Incidental Mutation 'R7767:Dennd3'
| ID |
598337 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd3
|
| Ensembl Gene |
ENSMUSG00000036661 |
| Gene Name |
DENN domain containing 3 |
| Synonyms |
E030003N15Rik |
| MMRRC Submission |
045823-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.189)
|
| Stock # |
R7767 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
73384409-73444091 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 73394079 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 35
(I35V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000046774
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043414]
[ENSMUST00000173292]
|
| AlphaFold |
A2RT67 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043414
AA Change: I35V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: I35V
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:uDENN
|
12 |
161 |
3e-78 |
BLAST |
|
DENN
|
187 |
373 |
1.54e-62 |
SMART |
|
dDENN
|
436 |
499 |
6.81e-14 |
SMART |
|
WD40
|
1015 |
1054 |
3.68e1 |
SMART |
|
WD40
|
1057 |
1098 |
3.32e-5 |
SMART |
|
WD40
|
1232 |
1272 |
1.1e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173292
AA Change: I35V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: I35V
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:uDENN
|
12 |
161 |
2e-78 |
BLAST |
|
DENN
|
187 |
373 |
1.54e-62 |
SMART |
|
dDENN
|
436 |
499 |
6.81e-14 |
SMART |
|
WD40
|
1015 |
1054 |
3.68e1 |
SMART |
|
WD40
|
1057 |
1098 |
3.32e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aox4 |
C |
A |
1: 58,274,366 (GRCm39) |
S384Y |
probably damaging |
Het |
| Arhgef15 |
T |
C |
11: 68,844,673 (GRCm39) |
E308G |
probably damaging |
Het |
| Asb15 |
A |
G |
6: 24,559,281 (GRCm39) |
D142G |
probably benign |
Het |
| Atg13 |
A |
G |
2: 91,509,711 (GRCm39) |
S394P |
probably damaging |
Het |
| Atp10a |
G |
C |
7: 58,308,597 (GRCm39) |
W132S |
probably damaging |
Het |
| Bltp1 |
G |
T |
3: 36,974,436 (GRCm39) |
|
probably null |
Het |
| Bod1l |
T |
A |
5: 41,974,099 (GRCm39) |
N2405I |
probably benign |
Het |
| Capsl |
C |
T |
15: 9,462,770 (GRCm39) |
R137C |
probably damaging |
Het |
| Cd109 |
T |
A |
9: 78,617,441 (GRCm39) |
M1313K |
probably damaging |
Het |
| Chst13 |
G |
A |
6: 90,286,566 (GRCm39) |
A132V |
possibly damaging |
Het |
| Cobl |
T |
C |
11: 12,362,117 (GRCm39) |
|
probably benign |
Het |
| Coq9 |
A |
T |
8: 95,577,214 (GRCm39) |
E193V |
probably benign |
Het |
| Cpd |
T |
A |
11: 76,704,385 (GRCm39) |
I410F |
probably benign |
Het |
| Cyth3 |
T |
G |
5: 143,693,229 (GRCm39) |
V351G |
probably damaging |
Het |
| Dcdc2c |
T |
C |
12: 28,520,256 (GRCm39) |
K607E |
|
Het |
| Dcp1a |
T |
C |
14: 30,201,775 (GRCm39) |
|
probably null |
Het |
| Dlgap4 |
C |
T |
2: 156,587,973 (GRCm39) |
R606W |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,343,817 (GRCm39) |
I1720M |
probably benign |
Het |
| Erbin |
A |
G |
13: 103,995,907 (GRCm39) |
L265P |
probably damaging |
Het |
| Ern1 |
T |
C |
11: 106,291,134 (GRCm39) |
D847G |
probably damaging |
Het |
| Esyt3 |
T |
G |
9: 99,207,024 (GRCm39) |
S342R |
probably benign |
Het |
| Exoc2 |
A |
T |
13: 31,060,752 (GRCm39) |
I584K |
probably benign |
Het |
| Fam240a |
T |
C |
9: 110,744,090 (GRCm39) |
R50G |
probably damaging |
Het |
| Glis3 |
A |
T |
19: 28,241,360 (GRCm39) |
M858K |
probably benign |
Het |
| Gls2 |
C |
T |
10: 128,030,998 (GRCm39) |
R86C |
unknown |
Het |
| Gm10972 |
C |
A |
3: 94,550,901 (GRCm39) |
Y25* |
probably null |
Het |
| H2-T10 |
A |
T |
17: 36,428,622 (GRCm39) |
M350K |
probably benign |
Het |
| Has1 |
A |
T |
17: 18,070,792 (GRCm39) |
V43D |
probably damaging |
Het |
| Herc2 |
T |
A |
7: 55,878,275 (GRCm39) |
S4609R |
probably benign |
Het |
| Hmgcs2 |
A |
C |
3: 98,198,582 (GRCm39) |
T162P |
probably damaging |
Het |
| Hspg2 |
G |
T |
4: 137,239,177 (GRCm39) |
C368F |
probably damaging |
Het |
| Ighv11-1 |
A |
G |
12: 113,945,722 (GRCm39) |
S44P |
probably damaging |
Het |
| Inppl1 |
A |
G |
7: 101,473,545 (GRCm39) |
V1035A |
probably benign |
Het |
| Kmt2a |
C |
T |
9: 44,730,295 (GRCm39) |
V3341I |
unknown |
Het |
| Lrp1b |
T |
C |
2: 40,691,517 (GRCm39) |
N3434S |
|
Het |
| Lrriq1 |
G |
C |
10: 103,051,815 (GRCm39) |
S312R |
probably damaging |
Het |
| Map1a |
G |
A |
2: 121,132,517 (GRCm39) |
S1111N |
probably damaging |
Het |
| Myo15a |
T |
C |
11: 60,392,922 (GRCm39) |
V1029A |
|
Het |
| Nol11 |
T |
C |
11: 107,069,908 (GRCm39) |
H314R |
possibly damaging |
Het |
| Nphs1 |
A |
T |
7: 30,162,733 (GRCm39) |
D404V |
probably damaging |
Het |
| Odr4 |
A |
G |
1: 150,247,788 (GRCm39) |
V387A |
probably benign |
Het |
| Or51r1 |
A |
T |
7: 102,220,971 (GRCm39) |
|
probably benign |
Het |
| Pabpc2 |
T |
C |
18: 39,907,607 (GRCm39) |
Y291H |
possibly damaging |
Het |
| Pcdh15 |
G |
A |
10: 74,322,088 (GRCm39) |
A1020T |
probably benign |
Het |
| Pla2g4f |
A |
C |
2: 120,135,490 (GRCm39) |
S395A |
possibly damaging |
Het |
| Ppp1r18 |
A |
G |
17: 36,178,176 (GRCm39) |
Q17R |
probably damaging |
Het |
| Prokr2 |
A |
T |
2: 132,215,996 (GRCm39) |
V155D |
probably damaging |
Het |
| Pwwp2a |
T |
G |
11: 43,596,696 (GRCm39) |
C620W |
probably damaging |
Het |
| Rabepk |
T |
C |
2: 34,675,605 (GRCm39) |
D175G |
probably damaging |
Het |
| Rad54l |
T |
C |
4: 115,956,866 (GRCm39) |
Y485C |
probably damaging |
Het |
| Rasef |
A |
G |
4: 73,652,771 (GRCm39) |
S577P |
probably damaging |
Het |
| Rgma |
C |
A |
7: 73,067,752 (GRCm39) |
L446I |
unknown |
Het |
| Rnf212b |
T |
C |
14: 55,079,825 (GRCm39) |
S182P |
probably damaging |
Het |
| Rnf6 |
C |
A |
5: 146,147,986 (GRCm39) |
R344I |
probably damaging |
Het |
| Rnf6 |
T |
A |
5: 146,147,987 (GRCm39) |
R344* |
probably null |
Het |
| Sgo1 |
A |
G |
17: 53,986,639 (GRCm39) |
I184T |
possibly damaging |
Het |
| Sgpl1 |
A |
T |
10: 60,953,502 (GRCm39) |
I78N |
possibly damaging |
Het |
| Snx13 |
T |
A |
12: 35,157,483 (GRCm39) |
Y510N |
probably damaging |
Het |
| Sptbn2 |
G |
A |
19: 4,784,171 (GRCm39) |
E638K |
possibly damaging |
Het |
| Sspo |
A |
G |
6: 48,428,316 (GRCm39) |
T349A |
probably damaging |
Het |
| Sv2c |
C |
T |
13: 96,126,223 (GRCm39) |
S343N |
probably damaging |
Het |
| Syne1 |
C |
A |
10: 5,283,560 (GRCm39) |
V1502F |
possibly damaging |
Het |
| Syne1 |
T |
A |
10: 5,283,632 (GRCm39) |
I1478F |
possibly damaging |
Het |
| Tmem121 |
C |
T |
12: 113,151,992 (GRCm39) |
A70V |
probably damaging |
Het |
| Tmem215 |
A |
G |
4: 40,474,042 (GRCm39) |
I40V |
possibly damaging |
Het |
| Trim25 |
A |
G |
11: 88,899,943 (GRCm39) |
|
probably null |
Het |
| Trio |
A |
G |
15: 27,889,504 (GRCm39) |
V534A |
unknown |
Het |
| Tyr |
T |
A |
7: 87,142,218 (GRCm39) |
E114V |
probably benign |
Het |
| Ush2a |
A |
T |
1: 188,285,457 (GRCm39) |
T1998S |
probably benign |
Het |
| Usp40 |
G |
T |
1: 87,909,900 (GRCm39) |
A518E |
probably benign |
Het |
| Usp48 |
T |
A |
4: 137,331,956 (GRCm39) |
|
probably null |
Het |
| Vash1 |
T |
A |
12: 86,733,767 (GRCm39) |
F152L |
probably damaging |
Het |
| Vsig10l |
C |
A |
7: 43,113,141 (GRCm39) |
P31Q |
probably damaging |
Het |
| Xab2 |
C |
T |
8: 3,669,018 (GRCm39) |
E43K |
probably benign |
Het |
| Zfp423 |
G |
A |
8: 88,507,512 (GRCm39) |
S944F |
probably damaging |
Het |
| Zp2 |
A |
T |
7: 119,736,392 (GRCm39) |
D350E |
probably benign |
Het |
| Zscan4e |
T |
G |
7: 11,041,461 (GRCm39) |
Q165P |
probably damaging |
Het |
|
| Other mutations in Dennd3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dennd3
|
APN |
15 |
73,438,982 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL00579:Dennd3
|
APN |
15 |
73,412,691 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL02101:Dennd3
|
APN |
15 |
73,399,794 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02164:Dennd3
|
APN |
15 |
73,416,297 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02389:Dennd3
|
APN |
15 |
73,438,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Dennd3
|
APN |
15 |
73,428,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Dennd3
|
APN |
15 |
73,396,085 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02885:Dennd3
|
APN |
15 |
73,440,545 (GRCm39) |
missense |
probably benign |
|
|
IGL03356:Dennd3
|
APN |
15 |
73,440,482 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03388:Dennd3
|
APN |
15 |
73,416,208 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB006:Dennd3
|
UTSW |
15 |
73,436,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB016:Dennd3
|
UTSW |
15 |
73,436,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0118:Dennd3
|
UTSW |
15 |
73,436,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0925:Dennd3
|
UTSW |
15 |
73,405,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1076:Dennd3
|
UTSW |
15 |
73,412,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1355:Dennd3
|
UTSW |
15 |
73,412,703 (GRCm39) |
splice site |
probably benign |
|
|
R1370:Dennd3
|
UTSW |
15 |
73,412,703 (GRCm39) |
splice site |
probably benign |
|
|
R1480:Dennd3
|
UTSW |
15 |
73,404,695 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1727:Dennd3
|
UTSW |
15 |
73,436,977 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1732:Dennd3
|
UTSW |
15 |
73,409,267 (GRCm39) |
splice site |
probably benign |
|
|
R1771:Dennd3
|
UTSW |
15 |
73,426,950 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1776:Dennd3
|
UTSW |
15 |
73,426,950 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1779:Dennd3
|
UTSW |
15 |
73,394,357 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1838:Dennd3
|
UTSW |
15 |
73,436,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2146:Dennd3
|
UTSW |
15 |
73,426,909 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2146:Dennd3
|
UTSW |
15 |
73,395,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2147:Dennd3
|
UTSW |
15 |
73,395,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Dennd3
|
UTSW |
15 |
73,426,909 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2149:Dennd3
|
UTSW |
15 |
73,426,909 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2150:Dennd3
|
UTSW |
15 |
73,426,909 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2174:Dennd3
|
UTSW |
15 |
73,427,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2295:Dennd3
|
UTSW |
15 |
73,395,404 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2905:Dennd3
|
UTSW |
15 |
73,429,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3106:Dennd3
|
UTSW |
15 |
73,436,973 (GRCm39) |
nonsense |
probably null |
|
|
R3757:Dennd3
|
UTSW |
15 |
73,394,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3785:Dennd3
|
UTSW |
15 |
73,419,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3786:Dennd3
|
UTSW |
15 |
73,419,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3787:Dennd3
|
UTSW |
15 |
73,419,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3847:Dennd3
|
UTSW |
15 |
73,414,581 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4369:Dennd3
|
UTSW |
15 |
73,412,658 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4601:Dennd3
|
UTSW |
15 |
73,439,009 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4666:Dennd3
|
UTSW |
15 |
73,442,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4680:Dennd3
|
UTSW |
15 |
73,405,225 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4708:Dennd3
|
UTSW |
15 |
73,395,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4789:Dennd3
|
UTSW |
15 |
73,394,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Dennd3
|
UTSW |
15 |
73,412,574 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5043:Dennd3
|
UTSW |
15 |
73,399,785 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5074:Dennd3
|
UTSW |
15 |
73,419,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5410:Dennd3
|
UTSW |
15 |
73,419,297 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5421:Dennd3
|
UTSW |
15 |
73,438,964 (GRCm39) |
missense |
probably benign |
|
|
R5560:Dennd3
|
UTSW |
15 |
73,404,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6008:Dennd3
|
UTSW |
15 |
73,438,929 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6357:Dennd3
|
UTSW |
15 |
73,428,321 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6563:Dennd3
|
UTSW |
15 |
73,416,229 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6687:Dennd3
|
UTSW |
15 |
73,428,215 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6837:Dennd3
|
UTSW |
15 |
73,429,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6910:Dennd3
|
UTSW |
15 |
73,426,965 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7125:Dennd3
|
UTSW |
15 |
73,405,140 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7297:Dennd3
|
UTSW |
15 |
73,429,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Dennd3
|
UTSW |
15 |
73,396,095 (GRCm39) |
nonsense |
probably null |
|
|
R7580:Dennd3
|
UTSW |
15 |
73,428,296 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7653:Dennd3
|
UTSW |
15 |
73,434,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7731:Dennd3
|
UTSW |
15 |
73,434,216 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7806:Dennd3
|
UTSW |
15 |
73,442,624 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7860:Dennd3
|
UTSW |
15 |
73,412,657 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7902:Dennd3
|
UTSW |
15 |
73,439,964 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R7929:Dennd3
|
UTSW |
15 |
73,436,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Dennd3
|
UTSW |
15 |
73,384,622 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8436:Dennd3
|
UTSW |
15 |
73,434,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8444:Dennd3
|
UTSW |
15 |
73,442,672 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8698:Dennd3
|
UTSW |
15 |
73,394,154 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8967:Dennd3
|
UTSW |
15 |
73,419,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9147:Dennd3
|
UTSW |
15 |
73,429,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9148:Dennd3
|
UTSW |
15 |
73,429,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9194:Dennd3
|
UTSW |
15 |
73,419,153 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9449:Dennd3
|
UTSW |
15 |
73,429,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9501:Dennd3
|
UTSW |
15 |
73,419,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9616:Dennd3
|
UTSW |
15 |
73,440,563 (GRCm39) |
missense |
probably benign |
|
|
R9730:Dennd3
|
UTSW |
15 |
73,426,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF006:Dennd3
|
UTSW |
15 |
73,419,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTTTAGCTCTGTTCACATGTATG -3'
(R):5'- TGACATCTTCAGAATCGGGC -3'
Sequencing Primer
(F):5'- CGTGTACATGCGCACATATG -3'
(R):5'- TTCAGAATCGGGCCCCTTG -3'
|
| Posted On |
2019-11-26 |
Incidental Mutation