|Institutional Source||Beutler Lab|
|Gene Name||ATP-binding cassette, sub-family C (CFTR/MRP), member 4|
|Synonyms||MRP4, D630049P08Rik, MOAT-B|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8044 (G1)|
|Chromosomal Location||118482692-118706219 bp(-) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||ACCAGCCC to ACC at 118615270 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000042186 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000036554] [ENSMUST00000166646]|
|Coding Region Coverage||
|Validation Efficiency||100% (36/36)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcc4||
(F):5'- GAGTATCATGACTTAGAGAACGCC -3'
(R):5'- AGCTGCAGCATCTAGTGACC -3'
(F):5'- AAGGCGGGCGTTTACAC -3'
(R):5'- GCAGCATCTAGTGACCTTTTATATG -3'