Incidental Mutation 'R5491:Or3a1d'
| ID |
432093 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or3a1d
|
| Ensembl Gene |
ENSMUSG00000054406 |
| Gene Name |
olfactory receptor family 3 subfamily A member 1D |
| Synonyms |
GA_x6K02T2P1NL-4481525-4480578, MOR255-3, Olfr411 |
| MMRRC Submission |
043052-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R5491 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
74237450-74238498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 74237740 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 103
(H103Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145878
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080365]
[ENSMUST00000141134]
[ENSMUST00000214769]
|
| AlphaFold |
Q7TRW8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080365
AA Change: H223Q
PolyPhen 2
Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000079235
Gene: ENSMUSG00000054406
AA Change: H223Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
34 |
311 |
7.1e-58 |
PFAM |
|
Pfam:7tm_1
|
44 |
293 |
8.5e-24 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141134
AA Change: H103Q
PolyPhen 2
Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214769
AA Change: H223Q
PolyPhen 2
Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
|
| Coding Region Coverage |
- 1x: 98.2%
- 3x: 97.2%
- 10x: 95.0%
- 20x: 89.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1cf |
G |
T |
19: 31,895,462 (GRCm39) |
A182S |
possibly damaging |
Het |
| Aldh1l2 |
A |
T |
10: 83,358,649 (GRCm39) |
D2E |
probably benign |
Het |
| Bach2 |
G |
T |
4: 32,562,681 (GRCm39) |
D383Y |
probably damaging |
Het |
| Cd248 |
T |
C |
19: 5,120,237 (GRCm39) |
L695P |
probably damaging |
Het |
| Cela1 |
T |
A |
15: 100,580,861 (GRCm39) |
N132Y |
probably damaging |
Het |
| Cisd2 |
A |
T |
3: 135,114,601 (GRCm39) |
D123E |
probably damaging |
Het |
| Col6a6 |
T |
A |
9: 105,615,435 (GRCm39) |
D1571V |
probably damaging |
Het |
| Eif4a3l1 |
C |
G |
6: 136,306,555 (GRCm39) |
R339G |
probably damaging |
Het |
| Fbxo48 |
C |
T |
11: 16,904,280 (GRCm39) |
T144M |
probably damaging |
Het |
| Fbxo7 |
C |
A |
10: 85,883,890 (GRCm39) |
P497Q |
probably damaging |
Het |
| Garin5b |
T |
C |
7: 4,760,925 (GRCm39) |
I596V |
probably benign |
Het |
| Gm12695 |
T |
A |
4: 96,657,905 (GRCm39) |
H88L |
possibly damaging |
Het |
| Gpat4 |
A |
G |
8: 23,670,680 (GRCm39) |
I133T |
probably benign |
Het |
| Hmcn1 |
C |
T |
1: 150,485,576 (GRCm39) |
|
probably null |
Het |
| Ncaph |
T |
C |
2: 126,965,595 (GRCm39) |
T252A |
probably benign |
Het |
| Nebl |
G |
T |
2: 17,439,783 (GRCm39) |
Y163* |
probably null |
Het |
| Neurod4 |
C |
T |
10: 130,106,936 (GRCm39) |
V113I |
possibly damaging |
Het |
| Or13j1 |
A |
G |
4: 43,705,990 (GRCm39) |
S193P |
probably damaging |
Het |
| Or4f56 |
T |
A |
2: 111,703,907 (GRCm39) |
I98F |
probably benign |
Het |
| Pbxip1 |
T |
A |
3: 89,350,466 (GRCm39) |
M37K |
probably benign |
Het |
| Phactr2 |
T |
C |
10: 13,137,590 (GRCm39) |
N184S |
possibly damaging |
Het |
| Phf20l1 |
C |
T |
15: 66,487,634 (GRCm39) |
P480L |
possibly damaging |
Het |
| Psme4 |
T |
C |
11: 30,765,246 (GRCm39) |
S538P |
possibly damaging |
Het |
| Rassf1 |
T |
A |
9: 107,438,614 (GRCm39) |
M228K |
possibly damaging |
Het |
| Rpn2 |
A |
G |
2: 157,139,303 (GRCm39) |
D231G |
probably damaging |
Het |
| She |
A |
T |
3: 89,739,097 (GRCm39) |
D96V |
probably damaging |
Het |
| Shisal1 |
C |
A |
15: 84,290,711 (GRCm39) |
V199L |
probably benign |
Het |
| Tmem260 |
T |
A |
14: 48,749,627 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,562,702 (GRCm39) |
I28751F |
probably damaging |
Het |
| Zfp60 |
T |
G |
7: 27,447,940 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Or3a1d |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00937:Or3a1d
|
APN |
11 |
74,238,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01308:Or3a1d
|
APN |
11 |
74,237,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01596:Or3a1d
|
APN |
11 |
74,238,245 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02233:Or3a1d
|
APN |
11 |
74,238,254 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL03407:Or3a1d
|
APN |
11 |
74,238,371 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R0371:Or3a1d
|
UTSW |
11 |
74,237,760 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0924:Or3a1d
|
UTSW |
11 |
74,237,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0926:Or3a1d
|
UTSW |
11 |
74,238,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1265:Or3a1d
|
UTSW |
11 |
74,237,766 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3712:Or3a1d
|
UTSW |
11 |
74,238,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4446:Or3a1d
|
UTSW |
11 |
74,237,588 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4669:Or3a1d
|
UTSW |
11 |
74,237,789 (GRCm39) |
missense |
probably benign |
|
|
R4851:Or3a1d
|
UTSW |
11 |
74,237,769 (GRCm39) |
missense |
probably benign |
|
|
R4990:Or3a1d
|
UTSW |
11 |
74,238,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Or3a1d
|
UTSW |
11 |
74,238,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5130:Or3a1d
|
UTSW |
11 |
74,237,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5171:Or3a1d
|
UTSW |
11 |
74,237,640 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5240:Or3a1d
|
UTSW |
11 |
74,238,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5346:Or3a1d
|
UTSW |
11 |
74,237,496 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5723:Or3a1d
|
UTSW |
11 |
74,237,954 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6581:Or3a1d
|
UTSW |
11 |
74,238,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7561:Or3a1d
|
UTSW |
11 |
74,238,436 (GRCm39) |
intron |
probably benign |
|
|
R8881:Or3a1d
|
UTSW |
11 |
74,237,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9028:Or3a1d
|
UTSW |
11 |
74,237,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9763:Or3a1d
|
UTSW |
11 |
74,238,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Or3a1d
|
UTSW |
11 |
74,238,306 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACATCAGGGTTCCTAAGGC -3'
(R):5'- CACACTTAACTTCTGCGGCC -3'
Sequencing Primer
(F):5'- CACATCAGGGTTCCTAAGGCTGTAG -3'
(R):5'- GCGGCCCCAATGTGATCAATC -3'
|
| Posted On |
2016-10-05 |
Incidental Mutation