Mutagenetix > Incidental Mutation

Incidental Mutation 'R7902:Zfp937'

610030

Institutional Source

Beutler Lab

Gene Symbol

Zfp937

Ensembl Gene

ENSMUSG00000060336

Gene Name

zinc finger protein 937

Synonyms

Gm4979

MMRRC Submission

045954-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R7902 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

150059993-150082645 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 150080681 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 237 (H237L)

Ref Sequence

ENSEMBL: ENSMUSP00000073454 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073782]

AlphaFold

A2ANU7

Predicted Effect

probably damaging
Transcript: ENSMUST00000073782
AA Change: H237L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: H237L

Domain	Start	End	E-Value	Type
KRAB	4	66	8.19e-20	SMART
ZnF_C2H2	103	125	1.28e-3	SMART
ZnF_C2H2	131	153	2.53e-2	SMART
ZnF_C2H2	159	181	9.58e-3	SMART
ZnF_C2H2	187	209	2.09e-3	SMART
ZnF_C2H2	215	237	2.2e-2	SMART
ZnF_C2H2	243	265	2.2e-2	SMART
ZnF_C2H2	271	293	2.2e-2	SMART
ZnF_C2H2	299	321	1.82e-3	SMART
ZnF_C2H2	327	349	3.69e-4	SMART
ZnF_C2H2	355	377	4.47e-3	SMART
ZnF_C2H2	383	405	3.89e-3	SMART
ZnF_C2H2	411	433	4.79e-3	SMART
ZnF_C2H2	439	461	8.47e-4	SMART
ZnF_C2H2	467	490	7.26e-3	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

97% (34/35)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A530084C06Rik	G	T	13: 31,742,978 (GRCm39)	R92S	unknown	Het
Adamts14	T	C	10: 61,041,176 (GRCm39)	S842G	possibly damaging	Het
C1ra	G	A	6: 124,494,684 (GRCm39)	E316K	probably benign	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,128,173 (GRCm39)		probably benign	Het
Ccdc7a	A	G	8: 129,562,654 (GRCm39)	I1108T	possibly damaging	Het
Col12a1	T	A	9: 79,548,863 (GRCm39)	M2161L	probably benign	Het
Col14a1	T	C	15: 55,364,832 (GRCm39)	I1647T	probably benign	Het
Defb26	A	T	2: 152,350,156 (GRCm39)	C41*	probably null	Het
Dennd3	T	G	15: 73,439,964 (GRCm39)		probably benign	Het
Edem1	C	T	6: 108,831,338 (GRCm39)	R600W	possibly damaging	Het
F13a1	C	A	13: 37,172,913 (GRCm39)	G156W	probably damaging	Het
Foxk2	A	G	11: 121,190,553 (GRCm39)	T565A	probably benign	Het
Fsip2	A	T	2: 82,808,168 (GRCm39)	I1496F	possibly damaging	Het
Fyb1	T	C	15: 6,690,197 (GRCm39)		probably null	Het
Gapdhs	T	C	7: 30,436,146 (GRCm39)	Y148C	probably damaging	Het
H1f3	T	C	13: 23,739,505 (GRCm39)	I81T	probably damaging	Het
Hddc2	A	T	10: 31,192,289 (GRCm39)	R64S	probably damaging	Het
Hddc2	T	A	10: 31,196,338 (GRCm39)		probably null	Het
Klk10	T	A	7: 43,432,942 (GRCm39)	S113T	probably benign	Het
Lin7a	T	C	10: 107,159,843 (GRCm39)	S52P	possibly damaging	Het
Nbeal1	A	T	1: 60,331,029 (GRCm39)	I2213L	probably damaging	Het
Nbeal2	T	C	9: 110,466,615 (GRCm39)	T763A	probably benign	Het
Nlrp4a	T	A	7: 26,149,482 (GRCm39)	I363N	possibly damaging	Het
Oat	C	T	7: 132,161,393 (GRCm39)	V381I	probably benign	Het
Or52n2c	A	G	7: 104,574,557 (GRCm39)	L138P	probably damaging	Het
Plpp2	A	T	10: 79,363,378 (GRCm39)	I207N	possibly damaging	Het
Rps6ka4	T	C	19: 6,808,679 (GRCm39)	E522G	possibly damaging	Het
Sars2	T	C	7: 28,441,628 (GRCm39)	V63A	probably benign	Het
Sgf29	C	T	7: 126,271,350 (GRCm39)	R209C	probably damaging	Het
Sptbn1	G	A	11: 30,086,048 (GRCm39)	A1220V	probably damaging	Het
Taf4	G	A	2: 179,573,822 (GRCm39)	T682M	probably damaging	Het
Tnrc18	T	C	5: 142,757,902 (GRCm39)	E1055G		Het
Vmn1r158	A	T	7: 22,489,433 (GRCm39)	C259S	possibly damaging	Het
Vmn2r120	T	G	17: 57,816,244 (GRCm39)	I704L	possibly damaging	Het
Vwa8	A	G	14: 79,329,731 (GRCm39)	S1188G	probably benign	Het
Zfp12	A	G	5: 143,231,535 (GRCm39)	K653E	probably damaging	Het
Zfp933	T	A	4: 147,911,058 (GRCm39)	R179S	probably damaging	Het
Zkscan5	A	C	5: 145,157,676 (GRCm39)	H726P	probably damaging	Het

Other mutations in Zfp937

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0350:Zfp937	UTSW	2	150,081,222 (GRCm39)	missense	possibly damaging	0.91
R0449:Zfp937	UTSW	2	150,081,466 (GRCm39)	missense	probably benign	0.13
R1403:Zfp937	UTSW	2	150,080,868 (GRCm39)	nonsense	probably null
R1403:Zfp937	UTSW	2	150,080,868 (GRCm39)	nonsense	probably null
R1465:Zfp937	UTSW	2	150,080,967 (GRCm39)	nonsense	probably null
R1465:Zfp937	UTSW	2	150,080,967 (GRCm39)	nonsense	probably null
R4510:Zfp937	UTSW	2	150,080,431 (GRCm39)	missense	probably damaging	0.98
R4511:Zfp937	UTSW	2	150,080,431 (GRCm39)	missense	probably damaging	0.98
R4689:Zfp937	UTSW	2	150,078,706 (GRCm39)	missense	probably damaging	1.00
R5290:Zfp937	UTSW	2	150,080,229 (GRCm39)	nonsense	probably null
R6287:Zfp937	UTSW	2	150,080,261 (GRCm39)	missense	possibly damaging	0.89
R6701:Zfp937	UTSW	2	150,081,136 (GRCm39)	missense	probably damaging	1.00
R6746:Zfp937	UTSW	2	150,081,343 (GRCm39)	nonsense	probably null
R6838:Zfp937	UTSW	2	150,081,266 (GRCm39)	missense	probably benign	0.01
R7162:Zfp937	UTSW	2	150,081,439 (GRCm39)	missense	probably benign	0.35
R7213:Zfp937	UTSW	2	150,081,385 (GRCm39)	missense	probably damaging	1.00
R7441:Zfp937	UTSW	2	150,080,630 (GRCm39)	frame shift	probably null
R7481:Zfp937	UTSW	2	150,081,266 (GRCm39)	missense	probably benign	0.01
R7694:Zfp937	UTSW	2	150,081,268 (GRCm39)	missense	probably damaging	1.00
R7856:Zfp937	UTSW	2	150,081,467 (GRCm39)	missense	probably benign	0.23
R7956:Zfp937	UTSW	2	150,081,076 (GRCm39)	missense	probably benign	0.03
R8058:Zfp937	UTSW	2	150,081,421 (GRCm39)	missense	probably benign	0.00
R8468:Zfp937	UTSW	2	150,080,634 (GRCm39)	missense	probably benign	0.02
R9514:Zfp937	UTSW	2	150,080,890 (GRCm39)	missense	possibly damaging	0.95
R9617:Zfp937	UTSW	2	150,080,452 (GRCm39)	missense	probably damaging	1.00
X0017:Zfp937	UTSW	2	150,060,081 (GRCm39)	splice site	probably null

Predicted Primers

PCR Primer
(F):5'- AGTGGTCTCCAACAGCATAAAAGAA -3'
(R):5'- TTGCAGACCACTTTGAAACCC -3'

Sequencing Primer
(F):5'- CTGTCATCTTCGAGGGCATCAAAG -3'
(R):5'- TACCACACTGCTTACATTCATAGGG -3'

Posted On

2019-12-20