|Institutional Source||Beutler Lab|
|Gene Name||meningioma 1|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||RF027 (G1)|
|Chromosomal Location||111417362-111457033 bp(+) (GRCm38)|
|Type of Mutation||small insertion (1 aa in frame mutation)|
|DNA Base Change (assembly)||CAG to CAGAAG at 111419705 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000092034 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000094463]|
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice die shortly after birth due to cleft palate. Development of several bones in the skull was abnormal with completely absent alisphenoid, squamosal, and vomer bones, hypoplastic basisphenoid, pterygoid, and presphenoid bones, and thinfrontal, parietal, and interparietal bones. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mn1||
(F):5'- TTTTGACTTTCCGGGCAGC -3'
(R):5'- AAAGTTCGTCTGGGCCAAG -3'
(F):5'- GCAGCATGCATAACGGTA -3'
(R):5'- AACCTCCGTGGACCAGG -3'