Incidental Mutation 'R5855:Lrrc27'
ID 454870
Institutional Source Beutler Lab
Gene Symbol Lrrc27
Ensembl Gene ENSMUSG00000015980
Gene Name leucine rich repeat containing 27
Synonyms 1700071K18Rik, 2310044E02Rik
MMRRC Submission 043229-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5855 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 139212988-139242979 bp(+) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 139218335 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116624 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016124] [ENSMUST00000106104] [ENSMUST00000135509] [ENSMUST00000156768]
AlphaFold Q80YS5
Predicted Effect silent
Transcript: ENSMUST00000016124
SMART Domains Protein: ENSMUSP00000016124
Gene: ENSMUSG00000015980

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
LRR_TYP 75 98 1.03e-2 SMART
LRR_TYP 99 122 3.69e-4 SMART
LRR 123 145 7.38e1 SMART
low complexity region 271 283 N/A INTRINSIC
coiled coil region 336 370 N/A INTRINSIC
coiled coil region 463 491 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000106104
SMART Domains Protein: ENSMUSP00000101710
Gene: ENSMUSG00000015980

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
LRR_TYP 75 98 1.03e-2 SMART
LRR_TYP 99 122 3.69e-4 SMART
LRR 123 145 7.38e1 SMART
low complexity region 271 283 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126199
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130248
Predicted Effect unknown
Transcript: ENSMUST00000135509
AA Change: S163P
SMART Domains Protein: ENSMUSP00000116827
Gene: ENSMUSG00000015980
AA Change: S163P

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156768
SMART Domains Protein: ENSMUSP00000116624
Gene: ENSMUSG00000015980

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
LRR_TYP 75 98 1.03e-2 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.8%
  • 20x: 89.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadsb T G 7: 131,424,599 (GRCm38) L57R probably damaging Het
Bmpr1b G A 3: 141,871,385 (GRCm38) T55M possibly damaging Het
Cep350 G A 1: 155,953,762 (GRCm38) T132I probably benign Het
Cops4 A T 5: 100,547,414 (GRCm38) M400L probably benign Het
Cul1 G A 6: 47,523,213 (GRCm38) D653N probably benign Het
Cyp3a13 C G 5: 137,919,056 (GRCm38) L36F probably damaging Het
Dcaf10 T C 4: 45,342,558 (GRCm38) F131L probably benign Het
Dgkh T C 14: 78,624,504 (GRCm38) probably null Het
Igll1 C T 16: 16,861,057 (GRCm38) V130M probably damaging Het
Kif2c C T 4: 117,182,542 (GRCm38) probably benign Het
Klra7 T C 6: 130,218,958 (GRCm38) D262G possibly damaging Het
Maf A G 8: 115,705,792 (GRCm38) S358P probably benign Het
Map1a A G 2: 121,303,674 (GRCm38) D1419G possibly damaging Het
Map3k1 G A 13: 111,755,979 (GRCm38) A914V probably benign Het
Naa25 T G 5: 121,423,692 (GRCm38) L436R possibly damaging Het
Ndc1 T C 4: 107,383,707 (GRCm38) I294T probably damaging Het
Nek1 A C 8: 61,016,272 (GRCm38) D121A probably damaging Het
Nfil3 C T 13: 52,968,710 (GRCm38) G53R probably benign Het
Olfr63 T C 17: 33,269,336 (GRCm38) V204A possibly damaging Het
Parp14 A T 16: 35,840,927 (GRCm38) Y1550* probably null Het
Patl1 A G 19: 11,921,516 (GRCm38) I192V probably damaging Het
Pax3 G A 1: 78,121,651 (GRCm38) T367I probably damaging Het
Pla2g4a C T 1: 149,880,063 (GRCm38) V208M probably damaging Het
Prdm10 A T 9: 31,337,323 (GRCm38) K347M probably damaging Het
Prkd1 A T 12: 50,392,916 (GRCm38) M376K probably benign Het
Prkg1 C T 19: 30,894,694 (GRCm38) V219I possibly damaging Het
Rictor G A 15: 6,794,006 (GRCm38) E1555K probably benign Het
Scn3a T C 2: 65,464,730 (GRCm38) I1550V possibly damaging Het
Skint8 C A 4: 111,950,193 (GRCm38) L359M probably damaging Het
Sox4 T C 13: 28,952,996 (GRCm38) E9G probably damaging Het
Spon1 T A 7: 114,029,072 (GRCm38) D354E probably damaging Het
Stat2 T A 10: 128,283,494 (GRCm38) L450H probably damaging Het
Tek T A 4: 94,853,553 (GRCm38) M849K probably damaging Het
Tmem63c G A 12: 87,075,726 (GRCm38) D433N probably damaging Het
Tnpo3 G A 6: 29,589,033 (GRCm38) T106I probably damaging Het
Tns1 G T 1: 73,918,033 (GRCm38) A1674D possibly damaging Het
Trim8 T C 19: 46,515,410 (GRCm38) V467A possibly damaging Het
Trmo T A 4: 46,382,568 (GRCm38) H183L probably benign Het
Trpm1 C A 7: 64,268,962 (GRCm38) C683* probably null Het
Vsig10 T G 5: 117,338,270 (GRCm38) L263R probably damaging Het
Zfp874a A T 13: 67,442,693 (GRCm38) Y291N probably benign Het
Other mutations in Lrrc27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01668:Lrrc27 APN 7 139,227,911 (GRCm38) intron probably benign
IGL02095:Lrrc27 APN 7 139,230,253 (GRCm38) missense probably benign 0.04
IGL02489:Lrrc27 APN 7 139,226,061 (GRCm38) missense probably benign 0.01
IGL03080:Lrrc27 APN 7 139,230,237 (GRCm38) missense probably benign 0.03
R0372:Lrrc27 UTSW 7 139,226,187 (GRCm38) missense probably benign 0.17
R1466:Lrrc27 UTSW 7 139,230,308 (GRCm38) unclassified probably benign
R2401:Lrrc27 UTSW 7 139,223,613 (GRCm38) missense probably damaging 1.00
R2876:Lrrc27 UTSW 7 139,228,684 (GRCm38) intron probably benign
R3113:Lrrc27 UTSW 7 139,218,307 (GRCm38) missense probably damaging 1.00
R4214:Lrrc27 UTSW 7 139,223,693 (GRCm38) missense probably damaging 1.00
R4707:Lrrc27 UTSW 7 139,242,698 (GRCm38) missense probably benign 0.02
R4784:Lrrc27 UTSW 7 139,242,698 (GRCm38) missense probably benign 0.02
R5070:Lrrc27 UTSW 7 139,214,799 (GRCm38) missense probably damaging 0.99
R6408:Lrrc27 UTSW 7 139,218,268 (GRCm38) missense probably benign 0.14
R6993:Lrrc27 UTSW 7 139,242,624 (GRCm38) missense probably damaging 0.99
R7332:Lrrc27 UTSW 7 139,242,745 (GRCm38) missense probably damaging 1.00
R7350:Lrrc27 UTSW 7 139,226,106 (GRCm38) missense probably benign 0.01
R7460:Lrrc27 UTSW 7 139,223,658 (GRCm38) missense probably damaging 1.00
R7502:Lrrc27 UTSW 7 139,214,832 (GRCm38) missense probably benign
R8020:Lrrc27 UTSW 7 139,236,877 (GRCm38) missense probably damaging 1.00
R8071:Lrrc27 UTSW 7 139,236,986 (GRCm38) missense probably benign 0.01
R8518:Lrrc27 UTSW 7 139,228,774 (GRCm38) missense probably benign 0.01
R8728:Lrrc27 UTSW 7 139,242,639 (GRCm38) missense probably damaging 1.00
R8734:Lrrc27 UTSW 7 139,216,599 (GRCm38) unclassified probably benign
R9141:Lrrc27 UTSW 7 139,227,945 (GRCm38) missense probably benign 0.03
R9355:Lrrc27 UTSW 7 139,242,732 (GRCm38) missense probably damaging 0.98
R9387:Lrrc27 UTSW 7 139,227,921 (GRCm38) nonsense probably null
R9627:Lrrc27 UTSW 7 139,228,666 (GRCm38) intron probably benign
R9742:Lrrc27 UTSW 7 139,226,313 (GRCm38) missense probably benign 0.39
R9779:Lrrc27 UTSW 7 139,236,970 (GRCm38) missense possibly damaging 0.95
R9800:Lrrc27 UTSW 7 139,227,997 (GRCm38) missense probably benign 0.16
RF018:Lrrc27 UTSW 7 139,226,100 (GRCm38) missense probably benign 0.03
X0065:Lrrc27 UTSW 7 139,230,246 (GRCm38) missense probably benign 0.00
X0065:Lrrc27 UTSW 7 139,230,245 (GRCm38) missense probably benign 0.00
Z1176:Lrrc27 UTSW 7 139,242,720 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTGAGTGTAGCCAGAGAG -3'
(R):5'- CTGCACTTTGAACCATCTGGAC -3'

Sequencing Primer
(F):5'- AATCTCTCTGGTTCTTGAGTCCG -3'
(R):5'- GGACTTTTTAATTCTGAGACGGCAAC -3'
Posted On 2017-02-10