|
EGF
|
201 |
235 |
8.07e-1 |
SMART |
|
LamG
|
279 |
413 |
7.19e-38 |
SMART |
|
LamG
|
467 |
619 |
3.28e-41 |
SMART |
|
EGF
|
646 |
680 |
4.1e-2 |
SMART |
|
LamG
|
705 |
843 |
4.87e-26 |
SMART |
|
LamG
|
891 |
1027 |
7.08e-37 |
SMART |
|
EGF
|
1052 |
1086 |
1.99e1 |
SMART |
|
LamG
|
1114 |
1271 |
1.14e-17 |
SMART |
|
low complexity region
|
1312 |
1328 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1406 |
N/A |
INTRINSIC |
|
low complexity region
|
1499 |
1514 |
N/A |
INTRINSIC |
|
4.1m
|
1517 |
1535 |
4.38e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167103
AA Change: I528F
PolyPhen 2
Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000127407
Gene: ENSMUSG00000066392
AA Change: I528F
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
47 |
184 |
9.8e-31 |
SMART |
|
EGF
|
201 |
235 |
8.07e-1 |
SMART |
|
LamG
|
279 |
413 |
7.19e-38 |
SMART |
|
LamG
|
467 |
619 |
3.28e-41 |
SMART |
|
EGF
|
646 |
680 |
4.1e-2 |
SMART |
|
LamG
|
705 |
834 |
5.76e-28 |
SMART |
|
LamG
|
882 |
1018 |
7.08e-37 |
SMART |
|
EGF
|
1043 |
1077 |
1.99e1 |
SMART |
|
LamG
|
1105 |
1262 |
1.14e-17 |
SMART |
|
low complexity region
|
1303 |
1319 |
N/A |
INTRINSIC |
|
low complexity region
|
1354 |
1382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167734
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167887
AA Change: I155F
PolyPhen 2
Score 0.898 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000127926
Gene: ENSMUSG00000066392
AA Change: I155F
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
3.28e-41 |
SMART |
|
EGF
|
273 |
307 |
4.1e-2 |
SMART |
|
LamG
|
332 |
470 |
4.87e-26 |
SMART |
|
LamG
|
518 |
654 |
7.08e-37 |
SMART |
|
EGF
|
688 |
722 |
1.99e1 |
SMART |
|
LamG
|
750 |
907 |
1.14e-17 |
SMART |
|
low complexity region
|
948 |
964 |
N/A |
INTRINSIC |
|
low complexity region
|
1028 |
1043 |
N/A |
INTRINSIC |
|
4.1m
|
1046 |
1064 |
4.38e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190626
AA Change: I155F
PolyPhen 2
Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000139879
Gene: ENSMUSG00000066392
AA Change: I155F
| Domain | Start | End | E-Value | Type |
|---|
|
LamG
|
94 |
246 |
2.1e-43 |
SMART |
|
EGF
|
273 |
307 |
2e-4 |
SMART |
|
LamG
|
332 |
470 |
3.1e-28 |
SMART |
|
LamG
|
518 |
654 |
4.4e-39 |
SMART |
|
EGF
|
688 |
722 |
9.6e-2 |
SMART |
|
LamG
|
750 |
877 |
1.1e-22 |
SMART |
|
low complexity region
|
918 |
934 |
N/A |
INTRINSIC |
|
low complexity region
|
972 |
1000 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194420
|
| Meta Mutation Damage Score |
0.2141 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.0%
|
| Validation Efficiency |
97% (118/122) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]
PHENOTYPE: Twenty percent of mice homozygous for a knock-out allele die postnatally prior to 20 days of age. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 120 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427D14Rik |
A |
T |
11: 72,057,581 (GRCm39) |
H739Q |
probably benign |
Het |
| Acad12 |
T |
A |
5: 121,748,152 (GRCm39) |
T89S |
probably benign |
Het |
| Adgb |
A |
G |
10: 10,233,722 (GRCm39) |
C1252R |
probably benign |
Het |
| Ankef1 |
A |
G |
2: 136,392,280 (GRCm39) |
|
probably null |
Het |
| Ankfy1 |
T |
C |
11: 72,650,745 (GRCm39) |
L976P |
probably damaging |
Het |
| Ankib1 |
T |
A |
5: 3,784,011 (GRCm39) |
I322F |
possibly damaging |
Het |
| Ankrd61 |
T |
A |
5: 143,831,613 (GRCm39) |
T64S |
probably benign |
Het |
| Anxa6 |
T |
G |
11: 54,892,062 (GRCm39) |
E298A |
possibly damaging |
Het |
| Apc2 |
A |
G |
10: 80,144,903 (GRCm39) |
S605G |
probably damaging |
Het |
| Arih1 |
T |
C |
9: 59,393,515 (GRCm39) |
N39S |
unknown |
Het |
| Bicc1 |
A |
G |
10: 70,783,713 (GRCm39) |
S393P |
possibly damaging |
Het |
| Bptf |
A |
T |
11: 106,973,354 (GRCm39) |
F693L |
probably damaging |
Het |
| Cacng4 |
A |
G |
11: 107,685,197 (GRCm39) |
Y32H |
probably damaging |
Het |
| Ccdc50 |
T |
A |
16: 27,257,092 (GRCm39) |
D252E |
probably benign |
Het |
| Ccdc92b |
C |
A |
11: 74,528,976 (GRCm39) |
T160K |
probably damaging |
Het |
| Cd163 |
C |
T |
6: 124,302,247 (GRCm39) |
T937I |
probably damaging |
Het |
| Cdh22 |
C |
A |
2: 164,958,063 (GRCm39) |
V635F |
probably damaging |
Het |
| Cenpe |
G |
T |
3: 134,926,074 (GRCm39) |
A243S |
probably benign |
Het |
| Cep295 |
A |
T |
9: 15,233,979 (GRCm39) |
H2272Q |
probably benign |
Het |
| Cgnl1 |
A |
T |
9: 71,632,076 (GRCm39) |
V425D |
probably damaging |
Het |
| Clec4b2 |
A |
T |
6: 123,177,915 (GRCm39) |
S77C |
probably null |
Het |
| Cntnap5a |
C |
T |
1: 115,612,943 (GRCm39) |
T26I |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,743,852 (GRCm39) |
K165R |
possibly damaging |
Het |
| Copb1 |
A |
T |
7: 113,825,997 (GRCm39) |
N662K |
probably benign |
Het |
| Crybg1 |
T |
A |
10: 43,865,104 (GRCm39) |
R1458* |
probably null |
Het |
| Cspp1 |
T |
A |
1: 10,145,186 (GRCm39) |
|
probably benign |
Het |
| Dhtkd1 |
A |
G |
2: 5,924,324 (GRCm39) |
C430R |
probably damaging |
Het |
| Dlg5 |
T |
C |
14: 24,186,690 (GRCm39) |
E1847G |
probably damaging |
Het |
| Dync2i1 |
A |
T |
12: 116,177,033 (GRCm39) |
N856K |
probably benign |
Het |
| Eif1ad16 |
A |
T |
12: 87,985,481 (GRCm39) |
S21T |
unknown |
Het |
| Ephb3 |
A |
G |
16: 21,039,197 (GRCm39) |
D351G |
probably damaging |
Het |
| Exd2 |
T |
A |
12: 80,543,564 (GRCm39) |
N582K |
probably damaging |
Het |
| Fam161a |
T |
A |
11: 22,970,397 (GRCm39) |
C192S |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,308,615 (GRCm39) |
V149A |
probably benign |
Het |
| Fbxw16 |
A |
G |
9: 109,270,232 (GRCm39) |
S170P |
probably damaging |
Het |
| Fndc1 |
T |
A |
17: 7,990,802 (GRCm39) |
R965* |
probably null |
Het |
| Frem2 |
T |
C |
3: 53,442,617 (GRCm39) |
D2640G |
probably benign |
Het |
| Gfm1 |
T |
C |
3: 67,380,877 (GRCm39) |
V664A |
probably damaging |
Het |
| Gm10803 |
A |
C |
2: 93,394,517 (GRCm39) |
L96F |
probably damaging |
Het |
| Gm14569 |
T |
C |
X: 35,694,470 (GRCm39) |
D1413G |
probably benign |
Het |
| Gm44501 |
A |
G |
17: 40,889,563 (GRCm39) |
T26A |
probably benign |
Het |
| Gpc4 |
G |
A |
X: 51,163,440 (GRCm39) |
R148C |
probably damaging |
Het |
| Gpsm1 |
G |
A |
2: 26,215,369 (GRCm39) |
R277Q |
probably damaging |
Het |
| Inmt |
T |
A |
6: 55,151,883 (GRCm39) |
H29L |
probably benign |
Het |
| Insrr |
T |
A |
3: 87,722,572 (GRCm39) |
C1265S |
probably benign |
Het |
| Kctd12 |
A |
G |
14: 103,219,045 (GRCm39) |
F278L |
possibly damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lag3 |
T |
A |
6: 124,882,318 (GRCm39) |
I393F |
possibly damaging |
Het |
| Lama2 |
C |
T |
10: 27,040,982 (GRCm39) |
C1447Y |
probably damaging |
Het |
| Lama3 |
G |
A |
18: 12,665,005 (GRCm39) |
G2275S |
probably null |
Het |
| Lrrc17 |
A |
T |
5: 21,780,307 (GRCm39) |
H427L |
probably benign |
Het |
| Med13l |
T |
A |
5: 118,856,558 (GRCm39) |
S164T |
probably damaging |
Het |
| Milr1 |
A |
G |
11: 106,657,791 (GRCm39) |
D131G |
possibly damaging |
Het |
| Myo5c |
A |
T |
9: 75,208,155 (GRCm39) |
T1630S |
probably damaging |
Het |
| Nbeal2 |
A |
T |
9: 110,460,073 (GRCm39) |
N1848K |
probably damaging |
Het |
| Ncor2 |
A |
T |
5: 125,125,130 (GRCm39) |
V307E |
possibly damaging |
Het |
| Ndufs3 |
C |
A |
2: 90,729,004 (GRCm39) |
A161S |
probably benign |
Het |
| Neo1 |
T |
C |
9: 58,897,554 (GRCm39) |
D134G |
probably damaging |
Het |
| Nexmif |
A |
T |
X: 103,130,956 (GRCm39) |
N320K |
probably damaging |
Het |
| Nipal3 |
T |
A |
4: 135,194,167 (GRCm39) |
I289F |
probably damaging |
Het |
| Nrg4 |
A |
G |
9: 55,189,880 (GRCm39) |
|
probably benign |
Het |
| Or11h23 |
A |
C |
14: 50,948,669 (GRCm39) |
N294T |
probably damaging |
Het |
| Or3a10 |
T |
A |
11: 73,935,881 (GRCm39) |
D73V |
probably damaging |
Het |
| Pate2 |
T |
C |
9: 35,597,407 (GRCm39) |
|
probably benign |
Het |
| Pcnx2 |
T |
C |
8: 126,581,930 (GRCm39) |
I935M |
possibly damaging |
Het |
| Pik3c2a |
G |
T |
7: 115,975,518 (GRCm39) |
T683K |
possibly damaging |
Het |
| Pip5k1c |
G |
A |
10: 81,146,723 (GRCm39) |
|
probably null |
Het |
| Pkd1l2 |
G |
A |
8: 117,781,747 (GRCm39) |
T766I |
probably benign |
Het |
| Polr3c |
C |
A |
3: 96,619,373 (GRCm39) |
L508F |
probably damaging |
Het |
| Por |
A |
G |
5: 135,759,756 (GRCm39) |
D189G |
probably damaging |
Het |
| Potefam1 |
A |
T |
2: 111,055,766 (GRCm39) |
F207I |
probably benign |
Het |
| Prim2 |
A |
T |
1: 33,669,441 (GRCm39) |
L178* |
probably null |
Het |
| Prima1 |
C |
A |
12: 103,168,864 (GRCm39) |
|
probably null |
Het |
| Ptpn21 |
G |
A |
12: 98,645,666 (GRCm39) |
R1091C |
probably damaging |
Het |
| Ptpn23 |
G |
A |
9: 110,217,624 (GRCm39) |
T744I |
probably benign |
Het |
| Rad21 |
A |
T |
15: 51,830,102 (GRCm39) |
I503K |
probably benign |
Het |
| Rbm12 |
A |
T |
2: 155,938,806 (GRCm39) |
C489S |
probably benign |
Het |
| Rpl10a |
A |
T |
17: 28,549,607 (GRCm39) |
H140L |
probably benign |
Het |
| Rpl7-ps8 |
A |
T |
15: 59,083,004 (GRCm39) |
|
noncoding transcript |
Het |
| Rtbdn |
T |
C |
8: 85,681,638 (GRCm39) |
F143S |
probably damaging |
Het |
| Scamp3 |
T |
A |
3: 89,089,600 (GRCm39) |
|
probably benign |
Het |
| Setd5 |
A |
G |
6: 113,114,922 (GRCm39) |
S848G |
probably damaging |
Het |
| Sez6 |
T |
C |
11: 77,863,979 (GRCm39) |
V487A |
probably damaging |
Het |
| Shc2 |
G |
A |
10: 79,459,706 (GRCm39) |
P413S |
probably benign |
Het |
| Sipa1l3 |
T |
C |
7: 29,070,618 (GRCm39) |
N966S |
probably damaging |
Het |
| Slc39a8 |
A |
G |
3: 135,554,790 (GRCm39) |
E78G |
probably benign |
Het |
| Slc8a3 |
A |
G |
12: 81,246,332 (GRCm39) |
V900A |
probably damaging |
Het |
| Slitrk3 |
T |
C |
3: 72,957,981 (GRCm39) |
T264A |
probably benign |
Het |
| Spire2 |
G |
A |
8: 124,084,940 (GRCm39) |
R260H |
probably damaging |
Het |
| Stk39 |
T |
A |
2: 68,051,292 (GRCm39) |
I518F |
probably damaging |
Het |
| Tardbp |
T |
A |
4: 148,703,813 (GRCm39) |
|
probably null |
Het |
| Tep1 |
A |
G |
14: 51,066,456 (GRCm39) |
Y2335H |
probably benign |
Het |
| Tesl1 |
G |
A |
X: 23,773,480 (GRCm39) |
G327E |
probably damaging |
Het |
| Tll2 |
A |
G |
19: 41,105,705 (GRCm39) |
V358A |
probably benign |
Het |
| Tmem268 |
C |
G |
4: 63,486,777 (GRCm39) |
S100C |
probably damaging |
Het |
| Tnfsf9 |
A |
G |
17: 57,412,444 (GRCm39) |
T5A |
probably benign |
Het |
| Trappc10 |
G |
T |
10: 78,052,994 (GRCm39) |
F260L |
possibly damaging |
Het |
| Trim5 |
A |
G |
7: 103,914,630 (GRCm39) |
Y480H |
probably damaging |
Het |
| Trmt112 |
T |
C |
19: 6,888,121 (GRCm39) |
V91A |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,577,379 (GRCm39) |
K22759* |
probably null |
Het |
| Ttn |
C |
A |
2: 76,748,988 (GRCm39) |
L4020F |
probably benign |
Het |
| Ubash3b |
A |
G |
9: 40,948,755 (GRCm39) |
C187R |
possibly damaging |
Het |
| Ube3b |
T |
C |
5: 114,544,318 (GRCm39) |
F572L |
probably benign |
Het |
| Ubr5 |
A |
G |
15: 38,004,353 (GRCm39) |
V1332A |
probably damaging |
Het |
| Ubtd2 |
C |
A |
11: 32,466,320 (GRCm39) |
R180S |
probably damaging |
Het |
| Ubtf |
A |
G |
11: 102,197,913 (GRCm39) |
S673P |
probably damaging |
Het |
| Ubtfl1 |
A |
T |
9: 18,320,487 (GRCm39) |
D5V |
possibly damaging |
Het |
| Usp17la |
G |
A |
7: 104,510,330 (GRCm39) |
V312I |
possibly damaging |
Het |
| Usp17ld |
G |
T |
7: 102,899,655 (GRCm39) |
H426N |
probably benign |
Het |
| Usp34 |
A |
G |
11: 23,408,086 (GRCm39) |
|
probably benign |
Het |
| Vmn1r199 |
A |
T |
13: 22,567,575 (GRCm39) |
T290S |
possibly damaging |
Het |
| Vmn1r33 |
T |
C |
6: 66,589,089 (GRCm39) |
N155S |
probably benign |
Het |
| Vmn2r28 |
T |
A |
7: 5,489,463 (GRCm39) |
I459L |
probably benign |
Het |
| Vmn2r6 |
T |
A |
3: 64,445,207 (GRCm39) |
K839N |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,589,819 (GRCm39) |
I699T |
probably damaging |
Het |
| Vps16 |
A |
G |
2: 130,281,372 (GRCm39) |
S235G |
probably benign |
Het |
| Vwde |
T |
C |
6: 13,192,641 (GRCm39) |
I421V |
possibly damaging |
Het |
| Xiap |
T |
C |
X: 41,183,342 (GRCm39) |
F23L |
probably benign |
Het |
| Xkr7 |
A |
G |
2: 152,896,300 (GRCm39) |
T385A |
probably benign |
Het |
| Znfx1 |
T |
C |
2: 166,881,746 (GRCm39) |
Y217C |
probably damaging |
Het |
|
| Other mutations in Nrxn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00911:Nrxn3
|
APN |
12 |
90,171,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Nrxn3
|
APN |
12 |
90,171,320 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01073:Nrxn3
|
APN |
12 |
89,221,510 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01338:Nrxn3
|
APN |
12 |
89,221,804 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01377:Nrxn3
|
APN |
12 |
89,499,782 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01409:Nrxn3
|
APN |
12 |
89,477,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Nrxn3
|
APN |
12 |
90,171,524 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02063:Nrxn3
|
APN |
12 |
88,762,565 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02171:Nrxn3
|
APN |
12 |
89,159,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Nrxn3
|
APN |
12 |
89,943,175 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02340:Nrxn3
|
APN |
12 |
90,171,402 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02343:Nrxn3
|
APN |
12 |
88,762,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02600:Nrxn3
|
APN |
12 |
89,478,682 (GRCm39) |
splice site |
probably benign |
|
|
IGL02735:Nrxn3
|
APN |
12 |
89,221,624 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03061:Nrxn3
|
APN |
12 |
89,478,698 (GRCm39) |
nonsense |
probably null |
|
|
IGL03206:Nrxn3
|
APN |
12 |
89,227,278 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03337:Nrxn3
|
APN |
12 |
89,221,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Nrxn3
|
UTSW |
12 |
89,226,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Nrxn3
|
UTSW |
12 |
89,226,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0144:Nrxn3
|
UTSW |
12 |
89,315,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0334:Nrxn3
|
UTSW |
12 |
89,780,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Nrxn3
|
UTSW |
12 |
88,762,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Nrxn3
|
UTSW |
12 |
90,298,567 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1324:Nrxn3
|
UTSW |
12 |
89,221,466 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1438:Nrxn3
|
UTSW |
12 |
90,298,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1484:Nrxn3
|
UTSW |
12 |
89,221,547 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1621:Nrxn3
|
UTSW |
12 |
88,762,480 (GRCm39) |
missense |
probably benign |
|
|
R1637:Nrxn3
|
UTSW |
12 |
89,321,238 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1659:Nrxn3
|
UTSW |
12 |
90,299,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Nrxn3
|
UTSW |
12 |
89,221,789 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1801:Nrxn3
|
UTSW |
12 |
90,250,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1912:Nrxn3
|
UTSW |
12 |
88,762,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1940:Nrxn3
|
UTSW |
12 |
89,227,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Nrxn3
|
UTSW |
12 |
89,227,181 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R2002:Nrxn3
|
UTSW |
12 |
90,299,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Nrxn3
|
UTSW |
12 |
89,227,290 (GRCm39) |
splice site |
probably null |
|
|
R2179:Nrxn3
|
UTSW |
12 |
89,221,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2207:Nrxn3
|
UTSW |
12 |
89,315,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Nrxn3
|
UTSW |
12 |
89,477,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2433:Nrxn3
|
UTSW |
12 |
89,943,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2969:Nrxn3
|
UTSW |
12 |
89,321,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3053:Nrxn3
|
UTSW |
12 |
89,221,871 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3076:Nrxn3
|
UTSW |
12 |
89,227,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3078:Nrxn3
|
UTSW |
12 |
89,227,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nrxn3
|
UTSW |
12 |
89,499,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Nrxn3
|
UTSW |
12 |
89,499,762 (GRCm39) |
nonsense |
probably null |
|
|
R4321:Nrxn3
|
UTSW |
12 |
90,166,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4470:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4471:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Nrxn3
|
UTSW |
12 |
90,171,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Nrxn3
|
UTSW |
12 |
89,477,421 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4776:Nrxn3
|
UTSW |
12 |
90,298,730 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4821:Nrxn3
|
UTSW |
12 |
90,171,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4869:Nrxn3
|
UTSW |
12 |
88,762,352 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4910:Nrxn3
|
UTSW |
12 |
89,227,130 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4960:Nrxn3
|
UTSW |
12 |
88,761,971 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4990:Nrxn3
|
UTSW |
12 |
89,227,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4991:Nrxn3
|
UTSW |
12 |
89,227,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Nrxn3
|
UTSW |
12 |
89,780,354 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5888:Nrxn3
|
UTSW |
12 |
89,478,855 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6249:Nrxn3
|
UTSW |
12 |
89,221,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6264:Nrxn3
|
UTSW |
12 |
90,299,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6373:Nrxn3
|
UTSW |
12 |
89,943,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6401:Nrxn3
|
UTSW |
12 |
89,221,770 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6434:Nrxn3
|
UTSW |
12 |
88,762,285 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6528:Nrxn3
|
UTSW |
12 |
89,479,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6612:Nrxn3
|
UTSW |
12 |
89,780,102 (GRCm39) |
intron |
probably benign |
|
|
R6632:Nrxn3
|
UTSW |
12 |
89,159,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6874:Nrxn3
|
UTSW |
12 |
90,298,964 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7122:Nrxn3
|
UTSW |
12 |
89,477,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7328:Nrxn3
|
UTSW |
12 |
88,762,345 (GRCm39) |
missense |
probably benign |
|
|
R7352:Nrxn3
|
UTSW |
12 |
88,817,063 (GRCm39) |
missense |
probably benign |
|
|
R7425:Nrxn3
|
UTSW |
12 |
89,479,870 (GRCm39) |
nonsense |
probably null |
|
|
R7444:Nrxn3
|
UTSW |
12 |
89,477,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Nrxn3
|
UTSW |
12 |
89,477,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Nrxn3
|
UTSW |
12 |
89,478,832 (GRCm39) |
missense |
probably benign |
|
|
R7738:Nrxn3
|
UTSW |
12 |
88,817,074 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7765:Nrxn3
|
UTSW |
12 |
89,780,254 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8139:Nrxn3
|
UTSW |
12 |
90,171,438 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8192:Nrxn3
|
UTSW |
12 |
90,171,569 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8351:Nrxn3
|
UTSW |
12 |
89,477,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8368:Nrxn3
|
UTSW |
12 |
90,298,815 (GRCm39) |
nonsense |
probably null |
|
|
R8397:Nrxn3
|
UTSW |
12 |
90,298,583 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8426:Nrxn3
|
UTSW |
12 |
88,762,097 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8451:Nrxn3
|
UTSW |
12 |
89,477,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777:Nrxn3
|
UTSW |
12 |
89,227,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8777-TAIL:Nrxn3
|
UTSW |
12 |
89,227,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8844:Nrxn3
|
UTSW |
12 |
89,153,920 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8870:Nrxn3
|
UTSW |
12 |
90,171,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9043:Nrxn3
|
UTSW |
12 |
89,227,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9102:Nrxn3
|
UTSW |
12 |
90,298,924 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9167:Nrxn3
|
UTSW |
12 |
89,154,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9445:Nrxn3
|
UTSW |
12 |
89,499,737 (GRCm39) |
nonsense |
probably null |
|
|
R9447:Nrxn3
|
UTSW |
12 |
89,221,678 (GRCm39) |
missense |
probably benign |
0.35 |
|
X0019:Nrxn3
|
UTSW |
12 |
90,165,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nrxn3
|
UTSW |
12 |
89,484,679 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
Z1176:Nrxn3
|
UTSW |
12 |
89,153,825 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Nrxn3
|
UTSW |
12 |
90,298,619 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1177:Nrxn3
|
UTSW |
12 |
89,227,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nrxn3
|
UTSW |
12 |
88,762,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Nrxn3
|
UTSW |
12 |
90,298,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATCAGCTTGCCCAAGTGG -3'
(R):5'- GTGAGCATGCAAGTTAGTGTCATC -3'
Sequencing Primer
(F):5'- ACCAAACGTATGGGCTCCATTTC -3'
(R):5'- TGGTCTCAATGCTAAGCC -3'
|
| Posted On |
2016-06-06 |
Incidental Mutation