Incidental Mutation 'R5616:Mplkipl1'
| ID |
439557 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mplkipl1
|
| Ensembl Gene |
ENSMUSG00000094649 |
| Gene Name |
M-phase specific PLK1 intereacting protein like 1 |
| Synonyms |
Gm7102 |
| MMRRC Submission |
043159-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
R5616 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
61163124-61164747 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 61164364 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Arginine
at position 24
(G24R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137574
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000180168]
|
| AlphaFold |
J3QQ10 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000180168
AA Change: G24R
|
| SMART Domains |
Protein: ENSMUSP00000137574
Gene: ENSMUSG00000094649
AA Change: G24R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MPLKIP
|
31 |
170 |
8.9e-27 |
PFAM |
|
| Meta Mutation Damage Score |
0.1094 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcd3 |
A |
T |
3: 121,566,009 (GRCm39) |
D443E |
probably benign |
Het |
| Arhgef5 |
A |
G |
6: 43,252,874 (GRCm39) |
D1037G |
probably benign |
Het |
| B3glct |
T |
A |
5: 149,653,399 (GRCm39) |
L148* |
probably null |
Het |
| Cacna1e |
G |
A |
1: 154,317,940 (GRCm39) |
P1481S |
probably damaging |
Het |
| Cacna1h |
C |
A |
17: 25,596,641 (GRCm39) |
R117L |
probably damaging |
Het |
| Cct6b |
A |
T |
11: 82,632,175 (GRCm39) |
V271E |
probably damaging |
Het |
| Cenpf |
A |
G |
1: 189,389,483 (GRCm39) |
S1450P |
probably damaging |
Het |
| Cul1 |
G |
A |
6: 47,500,722 (GRCm39) |
R707H |
probably damaging |
Het |
| Dcakd |
A |
G |
11: 102,885,831 (GRCm39) |
L191P |
possibly damaging |
Het |
| Dhx32 |
T |
C |
7: 133,322,957 (GRCm39) |
*612W |
probably null |
Het |
| Disp1 |
T |
A |
1: 182,869,913 (GRCm39) |
T836S |
probably benign |
Het |
| Dppa4 |
T |
A |
16: 48,111,393 (GRCm39) |
V126D |
probably damaging |
Het |
| Fam98b |
A |
G |
2: 117,098,267 (GRCm39) |
T246A |
possibly damaging |
Het |
| Fkbp4 |
A |
T |
6: 128,410,517 (GRCm39) |
V273E |
probably damaging |
Het |
| Gpr31b |
A |
G |
17: 13,270,831 (GRCm39) |
Y113H |
probably damaging |
Het |
| Gpr33 |
T |
C |
12: 52,070,377 (GRCm39) |
I221V |
probably damaging |
Het |
| Klhl1 |
A |
G |
14: 96,755,729 (GRCm39) |
F9L |
probably benign |
Het |
| Larp4b |
T |
A |
13: 9,208,695 (GRCm39) |
N449K |
probably damaging |
Het |
| Loxhd1 |
T |
C |
18: 77,492,647 (GRCm39) |
S1363P |
probably damaging |
Het |
| Lrrc8a |
T |
C |
2: 30,145,366 (GRCm39) |
V60A |
probably benign |
Het |
| Matn3 |
A |
G |
12: 8,998,195 (GRCm39) |
H51R |
probably benign |
Het |
| Mtrf1 |
T |
C |
14: 79,638,885 (GRCm39) |
C6R |
possibly damaging |
Het |
| Myh6 |
T |
C |
14: 55,194,038 (GRCm39) |
S784G |
probably benign |
Het |
| Nfkb2 |
G |
T |
19: 46,296,006 (GRCm39) |
E170D |
probably benign |
Het |
| Nipal3 |
T |
C |
4: 135,179,715 (GRCm39) |
Y401C |
probably benign |
Het |
| Pcdhb20 |
A |
G |
18: 37,637,585 (GRCm39) |
E37G |
probably damaging |
Het |
| Pelp1 |
G |
A |
11: 70,285,688 (GRCm39) |
P727S |
possibly damaging |
Het |
| Prkca |
T |
C |
11: 107,869,169 (GRCm39) |
D472G |
possibly damaging |
Het |
| Ptprg |
A |
G |
14: 12,122,120 (GRCm38) |
H328R |
probably benign |
Het |
| Rtl1 |
C |
T |
12: 109,559,173 (GRCm39) |
E889K |
unknown |
Het |
| Rubcn |
T |
C |
16: 32,647,293 (GRCm39) |
D715G |
possibly damaging |
Het |
| Snurf |
C |
T |
7: 59,649,133 (GRCm39) |
E15K |
possibly damaging |
Het |
| Sptbn5 |
G |
A |
2: 119,876,965 (GRCm39) |
|
probably benign |
Het |
| Srp72 |
T |
G |
5: 77,135,781 (GRCm39) |
L237R |
probably damaging |
Het |
| Syne3 |
T |
C |
12: 104,921,937 (GRCm39) |
E406G |
probably damaging |
Het |
| Tgm2 |
A |
G |
2: 157,970,640 (GRCm39) |
S340P |
probably damaging |
Het |
| Trim41 |
GCCTAGGCGCCCA |
G |
11: 48,698,192 (GRCm39) |
|
probably benign |
Het |
| Tsc22d1 |
T |
C |
14: 76,653,657 (GRCm39) |
|
probably benign |
Het |
| Tsc22d2 |
G |
T |
3: 58,324,583 (GRCm39) |
|
probably benign |
Het |
| Vmn1r42 |
T |
C |
6: 89,822,084 (GRCm39) |
I162V |
possibly damaging |
Het |
| Vmn2r59 |
A |
G |
7: 41,708,191 (GRCm39) |
|
probably null |
Het |
| Wnt3 |
T |
C |
11: 103,703,596 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Mplkipl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01718:Mplkipl1
|
APN |
19 |
61,164,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02958:Mplkipl1
|
APN |
19 |
61,164,118 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0427:Mplkipl1
|
UTSW |
19 |
61,163,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1886:Mplkipl1
|
UTSW |
19 |
61,164,136 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4576:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4578:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4615:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4616:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4617:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4621:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4622:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4623:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4826:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4827:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4829:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4830:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4870:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4871:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R4951:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5112:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5301:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5317:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5335:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5397:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5399:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5591:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5592:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5594:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5884:Mplkipl1
|
UTSW |
19 |
61,164,364 (GRCm39) |
missense |
unknown |
|
|
R5919:Mplkipl1
|
UTSW |
19 |
61,163,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7003:Mplkipl1
|
UTSW |
19 |
61,164,319 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7112:Mplkipl1
|
UTSW |
19 |
61,163,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7266:Mplkipl1
|
UTSW |
19 |
61,163,973 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8489:Mplkipl1
|
UTSW |
19 |
61,164,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8979:Mplkipl1
|
UTSW |
19 |
61,164,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Mplkipl1
|
UTSW |
19 |
61,164,188 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGTAGCCGAACTGATGCTG -3'
(R):5'- CAGTTGATCGCTGAGGTTCG -3'
Sequencing Primer
(F):5'- AACTGATGCTGGGACCCC -3'
(R):5'- AGGTTCGGCAGTTGAGGC -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation