Incidental Mutation 'IGL03189:Suco'
ID 412599
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suco
Ensembl Gene ENSMUSG00000040297
Gene Name SUN domain containing ossification factor
Synonyms AI848100, osteopotentia, Opt
Accession Numbers
Essential gene? Possibly essential (E-score: 0.559) question?
Stock # IGL03189
Quality Score
Status
Chromosome 1
Chromosomal Location 161643683-161704251 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 161684906 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000048377]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000048377
SMART Domains Protein: ENSMUSP00000044815
Gene: ENSMUSG00000040297

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
low complexity region 32 41 N/A INTRINSIC
low complexity region 117 145 N/A INTRINSIC
low complexity region 208 224 N/A INTRINSIC
low complexity region 272 284 N/A INTRINSIC
Pfam:Sad1_UNC 325 455 9e-43 PFAM
low complexity region 665 683 N/A INTRINSIC
low complexity region 745 758 N/A INTRINSIC
coiled coil region 933 1009 N/A INTRINSIC
low complexity region 1014 1030 N/A INTRINSIC
low complexity region 1105 1119 N/A INTRINSIC
low complexity region 1163 1176 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191975
Predicted Effect probably benign
Transcript: ENSMUST00000192570
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,895,814 (GRCm39) T916A probably benign Het
Adam22 A T 5: 8,161,897 (GRCm39) Y50* probably null Het
Adprs T C 4: 126,211,087 (GRCm39) probably benign Het
Ahnak G A 19: 8,988,603 (GRCm39) V3296M possibly damaging Het
Bfar A G 16: 13,505,365 (GRCm39) D125G possibly damaging Het
Bmp3 A T 5: 99,020,579 (GRCm39) Q334L probably benign Het
Camsap2 A T 1: 136,209,400 (GRCm39) D697E probably damaging Het
Car11 A G 7: 45,351,879 (GRCm39) T103A probably damaging Het
Cecr2 T A 6: 120,739,391 (GRCm39) S1373T probably benign Het
Cenpm A G 15: 82,118,634 (GRCm39) V160A possibly damaging Het
Chl1 A T 6: 103,660,168 (GRCm39) I365F possibly damaging Het
Col20a1 C T 2: 180,651,200 (GRCm39) Q1089* probably null Het
Csf1r A T 18: 61,239,058 (GRCm39) T13S probably benign Het
Fam13a T C 6: 58,933,843 (GRCm39) E249G probably damaging Het
Fgd6 G A 10: 93,880,318 (GRCm39) V391I probably benign Het
Fhdc1 G A 3: 84,362,368 (GRCm39) probably benign Het
Fn3krp T C 11: 121,320,456 (GRCm39) I267T probably damaging Het
Fras1 A T 5: 96,890,930 (GRCm39) I2820F probably benign Het
Fyb2 A G 4: 104,872,939 (GRCm39) I771V probably damaging Het
Gata3os A G 2: 9,888,634 (GRCm39) probably benign Het
Glis1 A G 4: 107,472,248 (GRCm39) Y275C probably damaging Het
Hdgf A G 3: 87,820,735 (GRCm39) T62A possibly damaging Het
Hsd17b3 C T 13: 64,210,901 (GRCm39) probably null Het
Ift56 C T 6: 38,402,166 (GRCm39) P553S probably benign Het
Iqgap1 T A 7: 80,363,590 (GRCm39) Y1655F probably benign Het
Izumo1 A G 7: 45,274,588 (GRCm39) D181G probably damaging Het
Lrp2 T C 2: 69,268,822 (GRCm39) probably benign Het
Mark1 T C 1: 184,651,890 (GRCm39) N95S probably damaging Het
Mbd5 A G 2: 49,147,763 (GRCm39) K658E probably damaging Het
Mcm6 C T 1: 128,272,039 (GRCm39) D453N probably damaging Het
Mfsd14a T C 3: 116,435,504 (GRCm39) D187G probably benign Het
Mrpl19 G T 6: 81,938,974 (GRCm39) S276* probably null Het
Ncoa2 G A 1: 13,260,360 (GRCm39) T105M probably damaging Het
Nop14 A G 5: 34,807,972 (GRCm39) probably benign Het
Or2ah1 A G 2: 85,653,902 (GRCm39) T196A probably benign Het
Or2aj5 T C 16: 19,425,341 (GRCm39) T26A probably benign Het
Or5w19 G A 2: 87,698,559 (GRCm39) A75T possibly damaging Het
Otud7b G A 3: 96,062,795 (GRCm39) S678N probably benign Het
Pcdhb6 G A 18: 37,469,205 (GRCm39) V25M probably damaging Het
Prpf39 G T 12: 65,090,076 (GRCm39) G5* probably null Het
Serpinb9d T C 13: 33,386,895 (GRCm39) V321A probably damaging Het
Sh2b1 A G 7: 126,067,702 (GRCm39) S613P possibly damaging Het
Snx30 T C 4: 59,857,452 (GRCm39) I55T probably benign Het
Spata13 T C 14: 60,929,063 (GRCm39) I207T possibly damaging Het
Svs5 A G 2: 164,079,032 (GRCm39) S292P possibly damaging Het
Tcam1 A G 11: 106,176,212 (GRCm39) I313V probably benign Het
Tmem45a A T 16: 56,631,936 (GRCm39) Y227* probably null Het
Tnfsf15 A G 4: 63,648,289 (GRCm39) probably benign Het
Vmn2r4 C A 3: 64,296,589 (GRCm39) R732L possibly damaging Het
Wdr7 C T 18: 63,893,672 (GRCm39) T602I probably benign Het
Other mutations in Suco
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Suco APN 1 161,661,689 (GRCm39) missense probably damaging 1.00
IGL01688:Suco APN 1 161,691,480 (GRCm39) splice site probably null
IGL01794:Suco APN 1 161,655,294 (GRCm39) missense probably benign 0.01
IGL01891:Suco APN 1 161,666,371 (GRCm39) missense probably damaging 1.00
IGL02028:Suco APN 1 161,684,428 (GRCm39) missense possibly damaging 0.95
IGL02102:Suco APN 1 161,655,274 (GRCm39) missense probably damaging 1.00
IGL02351:Suco APN 1 161,646,195 (GRCm39) missense probably benign 0.35
IGL02358:Suco APN 1 161,646,195 (GRCm39) missense probably benign 0.35
IGL02392:Suco APN 1 161,662,136 (GRCm39) missense probably benign 0.11
IGL02638:Suco APN 1 161,655,256 (GRCm39) missense probably damaging 1.00
IGL02650:Suco APN 1 161,676,322 (GRCm39) splice site probably benign
IGL03106:Suco APN 1 161,662,049 (GRCm39) missense possibly damaging 0.91
IGL03328:Suco APN 1 161,647,990 (GRCm39) missense probably damaging 0.99
girth UTSW 1 161,655,809 (GRCm39) missense possibly damaging 0.86
pleasingly UTSW 1 161,661,977 (GRCm39) missense possibly damaging 0.65
3-1:Suco UTSW 1 161,649,600 (GRCm39) intron probably benign
H8562:Suco UTSW 1 161,680,420 (GRCm39) missense probably damaging 1.00
H8786:Suco UTSW 1 161,680,420 (GRCm39) missense probably damaging 1.00
R0023:Suco UTSW 1 161,673,154 (GRCm39) splice site probably null
R0023:Suco UTSW 1 161,673,154 (GRCm39) splice site probably null
R0179:Suco UTSW 1 161,703,874 (GRCm39) splice site probably benign
R0299:Suco UTSW 1 161,681,379 (GRCm39) missense probably benign
R0418:Suco UTSW 1 161,662,419 (GRCm39) missense probably benign 0.11
R0481:Suco UTSW 1 161,689,882 (GRCm39) unclassified probably benign
R0610:Suco UTSW 1 161,691,601 (GRCm39) splice site probably benign
R0610:Suco UTSW 1 161,687,072 (GRCm39) missense probably benign
R0634:Suco UTSW 1 161,666,373 (GRCm39) missense possibly damaging 0.77
R0645:Suco UTSW 1 161,661,683 (GRCm39) missense probably damaging 1.00
R1276:Suco UTSW 1 161,685,025 (GRCm39) missense probably benign 0.10
R1720:Suco UTSW 1 161,661,623 (GRCm39) missense probably damaging 1.00
R1739:Suco UTSW 1 161,655,224 (GRCm39) critical splice donor site probably null
R1763:Suco UTSW 1 161,662,518 (GRCm39) missense possibly damaging 0.80
R1835:Suco UTSW 1 161,687,069 (GRCm39) nonsense probably null
R1988:Suco UTSW 1 161,646,380 (GRCm39) critical splice acceptor site probably null
R2939:Suco UTSW 1 161,676,220 (GRCm39) missense probably damaging 1.00
R3773:Suco UTSW 1 161,671,565 (GRCm39) splice site probably null
R3882:Suco UTSW 1 161,662,313 (GRCm39) missense probably benign 0.33
R4193:Suco UTSW 1 161,691,528 (GRCm39) missense probably benign 0.32
R4367:Suco UTSW 1 161,674,799 (GRCm39) missense probably damaging 1.00
R4397:Suco UTSW 1 161,672,421 (GRCm39) missense probably damaging 1.00
R4846:Suco UTSW 1 161,661,977 (GRCm39) missense possibly damaging 0.65
R4851:Suco UTSW 1 161,661,761 (GRCm39) missense probably damaging 1.00
R5224:Suco UTSW 1 161,662,274 (GRCm39) missense probably benign 0.06
R5329:Suco UTSW 1 161,660,999 (GRCm39) missense probably damaging 0.99
R6133:Suco UTSW 1 161,662,752 (GRCm39) nonsense probably null
R6632:Suco UTSW 1 161,655,809 (GRCm39) missense possibly damaging 0.86
R6643:Suco UTSW 1 161,687,001 (GRCm39) missense possibly damaging 0.71
R7378:Suco UTSW 1 161,689,780 (GRCm39) missense possibly damaging 0.76
R7405:Suco UTSW 1 161,655,783 (GRCm39) missense possibly damaging 0.65
R7509:Suco UTSW 1 161,672,903 (GRCm39) missense probably damaging 1.00
R7838:Suco UTSW 1 161,656,890 (GRCm39) missense probably benign 0.07
R7867:Suco UTSW 1 161,665,365 (GRCm39) missense possibly damaging 0.77
R7895:Suco UTSW 1 161,672,937 (GRCm39) splice site probably null
R8440:Suco UTSW 1 161,679,907 (GRCm39) missense probably damaging 1.00
R8453:Suco UTSW 1 161,650,586 (GRCm39) intron probably benign
R8781:Suco UTSW 1 161,645,951 (GRCm39) missense probably damaging 1.00
R8798:Suco UTSW 1 161,648,004 (GRCm39) missense probably damaging 1.00
R9292:Suco UTSW 1 161,671,574 (GRCm39) missense probably damaging 1.00
R9310:Suco UTSW 1 161,684,427 (GRCm39) missense probably damaging 1.00
R9380:Suco UTSW 1 161,646,074 (GRCm39) missense possibly damaging 0.61
R9411:Suco UTSW 1 161,666,356 (GRCm39) missense probably damaging 0.99
R9542:Suco UTSW 1 161,661,668 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02